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Prevention of Breast Cancer

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Prevention of Breast Cancer
Abstract
Background
Breast cancer is the second leading cause of cancer deaths in American women according to the National Cancer Institute. Breast cancer research has found no cure and treatments vary in effectiveness.
Objectives
This paper will review some of the various conventional and natural prevention methods of breast cancer and evaluate the effectiveness and risks of each.
Methods/Design
Published studies on early detection , non-steroidal anti-inflammatory drugs, physical activity and diet were reviewed. Opposing studies and risks of each were also sought and reviewed.
Major Findings
All methods were found to have a positive effect on reducing the risk of breast cancer except for early detection. All methods were also found to have a negative effect on breast cancer risk or have risks of other health problems except for physical activity and thermography.
Conclusion
Studies show that early detection does not prevent breast cancer and moderate physical activity can reduce the risk of breast cancer. All other methods have conflicting studies .

Early Detection:
Early detection is the most recommend method for the prevention of breast cancer, however it does not prevent breast cancer but studies show it can reduce the death rate of breast cancer. Mammography the most used and accurate form of non-evasive early detection will be examined in this paper as well as thermography, a new alternative to mammogram screenings.
Mammography
Mammography is a procedure that uses x-ray radiation to capture an image inside the body. Research has concluded that Mammograms can reduce the death rate from breast cancer but shows no reduce in the risk of developing breast cancer. Research also shows that mammograms can increase the risk of developing breast cancer and the occurrence of false positive results.
From 1986 to 2005 a study was conducted on women ages 40 to 49 years by the Department of Radiation Sciences (Hellquist, Duffy, Björneld, Abdsaleh, Bordás, Tabár, Viták & Zackrisson, 2011). 803 died from breast cancer in the study group and 1238 died in the control group . It was concluded that in women ages 40 to 49 mammogram screening was efficient for reducing breast cancer deaths. A similar study was done on women ages 50-69 years by The Department of Oncology (Jonsson, Nyström, Törnberg, & Lenner, 2001). It was also concluded that mammograms were efficient in reducing the death rate for breast cancer.
Mammography screening was found to significantly increase breast cancer risks of women in a study published in the British Journal of Cancer (Berrington de González, & Reeves, 2005). Estimates of radiation-induced breast cancer were calculated using an excess relative risk model with screening starting at ages 20, 30 and 40. In women under the age of 40 the number of radiation-induced breast cancer significantly outweighed breast cancer deaths. After age 40 the death rate begins to increase and after age 50 breast cancer deaths outweigh radiation-induced breast cancer. A similar study was also published in the Journal of the National Cancer Institute with similar results (Berrington de Gonzalez, Berg, Visvanathan, & Robson, 2009).
The New England Journal of Medicine published a study showing that Mammograms have a high rate of false-positive results (Elmore, Barton, Moceri, Polk, Arena, & Fletcher, 1988). A 10-year retrospective cohort study was performed on 2400 women ages 40 to 69 . The study concluded that one third of women that receive annual mammograms for a decade have false positive results. The false positive results lead to 870 outpatient appointments, 539 additional mammograms, 186 ultrasound examinations, 188 biopsies, and 1 hospitalization.
Infrared Thermography
Thermography is a radiation free procedure that captures infrared radiation from the skin allowing the viewing of temperature patterns within the body. Early studies of thermography have shown to be ineffective at detecting breast cancer and malignancies . However more recent studies have shown it to be an effective breast cancer risk factor predictor. Another study shows thermography to be more effective at detection when combined with other techniques. In 1976 a study published in the new England Journal of medicine screened 150 women with Thermography (Moskowitz, Milbrath, Gartside, Zermeno, & Mandel, 1976). 42 with stage 1 breast cancer, 44 confounding cases and 64 randomly selected subjects. Thermographers identified the patients with breast cancer correctly (true positive = 0.238) varied little from the ability of untrained readers (true positive = 0.301). Also in the expert group, the indexes of suspicion were so high (0.436) and the true-positive levels were so relatively low (0.238, P = 0.0005) it was concluded that thermography is ineffective at detecting stage 1 breast cancer.
In a 1980 study 58,000 women were examined between August 1965 and June 1977 (Gautherie Gross, 1980). 1,245 women were diagnosed at initial examination as either normal or benign disease by conventional means. These women also showed questionable thermal anomaly. Within five years, over a third of the group developed cancers. It was concluded that an abnormal thermogram is associated with a high risk of cancer that is consistent with the increased metabolic heat production associated with cancers.
A 2006 study used mathematical modeling and analysis in conjunction with thermography (Y-K Ng, & Sudharsan, 2004). Mathematical modeling and analysis is accepted in engineering design and is considered equal with experimental approaches. Computer simulations enable the performing of several analyses, cost efficiency, and in a shorter time frame. A numerical bio-heat model of a breast is developed and simulated and the results are incorporated with experimental results to enhance image processing. Clinical examination, patient history, and family history are also taken in to account when analyzing the results. 234 women in their early thirties and late forties were screened with thermograph and of the 234, three women were selected to combine mathematical modeling and analysis with their thermography images. One with a normal Breast, one with a benign lump, and one who had undergone a lumpectomy. It was concluded that this method reduces false positive results and can be an adjunct tool for the detection of breast cancer.

