...USE OF EUPHORBIA HIRTA (TAWA-TAWA) IN THE MANAGEMENT OF DENGUE PATIENTS USE OF EUPHORBIA HIRTA (TAWA-TAWA) IN THE MANAGEMENT OF DENGUE PATIENTS SUMMARY OF EFFICACY AND SAFETY/TOLERABILITY DATA Review of related literature revealed that there is no sufficient evidence to support the efficacy and safety of Euphorbia hirta (tawa-tawa) in the management of patients with dengue fever or dengue hemorrhagic fever INTRODUCTION Euphorbia hirta, more commonly known as tawa-tawa, gatas-gatas, or botobotonis in the Philippines, is a small, erect or ascending, slender-stemmed, annual herb, spreading up to 45 cm tall, though sometimes can be seen lying down. The plant has a hairy stem with many branches from the base to the top. The stem and leaves of E. hirta produce a white or milky juice when cut. This plant commonly grows in tropical countries, especially in roadsides and on wasteland. It is widely abundant in the Philippines.1,2,3 E. hirta is also known as E. pulifera, E. capitata, Chamaesyce hirta, snakeweed, pill-bearing spurge, hairy spurge, asthma weed, and asthma plant.4,5 Whole plant or leaf extracts of Euphorbia hirta is known to have a multitude of actions in the biological system.6 In Asia and Australia, the herb is widely used in traditional medicine to treat a variety of medical conditions including asthma, coughs, diarrhea, and dysentery. In east, central, and west Africa, a decoction of the herb is used to treat asthma, oral thrush, boils, sores, and...
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...Dr. Pauly also collaborated with other people to study the genetic and morphological activations of microglia after brain injury in the rat. There are many long term post-traumatic morbidities that are experienced by traumatic brain injury. In diffuse brain-injured rats, a chronic sensory sensitivity to whisker stimulation models the agitation of TBI survivors and provides anatomical landmarks across the whisker-barrel circuit to evaluate post-traumatic neuropathology. As a consequence of TBI, acute and chronic microglial activation can contribute to degenerative and reparative events underlying post-traumatic morbidity. Here we hypothesize that a temporal sequence of microglial activation states contributes to the circuit pathology responsible for post-traumatic morbidity, and test the hypothesis by examining microglial morphological activation and...
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...into germ layers. hESC’s are used for regeneration of and organ regeneration of tissues, like for myocardial regeneration to treat irreversible heart injuries. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor to promote the release of growth hormone. It is unclear is hESC’s can induce myocardial generation by ghrelin after in vivo engraftment into the myocardium. What was done: Adult male Sprague-Dawley rats that were eight weeks old were used. The hESC’s were cultured on y-irradiated mouse embryonic fibroblast feeder layers. The rats were induced with myocardial infarction (MI) by the ligation of the left anterior descending coronary artery (LAD). They used one millions undifferentiated hESC’s and injected them into the hearts. The Mi animals transplanted with hESC’s were put into two treatment groups: the subcutaneous injections of ghrelin or the phosphate buffered solution (PBS). The control group was the sham ligation and PBS. Transthoracic echocardiography was done 4 weeks after cell transplantation before the rats were sacrificed to measure the...
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...Animals: Young adult male Sprague Dawley rats (Harlan Laboratories, Madison, WI, USA), were used for these experiments. The rats weighed between 250 to 300 g at the start of the experiments. Rats were individually housed in ventilated polycarbonate Animal Care System Cages in a temperature and humidity controlled room on a 12:12 light:dark cycle with ad libitum food and water access, unless otherwise noted. All protocols and procedures were approved by the Institutional Animal Care and Use Committee at Georgia State University and conformed to the NIH Guide for the Care and Use of Laboratory Animals. Implantation of indwelling cannula: Rats were anesthetized with isoflurane, and put in a stereotaxic apparatus (David Kopf Instruments, Tujunga,...
