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Systematic Lupus Erythematosus

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Tyler Crow
Cameron Carroll
BIOL 2010
Disease Project
11-10-14

Systematic Lupus Erythematosus

My partner and I chose to do our project over systematic lupus erythematosus (SLE). SLE is a chronic inflammatory autoimmune disease that affects connective tissues. This disease has a “sister” form called discoid lupus erythematosus; this disease only affects the skin. For this project, however, we are only going to discuss the much more severe form of systematic lupus. A few facts about SLE is that it strikes women eight more times often than men; thus further, 15 times more often in childbearing years (Springhouse 433). This essay will cover the symptoms, etiology (cause), diagnosis, and treatment for SLE.

The symptoms of SLE include intense joint pain and swelling, extreme risk and often development of arthritis, skin rash, sensitivity to sunlight, hair loss, breathing discomfort, mouth sores and fatigue (National Institute of Health). If the disease is severe and affects multiple parts of the body the symptoms can then range from brain and nervous system issues, abdominal pain, arrhythmias, lung problems including coughing up blood, and renal complications. Renal complications can cause swelling in the legs, and weight gain. All these symptoms are rarely seen in a single patient. The symptoms depend on which part of the body is affected.

The cause of SLE is still unknown, however evidence strongly points to the antinuclear antibodies (ANAs) that attack its own cells. The newly formed antigen-antibody complexes then disrupt normal immunity and damage tissues (Springhouse 433). The severity of their antibody capabilities is due to the multiple tissue components it affects. The cells affected are as followed: red blood cells, neutrophils, platelets, lymphocytes, and many more. Other factors that contribute to leaving the body susceptible to SLE are

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