...Abstract: This is a case study regarding the effects of chronic alcohol abuse in Patient F43, F referring to the patient’s gender as Female; 43 referring to the age of the patient. Patient F43’s problems with alcohol are further complicated by anorexia nervosa, depression, and bipolar disorder, all of which were known to exist before any problems associated with drinking had developed. As a result of chronic alcohol abuse, Patient F43 is exhibiting signs of alcohol dementia and Korsakoff Syndrome, a brain disorder associated with the thiamine deficiency as a result of long-term heavy drinking. A reliance on primary and secondary evidence from renowned medical and psychological sources will be implemented to direct and assist the patient in understanding her condition as well as steps which should be taken in order to alleviate the symptoms experienced as a result of chronic drinking and nutrient deficiencies. This case study provides a critical review of the effects of alcoholism as traditionally defined within the medical or "disease" model of alcoholism. A detailed case study of memory deficiency is presented. The sequence of events in this case study is used to illustrate the possibilities of side effects of chronic alcohol abuse, namely Korsakoff syndrome. Highlights of the medical model of Korsakoff syndrome are then presented, with particular attention devoted to the key concepts of anterograde and retrograde amnesia. Lastly, suggestions for treatment and...
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...CASE REPORT FUNDING: The authors had no financial support in the production of this manuscript. FINANCIAL DISCLOSURE: The authors have no conflicts of interest relevant to the content of this article. ADDRESS FOR CORRESPONDENCE: Dr. David R. Spiegel, Eastern Virginia Medical School, Department of Psychiatry and Behavioral Sciences, 825 Fairfax Avenue, Norfolk, Virginia 23507; Phone: (757) 446-5888; Email: spiegedr@evms.edu KEY WORDS: Amnestic disorder, frontal lobe, diencephalic A Case of Probable Korsakoff’s Syndrome: A Syndrome of Frontal Lobe and Diencephalic Structural Pathogenesis and a Comparison with Medial Temporal Lobe Dementias by DAVID R. SPIEGEL, MD, and KHENG-JIM LIM, MD Drs. Spiegel and Lim are from the Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia. Innov Clin Neurosci. 2011;8(6):15–19 ABSTRACT Korsakoff’s Syndrome is an amnestic disorder that involves both anterograde and retrograde amnesia. Traditionally associated with longstanding alcohol misuse, thiamine deficiency has been long posited in its pathogenesis, as has dienecephalic lesions. Yet, through this case report, we highlight similarities (and differences) with medial temporal lobe memory disorders and the role of frontal lobe dysfunction in its retrograde amnesia. INTRODUCTION Wernicke’s encephalopathy (WE) and Korsakoff syndrome (KS) are generally viewed as two distinct stages of the same illness called Wernicke-Korsakoff syndrome (WK ...
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...Abstract: This is a case study regarding the effects of chronic alcohol abuse in Patient F43, F referring to the patient’s gender as Female; 43 referring to the age of the patient. Patient F43’s problems with alcohol are further complicated by anorexia nervosa, depression, and bipolar disorder, all of which were known to exist before any problems associated with drinking had developed. As a result of chronic alcohol abuse, Patient F43 is exhibiting signs of alcohol dementia and Korsakoff Syndrome, a brain disorder associated with the thiamine deficiency as a result of long-term heavy drinking. A reliance on primary and secondary evidence from renowned medical and psychological sources will be implemented to direct and assist the patient in understanding her condition as well as steps which should be taken in order to alleviate the symptoms experienced as a result of chronic drinking and nutrient deficiencies. This case study provides a critical review of the effects of alcoholism as traditionally defined within the medical or "disease" model of alcoholism. A detailed case study of memory deficiency is presented. The sequence of events in this case study is used to illustrate the possibilities of side effects of chronic alcohol abuse, namely Korsakoff syndrome. Highlights of the medical model of Korsakoff syndrome are then presented, with particular attention devoted to the key concepts of anterograde and retrograde amnesia. Lastly, suggestions for treatment and prevention...
