Premium Essay

B Cell Function

Submitted By
Words 1004
Pages 5
The B cells structure has specific receptors on its membrane that allow it to bind to chemical messengers. These receptors are BCR receptors; the presence of the BCR is what distinguishes B cells from T cells. By containing these receptors on its outer membrane, it therefore gives it a greater function as it is able to bind to a particular antigen, and express antibodies.
It has a large, round cell body, which is perfect for undergoing cell division in order to differentiate to a plasma cell. Its large body is perfect for engulfing a pathogen and performing phagocytises, as well as presenting antigens on its outer membrane.
The B cell contains the protein Major Histo compatibility complex II or MHC II on the surface of the cytoplasm, in …show more content…
It is the TCR receptors which they contain, that distinguish them from B cells. When the TCR receptors on the T cell comes in contact with another cell (B cell or dendridic cell) that has displayed antigen fragments bound to its MCH II complex, it becomes activated & can then differentiate into helper t cells or cytotoxic cells. So the presence of the receptors allows them to carry out function. The T cells also contain the protein Tyrosine Phosphatase, which is a key regulator in the immune cell signalling.
Like the B cells, T cells have a large, round cell body which allows for phagocytosis to occur. Its constituents, MHC II and other vesicles allow for the presenting of antigens. So, the MHC protein and TCR receptors are required for immune response and overall function.
Natural killer cells have specific proteins inside them, proteins which have the ability to punch holes in the membrane of the invader and destroy it.
The helper T cells, express the CD4 glycoprotein on their surface. This is fundamental as the help t cells role is to send signals to other types of immune cells. The presence of the CD4 protein is what sends the signals. The CD4 protein is also used to interact with the MHC II molecule on other leukocytes. The CD4 protein contains a special sequence of amino acids that allow it to interact with other leukocytes. So, the presence of these …show more content…
This fluid surrounds and bathes all the cells of the body. It gathers when blood is passing through capillaries, some of the constituents of blood pass through the pores of the capillaries. However, no proteins or blood cells pass through as their structures are too big.
This is due to capillaries being under high osmotic pressure, whereby this high pressure causes the fluid to get squeezed out. This is usually at the arterial end of capillaries.
This fluid has a number of functions related to homeostasis of the body. It acts as a medium for cells to send chemical messages to each other, and to carry substances from the blood to the cells, and vice versa. So, it acts as an exchange service, substances passing out of the blood capillaries (oxygen, nutrients), reach the body cells. Whilst waste products (carbon dioxide, urea), pass through the tissue fluid for entrance to the capillaries. It also, protects the cells and tissues from external damage.
The fluid which gets squeezed out of the blood vessels via osmotic pressure gets re entered into the blood stream. However, a percentage doesn’t, this then gets drained into the lymphatic vessels, for entrance into the lymphatic system. It is then called

Similar Documents

Free Essay

Anatomy

...Define anisocytosis. varying cell sizes Define poikilocytosis varying cell shapes From which cells do B cells arise? stem cells in bone marrow From which cells do plasma cells differentiate? B cells How can a Nissl stain be used to differentiate microglia from oligodendroglia? Microglia are not discernable in a Nissl stain while oligodendroglia appear as small dark nuclei with dark chromatin In what type of CNS tissue (white or grey) are oligodendroglia predominant? white matter Into what cell type does a monocyte differentiate in tissues? Macrophages Name 2 substances produced by an eosinophil. histiminase and arylsulfatase Name the three types of leukocytic granulocytes. basophils, eosinophils, and neutrophils Name the two types of mononuclear leukocytes. lymphocytes and monocytes What are 2 functions of T cell lymphocytes? - cellular immune response regulation of B lymphocytes and macrophages What are 2 morphological features of microglia? - small irregular nuclei - and relatively little cytoplasm What are 3 examples of peripheral lymphoid tissue? - follicles of lymph nodes white pulp of spleen unencapsulated lymphoid tissue What are 3 functions of a macrophage? - pagocytosis of bacteria, cell debris, and senescent red cells - scavenges damaged cells and tissues - can function as an antigen presenting cell What are 3 morphological characteristics of monocytes? - Large - Kidney-shaped nucleus...

