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Circulation

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Submitted By olson
Words 748
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Iron heme complex give blood their red color
Each hemoglobin can contain 4 oxygen molecules
Gases are not really soluble in water which is why CO2 is converted to carbonic acid which then has a slightly lower ph
Cooperative binding allows the next O2 molecules to bind to the hemoglobin
Hemoglobin in facilitating the binding and release of O2 which is why we get an S curve rather than a linear relationships on the graph
Co2 is converted to biocarbonate ions
Carbonic anhydrase speeds up the conversion in endothelial and red blood cells
The ph near tissues tend to have a lower pH
Near the lungs carbonic acid is once again converted to co2
Positive feedback for co2
Myoglobin has a high affinity for o2 – reserved for high metabolic demand for o2
Cartid and aortic bodies regulate ur heart beat according to co2 levels – when you need to breathe more often if u have high co2
High temp reduces the amount of dssolved gas
Countercurrent exchange maximizes the amount of o2 fish can get from the water
Alveoli increase surface area so they are the actual sites of gas exchange
Smaller animals tend to have single circulatory systems – 1 pump Larger animals have double circulation – 2 pumps
MEMORIZE THE ORDER OF BLOOD FLOW!!!
Blood cells are mainly made of plasma
Know the mechanism of blood clotting
Thrombin makes more of itself to make fibrinogen to make fibrin
Lymphocytes become B or T cells while myeloid make WBC and RBC
Atherosclerosis is caused by build up of plaque
LDL goes to tissues HDL leave the tissue to go to liver
HDL is the good cholesterol LDL is bad bc it takes it to the tissue
Hypertension is high blood pressure inflammation plays a role in atherosclerosis heart attack is the death of cardiac tissue and blockage from coronary arteries stoke is the death of brain resulting from a blockage of arteries in the heart angina pectoris is the partial blockage of coronary arteries

10 ^12 neurons and 10 ^4 synapse per neuron
CNS – brain + Spine
Involuntary movts involve more PNS since u don’t integrate it
Nernst equation allows u to know how many ions u have on the outside vs. the inside of a cell
Know if the answer to such equations should be positive or negative
Membrane potential Threshold = -40
Channels for Na+ and K+ are sensitive to depolarization
K+ channels open slower than Na+
Cell membrane is depolarized
Action potential can only go one way
Dimerization
Answer- an obvious difference btwn Na and K is that K is bigger and Na is smaller – so water can coordinate with it easier which explains Na’s higher hydration energy
Sodium channel cant dehydrate sodium bc of its high hydration energy

The ball is slightly positively charged
At resting, the inside of the cell is more negative
So the ball and chain is going to be attracted to the membrane
Resting is -70
The minimum threshold is going to allow the channel to open Once a stimulus is able to depolarize the resting potential just enough the sodium channels open once they open sodium is able to come into the cell – making the inside of the cell positive – making the ball and chain not so attacked to the membrane any anymore so they’re going to be in search of a slightly negative charge the negative charge s outside to its going to try to go back out so the ball and chains plug the channel

LOOK INTO MUTANT CHANNELS

The channels become inactivated at peak levels so they close quickly
Action potential cant go backwards, it only goes forward
Myelin sheath helps quicken he action potential

Metabotropic receptors
- broad, not so specific

Paper due next Thursday

Lower the overall costs if achieving objectives
-Incentivizing innovation

Dale Jamison lecture notes
- the importance of transparency
- flows and stocks – the amount of co2 that’s already in the atmosphere
- the problem is its already there so we have to cut emissions
- prevention – (we’ve given up on that, its out the window)
- mitigation – addressing the problem, to decrease the effects as much as possible there are 2 approached to this – abatement- trying to produce less and actual mitigation – actually trying ot get the greenhouse gasses out of the atmosphere
- adaptation – dealing with the consequences of the problem as they are already starting to occur
- geoengeering – actively manipulating our envt ex. How much sunlight we’re getting in , as a justification for our unsustainable behaviors
- butterfly effect
-

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