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...Therapeutic Exercise Prescription Concepts Applied to Patients Diagnosed With Fibromyalgia Pain is defined as an “unpleasant feeling, conveyed to the brain by sensory neurons” (Medical Dictionary, 2013). Pain is a subjective interpretation, which describes location, intensity and nature of sensory information resulted from noxious stimulation of nerve endings. The emotional response and other various conscious or unconscious responses add to the concept of pain. Acute pain usually results from tissue damage and it usually ends once the injury is healed. Chronic pain is a long term condition related to a persistent or degenerative disease or it doesn’t have an identifiable cause. Although there are different opinions about when a patient can be declared as suffering from chronic pain (after six months or twelve months), the presence of such sensation after the healing period usually leads to this diagnosis. One of the diseases with a generalized chronic pain as a symptom, which continues to generate many debates in the medical world, is fibromyalgia. Fibromyalgia, a disorder that affects the overall system and has an effect of generalized chronic pain, will be delineated in this paper, including its causes, manifestation, and part of the process of managing this disease in which a kinesiologist would have a central role. Fibromyalgia, estimated to affect 4% of the population, is a compilation of symptoms accompanying pain, which include fatigue, stiffness and sleep disturbance...
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...Patricia Scheler Biology 1030 Sue Knoll Journal Article Summary Cotard Syndrome Cortard Syndrome, also known as, Walking Corpse Syndrome was discovered and diagnosed by Dr. Jules Cotard in 1880. This syndrome is a neuropsychiatry condition typically associated with depressive symptoms. Cotards falls under the DSM-5 category on the Manual of Mental Disorders. Individuals with Cortard’s characteristically demonstrates behavior believing they have no internal organs, blood, or body parts. Their brain allows them to believe that they are dead, even though they are physically alive and breathing. Cortard Syndrome is frequently associated with schizophrenia, dissociative disorders, central nervous system infections, cerebrovascular disease,...
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...ion. Reference serum levels are less than 35 µmol/L. Excess ammonia is excreted as urea, which is synthesized in the liver through the urea cycle. Sources of ammonia include bacterial hydrolysis of urea and other nitrogenous compounds in the intestine, the purine-nucleotide cycle and amino acid transamination in skeletal muscle, and other metabolic processes in the kidneys and liver. Increased entry of ammonia to the brain is a primary cause of neurological disorders associated with hyperammonemia, such as congenital deficiencies of urea cycle enzymes, hepatic encephalopathies, Reye syndrome, several other metabolic disorders, and some toxic encephalopathies. Ammonia is a productof the metabolismof proteinsand other compounds,and itis required for the synthesis of essential cellular compounds. However,a 5- to 10-fold increase in ammonia in the blood induces toxic effects in mostanimal species, withalterations in the functionof the central nervous system. Bothacuteand chronic hyperammonemia result inalterationsof the neurotransmitter system. Based onanimal study findings, the mechanismofammonia neurotoxicityat the molecular level has been proposed.Acuteammonia intoxication inananimal model leads to increased extracellular concentrationof glutamate in the brainand results inactivationof the N-methyl D-aspartate (NMDA) receptor.Activationof this receptor mediatesATP depletionandammonia toxicity; sustained blockingof the NMDA receptor by continuousadministrationofantagonists dizocilpine...
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...Professor Campbell Shawn Ryan English 101 4/30/15 Concussions; Worse Than They Appear There is no better past time in the United States of America than American football. American football has been the favorite sport in America for the past decades. However, there have been studies which prove that football is incredibly dangerous to the players health. Studies have shown that football has caused concussions to players, damaged players permanently, and the higher chance of a shorter life. From thorough amounts of research; it’s proven that football causes concussions. Concussions occur when “the brain repeatedly collides with the skull, most often due to a blow to the head. Violent shaking of the head and upper body also can cause concussions”(Concussion Management in Football: Don't Shake It Off). Contrary to popular belief, concussions won’t always make the individual go unconscious for a period of time. Yes, that is true, but not all the time. Chris Miller, a retired quarterback, experienced the effects of a concussions when “he was knocked out of bounds and flew headfirst into equipment storage bins on the sideline. He got up and walked back to the huddle. The wrong huddle. Miller was confused, an effect of the concussion” (Concussion Management in Football: Don't Shake It Off). Although Miller didn’t lose consciousness, he still experienced a devastating concussion. After Miller got his first concussion all the rest concussions have been...
