...maintainable by the local villagers. The villagers of Devikulam have raised the issues of saline water, lack of constant supply of water due to power shortages, poor condition of taps and bacteria in the water supply. The poor conditions of the taps and plumbing, has been rectified in July 2010 (Buzza, 2011). The concern of bacteria within the water supply, we believe, is the most pressing issue that needs to be resolved. As a group we each collected data on different filtration options looking at ease of use and maintenance, power requirements, costs, if the process will remove the bacteria that are present in the Devikulam water supply, availability of materials and the life expectancy of each process. This data was collated into a trade-off analysis template and the criteria was weighted from most important requirements i.e. the removal of the bacteria to the least important. This template then calculated the best options for the village from the information we entered. Due to the simplicity but effectiveness, slow sand...
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...Challenges within a CMO Purification Process A Case Study of Crossflow Micro- and Ultrafiltration 6th European Downstream Technology Forum September 7, 2010, Sartorius College, Goettingen Agenda I. II. Introduction Overview applications for CFF at RHB III. Case study I & II IV. Strategies to maintain quality Richter-Helm offers services for (co-)development and manufacture of biopharmaceuticals Business Units and Services In- & Out-Licensing Marketing & Sales Contract development Contract manufacturing Business Development Team GMP-Production Facility, Bovenau 3 Richter-Helm was one of the first companies to produce recombinant proteins in accordance to GMP-guidelines History of Richter-Helm Timeline 1987 1989 1993 1998 2000 2001 Foundation of Pharma Biotechnologie Hannover and start of GMP production Entering contract GMP manufacturing Broadening service portfolio / establishment of contract development services Building up of development centre in Hamburg Planning and start of construction of the new large scale GMP facility in Bovenau First long-term commercial development and supply agreement for large scale facility signed Initiation of GMP production in Bovenau Acquisition by Gedeon Richter Plc and HELM AG Start of in-house development projects Fully remodelled Hannover facility in operation Capacity enlargement in Bovenau More than 20 years of experience in biopharmaceuticals production 3 development and production locations 2003...
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...of the Filtration Unit, Peter Vyas, asks for $ 2 million to launch RIMOS, that from my point of view is the right thing to do. He should handle the expenditure request by stressing all the improvements that his team has been able to bring to the mini-oxidation system (in terms of design, functioning, sustainability and efficiency). Moreover he should underline the increased probability of success given by the first-mover advantage that is obtainable in the new specified market (U.S. regions with governmental restrictions for irrigation). Vyas knows that he’s facing a critical decision, but he’s confident that his project is going into the right direction and that is necessary to go forward for the survival of the division and to recover full trust. In order to obtain the additional $ 2 million funds, he needs to satisfy Cynthia Jackson’s request, adding specific data about costs, sales and targets, so that the business plan will be clearer. To convince the vice-president, Vyas should demonstrate how the additional investment could be useful to implement the project, for example: an increase of $ 2 million in advertising expenditures, will educate customers to the new technology and will help people understand how their lives will be simplified by RIMOS, with a consequent increase in demand. Cynthia Jackson, vice-president of ART’s Water Management Division, has to decide on the commercialization of the mini-oxidation system, compromising the survival of the Filtration Unit....
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...cream mix supply company called Eastern Dairy. George is working at Eastern Dairy for the summer and he works the night shift. The night shift is unsupervised and ran by 4 or 5 assembly workers. George has gotten along with all his fellow employees and together they have formed quite the comradery. Paul, one of the assembly workers on the night shift, has become somewhat of a self elected supervisor of the shift. All of the employees of the night shift get along very well and enjoy their time together thoroughly which has allowed George to really enjoy his time at work. One night they are faced with a problem regarding the filtration of the mix. All the filters are getting clogged up due to a bad batch of mix filled with maggots. Now, the employees can either repeatedly unclog the filters and reattach them over and over until all the mix has completed the filtration process or they can remove all the filters and allow the maggots to stay in the mix until it has gone through the homogenizer and the pasteurization process, which according to Paul will “Pulverize” all solid matter and destroy any bacteria. The issue with constantly removing, unclogging and reattaching the filters is that it will slow down the filtering process so much that George and his fellow employees will have to stay past the end of their sift. Paul advises George to take the filters out so that they all can get home after their shift but George does not feel comfortable doing so. This leaves George with a difficult...