Words: 11777 - Pages: 48

Free Essay

Tribodies

...2741-901 Oeiras (Lisbon), Portugal/ Email: nm@biotecnol.com Abstract Tribodies are multifunctional recombinant antibody derivatives, which utilize the natural in vivo heterodimerization of the heavy chain (Fd fragment) and light chain (L) of a Fab fragment, to form a scaffold, upon which additional functions can be incorporated, such as additional binders - e.g. scFv binding domains. Each chain can be extended preferably at the C-terminus with an additional scFv binder. The chains are co-produced in mammalian cells, where the host-cell BiP chaperone drives the formation of the heavy chain-light chain heterodimer (Fd:L) - this reaction does not appear to be inhibited by the chain extensions, and leads to a very specific heterodimerization, using molecules abundantly present in serum (non-immunogenic) These heterodimers are stable, with each of the binders retaining their specific affinities, with the bivalent tribody having higher affinity, and higher activatation of T-cell proliferation and cytotoxicity in vivo. This design allows easy engineering of multispecificity in a single molecule, e.g. bispecific antibodies bivalent for the target and monovalent for effector activation (e.g. for T-cell activation), or trispecific antibodies pur sang. 1 Introduction ............................................................................................................................................................................................... 2 2 Tribody Structure, Production and...

Words: 4895 - Pages: 20

Premium Essay

Dendritic Cells Research Paper

...Dendritic Cells Dendritic cells, also known as professional antigen-presenting cell (APC), are one of the three types of APCs present within the multicellular aggregation of our bodies. They were first discovered in 1973 by Ralph Steinman who was studying spleen cells to understand the induction of immune responses in a major lymphoid organ of a mouse.(1) The importance of their existence lies in their function to orchestrate and stimulate cells within the immune system. Thus, dendritic cells can be purported as the indicative link between the innate and adaptive immune systems and may possibly give rise to future antitumor vaccines.(6) Dendritic cells play a significant role in the innate immune system as they have the ability to interact...

Words: 849 - Pages: 4

Premium Essay

Disorders of the Lymphatic System

...its incidence is on the rise, since the early 1970's, incidence rates for NHL have nearly doubled. Of the nearly 500,000 Americans with lymphoma, approximately 332,000 have this form. Over 65,000 cases of NHL are diagnosed annually in the United States. (www.LYMPHOMA. Org 2015, n.d.) Lymphoma occurs when lymphocytes, a type of white blood cell, grow abnormally. The body has two main types of lymphocytes that can develop into lymphomas: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Cancerous lymphocytes can travel to many parts of the body, including the lymph nodes, spleen, bone marrow, blood or other organs, and can accumulate to form tumors. The two main forms of lymphoma are Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Non-Hodgkin lymphoma is not a single disease, but a group of several closely related cancers. The World Health Organization estimates that there are at least 61 types of NHL. (www.LYMPHOMA. Org 2015, n.d.) Non-Hodgkin lymphomas are broadly divided into two major groups: B-cell lymphomas and T-cell lymphomas. B-cell lymphomas develop from abnormal B-lymphocytes and account for 85 percent of all NHLs. T-cell lymphomas develop from abnormal T-lymphocytes and account for the remaining 15 percent of all NHLs. Non-Hodgkin lymphomas may also be classified as indolent (slow-growing) or aggressive (fast-growing). (King, (2014). ) Although the various types of NHL have some things in common, they differ in their appearance under the microscope, their...

Words: 850 - Pages: 4

Free Essay

Outline the Processes by Which a B Cell Become Fully Activated

...by which B cells become fully activated B cell activation occurs in the secondary lymphoid organs such as the spleen and lymph nodes. After B cells mature in the bone marrow they migrate to the spleen and lymph nodes which receive a constant supply of antigen. B cell activation begins when the B cell bind to an antigen via its BCR. The antigen can either be free floating or presented by APCs such as macrophages or dendritic cells. The antigens can include proeins, glycoproteins, whole virus particles and whole bacterial cells. Mature B cells preferentially undergo T-cell dependant activation whilst marginal zone B cells and B1 B cells preferentially undergo T cell-independent activation. B cell activation is enhanced through the activity of CD21, a surface receptor in complex with surface proteins CD19 and CD81 which are together known as the B cell coreceptor complex. When a BCR binds an antigen tagged with C3 complement protein, CD21 binds the C3 fragment, co-ligates with the bound BCR and signals are transducer to lower the activation threshold of the cell. T cell-independent activation Antigens that activate B cells with the help of T cells are known as T cell dependant antigens and include foreign proteins. They are unable to induce a humeral response in organisms that lack T cells. B cell response to these antigens takes multiple days, though antibodies generated have a higher affinity and are more functionally versatile than those generated rom T cell-independent...

