...one of the condemned men. The letter to Mathilde helps her discover the whereabouts of a pair of German boots that have been traded several times among the soldiers. These boots lead her to a man who assisted Manech in no-man’s-land, carrying him out on his back. Mathilde and this man manage to crack the code of a letter from one of the condemned men to his wife, and with it she is able to find the one person who carries all the secrets that lead to Manech. With all of these new people and discoveries, Mathilde finds out her fiance is alive, but he suffers from amnesia, not even being able to identify his adoptive mother. Seeing Mathilde, Manech seems to be oblivious of her. However, he still expresses concern for her when he notices her polio stricken legs, asking her "does it...
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...virus that has paralyzed millions of people throughout the years. Although some cases of polio virus infections still occur (mostly in third-world countries), the mainstream spread of the virus was eradicated in 1988, when 99.9% of annual diagnosed cases were reduced. Now, 80% of the world’s population live in polio-free zones (Our Progress Against Polio, 2014). This vaccine is now considered to be one of the most successful vaccines ever discovered. Currently, there are four different types of polio vaccines: Oral Polio Vaccine (OPV), Monovalent Oral Polio Vaccines (mOPV1 and mOPV3), Bivalent Oral Polio Vaccine (bOPV) and Inactivated Polio Vaccine (IPV) (Inactivated Polio Vaccine, 2014). The OPV vaccine was created to have a unique ability to produce unmatched gastrointestinal immunity, thereby preventing infection with wild-type virus (Jesus, 2007). The OPV is composed of att strains of all three PV serotypes, grown in vitro. When creating the vaccine, scientists were looking for strains that would be able to replicate efficiently in the GI tract and central nervous system, as well as have the genetic stability to survive replication within the human host (Jesus, 2007). However, the temperature sensitive phenotype of the strains is thought to be the most efficient and important part of the vaccine, that lead to this medical phenomena (Jesus, 2007). Thus, the OPV became the preferred polio vaccine in most countries. The fact that the vaccine was able to produce antibodies...
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...The Polio Epidemic: In the summer of 1916, a polio epidemic was killing and crippling children. Polio is a deadly infectious disease caused by a virus that spreads from person to person and invades a person’s brain and spinal cord, causing paralysis (Bush 281). Because the outbreak of polio occurred in an Italian community in New York, immigrants were to blame. Polio became one of the most feared diseases in industrialized countries. This was because it paralyzed hundreds of thousands of children every year (Bush 281). It was easy for polio to spread because there were few sanitary regulations. It was predominately a summertime disease because it was easy for flies to carry fecal contamination to food in summer. In 1916, researchers had little...
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...Poliomyelitis in the USA Poliomyelitis is a dangerous and utterly infectious disease that may lead to breathing problems,paralysis or to death.It either can be classified as asymptomatic or symptomatic. About 95% of the cases are asymptomatic,and the rest 5% are symptomatic.USA has been suffering from this disease for a long period of time but in 1952 happened the worst polio outbreak in the history of this country.In that year, almost 58,000 cases were reported,3,145 died and 21,269 were paralyzed. Polio is caused by poliovirus.The virus is usually transferred from one person to another throughout the fecal matter.People that live in places with almost no access to running water,get the virus...
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...Coca: a gift from Mother Earth or poison for the body and madness for the mind. For the people of the Andean region of Bolivia and Peru, the growing and chewing of the coca leaf is a part of everyday life. It is not unusual for these people to chew coca leaves or drink coca tea in much the same way that people in the western world might drink a cup of tea or coffee. The problem comes in separating the traditional everyday use of a mild stimulant with its much stronger and highly addictive alter ego, cocaine. Indeed, it could be argued that cocaine is truly “poison for the body and madness for the mind”, but should this misuse of a valuable commodity justify the complete eradication of the coca plant? Or is the coca plant a gift from Mother earth, to be cherished and appreciated? The following pages shall compare and contrast the pros and cons of the coca plants controversial existence in an attempt to gain a greater understanding of this dilemma. The opposing sides of the argument and their standpoints shall be identified. The difficulty in differentiating coca from cocaine will be examined. A comparison of the health benefits of coca verses the negative impacts of cocaine shall be made. The economic importance of the coca plant in the Andean region scrutinised. Firstly, we must identify the two sides of this argument. The Andean people believe that coca is a gift from mother earth and an integral part of their culture and way of life. The United Nations Narcotics...
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...Culture and Environment Influence The environment one is born in and the cultural values they find themselves in have a great impact not only on their behavior and mental thinking but to their overall life as a human being. This is because what one experiences and interacts with shapes his or her mind towards a certain way of life which is very difficult to change since they keep seeing it on a day to day basis and this influences the way they live. Take for example someone born in a poor family which is struggling to raise their daily needs. This in most cases will motivate the individual to work hard in order to raise their living standards and ensure their life is not embroiled in poverty. However this may not always be the case as some of them may become demotivated by this environment and see it as way of life and they put no efforts to work hard to get themselves out of such situations. The culture one is born in is a very important factor in influencing the way of life of a human being. Different people born and brought up in different cultures perceive the world differently and thus they act and live in a certain way that is dictated by their culture. A child born in a Christian family will in most cases end up subscribing to the same faith while one born in an Islamic family...
