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Retinitis Pigmentosa

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Attempts at artificial vision began in the 18th century with the direct stimulation of blind eyes. In the 1920s, Otfrid Foerster developed this approach further by using electrodes to investigate direct electrical stimulation of the visual cortex. Several of his patients experienced limited subjective visual phenomena. In 1956, the first known proposal for a retinal prosthesis was outlined by Tassicker in Melbourne, Australia. However, research and design of it did not start until the late 1980s. In 2002, the first retinal prostheses began with clinical trials for the Argus Ⅰ. Nine years later, the next generation Argus Ⅱ was approved for marketing in Europe after successful implantation in 30 patients. Eventually in 2013, the Argus Ⅱ became …show more content…
Retinitis pigmentosa is a complex genetic disease usually characterized by retinal hyperpigmentation and photoreceptor death. It initially affects rod cells and low-contrast peripheral vision, while sparing high-acuity central vision. In more severe forms, visual acuity can fall to 20/200 or zero light sensitivity due to damage to macular cones. In the normal eye, photoreceptors located within the outer layers of the retina contain light-sensitive pigment that trigger the phototransduction cascade to generate neuronal signals in the presence of light stimuli. These signals are passed to and processed by a complex network of neurons within the middle layers of the retina before reaching the retinal ganglion cells. The retinal ganglion cells form the optic nerve to transmit neuronal signals to the visual cortex. In individuals with significant retina diseases, the outer layers of the retina where photoreceptors are located are gradually lost, therefore causing progressive visual loss. However, since the inner retinal layers are partially spared, the restoration of vision is possible by creating devices, retinal prostheses, that receive and process incoming light and then transmit the information in the form of electrical impulses to the remaining inner retinal layers for visual

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