...attitude about colon cancer screening among African Americans. The research process consists of nine parts that include; selecting a problem, formulating a hypothesis, reviewing the literature, listing the measures, describing the subjects, constructing a design, constructing and identifying measurement devices, analysis of the data, and generating conclusions (Neutens, Rubinson, 2010). Upon evaluating the research process to the article, the paper will discuss how the literature review is used in the research, what the ethical considerations are for data collection, what the data describes in terms of statistical analyses, whether or not the findings are statistically significant, state if the conclusions match the results of the study and if the conclusion answer the research question in the definition of the problem, explain whether or not the conclusions are appropriate, and detail if there is enough information on the effectiveness of the study. Research process components in the article The first step in the research process is selecting a problem that involves deciding what the research will focus on. Selecting the problem requires research to ask questions and communicate with peers who may also have knowledge of the research topic (Neutens, Rubinson, 2010). The problem selected in the article explains that lack of knowledge, personal attitude, and many barriers among African Americans leads to higher rates that result in not receiving colon cancer screenings (James,...
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...By Various Methods Rebecca Bruce Oklahoma City University Abstract Colorectal cancer screening (CRC-S) should be a simple, safe, convenient, and inexpensive as possible, with high sensitivity and specificity that allows increased patient participation (Stevenson, 1991). As the third leading cause of US cancer-related deaths, colorectal cancer (CRC) is a serious health concern (CDC, 2014). In 2007, an estimated 158,500 people in the United States were diagnosed with CRC and an estimated 53,000 people died from colon cancer related deaths (ACA, 2014). A goal of healthcare professionals should be to provide education and outreach to all eligible patients for colorectal cancer screening at every possible opportunity. This goal will involve many different screening methods or a combination of these methods. The effort to reach more patients for CRC-S is a group effort among all disciplines and education levels. Keywords: colon cancer, colorectal screening, patient participation, screening methods CRC-S Increasing By Various Methods In the United States, Colorectal cancer can be prevented by the detection and removal of adenomatous polyps. Whenever possible, providers should educate and discuss with their patients the various methods available. Background and Significance The U.S. Preventive Services Task Force (USPSTF) currently recommends screening for colorectal cancer using high-sensitivity fecal occult blood testing, flexible sigmoidoscopy or colonoscopy...
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...Positive Effects of Vegetarianism Vegetarianism is becoming ever more popular around the world. People are choosing vegetarian diets over other diets in hope of living a healthier lifestyle. Matthew B. Ruby defines vegetarianism as, “The practice of abstaining from eating meat.” According to recent polls, Ruby indicates, “approximately 8% of Canadians, 9% of Germans, 40% in India, and 3% of the United States identify themselves as vegetarians.” Vegetarians can be separated into four distinct groups. The first is lacto-ovo vegetarians, also known as partial vegetarians. They exclude red meat, fish, and poultry from their diets, but still eat dairy products and eggs. The second is lacto vegetarians which exclude red meat, fish, poultry, and eggs but still include dairy products. The third group is pescetarians. This group avoids red meat and poultry, but eats fish. The last group is vegans and they have the strictest diet as they avoid eating all animal products including red meat, fish, poultry, eggs, and dairy products. There are several reasons why people become vegetarian. Amita Handa expresses that people become vegetarians because “social reasons, political and religious beliefs, and financial problems.” Another notable reason people switch from nonvegetarian is because of their frustration with the cruel and unusual treatment of animals. Vegetarianism is mostly linked with positive effects on physical health as evidenced by lower body mass index, lower blood pressure, and...