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...3 Basic plate count techniques for the enumeration of microorganisms 3.1 Introduction Most of the recommendations and guidelines contained in this chapter are taken from American Public Health Association (APHA), as described in the Chapter 6 of the 4th Edition of the Compendium of Methods for the Microbiological Examination of Foods (Swanson et al., 2001). When different from or complementary to those of the Compendium, they were complemented with information and recommendations from ISO 6887-1:1999 and ISO 7218:2007, recommended for performing tests using methods developed by the International Organization for Standardization. Microbiological examination of foods is predominantly based on culturing techniques, to detect and enumerate living microorganisms. In view of the huge variety and multiplicity of groups, genera and species that may be present, a great number of tests are used, and which can be of one of two types: qualitative tests, which are aimed at detecting the presence or absence of the target microorganism(s), without quantifying, and quantitative tests which determine the quantity of the target microorganism(s) in the sample, generally per unit of weight or volume. Each of these tests follow differentiated procedures, which in turn depend on the target microorganism(s), but most of them utilize the same basic microbiological culturing techniques. These techniques are the detection of presence/absence (Chapter 5), the Most-Probable-Number counts (MPN)...
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...Opportunity: The Applied Research Technologies’ general manager, Peter Vyas alongside his team tried to launch the Filtration Unit Program twice but failed. Peter still managed to rebuild a low morale and a high turnover Unit selecting entrepreneurial minded people and the team was awarded two million dollars to finish their project. He ensured that it is a success after all their unsuccessful attempts it faced. They would at least for the first time celebrate a great innovation and achievement that is designed to help a lot of people both in developed and developing countries. Business and management strategy: first of all, they have to implement steps that would enable the plan to accommodate the two million dollar funding from the division for RIMOS. Secondly, the unit needs to go through extensive testing to pick out any possible flaws before it tries to launch the product for the third time. The unit should ask for assistance from its other IT specialists in other divisions within the organization to conceptualize if they can come up with the perfect product. Management venture, stage, and industry: The management exemplified a team that was right for this venture. Peter Vyas possessed knowledge by realizing the need and purpose for this project. Although, he had experienced two failed junctures in hopes of introducing the RIMOS idea but he was determined to resolved the kinks which contributed to his previous failures. Despite the pressure and uncertainty of his job depending...
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...Breaking up is hard to do – Separating Sand & Salt Purpose: The purpose of this experiment is to separate a mixture of sand and salt. Materials: * Small beaker * Electric balance * Sand * Salt * Water * Graduated cylinder * Stirring rod * Filter paper * Flask * Rubber policeman * Wash bottle * Funnel * Bunsen burner complete with rubber tubing and a source of gas * Hot hands * Insulator pad * Ring stand complete with a ring * Wire gauze * Striker Pre-lab Questions: 1. Water will be useful in separating the salt and sand because salt is soluble in water, which allows it to dissolve into a homogenous mixture, allowing for filtering of the sand. 2. Properties of sand and salt that will help separate them are that salt is water soluble, and the sand is insoluble in water. 3. The three things that could go wrong in this experiment are: * During the evaporation of water while using the Bunsen burner, the flask might crack or explode – this can be avoided by not heating the flask over a prolonged period of time, and not heating it too intensely. * Some of the sand may be lost during the filtration – this can be avoided by carefully filtering the mixture, and making sure that all of the sand has been washed off from the beaker, and the rubber policeman. * Some of the salt may be lost if the salt doesn’t dissolve completely or if some of the salt water is spilled – this can be...
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...Have you ever heard of a sand dune? Well, if you haven’t, I will tell you about them in this report. I will also tell you how I made a tasty model of a coastal sand dune. So….start reading! Sand dunes are fragile and formed by wind and water moving and sculpting the sand. The dune starts with wind that moves the sand. The wind moves it into piles just like a snow drift. The sand will build up on itself layer upon layer. Each new wind can make the dune larger and each new pile of sand can grow into a huge dune. Sand dunes form around stuff on the beach like rocks, drift wood and stuff that washes up on the beach during high tide. Inside sand dunes there are plant roots, which hold the sand together. This helps protect the sand dune from being destroyed. A dune holds the sand on the beach to help cut down erosion. Dunes are very important, without them the beaches would disappear. Coastal sand dunes can be found in North Carolina, South Carolina, Massachusetts, Maryland, Florida, Georgia and Texas. Dunes on the Georgia coast normally grow 10 to 12 feet tall and can be found all along Georgia’s barrier islands. These Dunes and islands have protected Georgia from the ocean tide. Plants are an important part of a dune. Plants that are on the fore dune must be able to take salt sprays, strong winds and burial by blowing sand. Plants like sea rocket, beach croton and Russian thistle grow here. On top of the dunes grass such as salt meadow cord grass...
