...Synopsis of Computational Analysis of Single Nucleotide Polymorphism (SNPs) of Liver cancer, Breast cancer, and Lung cancer B.Sc Hons. Biotechnology Institute of Industrial Biotechnology GOVT.COLLEGE UNIVERSITY LHR. INTRODUCTION Single nucleotide polymorphisms (SNPs), present in the protein encoding regions of the genome can have a profound influence on the structure and function of a protein. Simply these are the changes that could be silent or can be expressive, but mostly are silent. SNPs sometimes have very deleterious effects, such as change in only one nucleotide can cause missarrangement of whole of the sequence and thus codon is misread, accordingly wrong protein will form. In this study effect of SNPs on cancerous diseases will be studied. Many genes have been reported whicg have many silent and some expressive but deleterious mutations or SNPs. We will use different databases to collect the relevant data of SNPs and genes such as FASTA sequence, position, number of chromosome etc. then by usin different softwares for computational analysis of SNPs, this data will be explained on genomic level. To analyse the effect on protein level computational analysis of codones will be done. This give a brief role of SNPs(change) and its effect(disease). OBJECTIVE and SCOPE Main purpose of this work is to find out the mechanism through which SNPs cause changes at protein level. As the data will provide briefly the changes in the gene (at...
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...A mammogram is a radiograph of the breast tissue. It is an effective non-invasive means of examining the breast, commonly searching for masses and/or micro calcifications. Cancer is not preventable, but early detection leads to a much higher chance of recovery and lowers the mortality rate from this disease. Mammography plays a central part in early detection of breast cancers because it can show changes in the breast up to two years before a patient or physician can feel them. Digital Mammograms allow manipulation of fine differences in image contrast by means of image processing algorithms. Different Computer Aided Detection Systems (CAD) have been developed for the specific tasks required in breast imaging, diagnosis, and screening. The...
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...92093, USA 22nd Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany *Correspondence: karinoffice@ucsd.edu DOI 10.1016/j.cell.2010.01.025 Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention. Introduction The presence of leukocytes within tumors, observed in the 19th century by Rudolf Virchow, provided the first indication of a possible link between inflammation and cancer. Yet, it is only during the last decade that clear evidence has been obtained that inflammation plays a critical role in tumorigenesis, and some of the underlying molecular mechanisms have been elucidated (Box 1) (Karin, 2006). A role for inflammation in tumorigenesis is now generally accepted, and it has become evident that an inflammatory microenvironment is an essential component of all tumors, including some in which a direct causal relationship with inflammation is not yet proven (Mantovani et al., 2008). Only a minority...
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...Obesity and Cancer According to the National Institute of Health, nearly two-thirds of adults in the United States are overweight or obese (2007). Research suggests that obesity may be the most preventable risk factor of cancer for non-smokers, and many studies are testing for the effects that obesity has in all cancers and at specific cancer sites. It is known that obesity plays a significant role in cancer; however, the knowledge of the relationship to all cancers and the overall health effect of excess weight in terms of total mortality from cancer is limited (Calle, Redriguez, Walker-Thurmond, & Thun, 2003). In this paper I will examine the research available on obesity and its relationship to breast cancer (in post-menopausal women), endometrial, colon, esophagus, kidney, and pancreatic cancers, and briefly mention a few other cancers currently being studied for a possible link to obesity. The rise of obesity in the last 25 years has been most prominent in the United States. It is not, however, limited to the United States; for instance, similar trends are being seen in other developing countries. As it becomes easier to access tasty but unhealthy food options and as physical activity declines, caloric intake is now exceeding caloric expenditure. Genetic factors have been shown to predispose an individual to become obese, but environmental factors are the ultimate cause for the rise of obesity within populations. It is the metabolic consequences of obesity that are...
