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Positron Emission Tomography Research Paper

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Positron emission tomography (PET) is a nuclear medicine functional imaging technique based on the use of radioactive tracers that emits positrons. Following injection of a radioactive tracer labeled with a positron emitting radionuclide, the radionuclide decays and emits a positron. When a positron encounters an electron after travelling a short distance (~ 1 mm) in the tissue, both the positron and electron annihilates and produces a pair of gamma photons (rays) travelling in opposite directions in a 180-degree angle, each photon with an energy of 511 keV. The PET scanner consists of a ring of scintillation detectors. Gamma photons that arrive at the same time and in opposite directions are absorbed by scintillations crystals in the PET scanner. …show more content…
However, the 180-degree emission of the pair of gamma photons is not completely exact, because the positron and electron are not completely at rest when they encounter each other and annihilates. The spatial resolution of PET is consequently limited to approximately 2-4 mm.
One of the main limitations that apply to PET is lack of accurate anatomical information. PET may therefore benefit from fusion with either computer tomography (CT) or magnetic resonance imaging (MRI), both of which are capable of producing advanced anatomical information. Hybrid PET/CT systems have been commercially available since 2001 and hybrid PET/MRI systems since …show more content…
18F (~ 110 min), 11C (~ 20 min), 13N (~ 10 min), and 15O (~ 2 min). The isotopes are incorporated into a biological active molecule by replacing an atom in the molecule, often referred to as radioactive labeling. The most commonly used radioactive tracer in PET scanning is 18F-Fluorodeoxyglucose (18F-FDG). FDG is an analog to glucose that is labeled with fluorine-18 (18F). 18F is substituted with the hydroxyl group (-OH) at the C-2 position in the glucose molecule. Following injection, 8F-FDG is transported into glucose-using cells via glucose transporters (GLUT) and phosphorylated into 8F-FDG-6-phosphate by hexokinase. 18F-FDG is retained in the cells as the added phosphate prevents FDG to exit the cell and due to the substituted hydroxyl group further metabolism (glycolysis) in the cells cannot occur. The uptake of 18F-FDG in the cells is directly proportional to glucose

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