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...outcomes. However, optimal serum concentrations of 25-hydroxyvitamin D [25(OH)D] have not been defined. This review summarizes evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density (BMD), lowerextremity function, dental health, and risk of falls, fractures, and colorectal cancer. For all endpoints, the most advantageous serum concentrations of 25(OH)D begin at 75 nmol/L (30 ng/mL), and the best are between 90 and 100 nmol/L (36 – 40 ng/mL). In most persons, these concentrations could not be reached with the currently recommended intakes of 200 and 600 IU vitamin D/d for younger and older adults, respectively. A comparison of vitamin D intakes with achieved serum concentrations of 25(OH)D for the purpose of estimating optimal intakes led us to suggest that, for bone health in younger adults and all studied outcomes in older adults, an increase in the currently recommended intake of vitamin D is warranted. An intake for all adults of 1000 IU (40 g) vitamin D (cholecalciferol)/d is needed to bring vitamin D concentrations in no less than 50% of the population up to 75 nmol/L. The implications of higher doses for the entire adult population should be addressed in future studies. Am J Clin Nutr 2006;84:18 –28. KEY WORDS 25-Hydroxyvitamin D, vitamin D intake, bone density, lower-extremity strength, colorectal cancer INTRODUCTION suppression of PTH or optimal calcium absorption, including...
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...Arch Iran Med 2010; 13 (2): 143 – 146 Mini Review Five Common Cancers in Iran Shadi Kolahdoozan MD MPH*, Alireza Sadjadi MD MPH**, Amir Reza Radmard MD***, • Hooman Khademi MD MPH * Iran as a developing nation is in epidemiological transition from communicable to noncommunicable diseases. Although, cancer is the third cause of death in Iran, it`s mortality are on the rise during recent decades. This mini-review was carried out to provide a general viewpoint on common cancers incidence in Iran and to explain incidental differences that may help us to establish early detection programs and investigate population risk factors. A detailed PubMed, Scopus and Google scholar search were made from 2000 to 2009. The basic inclusion criteria were all relevant studies focused on cancer epidemiological data from Iran. Overall age-standard incidence rate per 100 000 population according to primary site is 110.43 in males and 98.23 in females. The five most common cancers (except skin cancer) are stomach, esophagus, colon-rectum, bladder and leukemia in males, and in females are breast, esophagus, stomach, colon-rectum and cervix uteri. The incidence rates of gastrointestinal cancers are high in Iran (it is one of the known areas with a high incidence of GI cancers). Breast cancer mainly affects Iranian women about a decade earlier than Western countries and younger cases are affected by an increasing rate of colorectal cancer in Iran, near the Western rates. Archives of Iranian Medicine...
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...com/1472-6963/12/481 RESEARCH ARTICLE Open Access Unsupported off-label chemotherapy in metastatic colon cancer Jonas A de Souza1,2*, Blase Polite1,2,3, Monica Perkins4, Neal J Meropol5, Mark J Ratain1,2,6, Lee N Newcomer4 and G Caleb Alexander7 Abstract Background: Newer systemic therapies have the potential to decrease morbidity and mortality from metastatic colorectal cancer, yet such therapies are costly and have side effects. Little is known about their non-evidence-based use. Methods: We conducted a retrospective cohort study using commercial insurance claims from UnitedHealthcare, and identified incident cases of metastatic colon cancer (mCC) from July 2007 through April 2010. We evaluated the use of three regimens with recommendations against their use in the National Comprehensive Cancer Center Network Guidelines, a commonly used standard of care: 1) bevacizumab beyond progression; 2) single agent capecitabine as a salvage therapy after failure on a fluoropyridimidine-containing regimen; 3) panitumumab or cetuximab after progression on a prior epidermal growth factor receptor antibody. We performed sensitivity analyses of key assumptions regarding cohort selection. Costs from a payer perspective were estimated using the average sales price for the entire duration and based on the number of claims. Results: A total of 7642 patients with incident colon cancer were identified, of which 1041 (14%) had mCC. Of those, 139 (13%) potentially received at least one of the...
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...Colon cancer develops in the large intestine (colon), the lower part of your digestive system. Rectal cancer develops in the rectum, which makes up the last several inches of your intestinal tract. Together, they're referred to as colorectal cancers. Rectal cancer begins as small clumps of cells called polyps. Although most polyps are noncancerous (benign), some become cancerous over time. Regular screening to find and remove precancerous polyps can prevent rectal cancer from developing. Changes in your diet and lifestyle — such as healthy eating and increasing your physical activity — can help prevent polyps from forming, greatly reducing your risk of rectal cancer. Colon cancerEmail this page to a friendShare on facebookShare on twitterBookmark & SharePrinter-friendly version Colon, or colorectal, cancer is cancer that starts in the large intestine (colon) or the rectum (end of the colon). Other types of cancer can affect the colon. These include lymphoma, carcinoid tumors, melanoma, and sarcomas. These are rare. In this article, colon cancer refers to colon carcinoma only. Causes Colorectal cancer is one of the leading causes of cancer-related deaths in the United States. Early diagnosis, though, can often lead to a complete cure. Almost all colon cancers start in glands in the lining of the colon and rectum. When doctors talk about colorectal cancer, this is usually what they are talking about. There is no single cause of colon cancer. Nearly all colon...