Words: 654 - Pages: 3

Free Essay

A&P - Pnb

...specific antigen into the body that triggers the primary immune response. T cells provide cellular immunity and B cells provide humoral immunity. Both work together to provide the immune response. First the weakened antigen fragment is inserted/injected into the body. A phagocyte will then engulf the abnormal antigen. Before destroying the bacterium a Class1 MHCP incorporates the bacterium and carries it to the plasma membrane for presentation. As a CD8 T Cell passes it first recognizes the antigen on the infected cell. Costimulation occurs to ensure that they are a match. Once confirmed the CD8 receptors bind to the antigen and it activates and undergoes clonal selection. It divides and differentiates into an Effector Cell which reacts to the antigen and a Memory Cell which remembers the antigen for the environmental exposure of the flu and its antigen. The Memory cell plays no role in the initial response, but waits for the second response. Cytotoxic cells destroy the cell by one of three ways and Helper T Cells coordinate the innate and adaptive immune response. You can’t tell by reading this, but the whole process has a window period of about two weeks. The reasoning behind the vaccine. Which is the first response, is to prime the body for the Naturally Acquired Active Immunity, the environmental exposure of the flu and its antigen into the body. This is the second response that the Memory Cells have primed for. They are prepared for the antigen with plenty of antibodies...

Words: 334 - Pages: 2

Free Essay

A215 Exam 1

...BODY ORGANIZATION A.  Chemical Level:  atoms and molecules B.  Cellular Level: Cell: 
basic structural and functional unit of life C.  Tissue Level: Tissue: similar cells that perform a common function D.  Organ Level: Organ: 
2 or more kinds of tissues integrated to perform specific functions E.  Organ System Level: Organ system: organs having related functions F.  Organismal Level: Organism: has several organ systems which work together to maintain life III. PLANES OF REFERENCE & DESCRIPTIVE TERMINOLOGY A. Anatomical Position: upright, feet parallel, eyes & palms forward B.  Planes of Reference: Imaginary lines or actual dissecting cuts (sections) which may be used to "section" the body or an organ. 1. Sagittal: divides the body or organ into unequal right and left portions. a. Midsagittal: 
divides the body or organ into equal HALVES 2. Coronal (= Frontal) Plane: divides the body or organ into anterior (front) and posterior (back) portions 3. Transverse (= Horizontal, Cross-sectional) Plane: 

Divides the body or organ into superior (top) and inferior (bottom) C.  Directional Terms for the Body:  Terms are in table 1.2 on p. 12, (and fig 1.7 on p. 13) - LEARN THEM!! Ex: Medial: closer to midline Lateral: away from the midline   IV.     BODY REGIONS A.  Cephalic Region or Head 1.  Facial Region                              a.  Orbital – eye                              b.  Nasal – nose 
                            c.  Buccal –cheek ...

Words: 3790 - Pages: 16

Premium Essay

Dhcuuf

...brief description of each. 3. Describe the functions and types of extracellular fluid (ECF). 4. Compare and contrast the structure and function of the three types of cell junctions. 5. Sketch a typical layer of epithelium. Label each structure and use this cell layer to discuss the characteristics of epithelia. 6. Explain how epithelia are nourished. 7. Discuss the classification scheme for epithelia. 8. For each of the following epithelial tissues, give a structural description (including any special features such as cilia, goblet cells, etc.), denote a key body location, and identify its function(s): A. B. C. D. E. F. G. Simple Squamous ET Simple Cuboidal ET Simple Columnar ET Pseudostratified Columnar ET Transitional ET Stratified Squamous ET (both keratinized and non-keratinized) Glandular ET 9. Distinguish between merocrine, apocrine, and holocrine exocrine glands and give an example of each. 10. Define the term carcinoma. 11. Describe the general characteristics of connective tissues (CT) and discuss the major structural differences from ET’s. 12. Explain how CT’s are composed of cells plus an intercellular matrix composed of ground substance and fibers. 84 CHAPTER 5: TISSUES 13. Describe ground substance, list the three CT fiber types, and name the many types of cells that may compose CT. 14. For each of the following CT’s, describe its structure, name a key body location, and identify its function(s): A. B. C. D. E. F. G. H. I. G. H. I. Mesenchyme...