Non-steroidal Anti-Inflammatory Drugs
Regular use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) have been found to reduced breast cancer risks. Many studies have also shown that long term use of NAID’s can have serious side effect.
80,741 postmenopausal women between 50 and 79 years of age who reported no history of breast cancer were used in a study on NSAID’s (Harris, Chlebowski, Jackson, Frid, Ascenseo, Anderson, & Loar, 2003).They regularly took NSAID’s(two or more tablets/week) with an average follow-up of 43 months. 1,392 of the women developed breast cancer. The study found that regular use of NSAID’s for 5–9 years produced a 21% reduction in the development of Breast cancer. 10 or more years produced a 28% reduction. With continued use of NSAID’ s the percentage of reduction continued to increase. Ibuprofen showed a greater percentage reduction than for aspirin. Regular use of acetaminophen or low-dose aspirin was unrelated to the reduction of Breast cancer development. The study concluded that the regular use of aspirin, ibuprofen, or other NSAIDs may prevent the development of breast cancer.
Many studies have found the long term use of NSAID’s is associated with acute myocardial infarction, gastrointestinal bleeding, acute renal failure, acute kidney injury, arrhythmia, congestive heart failure, and stroke (Rahme, E., & Nedja, H. (2007), (Schneider, Lévesque, Zhang, Hutchinson, & Brophy, 2006), (Winkelmayer, Waikar, Mogun, & Solomon, 2008), Zhang, Ding, & Song, 2006), (Mamdani, Juurlink, Lee, Rochon, Kopp, Naglie, & Austin, 2004), (Haag, Pharm, Bos, Hofman, Koudstaal, Breteler, & Stricker, 2880).

Physical activity`
Moderate physical activity has been associated with lower breast cancer risks in several studies and there is no apparent contradicting studies or major risk in healthy women.
The Archives of Internal Medicine published a study conducted from 1986–2006 by a mailed questionnaire to 95,396 women (Eliassen, Hankinson, Rosner, Holmes, & Willett, 2010). Information on lifestyle factors was collected on the initial questionnaire and was updated biannually throughout follow-up. Of 95,396 women 4,782 developed breast cancer. The study found women with a moderate physical activity level, including brisk walking, had reduce postmenopausal breast cancer risk. Women with higher physical activity after menopause had a lower risk for breast cancer.
Diet
Studies have shown diet not to be associated with breast cancer risk except for alcohol consumption. Other studies also show that diet does effect breast cancer risks.
In a study by Northern California Cancer Center 111,526 at-risk at risk women completed a dietary assessment, 711 were diagnosed with invasive breast cancer after joining the study (Horn-Ross, Hoggatt, West, Krone, Stewart, Anton, & Bernstei, 2002). Cox proportional hazards models were used to calculate relative hazards. The study found the following not associated with breast cancer risk: energy, fat, fiber, antioxidant vitamins, and phytoestrogens. Only alcohol consumption of approximately two or more glasses of wine was associated with increased risk .
The New England journal of medicine published a study on fat intake in relation to breast cancer risk identifying seven studies in four countries that analyzed data in a standardized manner (Hunter, Spiegelman, Adami, Beeson, van den Brandt, Folsom, & Fraser, G.1996). The estimates of the relation of fat intake to the risk of breast cancer were calculated and pooled. Data from study-specific validation studies were also used to adjust the results for error. The study found no evidence of dietary fat intake reducing the risk of breast cancer.
A study published by the International Journal of cancer found hi fiber intake may help prevent breast cancer (Baghurst, & Rohan, 1994). High-fiber diets and reduced risk of breast cancer. . Fiber intakes were estimated in 451 women with breast cancer and 451 controls. Fiber Intakes were estimated by questionnaire, and risks of breast cancer were estimated for each quintile of fiber density relative to an assigned risk of unity for women in the lowest quintile of fiber density. In women with the highest 20% estimated dietary fiber intake the relative risk of breast cancer was 0.46. The study suggests that hi fiber intake can reduce the risk of breast cancer.
Evidence of soy preventing premenopausal breast cancer was found in a study published in the American Journal of Clinical nutrition (Lee, S., Shu, Li, Yang, Cai, Wen, & Ji, 2009). 73,223 Chinese women aged 40–70 were interviewed with a follow-up of 7.4 years, 592 developed Brest cancer. Women who consumed a high amount of soy foods consistently during adolescence and adulthood had a substantially reduced risk of breast cancer. No significant association with soy food consumption was found for postmenopausal breast cancer.

