Molecular Systems Biology 4; Article number 228; doi:10.1038/msb.2008.60 Citation: Molecular Systems Biology 4:228 & 2008 EMBO and Macmillan Publishers Limited All rights reserved 1744-4292/08 www.molecularsystemsbiology.com Finding multiple target optimal intervention in diseaserelated molecular network Kun Yang1,2, Hongjun Bai1,2, Qi Ouyang2, Luhua Lai1,2,* and Chao Tang2,3 1 Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable
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This article was downloaded by: [Universite de Lorraine] On: 10 February 2012, At: 06:13 Publisher: Taylor & Francis Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances and Environmental Engineering Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/lesa20
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Discussion The results of the experiment did not support the created hypothesis that the poisonous enzyme PTU (Phenylthiourea) was a competitive inhibitor. In the experiment to test whether PTU was competitive a catechol oxidase substrate was added to the solution to determine it’s inhibition. As more of the substrate was added, no reaction occurred and the substance remained consistently clear. However, the results indicated that the catechol that was used continued to be inhibited
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Peroxidases are enzymes that use hydrogen peroxide as an electron acceptor to catalyze oxidative reactions. Peroxidase is believed to play a major role in synthesizing cell walls, preventing toxins and responding to stress. It is responsible for the purple color that is seen throughout the experiments. Peroxidase can be found in different locations in a plant in the form of isoenzymes. Many different experiments can be done to locate, visualize and quantify the activity of peroxidase enzymes. These include
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adenosine tri-phosphate (ATP). The process follows oxidation (catabolic) and reduction (anabolic) pathways. Processes involved are glycolysis, Krebs or tricarboxylic acid (TCA) cycle, and the electron transport chain. One step in the TCA cycle is the enzyme-catalyzed conversion of succinate to fumarate in a redox reaction. In intact cells succinate loses hydrogen ions and electrons to FAD to form fumarate. This step in the TCA cycle will be used to study the rate of cellular respiration under different
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|Action |Starting Dose |Target dose |Indications, Contraindications, Averse Effects | | |ACE Inhibitors |Block RAAS system, decrease |Lisinopril: 2.5-5 mg qd |Lisinopril: 20-40 mg qd |Initiate at low doses | |Lisinopril |symptoms and mortality |Enalapril: 2.5-5 mg bid |Enalapril: 10-20 mg bid |May cause angioedema, hyperkalemia, increased creatinine, symptomatic | |Enalapril
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Lab Write Up Identifying an Unknown Microbe Gregory Howard 10E The isolation I was given two unknown microbes and asked to identify them. The first step was to isolate each microbe. I did this by using the streak method to apply each microbe to an enrichment culture. The enrichment culture provides conditions to enhance growth of a species. Obataining a pure culture makes it easier to identify and study a particular species. The macconkey agar plate which is used to isolate and differentiate
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cycle and electron transport chain. Two enzymes that indicate the presence of electron transport chains (ETCs) are oxidase and catalase. Oxidase is an enzyme that is found in Cytochrome C of ETC. It is found in bacteria and mitochondria of eukaryotic organisms. Organism that possess ETC with directly move electrons to oxygen, which is the final electron acceptor. Catalase is common enzyme, which is found in living organisms. Catalase is very important enzyme that protects cell from hydrogen peroxide;
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Abstract: Staphylococcus aureus is the most pathogenic bacteria compared to other staphylococcal species. These mucus membrane colonizers are known for causing harmful diseases to humans such as endocarditis, brain and renal abscess, toxic shock syndrome, Staphylococcal scaled skin syndrome and many more. S. aureus has many virulence factors that contribute to its harmfulness. The cell surface structures of S. aureus are involved damage to the host and protection to the organism from the host’s
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Unknown Identification Introduction to Microbiology Lab Professor M Biology Lab 1913 11/11/2014 I. Introduction A series of tests was completed in order to identify an unknown microorganism. A gram stain reaction test was done. A gram stain reaction test is used to differentiate between two bacterial species. The two species; gram positive and gram negative bacteria have varying properties of their cell wall structural composition. The gram positive bacteria contain a thick
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