...1,4-Diaryl-azetidin-2-ones John W. Clader et al (J. Med. Chem. 1996, 39, 3684-3693) reported a series of azetidinone cholesterol absorption inhibitors related to compound 2(6 in paper). They focused on detailed structure-activity relationship of azetidinone compounds to probe the effect and sensitivity of the nature and pattern of substitution on the hypocholesterolemic activity in 7-day cholesterol-fed hamster model. Investigation identified that 4-alkoxyphenyl and absolute stereochemistry at C-4 (compound 23), well placed phenylalkyl group (compound 105) and monosubstitution at C-3, an aryl group at N-1 irrespective of substitutions (compound 65) and azetidinone scaffolds is essential for the in vivo CAI activity. Compound 23 Compound 105 Compound 65 Compound 6 X- 4-C2H5O X- OCH3 R- H X- 4-CH3O R1- Ph(CH2)3 Y- H R1- Ph(CH2)3 R2- H R1- F R2- Ph(CH2)3 R2- H SC- -52%(50mg/kg/day) -30%(50mg/kg/day) -49%(50mg/kg/day) -29% (50mg/kg/day) LCE- -98%(50mg/kg/day) -94% (20mg/kg/day) -95%(40mg/kg/day) -77.5%(50mg/kg/day) ...
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...Britain’s and Americans over cherished political standards. The following conflict between the Americans and the Britain’s brought forth another country. The New World sustained new thoughts regarding the way of citizens, society, and government. In the Old World, few individuals born to such permanent surroundings challenged to question their humble societal position however European immigrants were not easily extinguished. In the American wild, they experienced the world that was theirs to make. During this period the people of America were subjected to hostility, heavy taxes were imposed on to them to finance the colonial expenses. The objective of this paper is to evaluate the thesis of the four articles that are being closely related to the theme England was the safest place to live between the years of 1763-1775. This paper will effectively focus on the social, economic and political stands of England to its citizens as well as the colonies. Women in the American Revolution The author has clearly defined the term patriotism as an act of being an active member in the progression of a specific idea similar to independent from the states that are being denied. For this situation, there is a solid connection between the acts of women being patriotically active in the achievement of the war. In this circumstance, the poem “The Attempt is Praise,” was published in the Maryland Gazette, composed by an anonymous soldier. The poem demonstrated the subject according to the suggestion...
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...Research Paper: My Thought on Abortions On October 1, 2008, butterflies floated around in my stomach all day while walking the halls of Hillcrest High. I knew something wasn’t quite right. Afterschool, my boyfriend and I made a trip to Wal-Mart. I fidgeted with my fingers the whole ride there. We purchased a Clear Blue pregnancy test. When we arrived at his house, the both of us made our way to the downstairs bathroom. As the urine landed on the Clear Blue stick, something told me that this will determine my future. Would I go off to college? Would I have to stay home to care for a baby?? I contemplated. “Am I pregnant???” was the biggest question of them all. My boyfriend and I waited impatiently for the results to appear on the stick. Hot tears began to roll down my cheeks before I could view the results. My boyfriend gasped. The look on his face told me that our lives would be change forever. Or would it? The word ‘abortion’ was the only thing on my mind for the rest of the evening. I cried and sobbed as my boyfriend did his best to console me until I fell asleep. The next morning I woke up early. Before I could even say “good morning” I told my boyfriend that I wanted an abortion. He stared at me for what seemed like a century. – Weeks had passed and I kept putting the abortion off for a later date. The thought of actually aborting didn’t sit well with me. One evening after school, I called Planned Parenthood to set up an appointment to have an abortion. Come to find...
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...structures, or mental schema, than non-entrepreneurs (Mitchell, Smith, Seawright, & Morse, 2000). Interestingly, franchisees—often considered to be entrepreneurs (e.g., Baucus, Baucus, & Human 1996; Grunhagen & Mettelstadedt, 2005)—have been found to have entrepreneurship-related knowledge structures more closely resembling non-entrepreneurs than entrepreneurs, implying that the franchise business model may in many ways compensate for a franchisees’ lack of entrepreneurial skills. Applied to a development context, franchising can be employed as a social innovation—compensating for some of the shortcomings of traditional microfinance strategies that often assume a minimum level of entrepreneurial ability in their borrowers. The purpose of this paper...