Words: 3128 - Pages: 13

Premium Essay

Biology

...003 Chapter 03 Cell Biology and Genetics Student: ___________________________________________________________________________ 1. The structural and functional unit of all living organisms is the  A. ribosome. B. cell. C. organ. D. organelle. E. plasma membrane.   2. All of the chemical reactions within a cell are known as cell  A. reproduction. B. metabolism. C. communication. D. inheritance. E. movement.   3. Cells produce and respond to chemical and electrical signals as a means of  A. communicating. B. metabolizing. C. reproducing. D. synthesizing. E. using energy.   4. Which of the following is NOT a characteristic function of a cell?  A. reproduction and inheritance B. metabolism and energy use C. movement D. synthesis E. communication   5. Which of the following could be used to study general features of cells?  A. a magnifying glass B. scanning electron microscope C. transmission electron microscope D. binoculars E. light microscope   6. In order to study in detail the anatomy of internal cell parts, it would be best to use  A. x-rays. B. flashlights. C. a transmission electron microscope (TEM). D. tissue cultures. E. a scanning electron microscope (SEM).   7. The plasma membrane  A. separates the nucleus from the rest of the cell. B. is a rigid protein membrane. C. is not permeable. D. has a single layer of phospholipids. E. regulates movement of materials into and out of the cell.   8. The environment outside the plasma membrane is most appropriately...

Words: 9362 - Pages: 38

Premium Essay

Bio 101

...Objectives CELL BIOLOGY • Apply the scientific method to creating hypotheses and experiments. • Recognize the fundamental concepts of chemistry in biology. • Describe the energy metabolism of cells. • Compare structures and functions of different cell types. Content outline 1. WHAT IS SCIENCE? a. Science comes from the Latin for “to know.” b. Based on inquiry 1) Discovery science 2) Hypothesis-driven science 3) Case studies 4) Scientists use the scientific method to solve science problems. 2. What are the steps of the scientific method? a. Observation b. Hypothesis c. Experiment d. Data collection e. Analysis f. Conclusion g. Communication 3. What is biology? a. Biology means “the study of life.” b. Characteristics of life 1) Complex, organized (hierarchy of biology) a) Atoms b) Molecules c) Macromolecules d) Organelles e) Cells f) Tissues g) Organs h) Organ systems i) Organisms j) Populations k) Communities l) Ecosystems m) Biospheres 2) Grow and reproduce 3) Respond to external stimuli 4) Acquire and use energy and materials and change those into different forms 5) Reproduce using deoxyribonucleic acid (DNA) blueprint 6) Homeostasis – actively maintain structure and internal environment 7) Capacity to evolve c. Living organisms abide by the chemical and physical laws of nature. d. Energy systems 1) Photosynthesis in plants: chloroplasts 2) Cellular respiration in animals and plants a) Mitochondria b) ATP 4. What is cell biology...

Words: 346 - Pages: 2

Premium Essay

Final Exam

...upper-left corner of a cell indicates that Select one: a. the cell contains a comment b. the cell has been changed by a user c. the cell contains a circular reference d. the cell may contain an error Question 2 A ___ is a numeric description of a single item on a scatter plot Select one: a. data series b. outlier c. catagory label d. data point Question 3 A ___ is a symbol used to compare one cell's contents to another cell or a value Select one: a. Linear Regression b. Relational Operator c. Range Criteria d. Integrator Question 4 A(n) ___ is a preconstructed formula that makes difficult computations less complicated Select one: a. syntax b. argument c. formula d. function Question 5 Add, enter, or delete records in an Access database table by using the Select one: a. Relationship view b. Import view c. Design view d. Datasheet view Question 6 Field properties are shown in Select one: a. Design view b. Datasheet view c. Both Design and Datasheet views d. Neither Design nor Datasheet view Question 7 Given a single data series, what kind of chart visually indicates the relative size of each entry? Select one: a. line chart b. bar chart c. pie chart d. histogram chart Question 8 Given the function =VLOOKUP(C6,D12:F18,3) Select one: a. the entries in cells D12 through D18 are in ascending order b. the entries in cells D12 through D18 are in descending order c. the entries in cells F12 through F18 are...

