...Review of article: “Statin Use and Risk of Cerebral Aneurysm Rupture: A Hospital-based Case-control Study in Japan,” Y. Yoshimura, Y. Murakami, et al. Design and Data Collection The presented study is a case-control study design, meaning it is based on measuring the associations between statin administration and the likely rupture of a cerebral aneurysm in purposefully selected indicator and control populations. The foundation of the study grew from theoretical components tied to animal models used in the past. The underlying conditions of interest are important but not commonly seen in humans, making it difficult to know the best medical measurements and, if possible, prescriptive interventions for unruptured neurological disorders, which generally now can be dealt with by way of surgical interventions. The written assessment of the study indicated limited evidence of human studies showing the effect of statin drugs in reducing the risk of aneurysmal ruptures. The study model used in this investigation (case-control) is readily suitable to study uncommon diseases with low overall prevalence rates. However, given the impact such a condition could have on a population segment thought to have many years of productivity – and because of promising animal studies – the study was deemed beneficial as an initial step toward learning more about the drug’s beneficial indicators. The primary endpoint of focus was the likelihood of the rupture of an aneurism and the protective effect...
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...Statins Assignment What is cholesterol? Cholesterol is an example of a class of lipids called sterols. Sterols (also known as steroids) are compact hydrophobic molecules that contain four fused hydrocarbon ring and a number of different functional groups. Cholesterol is an important component of the plasma membranes in animal cells. It is essential for the production of sex hormones, producing bile salts, converting sunlight into vitamin D, and the up-keeping/forming of cell membranes. The leading organ responsible for producing cholesterol is the liver. Before cholesterol is released into the bloodstream the liver packs it with proteins and other compounds. This forms a lipoprotein. Lipoproteins are formed so that cholesterol can be transported through the bloodstream to where it is required. The two main types of lipoproteins are high-density...
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...from a professional resource. Zetia is a drug that is prescribed to about 1 million people a week for the purpose of lowering cholesterol (Berenson, 2008). According to the article, the drug company Merck and Schering-Plough had stated that Zetia has failed to show any medical benefits (Berenson, 2008). The information to be presented is going to be about the drug Zetia (ezetimibe) and Zocor (simvastatin) combined and is called Vytorin. Discussion Zetia is a newer cholesterol drug that works by blocking the cholesterol in food from crossing the intestinal wall and getting into the bloodstream (Ijioma & Robinson, 2011). Statins prevent cholesterol from being absorbed in the liver, and also reduce inflammation, another cause of cardiovascular disease. Adding Zetia to a statin cuts cholesterol levels much more than just increasing the dose of the statin. Vytorin is a combo pill; it combines simvastatin, which blocks production of cholesterol in the liver, and ezetimibe, which blocks absorption of cholesterol in the intestines (Ijioma & Robinson, 2011). Vytorin is indicated for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments or if such treatments are unavailable (RxList, nd). The New York Times and the professional article both talk about the effects of Zetia. The lay article states that Zetia lowers cholesterol by 15 – 20 percent in most patients, but no clinical...
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...College Course Date Objectives In doing this research I wanted to understand more about Lipitor as a drug. The diseases it treats, its chemical components and its medical benefits. In addition to that I also wanted to know the toxicological and physiological effects on human body, its drawbacks and also look into its specific medical documents. Introduction According to Macmillan (2006), “drug can be best defined as substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication” (p. 302). Lipitor whose generic name is atorvastatin (Webster, 2009) is a synthetic lipid-lowering agent. It is an oral drug that lowers the level of cholesterol in blood. It belongs to a class of drugs referred to as statins, thus Lipitor is classified as a drug (Smith and Knapp, 1972). This research was intended to best understand the drug Lipitor. How it works and generally gets some vital information about the drug so that at the end of this research I can have a vivid understanding of its expected effects. Materials and methods This research was done by going through medical books and online journals medical articles. I also requested for clarification from Medical personnel who were of so much help as far as how the drug generally works is concerned and its side effects. I interviewed some patients that were under Lipitor dosage and also patients that have been treated using Lipitor dosage before. I also got information from the information printed on...