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...Pericarditis is an inflammation of the pericardium, which is the membranous sac that encloses the heart and great vessels. The inflammatory response causes an accumulation of leukocytes, platelets, fibrin, and fluid between the parietal and the visceral layers of the pericardial sac, thus producing a variety of symptoms, depending on the amount of fluid accumulation, how quickly it accumulates, and whether the inflammation resolves after the acute phase or becomes chronic. An acute pericardial effusion is caused by an accumulation of fluid in the pericardial sac. The fluid accumulation interferes with cardiac function by compressing the cardiac chambers. Chronic constrictive pericarditis usually begins as an acute inflammatory pericarditis and progresses over time to a chronic, constrictive form because of pericardial thickening and stiffening. The thickened, scarred pericardium becomes nondistensible and decreases diastolic filling of the cardiac chambers and cardiac output. Chronic pericardial effusion is a gradual accumulation of fluid in the pericardial sac. The pericardium is slowly stretched and can accommodate more than 1 L of fluid at a time. Between 26% and 86% of people with pericarditis have illnesses that are considered idiopathic (occurring without a known cause). Pericarditis may also be classified etiologically into three broad categories: infectious pericarditis, noninfectious pericarditis, and pericarditis presumably related to hypersensitivity or autoimmunity...
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...Functions of Reproductive System ❑ Procreate species ❑ Manufacture important hormones ❑ Pleasure Stages of Life ← Embryologically, males and females start out “sexually indifferent” ← Gonads, ducts and externally identical structures ← At 5 weeks gestation changes start to take place ← Puberty: reproductive organs grow to adult size and reproduction becomes possible ← Between 10 and 15 ← Influence of rising levels of gonadal hormones ← Testosterone in males ← Estrogen in females I. Male Reproductive System: Structure ← Scrotum ← Function: Protects the testes, epididymis, and spermatic cord ← Holds testes away from body ← Temperature: 1° below body temperature ← Lined with serous membrane that secrets fluid ← Testes move freely ← Penis ← Function ← Deliver sperms to female ← Urination ← Shaft ← Erectile tissues surround urethra ← Glans ← Cone-shaped structure on end of penis ← Prepuce (foreskin) ← Skin covering in uncircumcised males ← Epididymis ← Sits on top of each testis ← Receives spermatids from seminiferous tubules ← Spermatids become sperm cells ← Vas deferens ← Tube connected...
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...a project cancer and dna oncology information system with numerous illustrations oη by okeke chika tochukwu Department of computer science madonna unversity, elele campus ©august, 2012 TABLE OF CONTENTS declaration ��������������������������������������������������������������������������������������������� i dedication ������������������������������������������������������������������������������������������������ ii acKnoWledgement ���������������������������������������������������������������������������� iii aBstract ��������������������������������������������������������������������������������������������������� iv CHAPTER ONE �������������������������������������������������������� 1 introdUction �������������������������������������������������������������������������������� 1 BackGround oF study ���������������������������������������������������������������������������������������������������������������������1 oBJectives oF study ��������������������������������������������������������������������������������������������������������������������������1 scope oF the study ���������������������������������������������������������������������������������������������������������������������������2 JustiFication oF study ��������������������������������������������������������������������������������������������������������������������2 statement oF proBlem �������������������������������������������������������������������������������������������������������������������3...
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...In most tissues, COX-1 is expressed constitutively, whereas COX-2 is induced by growth factors, cytokines, and carcinogens. Epidemiologic and experimental studies have shown that COX-2 inhibitors are effective chemopreventive agents, reducing the risks of many types of tumors, including breast, colon, lung, prostate, and gastric cancers 10-12. Recently, COX-2 inhibitors have also gained attention, either alone or in combination with other chemotherapeutic agents and/or radiation therapy, in the treatment of cancer 13. For example, Celecoxib, a COX-2-selective inhibitor, exerted antitumor effects in a wide variety of cancers...
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...routine Haematoxylin and Eosin stains, cannibalistic cells could easily be viewed and identified. Cannibalistic cells have a high nuclear: cytoplasm ratio with dispersed chromatin. The cytoplasm contain few rough endoplasmic reticulum, and a distinct golgi apparatus. Sometimes few dense core vesicles (100-150 nm) are present. [6] Cannibalistic cells have no selectivity, affecting living or dead cells and involves cells either homogenous or heterogeneous. It usually targets cells that are more passive. Heterotypic live cell engulfment is associated with leukocytes being ingested into a variety of host cells viz. epithelial cells, fibroblasts, neural cells etc. whereas homotypic live cell engulfment is visualised in tumour cells of breast, lung and gastric carcinoma. [1] [7] Mechanism of Cannibalism Brouwer et.al. [6] Molecular aspects of Cannibalism Various hypothesis has been put forward as to how tumour cells nurture other living cells and very few evidences have come forward till date. Although it is believed that cannibalism occurs as tumour cells feed on ingested cells and may be related to tumour cell nutritional deficiencies, but its exact mechanism is yet to be ascertained. The acidic microenvironment created during carcinogenesis as a result of shift in the metabolic pathway encourages a selected group of cell phenotypes to survive in this caustic environment than other cell types. These selected malignant cells are extremely virulent and has the capability...