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...2_02 My recent trip to the beaches at The Yucatán Peninsula, in southeastern Mexico reminds me of one of the most beautiful and spectacular places I’ve ever been. The beach smells fresh, almost like a new tropical breeze air freshener. Next to me is the Caribbean ocean, bright as a cloudless noon sky, washes onto the white sand. Looking at the waves’ white foam; then, I let my senses enjoy the sound as they break on the beach, almost like a shaken-up champagne bottle being opened. The sand is hot and looks like gold blended in with little white crumbs; it sparkles like the diamonds showcased in a high-end jewelry store and feels like walking on ashes from freshly extinguished fire. Despite the heat, walking on the warm, crystal sand pacifies my soul. I set up my folding lounger under the shade of a palm tree and explore my surroundings. The colorful towels spread out all over the beach are covered by bronzed figures. A net is up towards the water, and a few more figures dive to save a falling volleyball. Not far from the shore, you can see the coral sitting still in the wild and shallow water. People are laughing and playing in the burning sand, and others are relaxing on the beach reading their books while enjoying the bright rays of light coming from the sun. In a distance, I see occasional jet skis speeding over the waves, and sometimes, I can see a fish hop out of the water, its body shining in the sun. Not far away, a resort is attractively located right by the water...
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...English Coursework The sands were pearly white. I was memorised by the sea, as sapphire blue as my dear wife’s eyes. It was peaceful. Tranquil. The sun starred it’s raze down on the razor sharp sand. The aroma of hot dogs and filled my nostrils, permeating through the air. Just like the busy streets of New York, but the calm morning breeze of amity island was all I could feel around me. Not a single cloud in the sky, the day seemed as though it was going to be a perfect day, but what is perfect? Then like a flock of birds, they started to arrive, propelling and fighting over the best spots of the beach they could find. I gaze over like an eagle stalking its prey. Piercing screams, high-pitched laughter, children splashing, squishing, and shouting with joy. Beads of sweat trickled down my face as the sun, a gold coin in sky, effervescent, piercing through my skin like the diamond encrusted sand on the soles of my feet. I felt as though I was in paradise. I begin to notice the smiling shore ripple with force, accompanied by piercing screams and shouting. I emerge from my deck chair in alertness. Suddenly, a slim figure is swallowed by the gaping mouth of the Pacific Ocean. My heart begins to beat, race and pulsate, almost like the prey running away from the predator. In relief, she emerged, like a moth cradled in its cocoon, cradled on the shoulders of a friend. I declined back into the embracing arms of my chair feeling composed. I am still on edge, it almost seemed that...
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...rays, making the shady beach of Barry Island seem like paradise, heat comparable to the Sahara desert. A child desperately tries to prevent his ice cream from a sand encrusted death as it plummets to the floor, debating whether or not he wants a vanilla and sand flavour ice cream, his face puzzled as he decides on retrieval, he would soon be distracted by the horde of people rapidly rushing to the depths of the sea. The sea sits calm and patient, almost inviting to the untrained eye. From afar the sea seems crystal-like projecting as it does a near perfect mirror image as if the sky and sea are at one. The closer you get to the sea you soon start to see its cracks as if it was a porcelain doll, beautiful and almost elegant from a distance. It's too late to turn back now the seas illusion has set in, the soggy sand has captured your footprint. Suddenly the sea shows its true colours a horrible musk of black filth, home to all types of disgusting bacteria waiting to pounce on the weak immune system. The stench of chip fat rules the air like a corrupt king slaying the sense of smell. Enticing the beach goers into a calorific snack, washed down by the warmth of a flat lifeless beer, where the rules of 'best served chilled' have been extremely violated. Seagulls circle the area ready to raid the sand for the food the sea has not yet claimed, Vermin of the air are hunting their prey. Litter clutters the beach, making a kaleidoscope of colours created by the metallic...