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...IDENTIFICATION OF STATINS IN RICE FERMENTED WITH MONASCUS SPECIES FROM THE MUSEUM OF NATURAL HISTORY Jude Carlo J. Muca1, Reigna S. Romero1, Ricardo R. Santos², Roberto Z. Yuseco3, Florence M. Blanco1, Lei Anne C. Carolino1, Engkhuan Chew1, Ericka Joy B. De Guzman1, Jordan Carlo S. Galang1, Jin-Gu Lee1, Lawrence Y. Maliwat1, Marixie Ann Q. Manarang1, Jeshua Caleb B. Miole1, Michael Henry B. Piano1, Lou Anthony S. Sico1, Mark Lester I. Tolenada1, Mellanie B. Victoria1 1 Medical Student, Angeles University Foundation, Angeles City 2009; ²Head, Department of Biochemistry, School of Medicine, Angeles University Foundation, Angeles City 2009; 3 Faculty, Department of Biochemistry, School of Medicine, Angeles University Foundation, Angeles City 2009; ABSTRACT Pharmaceutical intervention through statin drugs is the most common way of slowing down the adverse effects of heart disease due to cholesterol deposition by regulating the activity of HMG-CoA reductase which catalyzes conversion of HMG-CoA to mevalonate. In order to seek alternatives for commercially available statin drugs, this study idnetified the statins that can be produced by fermentation of rice by Monascus strains available at the Museum of Natural History (MNH). It also shall serve as a set-off point for further studies regarding the use of fermentation products for treatment of certain ailments, such as heart disease. A total of eight (8) isolates available at the Museum of Natural History (MNH) of the University...
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...Drug Study Atorvastatin(lipitor) fourty mg one tablet once a day at HS eight pm DRUG CLASS AND MECHANISM: Atorvastatin is an oral drug that lowers the level of cholesterol in the blood. It belongs to a class of drugs referred to as statins, which includes lovastatin (Mevacor), simvastatin, (Zocor), fluvastatin (Lescol), and pravastatin (Pravachol) and rosuvastatin (Crestor). All statins, including atorvastatin, prevent the production of cholesterol in the liver by blocking HMG-CoA reductase, an enzyme that makes cholesterol. Statins reduce total cholesterol as well as LDL cholesterol in blood. LDL cholesterol is believed to be the "bad" cholesterol that is primarily responsible for the development of coronary artery disease. Reducing LDL cholesterol levels retards progression and may even reverse coronary artery disease. Atorvastatin also raises the concentrations of HDL ("good") cholesterol that protects against coronary artery disease and reduces the concentration of triglycerides in the blood. Indications Reduce risk of stroke & heart attack in type 2 diabetes patients without evidence of heart disease but with other risk CV factors Reduce risk of stroke, heart attack and revascularizations procedures in patients without evidence of coronary heart disease (CHD) but with multiple risk factors other than diabetes (eg, smoking, HTN, low HDL-C, family history of early CHD) Patients with CHD to reduce risks of MI, stroke, revascularization procedures, hospitalization...
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...and drawers or cases to keep and transport supplies. The supplies I will need are anything used for collection of samples including syringes and vials, or kits and devices used for less aggressive testing of cholesterol. 2. Regulations include that the site must be licensed to perform testing and must have a “Certificate of Waiver” license if it performs only waived tests. The sites must adhere to manufacturer’s instructions to perform the test, including “Good Laboratory Practice” such as trained personnel, competency, and evaluation. Must also agree to permit announced inspections of the site. 3. OSHA covers every aspect of workplace hazard avoidance. Regulations include health care workers and needle stick precautions, consistent use of personal protective equipment, and work practice and engineering controls in needle stick precautions. 4. Lipoproteins commonly tested for are LDL, HDL, and VLDL. LDL and HDL are the most important when discussing with a patient. 5. It is best to measure her total cholesterol and HDL. LDL can shoot up significantly after a meal. 6. Yes, her age, smoking, high blood pressure, and close relative put her as a candidate for CHD. 7. She has 4 countable NCEP factors: age, relative, smoking, and hypertension 8. Her 10 year risk score is 8%. 9. Her BMI is on the high side and she is overweight being close to obese. 10. I would suggest for lifestyle modifications first and foremost. Advise her to quit smoking and begin developing...