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...Cirrhosis and Related Liver Disorders The liver is the largest gland and second largest organ in the human body. It is also the only internal organ capable of regeneration following injury. Located in the abdominal cavity, this reddish brown organ is divided into lobes of different size and shape. The liver plays a critical role in metabolism, digestion, elimination, and detoxification, among other processes. This organ performs a surprisingly large number of functions that influence virtually all other body systems. This is why diseases of the liver can be so devastating. One class of chronic diseases affecting the liver is cirrhosis. (Kasper, 2008) Cirrhosis is a condition in which normal liver cells are damaged and replaced by scar tissue. As the scar tissue accumulates, blood flow through the organ is obstructed which prevents the liver from functioning normally. Cirrhosis can be difficult to notice early because the preliminary stages rarely demonstrate any signs or symptoms. As liver function deteriorates, the effects of cirrhosis become evident. Complications include swelling of the legs and abdomen, weight loss, jaundice, bleeding from the gastrointestinal tract and intense inching. (Kasper, 2008) The most common causes of cirrhosis are hepatitis C, fatty liver, and alcohol abuse. Other causes include repeated bouts of heart failure, cystic fibrosis, antitrypsin deficiency, and Wilson’s disease. Once diagnosed, treatment depends on the cause of the disease and...
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...Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2014, Article ID 369204, 32 pages http://dx.doi.org/10.1155/2014/369204 Review Article Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant Juliana Félix-Silva,1 Raquel Brandt Giordani,2 Arnóbio Antonio da Silva-Jr,1 Silvana Maria Zucolotto,2 and Matheus de Freitas Fernandes-Pedrosa1 1 Laborat´rio de Tecnologia & Biotecnologia Farmacˆutica (TecBioFar), Programa de P´ s-graduacao em Ciˆncias o e o ¸˜ e Farmacˆuticas (PPgCF), Universidade Federal do Rio Grande do Norte (UFRN), Rua General Cordeiro de Farias, s/n, e Petr´ polis, 59012-570 Natal, RN, Brazil o 2 Laborat´rio de Farmacognosia, Departamento de Farm´ cia, Universidade Federal do Rio Grande do Norte (UFRN), o a Rua General Cordeiro de Farias, s/n, Petr´ polis, 59012-570 Natal, RN, Brazil o Correspondence should be addressed to Matheus de Freitas Fernandes-Pedrosa; mpedrosa31@uol.com.br Received 24 February 2014; Revised 1 May 2014; Accepted 1 May 2014; Published 5 June 2014 Academic Editor: Shi-Biao Wu Copyright © 2014 Juliana F´lix-Silva et al. This is an open access article distributed under the Creative Commons Attribution e License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Jatropha gossypiifolia L. (Euphorbiaceae), widely known as “bellyache bush,”...
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...Chapter 1 Introduction to Pathophysiology Lee-Ellen C. Copstead Key Questions • What is pathophysiology? • How are etiology and pathogenesis used to predict clinical manifestations and response to therapy? • How are normal and abnormal physiologic parameters defined? • What general factors affect the expression of disease in a particular person? • What kinds of information about disease can be gained through understanding concepts of epidemiology? http://evolve.elsevier.com/Copstead/ • Review Questions and Answers • Glossary (with audio pronunciations for selected terms) • Animations • Case Studies • Key Points Review Pathophysiology derives from the intersection of two older, related disciplines: pathology (from pathos, suffering) and physiology (from physis, nature). Pathology is the study and diagnosis of disease through examination of organs, tissues, cells, and bodily fluids. Physiology is the study of the mechanical, physical, and biochemical functions of living organisms. Together, as pathophysiology, the term refers to the study of abnormalities in physiologic functioning of living beings. Pathophysiology seeks to reveal physiologic responses of an organism to disruptions in its internal or external environment. Because humans exhibit considerable diversity, healthy structure and function are not precisely the same in any two individuals. However, discovering the common and expected responses to abnormalities in physiologic functioning is useful, and it...