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...not surprising that there is plenty of literature, opera and movies about Elizabeth I. The following term paper examines three movies, where Elizabeth I is the protagonist. “Elizabeth“, with Cate Blanchett in the leading role, is about the days of her youth. The 1998 movie shows the development of a young princess, who was crowned after the death of her half sister Maria. The first years of her reign are very turbulent, because the creation of a Protestant Church by her father Henry VIII and the return to Catholicism under Maria split the nation. The inexperienced Elizabeth has to determine which religion should be the official one in order to prevent a civil war. Meanwhile her consultants give her advice to keep the line of succession by marriage. But to whom shall she entrust her heart and kingdom? At the end of the movie all problems are solved and Elizabeth creates the icon of the “virgin queen“. Nine years later, the sequel of the movie from 1998, “Elizabeth: The Golden Age“ was released. She is in her 26th year of reign and still without descendants. In spite of many men who wish to marry her, she refuses entering into the bond of marriage. Only the sailor Sir Walter Raleigh attracts her attention. Inside England, the reign of Elizabeth is threatened by an intrigue of her cousin Maria Stuart, the sovereign of Scotland. Philipp of Spain sees the execution of Maria Stuart as a provocation against...
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...Style 1. In-text citation In-text citation should include the information for the reader to find the full entry in the list of Works Cited at the end of the paper. a. If the author’s name is mentioned in the text, only the page number is given in parentheses at the end of the citation b. If the author’s name is not mentioned in the text, then both the last name of the author and the page number should be given in parentheses. c. REMEMBER to shift the punctuation mark if there is one, such as a period, a comma, to the place after the parenthesis. For example: 1. Stuart Hall says,”Identity is formed at the unstable point where the ‘unspeakable’ storied of subjectivity meet the narratives of history, of a culture”(135) . 2. Some scholars believe that “Identity is formed at the unstable point where the ‘unspeakable’ storied of subjectivity meet the narratives of history, of a culture”(Hall 135). If you have cited two or more works by the same author in your paper, a shortened title, which is enough to indicate which of the author’s work is cited, should be given in parentheses before the page nnumber. The items in parentheses should be divided by a comma. For example: 1. Joseph Gibaldi points out,“Nearly all research builds on previous research. Researchers commonly begin a project by studying past work in the area and deriving relevant informaton and ideas from their predecessors. This processs is largely...
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...SAMPLE BIBLIOGRAPHY KEY POINTS TO NOTE WHEN COMPILING YOUR BIBLIOGRAPHY • Choose a topic on which you will not have to struggle to find enough material • Put a title on your bibliography, so that it is clear what subject you are writing about • Include your search strategy - how you selected your references. • Count your references and make sure that the number is within the limit of 40-50 • Arrange your references in alphabetical order • Cite them properly according to the MHRA (Modern Humanities Research Association) guidelines for referencing your work. These are laid out in Section 10 of the MHRA Style Guide. At http://www.library.soton.ac.uk/infoskills/referencing.shtml#MHRA you will find a link to the Style Guide. There you will also find links to documents containing MHRA-format examples from the Guide, and from the New College Humanities Programme Handbook. • Check and double-check for inaccuracies and inconsistencies in spelling, punctuation and spacing • Include as wide a range of types of information sources on your topic as you can find. The main ones are books, journal articles, electronic journal articles, conferences, theses, websites, and newspaper articles, reports and government publications (though the last two types are unlikely for the subject of this sample bibliography) • Choose references that are up to date, unless your topic has a historical slant, in which case older material will be appropriate ...