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...Cryobiology of Rat Embryos I: Determination of Zygote Membrane Permeability Coefficients for Water and Cryoprotectants, Their Activation Energies, and the Development of Improved Cryopreservation Methods During the 1nd Semester 2012-2013 A Research Paper Presented to Mr. Luis Gallardo Mago In partial fulfillment Of the requirements in Nat. Sci. Subject By: Table of contents Abstract Materials and methods Results Discussion References Figures Tables Abstract Cryobiology of Rat Embryos I: Determination of Zygote Membrane Permeability Coefficients for Water and Cryoprotectants, Their Activation Energies, and the Development of Improved Cryopreservation Methods. Reinhold T. Pfaffa,b, Yuksel Agcaa,b, Jun Liua, Erik J. Woodsa, Augustine T. Peterb and John K. Critser2,,a,b a Cryobiology Research Institute, Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202 Department of Veterinary Clinical Sciences, b School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907 New rat models are being developed at an exponential rate, making improved methods to cryopreserve rat embryos extremely important. However, cryopreservation of rat embryos has proven to be difficult and expensive. In this study, a series of experiments was performed to characterize the fundamental cryobiology of rat fertilized 1-cell embryos (zygotes)...
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...ABSTRACT The surface properties of materials contribute to host cellular response and play a significant role in determining the overall success or failure of an implanted biomaterial. Rough titanium (Ti) surface microtopography and high surface free energy have been shown to enhance osteoblast maturation in vitro and increase bone formation in vivo. Whereas the surface properties of Ti are known to affect osteoblast response, host bone quality also plays a significant role in determining successful osseointegration. One factor affecting host bone quality is patient age. We examined both in vitro and in vivo whether response to Ti surface features was affected by animal age. Calvarial osteoblasts isolated from 1-, 3-, and 11-month-old rats all displayed a reduction in cell number and increases in alkaline phosphatase–specific activity and osteocalcin in response to increasing Ti surface microtopography and surface energy. Further, osteoblasts from the three ages examined displayed increased production of osteocalcin and local factors osteoprotegerin, vascular endothelial growth factor (VEGF)-A, and active transforming growth factor (TGF)-b1 in response to increasing Ti surface roughness and surface energy. Latent TGF-b1 only increased in cultures of osteoblasts from 1- and 3-month-old...
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...European Medicines Agency Evaluation of Medicines for Human Use Doc.Ref:EMEA/501324/2008 ASSESSMENT REPORT FOR FILGRASTIM RATIOPHARM International Nonproprietary Name: filgrastim Procedure No. EMEA/H/C/824 Assessment Report as adopted by the CHMP with all information of a commercially confidential nature deleted. 7 Westferry Circus, Canary Wharf, London E14 4HB, UK Tel. (44-20) 74 18 84 00 Fax (44-20) 74 18 84 16 E-mail: mail@emea.europa.eu http://www.emea.europa.eu © European Medicines Agency, 2008. Reproduction is authorised provided the source is acknowledged. TABLE OF CONTENTS 1 BACKGROUND INFORMATION ON THE PROCEDURE................................................... 3 1.1 Submission of the dossier ...................................................................................................... 3 1.2 Steps taken for the assessment of the product........................................................................ 3 2 SCIENTIFIC DISCUSSION......................................................................................................... 5 2.1 Introduction............................................................................................................................ 5 2.2 Quality aspects ....................................................................................................................... 5 2.3 Non-clinical aspects ..................................................................................................
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...object recognition memory in rats Jessica E. Beilharz a, Jayanthi Maniam b, Margaret J. Morris b,⇑ a b School of Medical Sciences, University of New South Wales, Australia Department of Pharmacology, School of Medical Sciences, University of New South Wales, Australia a r t i c l e i n f o Article history: Received 10 October 2013 Received in revised form 11 November 2013 Accepted 25 November 2013 Available online 3 December 2013 Keywords: Diet Fat Sugar Obesity Memory Learning Hippocampus Inflammation Oxidative stress a b s t r a c t High energy diets have been shown to impair cognition however, the rapidity of these effects, and the dietary component/s responsible are currently unclear. We conducted two experiments in rats to examine the effects of short-term exposure to a diet rich in sugar and fat or rich in sugar on object (perirhinaldependent) and place (hippocampal-dependent) recognition memory, and the role of inflammatory mediators in these responses. In Experiment 1, rats fed a cafeteria style diet containing chow supplemented with lard, cakes, biscuits, and a 10% sucrose solution performed worse on the place, but not the object recognition task, than chow fed control rats when tested after 5, 11, and 20 days. In Experiment 2, rats fed the cafeteria style diet either with or without sucrose and rats fed chow supplemented with sucrose also performed worse on the place, but not the object recognition task when tested after 5, 11, and 20 days. Rats fed the cafeteria diets...