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...Hindawi Publishing Corporation Obstetrics and Gynecology International Volume 2013, Article ID 173184, 11 pages http://dx.doi.org/10.1155/2013/173184 Review Article Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction Andrea Ciavattini,1 Jacopo Di Giuseppe,1 Piergiorgio Stortoni,1 Nina Montik,1 Stefano R. Giannubilo,1 Pietro Litta,2 Md. Soriful Islam,3 Andrea L. Tranquilli,1 Fernando M. Reis,4 and Pasquapina Ciarmela3 1 Woman’s Health Sciences Department, Faculty of Medicine, Polytechnic University of Marche, Via Corridoni 11, 60123 Ancona, Italy Department of Gynaecological Sciences and Human Reproduction, University of Padova, Via Giustiniani 3, 35128 Padova, Italy 3 Department of Experimental and Clinical Medicine, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60126 Ancona, Italy 4 Department of Obstetrics and Gynecology, Federal University of Minas Gerais and National Institute of Hormones and Women’s Health, 30130-100 Belo Horizonte, MG, Brazil 2 Correspondence should be addressed to Andrea Ciavattini; ciavattini.a@libero.it Received 28 February 2013; Revised 10 June 2013; Accepted 13 August 2013 Academic Editor: Hilary Critchley Copyright © 2013 Andrea Ciavattini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Uterine leiomyomas (fibroids...
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...REGULATION OF PHYSIOLOGICAL SYSTEMS BY NUTRIENTS Free Radicals, Antioxidants, and Nutrition Yun-Zhong Fang, Sheng Yang, and Guoyao Wu, PhD From the Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China; the Division of Animal Nutrition, Department of Animal Science, China Agricultural University, Beijing, China; and the Department of Animal Science and Faculty of Nutrition, Texas A&M University, College Station, Texas, USA Radiation hazards in outer space present an enormous challenge for the biological safety of astronauts. A deleterious effect of radiation is the production of reactive oxygen species, which result in damage to biomolecules (e.g., lipid, protein, amino acids, and DNA). Understanding free radical biology is necessary for designing an optimal nutritional countermeasure against space radiation–induced cytotoxicity. Free radicals (e.g., superoxide, nitric oxide, and hydroxyl radicals) and other reactive species (e.g., hydrogen peroxide, peroxynitrite, and hypochlorous acid) are produced in the body, primarily as a result of aerobic metabolism. Antioxidants (e.g., glutathione, arginine, citrulline, taurine, creatine, selenium, zinc, vitamin E, vitamin C, vitamin A, and tea polyphenols) and antioxidant enzymes (e.g., superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidases) exert synergistic actions in scavenging free radicals. There has been growing evidence over the past three decades...
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...SCHOOL OF PHARMACY REPORT WRITING UCS 1263 Assignment 1 Hospital Attachment Report Name : Thiban Ellumalay ID : 012011051056 Programme : BPH Lecturer Name : Dr. Jiyauddin Khan Submission Date : 30th September 2013 An attachment report based on the lesson learned, activity being carried out, experience gained, problem faced and suggestion at Hospital Tuanku Ampuan Rahimah, Klang in various pharmacy departments for period of 3 weeks Submitted to Dr. Jiyauddin Khan, PhD Report writing lecturer, School of Pharmacy Management & Science University Shah Alam, Selangor Darul Ehsan, Malaysia. Prepared by, Thiban Ellumalay, 012011051056 3rd year Bachelor of Pharmacy, Management & Science University Shah Alam, Selangor Darul Ehsan, Malaysia. 30th September 2013 Acknowledgement First and foremost I would like to thank the almighty lord for giving me wisdom to get my attachment done with successfully as well as with the preparation of the report. Without his blessings I wouldn’t have achieved this stage. Besides that, throughout my attachment accomplishment, many people have inspired me, influenced me and contributed their time, energy, ideas, and suggestions for improving my report. I will always be in debt to these people, too numerous to mention. I would...
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