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A Comparative Development Approach of Brain

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Submitted By campeldennis
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Running Head: BRAIN ASYMMETRY
A COMPARATIVE DEVELOPMENT APPROACH OF BRAIN ASYMMETRY:
ZEBRAFISH (Danio rerio) AND MEDAKA (Oryzias latipes).
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BRAIN ASYMMETRY
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Introduction
Asymmetry is an essential and conserved element of the mind, which is conceived to enhance data processing and task execution in traits central for species continued existence, such as nurturing, predator uncovering and memory (Güntürkün et al. 2000; Rogers 2000;
Pascual et al. 2004; Vallortigara & Rogers 2005; Rogers & Vallortigara 2008). Moreover, asymmetry has been suggested as the basis of language and other behavioural traits (Sherman et al. 1982; Rogers & Andrew 2002; Hutsler & Galuske 2003; Toga & Thompson 2003) and anomalous asymmetry appears to relate with numerous neuropathologies comprising schizophrenia (Li et al. 2007), autism (Escalante-Mead et al. 2003) and neuronal degenerative disorders (Toth et al. 2004). In the past decade, scientific studies have provided vital insights into the developmental basis of brain imbalance. Exceptionally helpful are genetic model organisms that accept a comprehensive gene to behaviour analysis of this phenomenon
(Concha 2004). For instance, recent research in the teleost zebrafish has revealed genetic mechanisms that regulate the growth of neuroanatomical asymmetries ( Halpern et al. 2003;
Concha 2004) and recognized the first operational relations among genetics, asymmetric morphology and lateralized traits (Barth et al. 2005).
Back ground information on the Zebrafish (Danio rerio)
 The cerebellum roles in the control of smooth and proficient movements. It is also concerned in cognitive and emotional functions (Ito, 2008 and Rodriguez et al., 2005).
 There are different types of neurons in Zebrefish (teleost) cerebellum. They are categorized based on their roles as excitatory or inhibitory neurons (Altman and
Bayer, 1997 and Butler and Hodos, 1996).
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 The zebrafish (Danio rerio) is a little tropical fresh-water fish which lives in rivers of northern India, northern Pakistan, Nepal, and Bhutan in South Asia. (Westerfield
1996).
 Zebrafish (Danio rerio) shares anatomical and physiological traits with other vertebrates like humans, and have materialised as a premiere organism to research vertebrate development and genetics. (Kuan et al. 2007).
Back ground information on the MEDAKA (Oryzias latipes).
 Cilia and flagella are hair-like structures projecting from the cell surface that are vital for a multiplicity of cell functions. flaws in the structure and purpose of cilia leads to pleiotropic disorders, ciliopathies (Badano et al., 2006).
 Medaka (Oryzias latipes) is an emergent model vertebrate system ( Ishikawa, 2000 ).
The phenotypes of fish mutants are often indicative of human ailments, providing useful resources with which to gather insight into conforming human pathologies (
Dooley and Zon, 2000 and Drummond, 2005).
 medaka is small (up to 3.2 cm or 1.3 in) mainly found in East and Mainland Southeast
Asia is a common dweller of rice paddies, marshes, ponds, slow-moving streams and pools. (Concha & Wilson 2001)
 Transgenic medaka have been genetically designed to produce various human hormones, explicit promoter sequences from other fish, and to manufacture antimicrobial proteins and some protein that makes it glow fluorescent green. (Borg et al. 1983)
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BRAIN ASYMMETRY
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Overall conservation of asymmetry in the parapineal–habenular-IPN system of teleosts.
 This idea is reinforced by recent research evidence showing that habenular asymmetry is influenced by removal of the parapineal organ part (Concha et al.
2003; Gamse et al. 2003; Bianco et al. 2008).
 Segregation of habenular efferents in the IPN relies on the well development of asymmetry in the habenulae (Aizawa et al. 2005)
 Evolutionary conservation indicates that the overall outline of asymmetry in the parapineal–habenular is plesiomorphic to teleosts. (Concha & Wilson 2001)
 The segregation of left–right habenular efferents within the dorsoventral axis of the IPN is distinctive to teleosts as it is not present in frogs (Rana clamitans),
(Kuan et al. 2007).
Heterotopic parapineal efferent connectivity suggests divergent principles of development between zebrafish and medaka
 The outcomes provision the idea that left-sided situation of the parapineal organ is a shared trait of asymmetric brain morphogenesis among the teleost faction (Borg et al.
1983; Concha & Wilson 2001).
 Such a deviation in the size of pineal and parapineal organs is not sole to teleosts as it is also viewed within species of reptiles evolving a parietal eye (Concha & Wilson
2001).
 Originally, previous asymmetry in the presumptive habenular area is assumed to guide asymmetric parapineal migration (Concha et al. 2003).
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 Conclusively, parapineal axons relay in areas of the left habenula, which shows enlarged neuropil (Concha et al. 2003) and asymmetric leftover appearance (Gamse et al. 2003).
Heterochronic shifts and the ontogeny of epithalamic asymmetry
 The aspect of time is essential for improvement and a key element in the production of evolutionary diversity (Gould 1977).
 The making of suppositions over the coupling and uncoupling of developmental components and the reconstruction of the ancestral classification of developmental occasions (Reiss 2003; Zelditch 2003).
 This result provides back up to the importance of this normalization procedure for the similarity of developmental period within related species, evaluated with that of other methods (Dettlaff & Dettlaff 1961; Reiss 1989)
 The bearing of these alterations is coherent with earlier reports indicating that brain development is overdue relative to somitogenesis in zebrafish in comparison with medaka (Wittbrodt et al. 2002).
Conclusions.
Since the original proposal of medaka and zebrafish as complementary model organisms ideal for comparative developmental biology (Furutani-Seiki & Wittbrodt 2004), several researchs have used the experimental and evolutionary plusses of these genetic beings to start producing conserved and species-specific philosophies of vertebrate development
(e.g. Lynn Lamoreux et al. 2005; Gajewski et al. 2006; Carl et al. 2007).
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BRAIN ASYMMETRY
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REFERENCES
Aizawa H, Bianco I.H, Hamaoka T, Miyashita T, Uemura O, Concha M.L, Russell C, Wilson
S.W, Okamoto H2005 Laterotopic representation of left–right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus.
Barth K.A, Miklosi A, Watkins J, Bianco I.H, Wilson S.W,Andrew R.J 2005 fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses.
Bianco I.H, Carl M, Russell C, Clarke J.D, Wilson S.W 2008 Brain asymmetry is encoded at the level of axon terminal morphology. Neural Dev. 3, 9
Bisgrove B.W, Essner J.J, Yost H.J 1999 Regulation of midline development by antagonism of lefty and nodal signaling. Development (Camb. Engl.
Chipman A.D, Haas A, Tchernov E, Khaner O 2000 Variation in anuran embryogenesis: differences in sequence and timing of early developmental events. J. Exp. Zool.
288, 352–365
Concha M.L 2004 The dorsal diencephalic conduction system of zebrafish as a model of vertebrate brain lateralisation. Neuroreport. 15, 1843–1846
Ekstrom P, Borg B, Van Veen T 1983 Ontogenetic development of the pineal organ, parapineal organ, and retina of the three-spined stickleback, Gasterosteus aculeatus
L. (Teleostei). Development of photoreceptors. Cell Tiss. Res. 233, 593–609

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