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Peptic Ulcer and Its Effect

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Peptic ulcer
A peptic ulcer, also known as PUD or peptic ulcer disease,[1] is the most common ulcer of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. It is defined as mucosal erosions equal to or greater than 0.5 cm. As many as 70–90% of such ulcers are associated with Helicobacter pylori, a spiral-shaped bacterium that lives in the acidic environment of the stomach; however, only 40% of those cases go to a doctor. Ulcers can also be caused or worsened by drugs such as aspirin, ibuprofen, and other NSAIDs.[2]
Four times as many peptic ulcers arise in the duodenum—the first part of the small intestine, just after the stomach—as in the stomach itself. About 4% of gastric ulcers are caused by a malignant tumor, so multiple biopsies are needed to exclude cancer. Duodenal ulcers are generally benign.
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[edit]Classification
By Region/Location * Duodenum (called duodenal ulcer) * Oesophagus (called esophageal ulcer) * Stomach (called gastric ulcer) * Meckel's diverticulum (called Meckel's diverticulum ulcer; is very tender with palpation)

Modified Johnson Classification of peptic ulcers: * Type I: Ulcer along the body of the stomach, most often along the lesser curve at incisura angularis along the locus minoris resistantiae. * Type II: Ulcer in the body in combination with duodenal ulcers. Associated with acid oversecretion. * Type III: In the pyloric channel within 3 cm of pylorus. Associated with acid oversecretion. * Type IV: Proximal gastroesophageal ulcer * Type V: Can occur throughout the stomach. Associated with chronic NSAID use (such as aspirin).
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