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Pathophysiological Processes: Coronary Artery Disease

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Pathophysiological Processes: Coronary Artery Disease
Andriy Melnychenko
Chamberlain College of Nursing
NR 283: Pathophysiology
June 9, 2018

Pathophysiological Processes: Coronary Artery Disease Coronary artery disease (CAD), also known as coronary heart disease (CHD), is the most common type of heart disease and is the leading cause of mortality in the United States. CAD is responsible for around one – third of all deaths (Chen, M. A. 2015). CAD causes the coronary arteries to narrow and harden. Coronary arteries are the blood vessels of the heart. They are responsible for oxygenation of the heart and supplying it with blood. The biggest blood vessels of the heart are the right and left coronary arteries.
Atherosclerosis, a plaque that forms fat deposits …show more content…
It is characterized by a focal accumulation of lipids and cholesterol on the endothelium. The process of formation of the plaque is the result of interaction between the components of blood and parts forming the vascular wall. Intimal wall injury and inflammation play a crucial role in the progression of atherosclerosis.
Not damaged or impaired endothelium is more than a simple barrier between the vessel wall and the lumen of the vessel. Under normal conditions, it is nonreactive to platelets and leukocytes. It also does not respond to coagulation, fibrinolytic, and complement factors. However, the internal wall of the arteries can be damaged. Many factors like high blood cholesterol, hypertension, diabetes, obesity, smoking, age, stress, gender, family history, unhealthy diet, lack of physical activity, etc., contribute to CAD. Some other factors that may contribute include:
• Diabetes mellitus: high blood sugar level can lead to increased plaque buildup in your arteries. Approximately 46% of individuals with diabetes mellitus are at a high-risk category (Bravo, P. E., Psaty, B. M., Di Carli, M. F., & Branch, K. R.

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