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Pernicious Anemia Research Paper

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Thomas Addison was the first person to discover Pernicious Anemia in 1849. Addison also discovered Addison’s Disease which at the time of his discovery he believed pernicious anemia was a cause of or a was directly related to Addison’s disease which was later discovered that it was not the same. Pernicious anemia was first called Addison’s anemia. Addison was not the only person responsible for the research and treatment of individuals whom presented symptoms that indicated pernicious anemia. A noble peace prize in Physiology and Medicine was given to George H. Whipple, George R. Minot and William P. Murphy in 1934 for their study. Whipple was the first person to associate that a patient with a diet lacking in a sufficient amount of vitamin …show more content…
These tests include a CBC-complete blood count, a reticulocyte test, serum iron, total iron binding capacity, and folate. CBC results would reveal a MCV value >100 fL, the MCH value would be >31pg, and the MCHC would be normal, which fall in the range of 32-36 g/dL. Both the MCV and MCH are above the normal ranges. This would indicate a macrocytic/normochromic anemia. On a peripheral smear, the red blood cells will appear larger than usual, this is dedicated by the high MCV report which is called macrocytic and the MCHC is within a normal range which is called normochromic. Pernicious anemia falls under a type of Megaloblastic anemia. This anemia is categorized as a megaloblastic anemia because of the abnormal red blood cells that are produced from a lack of vitamin b12 which then results in the bone marrow releasing larger red blood cells that are not as mature. A peripheral smear would also show abnormal red blood cells called dacryocytes. These cells have an appearance of a tear drop or pear shape. As for the other CBC factors that will be abnormal, a decreased absorption of iron will result in a low hemoglobin level and the level of white blood cells and the number of platelets can also be decreased. Other blood results that will be affected by pernicious anemia are folic acid level, vitamin b12 level will both be decreased as well as an increase in the appearance of reticulocytes can indicate that there is an increased amount of immature red blood cells in the blood, and a result of an elevated level of homocysteine and methylmalonic acid would also be

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