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Induced Pluripotent Stem Cells

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Submitted By dolphins1323
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The topic I picked is epigenetics and more specifically Induced Pluripotent stem cells (IPSCs). IPSCs are artificially derived typically adult somatic cells. IPSCs have become important in research due to them being a better option than embryo derived stem cells. Epigenetics means above the gene. Epigenetics is the study of changes in the way the genes are expressed by a mechanism other than by changing the nucleotide sequence. In epigenetics can activate genes that aren’t expressed while not changing the DNA sequence. Epigenetics is a relatively new area of research that has been evolving rapidly.
Controversy that surrounds epigenetic research is due to stem cells being apart of the equation. When stem cells are thought of in the general public, people tend to think of embryonic stem cells (ESCs) and all the practical and ethical issues. IPSCs are very similar in that regard to ESCs. Since ESCs had so many ethical issues attached to them it made it impossible to use ESCs in a clinical setting.
Epigenetics its self is controversial due to the changing of the genome and having certain genes being activated. Some think that the changing of the genome is highly unethical. Studies have been done though to prove that epigenetics can be changed by what a mother eats during development of the new born. All that was done in this study was that they changed what the mother mouse would eat and when the baby mouse came out they were genetically different from each other due to what each mother was fed.
Induced Pluripotent Stem Cells are somatic cells that have been reprogrammed to a pluripotent state by specific factors. These stem cells can be generated from hepatocytes, fibroblasts, and keratinocytes. IPSCs are very similar to ESCs by ways of morphology and the expression of the markers. IPSCs are thought be good candidates for regenerative medicine. For example to have

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