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...Letter to Members Dear Guys, How’s going? Hope you feel good in this cold day! I believe all of us know Lipitor and now taking it frequently, here are news about Lipitor and I know you would like to hear. Pfizer’s Lipitor was so nice that we choose to take before. The company made every efforts to brand its Lipitor and we know it is really good to use. Now the most important thing is, the Lipitor will move from a lower price to a higher price while we cannot do anything about that since the decision was made by the Pharmacy and Therapeutics Advisory Committee. But-- We have a new choice—the generic lipid regulator. Don’t worry it is not a fake drug, just because of the patents expiration, drag companies other than Pfizer can produce generic versions. You may heard that the generic prescriptions increased every year quickly, for example, nearly 6% in 2009 and covered 75% of all prescriptions written in the U.S. The generic versions are safe and mature enough. I know you guys may not care about the money but just the result, or just habit to take Lipitor. The clinical trials established that they were as safe and as effective as brand name drugs such as Lipitor. Why we need to know this? It’s the time to switch. You know GHCM used a three-tier system for co-pays depends on the plan and prescription. Raising of the co-pay (to tier3 which is 100% higher than tier1) is made for Lipitor due to Lipitor’s price changing. It’s the time to make a better choice. Below...
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...Marketing Management 2 – Final Exam The questions are specific and do not require long answers. We encourage you to use bullet points, tables, and graphs where appropriate. However, we will not read meaning into unclear, vague or incomplete answers. Make sure you explain clearly what you wish to say. Note that the different questions are worth a different number of points. Make sure you base your answer on facts in the case, rather than on any real-world knowledge you may have. If you must make an assumption about information you feel is missing, or about the meaning of a word or phrase that you are not sure about, note your assumption explicitly in your answer. A note of caution– while this case study may seem similar to the Zantac case, you should not assume that what was appropriate in that case is necessarily true here. Questions 1. What were the risks associated with the three specific actions (see p. 4) Warner-Lambert had taken during the development of Lipitor? Why did it take these actions? (10 points) 2. Do a SWOT (strength-weakness-opportunity-threat) analysis of Lipitor and Warner-Lambert (prior to the partnership with Pfizer). Also indicate what you think are the main challenges Lipitor’s marketing strategy should address (List no more than 3 challenges). (25 points) 3. Why did Warner-Lambert/Pfizer team up with the American Heart Association for the pre-launch advertising campaign even though it could not promote its brand name...
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...At one time, the lip balm market in America consisted of 3 main players. Those companies ruled the lip balm market for decades. A new startup came along and changed that fact. How did they accomplish this feat? Well, it all started with EOS or the Evolution Of Smooth studying the current lip balm market. They realized that all the lip balms were basically the same. Few of the companies varied from their original products. In addition, they discovered some interesting marketing information concerning the average lip balm consumer. Here is more on the Y EOS domination of the lip balm market. Answering Consumer Demands Clearly, EOS was answering a demand. They discovered that the average lip balm user was a woman. EOS decided to focus on women...
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...Argumentative Writing Rubric 9-10 | Advanced | Proficient | Basic | Not Yet | Claim: The text introduces a clear, arguable claim that can be supported by reasons and evidence. | The text introduces a compelling claim that is clearly arguable and takes a purposeful position on an issue. The text has a structure and organization that is carefully crafted to support the claim. | The text introduces a precise claim that is clearly arguable and takes an identifiable position on an issue. The text has an effective structure and organization that is aligned with the claim. | The text introduces a claim that is arguable and takes a position. The text has a structure and organization that is aligned with the claim. | The text contains an unclear or emerging claim that suggests a vague position. The text attempts a structure and organization to support the position. | Development: The text provides sufficient data and evidence to back up the claim as well as a conclusion that supports the argument. | The text provides convincing and relevant data and evidence to back up the claim and effectively addresses counterclaims. The conclusion strengthens the claim and evidence. | The text provides sufficient and relevant data and evidence to back up the claim and addresses counterclaims fairly. The conclusion effectively reinforces the claim and evidence. | The text provides sufficient data and evidence to back up the claim and addresses counterclaims. The conclusion ties to the claim and...