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...Football is the epitome of strategic warfare, encapsulating violence, might, strength and valor into a colossally barbaric sporting event. Hall of Fame legend, and former wide-receiver of the New York Giants, Frank Gifford once said, “Football is like nuclear warfare. There are no winners, only survivors." Over the last fifty years, football has grown to become America’s most popular game, however, this fame and glory is accompanied by an alarming rise in tragic accidents on the field of competition. Even with rules and regulations meant for the protection of both the players and the integrity of game, traumatic injuries are escalating at an alarming rate. In all leagues ranging from pee-wee to the National Football League (NFL), the athleticism and size of the players are at an all-time high and continues to increase each season. However, such increases in athleticism have highlighted the greatest flaw in modern football: the iconic football helmet has become the single most destructive weapon in sports. Helmets have become the heads of missiles that launch through the air and crush into opponents’ skulls, leaving players with closed head injuries as a result of multiple concussions. The football helmet found its roots with the leatherheads; however the false sense of security and protection the helmet provides has led to the worst injuries the sports industry has ever seen. The multiple hits to the head can and will eventually lead a player to the emergency room with a concussion...
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...evidence and only theories to date, we can at least see ways to help ease the pain; therapies to help make the patients more active and have a better quality of life. Fibromyalgia: The Pathophysiology Much debate of Fibromyalgia has existed since the first diagnosis. Some people are lead to believe that it replaced Chronic Pain Syndrome and/or Chronic Fatigue Syndrome. Did it, we will examine that here. Depending on who you talk to Fibromyalgia exists, Endocrinology says no and Neurology says yes. Who’s right, which is what we will find out? What we do know; “Fibromyalgia is a chronic musculoskeletal syndrome characterized by widespread joint and muscle pain, fatigue, and tender points” (McCance RN & Huether RN, 2010, p. 1606). If that is Fibromyalgia does that not describe Chronic Pain Syndrome? Well yes and no, Chronic Pain Syndrome usually stays, is always with you all the time, whereas Fibromyalgia has exacerbations that come and go. Chronic pain Syndrome can also incorporate two different syndromes such as Fibromyalgia and Chronic Fatigue Syndrome together ("Pain," n.d.). While the exacerbations of Fibromyalgia seem to come and go, long term studies indicate that signs and symptoms stabilize within the...
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...evidence and only theories to date, we can at least see ways to help ease the pain; therapies to help make the patients more active and have a better quality of life. Fibromyalgia: The Pathophysiology Much debate of Fibromyalgia has existed since the first diagnosis. Some people are lead to believe that it replaced Chronic Pain Syndrome and/or Chronic Fatigue Syndrome. Did it, we will examine that here. Depending on who you talk to Fibromyalgia exists, Endocrinology says no and Neurology says yes. Who’s right, which is what we will find out? What we do know; “Fibromyalgia is a chronic musculoskeletal syndrome characterized by widespread joint and muscle pain, fatigue, and tender points” (McCance RN & Huether RN, 2010, p. 1606). If that is Fibromyalgia does that not describe Chronic Pain Syndrome? Well yes and no, Chronic Pain Syndrome usually stays, is always with you all the time, whereas Fibromyalgia has exacerbations that come and go. Chronic pain Syndrome can also incorporate two different syndromes such as Fibromyalgia and Chronic Fatigue Syndrome together ("Pain," n.d.). While the exacerbations of Fibromyalgia seem to come and go, long term studies indicate that signs and symptoms stabilize within the first year and rarely change over time (Wierwille, 2010). Fibromyalgia (FM)...