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...| | IMI International Medical Innovations | | | | TABLE OF CONTENTS Executive Summary.........................................................................................................................2 Problem Statement...........................................................................................................................3 Methodology....................................................................................................................................3 General Assumptions.......................................................................................................................3 Qualitative Analysis.........................................................................................................................4 Quantitative Analysis.......................................................................................................................5 Option 1 - Complete further Testing Alone.....................................................................................6 Option 2 - Complete Studies with Government...............................................................................6 Option 3 - Co-Develop with Another Company..............................................................................7 Option 4 - Fully Out-License...........................................................................................................8 Option 5 - Seek "Home Brew" Status..........
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...COLDWATER CANCER RATES 1 Community Project Proposal Investigation of Cancer Rates in Coldwater, British Columbia 9555093; 9555944; 9576304; T00044589 Thompson Rivers University NURS3500 Section 01 M. Taylor February 11, 2013 COLDWATER CANCER RATES Table of Contents Introduction…………………………………………………………………………… 3 Purpose…………………………………………………………………………3 Importance of the Issue………………………………………………………...3 Assessment……………………………………………………………………...……...4 Determinants of Health ………………………………………………………………...5 Lifestyle Choices……………………………………………………………….5 Accessing Health Care………………………………………………………….6 Education ……………………………………………………………………….6 Literature Review……………………………………………………………………….6 Interventions……………………………………… …………………..………..………7 Creating Trusting Relationships……………………………………………….. 7 Increase Screening………………………………………………………………8 Education……………………………………..…………………………………9 Evaluation and Sustainability …………………………………………………………..9 References………………………………………………………………………………10 2 COLDWATER CANCER RATES Investigation of Cancer Rates in Coldwater, British Columbia Introduction The target population for this project is the band members of the Coldwater First Nations 3 Community (FNC), located 14 kilometers north of Merritt, British Columbia. There is a growing suspicion within the community that there is an increased prevalence of cancer which has been brought to the attention of the Scw’exmx Community Health Services Society (SCHSS). Purpose The purpose of this project is to collaborate with...
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...The pathway consists of many steps with 30 proteins at the damaged site at most. A person born with NER defects is likely to develop a disease called Xeroderma Pigmentosum (XP). These patients are highly susceptible in developing skin cancer when exposed to UV light, which indicates that the disease arises from a defect in the NER system accountable for DNA damaged caused by UV radiation. One of the other syndromes related to faulty NER is Cockayne syndrome that shows neurological disorder and sun sensitivity (Perera and Bapat, 2007) BER is another DNA repair pathway, which repairs non-bulky damaged nucleotides, sites without a nucleotide base, and single strand breaks (Perera and Bapat, 2007). Mutations in a BER gene causes an inherited recessive colorectal cancer called MYH-associated polyposis (Negrini et al, 2010). Besides nucleotide instability, most cancers are caused by chromosomal instability (CIN), the major form of genomic instability, which is defined as the high rate of defects in chromosome structure and number (Negrini et al, 2010). Indeed, CIN generates aneuploidy, which is shown in most cancer cells by abnormal chromosome numbers and chromosomal...
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...SCREENING AND EARLY DETECTION OF CANCER SAVES LIVES (THE PROS AND CONS) Cancer screening and early detection have major importance in the survival of patients with cancer. For virtually every site, statistics show far better survival rates for early cancers than for advanced cancers. The success of treatment is largely determined by the extent of disease at the time of diagnosis with the exception of the leukemias and lymphomas. Treatment of advanced cancers, using any known modalities, is seldom curative. The objective of early detection and screening is to shift the extent of disease at diagnosis from advanced to early through the systematic examination of asymptomatic and symptomatic people. The examinations vary from self-examination...