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...the internet. It is important that bloggers protect themselves from committing this crime. It is okay to use copyrighed material for certain purposes such as: teaching, research, and news reporting. However, one must use caution when posting pictures and text messages from other people in blogs. Using the work of others without permission is equivalent to stealing a photo album or journal from your next door neighbor. Just because you may not sell it to make a profit, does not benign the fact that the material was stolen. Bloggers must become educated about copyright infringement and fair use. When unsure whether they are committing copyright infringement, they should refrain from using copyrighted material. Although it is common knowledge that blogs are the opinions and points of view from various people, bloggers themselves should not deliberately spread false information. Furthermore, the opinions in blogs should always be easily identified, as well as the facts. Bloggers may not have the responsibilities of journalists, but they have the responsibility not to steal or mislead followers. Bloggers should have enough integrity to preserve the credibility in their discussions. If the topic that is being discussed contains false information, then the entire blog loses credibility. Bloggers may not be news reporters, but they must pride themselves in their ability to use the news and current events to spark educated and meaningful...
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...many different types of drones in the marketing world. The most common ones have been used for military purposes. The US military has two types of drones. UAV’s, unmanned aerial vehicles, are used for high tech surveillance. UACV’s, unmanned aerial combat vehicles, are used for destroying targeted objects in war (Pugliese). There are many drones that can be mistaken for remote controlled helicopters as well. These are now issued to some police forces around the US in order to keep a closer eye on cities. Civilians are starting to demand the use of drones in many different areas. Farmers are asking for drones to watch their crops better, and to annihilate any crows that try to destroy them. Boarder patrol wants them for surveillance. This could help patrol the boarder between Mexico and the United States better. Newscasters want them to videotape footage that most reporters cannot get to very easily. Also police departments want to use them to keep an eye in the sky and watch out for crime in...
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...Deviance? Defined as anything of violation of the norm. In the sociological perspective of functionalist, deviance is important for society to remain functional. For it contributes to the social order. Piracy is defined as an act of robbery or criminal violence at sea. The idea of categorizing the transgression of private rights in creative works as "piracy" predates statutory copyright law. The Sean Parker joined friend Shawn Fanning and started the file-sharing service Napster in 1999. Napster's popularity among music lovers quickly escalated. Within its first year, the service attracted tens of millions of users, but also became a target of the music industry, which saw the start-up as a huge threat to its business. Napster was opposed by recording labels, the Recording Industry Association of America, and the heavy metal band Metallica, among others. Lawsuits by various industry associations eventually shut down the service Napster has been called the fastest growing business of all time, is credited with revolutionizing the music industry, and is considered by some to be a precursor to iTunes. I can actually agree with what happened, as piracy is wrong. But I must stress that it was a needed action. Which resulted in all of these companies expanding their industry. Focusing the music, film industry into evolving. Expanding. Into the new era, the era of the internet. In February 2003, Dotcom set up another company called Data Protect Limited, but changed...
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.............................................................4 2.1 Company Information………………………………………………………………4 2.2 Site Goal……………………………………………………………………………..4 2.3 Organizational Culture…………………………………………………….............4 2.4 Affects of Physical Settings on Information Access and Use...........................4 2.5 Primary Audience and Secondary Users…………………………………………5 2.6 Audience Demographics and Psychographics…………………………………..5 2.7 Primary Use of Product or Service………………………………………………..5 2.8 Role of Current Resources………………………………………………………...5 2.0 VISUAL AND FUNCTIONAL DETAILS..............................................................5 3.9 Internal/External User Site Map…………………………………………………...6 3.0 SPECIFIC REQUIREMENTS..............................................................................7 4.10 Performance Requirements………………………………………………………..7 4.11 Platform………………………………………………………………………………7 4.12 Database…………………………………………………………………………….7 4.13 Security………………………………………………………………………………7 4.14 Site Hosting………………………………………………………………………….8 4.15 Major Pages, Functions, Features and Use Cases……………………………..8 4.16.1 Home Page…………………………………………………………………9 4.16.2 Search……………………………………………………………………....9 4.16.3 Search Result Page(s)…………………………………………………….9 4.16.4 Shopping Cart………………………………………………………….......9 4.16.5 Checkout…………………………………………………………………….9 ...
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