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...(fibro) such as tendons and ligaments. It is usually accompanied by other symptoms in addition to the pains and is sometimes called fibromyalgia syndrome. It is a chronic persistant condition. “ The cause of fibromyalgia is not known....research has shown that people with fybromyalgaia have certain subtle changes in some chemicals in the brain and nervous system.....there seems to be a minor change in the level of neurotransmitters, the chemicals responsible for transmitting messages between nerves and brain cells. Research studies have shown that there is also an increased amount of a chemical substance called substance P in the cerebrospinal fluid and that this may be involved in the way pain messages are transmitted.” ( www.patient.co.uk/health/fybromyalgia) As the cause of fibromyalgia is thought to be from the processes in the brain and spinal cord there is little evidence that the disease is due to a problem with the peripheral muscles, tendons and ligaments although the pain is often felt there. Fybromyalgia affects one in fifty people, it usually develops between the ages of twenty five to fifty five and is more common in women. Common symptoms of fibromyalgia are pain, particularly in the neck and back, sensitivity to touch, joint sorenesss, tiredness, and problems sleeping. “ People diagnosed with fibromyalgia often experience chronic pain that can be very debilitating to their lives and careers. As many as 30% of people with fibromyalgia report having trouble simply doing...
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... causing obesity, cancer, addiction and other diet related diseases. Sugar has become one of the longterm health disasters to consumers. For instance, Robert Lustig, Pediatric Endocrinologist at UC San Francisco, offers his analysis in the Public Health article “The Toxic Truth About Sugar” that for the first time in human history, chronic noncommunicable diseases like cancer, diabetes, obesity and heart diseases pose a greater health burden worldwide than do infectious diseases, resulting in 35 million deaths annually, mainly caused from excessive sugar consumption (10). We consume it and think it will be burned away through any type of physical activity such as working out, not realizing the fact that it leaves back permanent traces in our body that slowly develop over time and lead to serious and lifethreatening diseases. Additionally, a USDA study shows that authorities consider sugar as ‘empty calories’ — but there is nothing empty about these calories. A growing body of scientific Halabi 2 evidence is proving that fructose can trigger processes that lead to liver toxicity and a host of other chronic diseases. Consuming a little amount is not a problem, but a lot kills—slowly. It may be calories that...
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...their own definitions of what constitutes child abuse for the purposes of removing a child from his/her family and/or prosecuting a criminal charge. According to the Journal of Child Abuse and Neglect, child abuse is "any recent act or failure to act on the part of a parent or caretaker which results in death, serious physical or emotional harm, sexual abuse or exploitation, an act or failure to act which presents an imminent risk of serious harm". Types Child abuse can take several forms: The four main types are physical, sexual, psychological, and neglect. There are many effects of child neglect, such as children not being able to interact with other children around them. The continuous refusal of a child's basic needs is considered chronic neglect. Physical abuse Physical abuse involves physical aggression directed at a child by an adult. Most nations with child-abuse laws consider the deliberate infliction of serious injuries, or actions that place the child at obvious risk of serious injury or death, to be illegal. Beyond this, there is considerable variation. The distinction between child discipline and abuse is often poorly defined. Cultural norms about what constitutes abuse vary widely: among professionals as well as the wider public, people do not agree on what behaviors constitute abuse. Some...
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...The CDC, United States Centers for Disease Control and Prevention, have done multiple studies which have shown that anywhere ranging between 1.6 million to 3.6 million concussions happen each year. It is stated that “5-10% of athletes will experience a concussion in any given sport season” (Sport Concussion Institute n.d.). Concussions are caused by a hard hit or blow to the head, face, or neck which causes ones brain to move and forcefully knock against the inside walls of ones skull. In result of this, one could feel a variety number of symptoms. Symptoms of a concussion can include the following: “seeing stars” or blurred vision, nausea or vomiting, and confusion, blacking out, irritability, slow or delayed responsiveness, slurred speech,...
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...and 1 pair is sex chromosome. The autosomes carry information regarding the whole body except for sex of that human. The sex is determined with the sex chromosome. If the sex chromosome contains two XX then the sex is said to be female, and if it is XY it is male. A trisomy is a chromosomal abnormality in which the total number of chromosomes exceeds, and the person has 47 chromosomes instead of 46. There are three major types of trisomy, depending upon the addition of chromosomes. These are Patau Syndrome, Edward Syndrome and Down’s syndrome. Children born with trisomy have multiple birth defects, which include poor intellect and delayed milestone....
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