Words: 1789 - Pages: 8

Premium Essay

Excel Chapter Questions

... b) How many worksheets does a new workbook contain? 3) a) How are individual columns identified on a worksheet? b) How are individual rows identified on a worksheet? c) What is a cell? d) Give an example of cell reference. e) What does the name box display? f) What does the formula bar display? 4) When does a cell display ####? 5) a) Explain what a formula is and give two examples. b) If 10/20 is entered into a cell, Excel considers it a label. How must the entry be changed so that 10 will be divided by 20? c) How can a cell be formatted so that =10/20 will appear in the cell? 6) a) Which specific order of operations does Excel use to evaluate a mathematical expression/equation? 7) What is circular reference? 8) a) What is a relative cell reference? b) What are the contents of cells D22 and E22 after copying cell C22, which stores the formula =C5+C6, into cells D22 and E22? 9) Determine if the following is true or false. If False explain why. a) A cell reference consists of a column letter only. b) Selected cell and active cell mean the same thing. c) The contents of the active cell are displayed in the name box. d) There are over a million rows on a worksheet. e) The width of just a single cell can be changed/adjusted. f) A cell can contain only one line of text. g) The Accounting and Currency formats are the same. h) A range can consist of non-adjacent cells. CHAPTER 6: Functions and...

Words: 986 - Pages: 4

Premium Essay

Basic Human Body Structure Units and Their Functions

...1.1 Describe the four basic human body structure units and their functions The four basic human body structures and their functions are as follows: • Cells • Tissues • Organs • Systems Cells Cells have been identified as the simplest unit of living matter that can maintain life. A cell is the simplest and smallest unit of living matter and cells can live independently and can also reproduce themselves. Cells exist in a varity of shapes and sizes including elongated, oval, and square, cells also have many different function. A group of cells is called a tissue and the study of the structure, form of cells and tissue is called histology. Tissues Tissue is a group/organisation of a number of similar cells, not all identical but from the same origin, that carry out a similar function, which also consists of varying amounts and varity of non-living, intercellular substance between them. It is the level between cells and organs. There are four types of tissue: Epithelial – tissue that is widespread throughout the body. They form the covering of all the body surfaces and are the main tissue found in glands. Epithelial tissue performs a variety of functions that include protection, secretion, absorption, filtration and sensory reception. Connective - tissue that binds structures together, and forms a framework and support for organs and the body as a whole. Connective tissue also acts as a transport system for substances to be carried around the body, and...

Words: 702 - Pages: 3

Free Essay

Computer Science

...Chapter 4: More on Logical, Information, and Text Functions Introduction Logical functions are those that involve Boolean values. The Boolean values are TRUE and FALSE. Some logical functions return a Boolean value as their result, others use the Boolean result of a comparison to choose between alternative calculations. There are six functions listed in the logical group in Excel 2003 – the functions AND, FALSE, IF, NOT, OR, TRUE – and a seventh in Excel 2007 – the function IFERROR. You’ll see the use of most of these in this lab. First, however, it’s worthwhile to become familiar with the logical operators. Logical Operators TRUE and FALSE are common concepts. They are values which pertain to statements. For example, the statement “It is morning.” is either TRUE or FALSE. We recognize that its truth value may change, but at any particular time the statement is either TRUE or FALSE. What may be hidden here is the existence of an implied comparison. To determine the truth value of any statement we compare our understanding of the meaning of the claim with the facts. Strictly speaking the statement “It is morning.” means the time of day is after midnight and before noon. To decide if it’s TRUE we need to know the actual time of day and compare it to our criteria. It’s in these comparisons that we use Logical Operators: |Comparison |Symbol | |less than |< | |less...

Words: 2638 - Pages: 11

Premium Essay

Structure and Function of Some Proteins

...elastic fibres that are found in connective tissue. Like collagen, the amino acid composition is unusual with 30% of residues being glycine and with a high proline content. Cross-linking depends upon formation of desmosine from four lysine side groups. The mechanical properties of elastin are poorer in old animals. 3. keratins Group of highly insoluble fibrous proteins (of high _-helical content) which are found as constituents of the outer layer of vertebrate skin and of skin-related structures such as hair, wool, hoof and horn, claws, beaks and feathers. Extracellular keratins are derived from cytokeratins, a large and diverse group of intermediate filament proteins. 4. glucagon A polypeptide hormone (3485 Da) secreted by the A cells of the Islets of Langerhans in the pancreas in response to a fall in blood sugar levels. Induces hyperglycaemia. A family of structurally related peptides includes glucagon-like peptides 1 and 2 (encoded by the same gene); gastric inhibitory polypeptide; secretin; vasoactive...

Words: 3658 - Pages: 15