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...Behavioral Problem The behavioral problem presented is a refusal for a colposcopy following an abnormal PAP smear from a 22-year-old woman. After missing two appointments, she has expressed that she no longer wants to proceed with the procedure as she fears experiencing pain and the test results. The purpose of using motivational interviewing techniques with this patient is fueled by the importance of follow up from abnormal PAP smear results. High-grade squamous intraepithelial lesion (HSIL) depicts changes to the cervical cells with a high association to precancerous or cancer cells (American Congress of Obstetrics and Gynecology, 2016a). Further, the patient has a potential cervical intraepithelial lesion (CIN) that may be a precancerous lesion and requires diagnosis by colposcopy (ACOG, 2016a). Cervical changes,...
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...Authors 17 December 2013, Vol 159, No. 12> Advertisement Email Share Get Permissions Get Citation Figures Slideset (.ppt) PDF Reviews | 17 December 2013 Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force FREE Stephen P. Fortmann, MD; Brittany U. Burda, MPH; Caitlyn A. Senger, MPH; Jennifer S. Lin, MD, MCR; and Evelyn P. Whitlock, MD, MPH [+] Article and Author Information See Also: Published Letter: Padayatty et al Published Letter: Dror et al Published Letter: Hemilä Published Letter: Bolland et al Published Letter: Fortmann et al Oral High-Dose Multivitamins and Minerals After Myocardial Infarction: A Randomized Trial Long-Term Multivitamin Supplementation and Cognitive Function in Men: A Randomized Trial Enough Is Enough: Stop Wasting Money on Vitamin and Mineral Supplements Ann Intern Med. 2013;159(12):824-834. doi:10.7326/0003-4819-159-12-20131217000729 Text Size: A Related Articles Filter By Topic > Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: U.S. Preventive Services Task Force Recommendation Statement Ann Intern Med. 2014;160(8):558-564. Routine Vitamin Supplementation To Prevent Cancer and Cardiovascular Disease: Recommendations and Rationale Ann Intern Med. 2003;139(1):51-55. CME [+] View More A A This article was published online...
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...WRITING AN EFFECTIVE RESEARCH PROPOSAL The purpose of this handout is not to teach you how to design a research project. Rather it is to help you translate your research plans into an effective research proposal. A well-written proposal will ease the process of obtaining institutional and ethical approval and will increase your chances of obtaining funding for your project. The writing of this booklet was guided by our experience writing proposals but also on our experiences as reviewers on institutional and granting agency review panels. The booklet is designed for health sciences researchers conducting quantitative, clinical research. However, the general concepts are applicable to most areas of inquiry. Writing an Effective Research Proposal 2 ELEMENTS OF A RESEARCH PROPOSAL ∗ ∗ ∗ ∗ ∗ ∗ ∗ Title Abstract Study Problem Rationale/Relevance of the Project Literature Review Specific Study Objectives Research Methods I. Study design II. Subjects Inclusion/exclusion criteria Sampling Recruitment plans Method of assignment to study groups III. Data collection Variables: outcomes, predictors, confounders Measures/instruments Procedures IV. Intervention V. Statistical considerations Sample size Data analysis Ethical Considerations Consent form Privacy of information Work Plan Budget Research team Dissemination Plan 3 ∗ ∗ ∗ ∗ ∗ Writing an Effective Research Proposal KEYS TO SUCCESS TO WRITING A GOOD PROPOSAL Overall Quality of the Study ∗ Good research question...
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...Leading Edge Review Immunity, Inflammation, and Cancer Sergei I. Grivennikov,1 Florian R. Greten,2 and Michael Karin1,* 1Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA 22nd Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany *Correspondence: karinoffice@ucsd.edu DOI 10.1016/j.cell.2010.01.025 Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention. Introduction The presence of leukocytes within tumors, observed in the 19th century by Rudolf Virchow, provided the first indication of a possible link between inflammation and cancer. Yet, it is only during the last decade that clear evidence has been obtained that inflammation plays a critical role in tumorigenesis, and some of the underlying molecular mechanisms have been elucidated (Box 1)...
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