References
Baghurst, P., & Rohan, T. (1994, January 15). High-fiber diets and reduced risk of breast cancer. International Journal of Cancer, 56(2), 173-176. Retrieved November 15, 2011, from http://onlinelibrary.wiley.com/doi/10.1002/ijc.2910560204/abstract
Berrington de Gonzalez, A., Berg, C., Visvanathan, K., & Robson, M. (2009, January 27). Estimated Risk of Radiation-Induced Breast Cancer From Mammographic Screening for Young BRCA Mutation Carriers. Journal of the National Cancer Institute, 101(3), 205-209. Retrieved from http://jnci.oxfordjournals.org/content/101/3/205.full
Berrington de González, A., & Reeves, G. (2005, August 31). Mammographic screening before age 50 years in the UK: comparison of the radiation risks with the mortality benefits. British Journal of Cancer, 2005(93), 590-596. Retrieved from http://www.nature.com/bjc/journal/v93/n5/full/6602683a.html
Eliassen, A., Hankinson, S., Rosner, B., Holmes, M., & Willett, W. (2010, October 25). Physical activity and risk of breast cancer among postmenopausal women. Archives of Internal Medicine, 107(19), 1758-1764. Retrieved November 15, 2011, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142573/?tool=pubmed
Elmore, J., Barton, M., Moceri, V., Polk, S., Arena, P., & Fletcher, S. (1988, April 16). Ten-Year Risk of False Positive Screening Mammograms and Clinical Breast Examinations. New England Journal of Medicine, 1998(338), 1089-1096. Retrieved November 15, 2011, from http://www.nejm.org/doi/full/10.1056/NEJM199804163381601
Gautherie M, & Gross, C. (1980). Breast thermography and cancer risk prediction. Cancer, 45(1), 6-51. Retrieved November 15, 2011, from http://www.ncbi.nlm.nih.gov/pubmed/7351006?dopt=AbstractPlus&holding=f1000,f1000m,isrctn
Haag, M., Pharm, D., Bos, M., Hofman, A., Koudstaal, P., Breteler, M., & Stricker, B. (2880). Cyclooxygenase Selectivity of Nonsteroidal Anti-inflammatory Drugs and Risk of Stroke. Archives of Internal Medicine, 168(11), 1219-1224. Retrieved November 15, 2011, from http://archinte.ama-assn.org/cgi/content/full/168/11/1219
Harris, R., Chlebowski, R., Jackson, R., Frid, D., Ascenseo, A., Anderson, G., & Loar, A. (2003, September 15). Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs. Cancer Res, 63(6096). Retrieved November 15, 2011, from http://cancerres.aacrjournals.org/content/63/18/6096.full
Hellquist, B., Duffy, S., Björneld, L., Abdsaleh, S., Bordás, P., Tabár, L., Viták, B. & Zackrisson, S, . (2011, February 15). Effectiveness of population-based service screening with mammography for women ages 40 to 49 years: evaluation of the Swedish Mammography Screening in Young Women (SCRY) cohort. Cancer, 117(4), 22-714. Retrieved November 15, 2011, from http://www.ncbi.nlm.nih.gov/pubmed/20882563?dopt=Abstract