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...Carolina Oquendo Sociology of Gender Final Project Gender roles in religion have always been a controversial topic. All of the major world religions belittle women to some degree. It is not a secret that women have historically gotten the short end of the stick, so to speak, when it comes to how they are treated and viewed in religion. After researching this topic, I can safely say that the women do all the work and the men take all the credit. Women are treated less than equal to men in most religious settings. Below I will touch upon women’s roles in Christianity, Judaism, Buddhism, Hinduism, the Rastafari Movement, Mormonism and Islam and how they have in fact, gotten the “short end of the stick” and how women have been belittled in every major religion. Christianity is a religion wholly based on the life teachings of Jesus Christ as presented by the gospel. Followers of this faith, known as Christians, believe that Jesus is the son of God. They refer to Jesus as Christ or the Messiah. There are many denominations within Christianity. Some of these include Catholicism, Orthodox, Protestant and Restorationists. The Roman Catholic Church is headed by the pope. Catholics believe that there is one holy catholic and apostolic church founded by Jesus. The Protestants are people that separated from the Catholic Church in the 16th century. They often refer to themselves as being born again and when asked what religion they follow, they answer that they are Christian. All...
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...Welcome to OPERATIONS MANAGEMENT Operations Management is important, exciting, challenging, and everywhere your look! Important, because it’s concerned with creating all of the products and services upon which we depend. Exciting, because it’s at the centre of so many of the changes affecting the world of business. Challenging, because the solutions that we find need to work globally and responsibly within society and the environment. And everywhere, because every service and product that you use – the cereal you eat at breakfast, the chair you sit on, and the radio station you listen to while you eat – is the result of an operation or process. Our aim in writing Operations Management is to give you a comprehensive understanding of the issues and techniques of operations management, and to help you get a great final result in your course. Here’s how you might make the most of the text: ● Get ahead with the latest developments – from the up-to-the-minute Operations in practice features in every chapter to the focus on corporate social responsibility in the final chapter – these put you at the cutting edge. ● Use the Worked examples and Problems and applications to improve your use of key quantitative and qualitative techniques, and work your way to better grades in your assignments and exams. ● Follow up on the recommended readings at the end of each chapter. They’re specially selected to enhance your learning and give you an edge in your course...
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...M A G A Z I N E FA L L 2 0 0 2 Volume 20 Number 2 SPANNING THE GLOBE Duke Leads the Way in International Law Teaching and Scholarship inside plus Duke admits smaller, exceptionally well-qualified class Duke’s Global Capital Markets Center to launch new Directors’ Education Institute from the dean Dear Alumni and Friends, It is not possible, these days, for a top law school to be anything other than an international one. At Duke Law, we no longer think of “international” as a separate category. Virtually everything we do has some international dimension, whether it concerns international treaties and protocols, commercial transactions across national borders, international child custody disputes, criminal behavior that violates international human rights law, international sports competitions, global environmental regulation, international terrorism, or any number of other topics. And, of course, there is little that we do at Duke that does not involve scholars and students from other countries, who are entirely integrated with U.S. scholars and students. Students enrolled in our joint JD/LLM program in international and comparative law receive an in-depth education in both the public and private aspects of international and comparative law, enriched by the ubiquitous presence of foreign students; likewise, the foreign lawyers who enroll in our one-year LLM program in American law enroll in the same courses, attend the same conferences...
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...www.the-criterion.com The Criterion: An International Journal in English ISSN 0976-8165 Empire and Excess: Kipling and the Critique of Said’s Orientalism Sourit Bhattacharya Edward Said’s Orientalism remains one of the most influential books of the last quarter of twentieth century. In an informative manner, Said locates the seeds of Orientalism right in the medieval European imagination that solidifies itself in the nineteenth century. It is through knowledge, power, reason, scientific technologies and disciplinary set-up, philosophical supremacy and commercial benefit that the Europeans tried to redefine and restructure the East. The result was the emergence of a new form of ‘power’ based on information and control. Behind all the sacrificial and religious garb of the ‘white man’s burden’, Said notes, there runs hideous machinery that distorts the forms of knowledge, and remoulds the subject-object relationship in a Eurocentric mirror reflection. The orient becomes a textual study, a place, seen in mass, and considered to be transformed in such implacable homogeneity. Said writes: “In the system of knowledge about the Orient, the orient is less a place than a topos, a set of references, a congeries of characteristics, that seems to have its origin in a quotation, or a fragment of a text, or a citation from someone’s work on the Orient.”1 The Orient, like the ‘terra nullius’ notion of Australian imperialism, never exists, or exists in a manner which is vast, amorphous...