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...Kramer Gibson English 2010 August 12, 2011 Simian 40 Virus (Monkey Virus) The scientific medical community must accept the fact that the Simian 40 Virus that was introduced through the Polio Vaccine back in the 50's, is, in deed the base cause of many of today's cancers and immune deficiency diseases. So that once this argument is accepted, positive research can be done in finding a way to kill this virus, kill the cancer it has caused, and rebuilds the immune system, thus finding the real cure for cancer. Between 1952 and 1955 many Researchers including Jonas Salk were frantically trying to perfect a vaccination to stop the horrible effects of the deadly Polio Virus that had swept the Nation as well as the world. The vaccine had to be developed in live tissue, more specifically, a fresh kidney that most closely resembled that of a human's kidney. As the Rhesus Monkey from India was already so abundantly used in laboratories, not much debate went into the choice of subject. Even though the monkey is dirty, temperamental, and it’s bite has already proven to be deadly, the rhesus monkey’s kidney was the tissue used to grow the Polio vaccine. The kidney was extracted from the monkey while still alive, then injected with the live Polio Virus where it was grown and tested. The monkey’s kidney was full of unknown viruses, while totally safe for monkeys, still harmful when injected into the human’s blood stream. The researchers, especially Jonas Salk...
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...One medical issue that has always made me ponder is polio. This virus struck America in 1916, causing many U.S. citizens fall ill. This disease has flu-like symptoms and paralyzes your body in certain areas depending on where the virus strikes. One of the most famous presidents, Franklin Roosevelt got polio in the late 1920’s. There is no such thing as a cure for polio, just vaccines and treatments, and I want to dive deeper into these specifics that could potentially benefit Americans. Although polio is no longer affecting Americans, I would like to learn more about the causes of this deadly virus such as where it came from. One thing that has helped people with polio is the Iron Lung. The Iron Lung came into play when physicians first...
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...Additionally, there are two cool restaurants in which your family can enjoy exotic foods. Learn all about the deadly virus in Polio Park! Featuring fun for the whole family, along with a valuable learning experience, Polio Park is themed around the highly infectious virus that swept the world. Being depicted as early as pre-history, polio is a virus that can affect the central nervous system and lead to the destruction of the motor neurons. This can lead to muscle weakness and paralysis. Before the 20th century, polio was found mostly in children between 6 months and 4 years old. However, before the mid-19th century, people who lived in poorer sanitation areas were constantly exposed to the virus, thus creating immunity. By the early 20th century, huge improvements were made in community sanitation. This lead to a pandemic outbreak of polio in Europe, North America, Australia, and New Zealand during the first half of the 19th century. By the mid-1950s, there were not one but two different versions of the polio vaccine. This cut polio outbreaks drastically. In this park, all of the rides have something to do with the polio pandemic during the 20th century. In the Jonas Salk/Albert Sabin Rollercoaster Race, the dual roller-coasters (one named Salk, one named Sabin) race each other to see which ‘vaccine’ wins. Jonas Salk and Albert Sabin both created a vaccine for polio. They were, however, complete opposites. The vaccines, that is. Salk, born in New York, was an American...
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...Treatment of Animals in chemical testing Animal testing is an issue in today's society that, whether anyone realizes it, does affect each of us. Such as transplants, vaccines, and medicine. Nearly each and every one of us today have received vaccine shots. We have all used medications. We have all heard of transplant technology. This above example I have used is farfetched. Brain transplants are not an everyday occurrence. They are not yet, at least. However, kidney and heart transplants are beginning to become a more and more common every day. Who knows what is possible with the proper research. Today there are a great deal of people who oppose animal testing in laboratory research. This is limiting our medical capabilities . Could we be holding ourselves back from medical breakthroughs such as a cure for cancer or AIDS? Animal testing is already controlled to a great extent. Many cats and dogs are killed annually by shelters and pounds. Animal testing is not as cruel as it is portrayed and is an essential to reaching medical breakthroughs. Special controls on laboratory animals have been in place since 1876. These have been revised in 1986. These laws are now more commonly known as the revised Animals Act of 1986. This law allows for scientist to perform testing while also safe guarding the animals. Prior to any testing a cost benefit analysis must be applied. In this analysis they review the potential research benefits with the potential...
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...Poliomyelitis (shortened to polio) has been around for thousands of years, and there is still no cure, but at the peak of its devastation in the United States, Dr. Jonas Salk introduced a way to prevent it. Polio attacks the nerve cells and sometimes the central nervous system, causing muscle wasting, paralysis, and even death. The disease, whose symptoms are flu like, struck mostly children, and in the first half of the 20th century the epidemics of polio were becoming more devastating. Salk, while working at the Virus Research Lab at the University of Pittsburgh, developed a polio vaccine, and the medical trials to prove its effectiveness and safety are still being analyzed. Fifty years ago the largest medical experiment in history took place to test Salk’s poliomyelitis vaccine. Close to two million children across the United States and Canada were involved in the trial, which was administered by the National Foundation for Infantile Paralysis (NFIP), also known as the March of Dimes. The foundation, created in 1938 by President Franklin D. Roosevelt (a polio victim) and his law partner Basil O’Connor. Across the United States, 623,972 school children were injected with the vaccine or a placebo, using a double blind technique in which neither recipient nor administrator knew which one there were getting. The results, announced in 1955, showed good statistical evidence that Jonas Salk’s “killed virus” preparation was 80-90% effective in preventing paralytic...