Horn-Ross, P., Hoggatt, K., West, D., Krone, M., Stewart, S., Anton, H., & Bernstei, C. (2002, June 13). Recent diet and breast cancer risk: the California Teachers Study (USA). Cancer Causes Control., 13(5), 15-407. Retrieved November 15, 2011, from http://www.ncbi.nlm.nih.gov/pubmed/12146845?dopt=Abstract
Hunter, D., Spiegelman, D., Adami, H., Beeson, L., van den Brandt, P., Folsom, A., & Fraser, G. (1996, February 8). Cohort Studies of Fat Intake and the Risk of Breast Cancer — A Pooled Analysis. New England Journal of Medicine, 356-361. Retrieved November 15, 2011, from http://www.nejm.org/doi/full/10.1056/NEJM199602083340603
Jonsson, H., Nyström, L., Törnberg, S., & Lenner, P., (2001, April 2). Service screening with mammography of women aged 50–69 years in Sweden: effects on mortality from breast cancer. Journal of Medical Screening, 8(8), 60-152. Retrieved November 15, 2011, from http://jms.rsmjournals.com/content/8/3/152.long
Lee, S., Shu, X., Li, H., Yang, G., Cai, H., Wen, W., & Ji, B. (2009, April 29). Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study. American Journal of Clinical Nutrition, 89(6), 1920-1926. Retrieved November 15, 2011, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683002/?tool=pmcentrez
Mamdani, M., Juurlink, D., Lee, D., Rochon, P., Kopp, A., Naglie, G., & Austin, P. (2004, May 29). Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study. Lancet., 363(9423), 6-1751. Retrieved November 15, 2011, from http://www.ncbi.nlm.nih.gov/pubmed/15172772
Moskowitz, M., Milbrath, J., Gartside, P., Zermeno, A., & Mandel, D. (1976, July 26). Lack of Efficacy of Thermography as a Screening Tool for Minimal and Stage I Breast Cancer. New England Journal of Medicine, 1976(295), 249-252. Retrieved November 15, 2011, from http://www.nejm.org/doi/pdf/10.1056/NEJM197607292950504
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Schneider, V., Lévesque, L., Zhang, B., Hutchinson, T., & Brophy, J. (2006, November 1). Association of Selective and Conventional Nonsteroidal Antiinflammatory Drugs with Acute Renal Failure: A Population-based, Nested Case-Control Analysis. American Journal of Epidemiology, 164(9), 181-189. Retrieved November 15, 2011, from http://aje.oxfordjournals.org/content/164/9/881.full
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...Breast Cancer Manoela Colindres Professor Susan Barnett Colorado Christian University November 15, 2014 Due to the large amount of commercials, fundraisers, 5K runs and walks it is rare to find someone who has not heard about breast cancer, but do they actually know what all takes place in breast cancer? Breast cancer is a malignant tumor that starts in the cells of the breast, which means that the tumor is a group of cells that grow and spread to other areas of the body. STATISTICS Breast cancer can occur in both men and women, but it is most commonly seen in women. Approximately affecting 1 in 8 women in the United States, about 232,670 new cases of invasive breast cancer will be diagnosed in women, about 62,570 new cases of carcinoma in situ (CIS) will be diagnosed (CIS is non-invasive and is the earliest form of breast cancer), and about 40,000 women will die from breast cancer. Breast Cancer is the second leading cause of death, but is responsible of only has 3%, or 1 out of 36 of death in women. Studies done by the Center for Disease Control and Prevention (CDC) show that breast cancer is not only the most common cause of death in Hispanic women, but also the second leading cause of death in African American, Asian/Pacific Islanders, and Americans. Although all we hear are the negative information and deaths from breast cancer, the survival rate in the United States of women who have survived breast cancer is 2.8 million...

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Premium Essay

Breast Cancer

...Breast cancer is a malignant tumor that starts in the cells of the breast. A malignant tumor is a group of cancer cells that can grow into and invade surrounding tissues or spread to distant areas of the body (American Cancer Society, 2015). The disease occurs almost entirely in women, but men can also get it. Although breast cancer can affect both men and women, it is much more dominant in women. The risk for developing breast cancer is the highest in women over the age of 50, and it is higher for women who also have a family history of breast cancer (Breastcancer.com, 2015). Breast cancer is the most common cancer in women worldwide. It’s a devastating disease, and thousands of cases of breast cancer are reported to occur among women around the world each year. Breasts contain the mammary glands which are the organs of milk production. Breasts mostly consist of adipose tissue. The breast is made up of sections, which are called lobes and each of these lobes are made up of smaller lobules, which produce milk in women (Breast Anatomy, 2015). Both the lobes and lobules are connected by milk ducts and the milk ducts carry the milk to the nipple. The lobules and ducts are located throughout the fibrous tissue and adipose tissue that make up the main mass of the breast (Breast Anatomy, 2015). Most cancers of the breast arise from the epithelium, which form the lobules and terminal ducts (Seeley, 2011 p 1042). There are a few different types of breast cancers that...

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Breast Cancer Research Paper

...Maria Pianka Meredith LeDoux Breast Cancer Breast cancer is the second leading cause of death among women in the United States. Breast cancer is a kind of cancer where cells grow out of control in the breast. The breast is the first site of cancer but overtime, the cells can spread to other parts of the body. Breast cancer is a malignant tumor that can grow into surrounding tissues or spread to other areas of the body. Breast cancer can occur in both women and men, even though there is only a 1% chance for men to be diagnosed with breast cancer. (The American Cancer Society) The Centers for Disease Control and Prevention states that there is a few different types of breast cancers and the most common types are Ductal Carcinoma and Lobular...

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