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Epigenetic Research Paper

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Epigenetics
What is epigenetics? Epigenetics refers to external modifications to DNA that turns genes "on" or "off". The DNA sequence is not changed, these modifications just affect how the genes are read. Epigenetic regulation involves the modification of DNA and the proteins associated with DNA, which results in changes to the conformation of DNA without a change in its sequence. In some cases, epigenetic modifications are stable and passed down to future generations, but in others cases they are dynamic and change in response to environmental stimuli. Two common molecular mechanisms that regulate epigenetics are DNA methylation and histone modifications. Epigenetic processes are essential for development and differentiation, but they …show more content…
Recent research has shown that complex epigenetic mechanisms have long-lasting effects within mature neurons. These epigenetic mechanisms of gene regulation in neurons have been implicated in the regulation of complex behavior, including abnormalities in several psychiatric disorders including drug addiction, schizophrenia, and depression. Most psychiatric disorders have common features such as genetic predisposition and contribution from environmental factors. Another common attribute of psychiatric conditions is long-lasting behavioral abnormalities. In most individuals, these illnesses develop gradually and follow a chronic, remitting course. In a similar manner, the reversal of symptoms in response to treatment occurs gradually. Therefore, psychiatric medications work in a unique way in that they require rigorous administration to achieve their full effectiveness. Due to this pathway of psychiatric disorders, an important challenge in psychiatric research has been to identify the molecular basis of stable changes in behavior that account for both the symptoms of mental illness and their reversal during …show more content…
There are two classes of monogenic epigenetic disease: those involving genes that are regulated epigenetically, such as imprinted genes, and those that affect the epigenome as a whole, such as modifiers of DNA methylation. Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner; that is the expression of a gene depends on the parent who passed on the gene. For example, if the allele inherited from the father is imprinted, it is silenced, and only the allele from the mother is expressed. The other class of single-gene-controlled epigenetic disease involves genes that encode components of the machinery that regulates the epigenome itself. Mutation of these genes causes developmental

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