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...Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3(2): 141-164 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4 Traditional uses, phytochemistry and pharmacological properties of Moringa oleifera plant: An overview Garima Mishra1*, Pradeep Singh1, Ramesh Verma1, Sunil Kumar1, Saurabh Srivastav1, K. K. Jha1 and R. L. Khosa2 Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India, 2 Deptt. of Pharmacy, Bharat Institute of Technology, Partapur Bypass, Delhi Road, Meerut ______________________________________________________________________________ ABSTRACT Moringa oleifera, an important medicinal plant is one of the most widely cultivated species of the family Moringaceae. It is highly valued from time immemorial because of its vast medicinal properties. The present article provides all necessary information regarding its phytochemical investigations, pharmacological actions and medicinal properties like anemia, anxiety, asthma, blackheads, blood impurities, bronchitis, catarrh, chest congestion, cholera, conjunctivitis, cough, diarrhoea, eye and ear infections, fever, abnormal blood pressure, pain in joints, scurvy, semen deficiency, headaches and tuberculosis. It gives an account of all the data and reports which have been appeared to prove its medicinal and nutritional importance. Its utility as a nonfood...
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...Journal of Controlled Release 113 (2006) 189 – 207 www.elsevier.com/locate/jconrel Review Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective D. Venkat Ratnam, D.D. Ankola, V. Bhardwaj, D.K. Sahana, M.N.V. Ravi Kumar ⁎ Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Phase-X, S.A.S. Nagar, Mohali, Punjab, India - 160062 Received 31 January 2006; accepted 26 April 2006 Available online 13 May 2006 Abstract Antioxidants are emerging as prophylactic and therapeutic agents. These are the agents, which scavenge free radicals otherwise reactive oxygen species and prevent the damage caused by them. Free radicals have been associated with pathogenesis of various disorders like cancer, diabetes, cardiovascular diseases, autoimmune diseases, neurodegenerative disorders and are implicated in aging. Several antioxidants like SOD, CAT, epigallocatechin-3-O-gallate, lycopene, ellagic acid, coenzyme Q10, indole-3-carbinol, genistein, quercetin, vitamin C and vitamin E have been found to be pharmacologically active as prophylactic and therapeutic agents for above mentioned diseases. Antioxidants are part of diet but their bioavailability through dietary supplementation depends on several factors. This major drawback of dietary agents may be due to one or many of the several factors like poor solubility, inefficient permeability, instability due to storage of food, first pass effect and GI degradation. Conventional...
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...Annual Report 2011 Industrial Technology Institute Your Partner in Technological and Industrial Growth Contents ITI Quality Policy 1 Act & Legislation 2 Mandate 2 Vision 2 Mission 2 Board of Management and Committees 3 Organization Structure 4 Senior Management 5 Chairman’s Message 6 Executive Report 8 Performance Highlights 15 Quality Infrastructure 19 Accelerating Industrial Technology Development 22 Benchmarking for Competitiveness 28 Monitoring and Mitigating Pollution 33 Technology for Human welfare and Socio-economic Upliftment 37 Training Programs & Workshops 38 Capacity Building 40 New Initiatives 43 Corporate Awareness 46 Information for Industry 48 Awards and Recognition 52 Corporate Social Responsibility 54 Social, Welfare and Religious Activities 55 Publications, Presentations and Patents 57 Human Resources 62 Executive Staff 65 Financial Report 2011 Auditor's Report AG's Report Reply ITI Quality Policy “The management of the Industrial Technology Institute is unreservedly committed to maintain the ISO 17025 Quality Management System for the Testing and Calibration services and ISO 9000 Quality Management System for the entire Institute, in keeping with the National Quality Policy, thus providing customers with services of the highest professional standards. All ITI staff has been made fully...
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