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Renal Failure and Organ Transplant
Andy Nguyen, Pradip Gautam
The University of Texas at Arlington College of Nursing

In partial fulfillment of the requirements of
N4581 Critical Care
Mrs. McClellan Clinical Instructor
April 09, 2014

Introduction
The purpose of this teaching project is to give our clinical group a good review over renal failure and organ transplantation. By the end of our presentation, students will be able to grasp the most important concept of renal failure and transplantations. We have gathered resources from our text books, lecture notes, trusted web pages, and YouTube videos for demonstration.
Kidney Failure Overview
Kidney failure is the partial or complete impairment of kidney function. It results in an inability to excrete metabolic waste products and water, as well as contributing to disturbances of all body systems. Kidney disease can be classified as acute or chronic. Acute renal failure (ARF) has a rapid onset. Chronic kidney disease usually develops slowly over months to years and renal replacement therapy (dialysis or transplantation) is needed for long-term survival (Lewis 1165).
ARF is a clinical syndrome characterized by a rapid loss of renal function with progressive azotemia, such as BUN and increasing levels of serum creatinine. ARF is often associated with oliguria and usually develops over hours or days. It most commonly follow severe, prolonged hypotension, hypovolemia, or exposure to a nephrotoxic agent.
Chronic kidney disease (CKD) is defined as the presence of kidney damage for at least 3 months with functional or structural abnormalities of the kidneys, with or without decrease GFR. CKD is also defined as a GFR of less than 60 ml/min/1.73 m2 for at least 3 months. Five stages of CKD have been identified based on the level of kidney function as determined by the GFR. The last stage of CKD occurs when the GFR is less than 15 ml/min (Skyscape PDA Software).
Dialysis
Dialysis is a technique in which substances move from the blood through a semipermeable membrane and into a dialysis solution. Dialysis is used to correct fluid and electrolyte imbalances and to remove waste products in renal failure. It can also be used to treat drug overdoses (Lewis 1165).
Two methods of dialysis are peritoneal dialysis (PD) and hemodialysis (HD). In PD the peritoneal membrane acts as the semipermeable membrane. In HD an artificial membrane is used as the semipermeable membrane and is in contact with patient's blood. Generally dialysis is initiated when the GFR is less than 15 ml/min. Certain uremic complications, including encephalopathy, neuropathies, uncontrollable hyperkalemia, pericarditis, and accelerated HTN, indicate a need for immediate dialysis (Lewis 1216-1224).
Organ Transplantation An organ transplant replaces a failing organ with a healthy organ from another person. Transplantation success has improved with advances in surgical technique, advances in histocompatibility testing, and more effective immunosuppressants. Now, most organs and tissues are transplanted successfully with good survival rates (Lewis 228). Organs most often transplanted are kidney, liver, heart, pancreas, lung, and small intestine. Not everyone is a good candidate for an organ transplant. Patient who is not a good candidate if he/she has an infection, heart disease that is not under control, a drug or alcohol problem, or another serious problem (Healthwise, 2012).
Reference
Lewis, Sharon. Medical-Surgical Nursing (with Media), 8th Edition. Mosby, 112010. VitalBook file.
Healthwise. (2012). Organ transplant. Retrieved from http://www.webmd.com/a-to-z-guides/organ-transplant-overview
Perry, Shannon. Clinical Companion for Medical-Surgical Nursing. Mosby, 2012. [Skyscape PDA Software]

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