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...beach, there are some very distinct smells. You can smell the salt from the water along with the heat from the sand. My most favorite smell of all is the sweet coconut smell of sun tanning lotion that people put on themselves while they lay into the sun to basically "cook." If you're looking for a quiet day of relaxation at the beach, I don't think that will work out too well. The beach is always really loud throughout the day. You can hear the loud motors of the boats and the waves of the water as they come crashing through to shore. You'll definitely be able to hear the laughter and the excitement of the kids of all ages as they splash around, play games, and build sandcastles. While you're at the beach you can always get involved in some fun activities, if you aren't able to relax. You can go fishing, if you like touching the slimy scales of the fish and the soft touch of the cold water. Just make sure you don't get the rough, coarse sand in your shorts because you won't like that too much. Overall the beach is lots of fun to go to, if you just want to get away from the busy everyday city life. If you are there early enough, you will be able to see a beautiful, bright sunrise and if you enjoy staying out on the beach until the evening, I'm sure you can catch a calming and loving sunset. After the sun has gone down for the night, you can sit in the sand and stare up at the amazing dark blue sky and bright shining...
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...hildren have been intrigued by sand for many generations. Sand is a foundational part of the ground in the same way that dirt or clay is, making it available to children for centuries. Before the advent of the toys and electronics of today’s society, children were forced to find creative methods to play with the outdoor materials found all around them, including sand. Children have played in sand by digging, sifting, building, pouring, and exploring throughout time, and they should be encouraged to continue this method of play. Sand is very well-suited to the urge to explore and to the imagination inherent in young children. Reasons Why Playing in the Sand Is Good for Kids Like playing with water, playing in sand is soothing and entertaining for children. Even adults can occasionally be caught running their fingers and toes through sand and enjoying its texture. Although sand is naturally found outdoors and can be played with in sandboxes or on beaches, it can also be brought inside for children to play on the floor or on sand tables. No matter the location of the sand play, these are eight reasons why playing in the sand is good for kids: 1. It Is an Open-Ended Medium Children learn the most when faced with open-ended questions and open-ended tasks, and sand is a medium that is inherently open-ended. No matter the skill or cognitive level of the child, sand is an appropriate play object. Very young or underdeveloped children can simply sit in sand and take in the texture and...
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... Imagine getting away from the monotony of your everyday life. You can lie on the beach sipping a chilled drink miles away from your worries of getting a paper done or helping a customer at work. You can be on top of a mountain overlooking pretty lands that are different from your own yard. Then London is your answer. London is a vibrant, bustling city to visit. The diverse population is over 8.6 million and consists of 13 races and 8 religions. The people here are very friendly and extremely proud of their city. There are 12 inner-London boroughs which each boast different styles appealing to a wide cross-section of tourists. From Shoreditch, the hub of fashion and creativity in the city to the more upmarket Chelsea, there is something for everyone. London is one of the top tourist attractions in the world attracting millions of tourists annually. There are so many tourist attractions; it is, in fact, difficult to choose a few from among them. You name it, they have it! The London Eye, London Bridge and the Tower of London are some of the most historic places which draw the highest number of visitors within the whole of Europe. Don’t think the attractions are only for adults! If you have kids then London is your destination. One of the most engaging places for kids is WaterWorld. A warning to parents: if your kids see this place they won't want to leave. Another intriguing attraction is the British Museum. Here you can examine the world's most precious treasures or enlighten...
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...ways of separating mixtures and substances. II. Materials: STATION 1 * White sand * Clean bottle * Rice grains * Spoons * Rags * Strainers STATION 2 * A glass of water * Table esalt * Alcohol lamp * Matches * Clean bottles * Stirring rods * Small beakers * Biscuit can cover * Tripod * White Sand * Rags STATION 3 * Ground charcoals * Rags * Iron filings * Magnet * 2 clean cups * Stirring rods III. Procedures: STATION 1 1. Examine each sample of sand and rice grains. 2. Name some properties of each sample. Prepare a data table for observations. 3. Put a tablespoon each of the sand and rice grains in a clean bottle and stir. 4. Again observe the properties of sand and rice grains and note down any changes. 5. Describe some methods for separating sand from rice. 6. Try the method that your group thinks is the most efficient. 7. Describe your results. STATION 2 1. Examine samples of water, sand and table salt. 2. Name some properties. 3. Fill a small beaker with water. 4. And in small propertions,half a spoon of salt, stirring the water after each addition. 5. Compare the appearance of salt before and after adding it to water. 6. Apply heat to the beaker and observe what happened when it was heated. 7. Repeat step 2 but using sand instead of salt. STATION 3 1. Examine the sample of iron filings and the sample of...
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