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...M A G A Z I N E FA L L 2 0 0 2 Volume 20 Number 2 SPANNING THE GLOBE Duke Leads the Way in International Law Teaching and Scholarship inside plus Duke admits smaller, exceptionally well-qualified class Duke’s Global Capital Markets Center to launch new Directors’ Education Institute from the dean Dear Alumni and Friends, It is not possible, these days, for a top law school to be anything other than an international one. At Duke Law, we no longer think of “international” as a separate category. Virtually everything we do has some international dimension, whether it concerns international treaties and protocols, commercial transactions across national borders, international child custody disputes, criminal behavior that violates international human rights law, international sports competitions, global environmental regulation, international terrorism, or any number of other topics. And, of course, there is little that we do at Duke that does not involve scholars and students from other countries, who are entirely integrated with U.S. scholars and students. Students enrolled in our joint JD/LLM program in international and comparative law receive an in-depth education in both the public and private aspects of international and comparative law, enriched by the ubiquitous presence of foreign students; likewise, the foreign lawyers who enroll in our one-year LLM program in American law enroll in the same courses, attend the same conferences...
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...Many college students face a great difficulty in writing and reading in an academic setting. However, if college students follow the right approach to this, they can overcome the problems of academic writing and reading. Stuart Greene, a composition scholar and an author of “Argument as Conversation: The Role of Inquiry in Writing a Researched Argument”, claims that academic writing and conversation share some similarities. Mike Rose, another expert in academic writing and an author of “The Politics of Remediation”, asserts that professors should develop college students’ reading and writing skills by not criticizing their mistake but welcome it. By understanding what are important approaches or strategies of studying in academic setting that...
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...Abstract The most prevalent female sexual dysfunction by women is arousal and orgasm. Many women have encountered orgasmic disorder their whole life. It is known as Female Orgasmic Disorder (Ohl, 2007). Female Orgasmic Disorder is one of the female sexual disorders, affecting 22-28 percent of female women (Zakhari, 2009). It is defined as a persistent or recurrent delay or an absence of orgasm during normal sexual activity marked by distress over the lifespan (Ohl, 2007). This paper will demonstrate Counseling Plan a woman who was referred by her gynecologist for counseling because she has never experienced an orgasm. It will include assessment of the dynamics of the couple’s relationship as well as issues regarding their sexual functioning, possible sexual dysfunction within the framework of the sexual response cycle, sexual normality as well as a evidence-based counseling interventions grounded through research and treatment plan with ethical considerations. . Table of Contents Abstract 2 Case Study: Michelle and Tom 5 Assessment of Sexual Issues 6 Biological Assessment of Sexuality 6 Cultural Assessment of Sexuality 6 Religious Assessment of Sexuality 7 Psychological Assessment of Sexuality 8 Assessment of Dynamics of the Relationship 8 Family and Couples 8 Diagnostic and Multi-Axial Impressions 9 Diagnostic 9 Multi-Axial 10 Integration of Disorder ...
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...HISTORY 4C: WESTERN CIVILIZATION: 1715-PRESENT Description of the Course: This course surveys the history of Europe from the beginning of the 18th century until the end of the 20th century. We will study major political, economic, social and intellectual developments that affected European societies during that time period and changed lives of people throughout the world. Major themes of the course will include the French and Industrial Revolutions, emergence of ideologies such as liberalism, nationalism and socialism as well as their practical impact on politics and culture, the rise and fall of European global dominance, wars and revolution of the 20th century. Goals of the Course: I. Understanding Historical Heritage of our Civilization: The major purpose of this course is to familiarize you with heritage of the western civilization and help you understand significance of its impact on contemporary world. This class will aim to illustrate how the past impacts people’s lives in the present and how our actions, ideas, and self-image are shaped by historical developments. II. Acquiring Critical Thinking: History consists of more than just memorization of names, dates and narratives of historical events. Although knowledge of factual information is imperative, it is important to realize that history is interpretation of facts, trends and ideas. Therefore, neither professor nor Teaching Assistants will give you “right” or “wrong” answers. Instead, another major...
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