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...Offshore Drilling. A CNN/Opinion Research Corporation poll of more than 500 U.S adults, taken in July 2008, revealed that a majority of Americans favor offshore drilling for oil and natural gas; specifically, of those sampled, about 69% were in favor. Answer: a. Identify the population and sample for this study. 1. Population is 500 U.S adults 2. Sample- 69% b. Is the percentage provided a descriptive statistic or an inferential statistic> Explain your answer. 1. Inferential because it is measuring the reliability of conclusions about a population based on information obtained. 1.17 The Salk Vaccine. In the 1940s and early 1950s, the public was greatly concerned about polio. In an attempt to prevent this disease, Jonas Salk of the University of Pittsburgh developed a polio vaccine. In a test of the vaccine’s efficacy, involving nearly 2 million grade-school children, half of the children received the Salk vaccine; the other half received a placebo, in this case an injection of salt dissolved in water. Neither the children nor the doctors performing the...
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...Offshore Drilling. A CNN/Opinion Research Corporation poll of more than 500 U.S adults, taken in July 2008, revealed that a majority of Americans favor offshore drilling for oil and natural gas; specifically, of those sampled, about 69% were in favor. Answer: a. Identify the population and sample for this study. 1. Population is 500 U.S adults 2. Sample- 69% b. Is the percentage provided a descriptive statistic or an inferential statistic> Explain your answer. 1. Inferential because it is measuring the reliability of conclusions about a population based on information obtained. 1.17 The Salk Vaccine. In the 1940s and early 1950s, the public was greatly concerned about polio. In an attempt to prevent this disease, Jonas Salk of the University of Pittsburgh developed a polio vaccine. In a test of the vaccine’s efficacy, involving nearly 2 million grade-school children, half of the children received the Salk vaccine; the other half received a placebo, in this case an injection of salt dissolved in water. Neither the children nor the doctors performing the diagnoses...
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... Exploring the Americas 1400- 1625 6. Looking at the Chapter 3 timeline, in what year did King Phillip’s War begin? 1675 7. Using the Auto Sales graph on page 710, between what years was the biggest down turn in auto sales? 1926-1927 8. What artist created Fight for the Colors? Reenact and take a picture of it. p. 459 9. What artist created Bunker Hill? Reenact and take a picture of it. Don Troinai Pl 131 9. What artist created Patrick Henry Before the Virginia House of Burgesses? Reenact and take a picture of it. Peter F. Rothermel p. 135 9. What artist created Washington Crossing the Delaware Reenact and take a picture of it? Emanuel Gottlieb Leutze p. 128 10. What did Jonas Salk discover? Cure for polio (polio vaccine) 11. According to the Chapter 23 Summary, what event occurred in 1919? p. 682, Treaty of Versailles signed 12. What is the title of Chapter 14’a Technology Skill Builder? Evaluating a Web Site 13. On what page does the Primary Source Library start? On what page would you find the Fallout Fears? p. 956 p. 976 14. Looking at the National Geographic map on page 117, what country claimed (to own) Florida? Spain 15. How many authors are listed on the title page? 3 15. Page FL 41 points out what information can be found on each chapters’ title page. What are the 6 items listed? 16. In the Previewing Your Textbook section in the beginning of the book, what are the elements listed on the Reading Roadmap...
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...poliovirus infection by the normal route of infection. 3. a. The purpose of the experiment in Figure 2C was to test if and how antibiotics affect poliovirus pathogenesis. b. The light sensitive poliovirus was created with a mixture of four different antibiotics. Subsequently, the mice were either left untreated or the growth of antibiotic-resistant bacteria was promoted. Then, the mice were either administered poliovirus or poliovirus mixed antibiotics (in vivo). Mouse mortality rate was measured for 12 days post challenge. c. The two controls were mice without antibiotic treatment and antibiotic-treated mice that were administered poliovirus. i. Mice without antibiotic treatment-negative control; looking at how normal flora affect polio survival ii. Antibiotic-treated mice-positive control; mice majorly depleted of flora and how it affects survival d. After mice were treated with antibiotics, resistant bacteria remained and pathogenesis remained high, though lower than untreated. Reduced survival as a result of the presence of antibiotic-resistant bacteria as a result pathogenesis remained high. Were the mice that were left untreated had a lower survival rate. Mice that were coadministered antibiotics and poliovirus followed by harbored antibiotic-resistant bacteria. The only ones that had higher survival rate are the ones that had received antibiotic treatment. e. Antibiotic administration with infection does not significantly affect pathogenesis suggesting that antibiotics...
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