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Head Direction Cell Observation

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Assessment of the Retrosplenial Cortex in Head Direction cell Landmark Acquisition and Maintenance
Key Words: Head Direction Cells, visual integration, retrosplenial cortex, episodic memory
BACKGROUND: Spatial navigation serves as the foundation of episodic memory. Without navigational memory, locating the nearest grocery store, your home or even an object in your home could prove debilitating. Spatial navigation is a trait found in primates and most mobile animals, making this a worthwhile topic of study to contribute to identifying the functional connectomes in the mammalian brain.
Direction is a fundamental component of navigation. The neural network that computes direction functions like a compass. Cells in this system are termed head direction (HD) cells and each cell will become active at one direction within the azimuth, called the preferred direction (PD). Computational models point to a “continuous ring attractor” where an “activity hill” results when the head is oriented in one direction. Cells with similar PDs will be active at a given direction, whereas all other cells are quiescent. Head movements drive the activity hill and the visual system corrects for error. Though there is physiological and anatomical evidence for vestibular components of this system, little is known about how the visual stimuli enact …show more content…
METHODS: Three experiments will address Aim’s 1 and 2 using immediate early gene expression (IEG) and in-vivo electrophysiological methods, respectively.
Subjects: Experiment 1: 16 male FosCreEr transgenic mice (6 home cage controls, 6 experimental/medication, 4 experimental/vehichle); Experiment 2: 18 male FosCreEr transgenic mice (6 home cage controls, 6 experimental/medication/cue-shift, 3 experimental/vehichle/cue-shift, 3 experimental/medication/vestibular-shift); Experiment 3: Three male FosCreEr transgenic mice.

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