...Poliomyelitis in the USA Poliomyelitis is a dangerous and utterly infectious disease that may lead to breathing problems,paralysis or to death.It either can be classified as asymptomatic or symptomatic. About 95% of the cases are asymptomatic,and the rest 5% are symptomatic.USA has been suffering from this disease for a long period of time but in 1952 happened the worst polio outbreak in the history of this country.In that year, almost 58,000 cases were reported,3,145 died and 21,269 were paralyzed. Polio is caused by poliovirus.The virus is usually transferred from one person to another throughout the fecal matter.People that live in places with almost no access to running water,get the virus...
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...Since the beginnings of recorded history, humans have shown great interest in the state of their health and have recognised the vulnerability of the immune system to the attack from disease-causing agents. Although due to the contribution of MacFarlane Burnet’s work in the middle of the 20th century and advancements in medical technology; vaccination programs have become an effective ‘lifeline’ in preventing the spread and occurrence of common diseases such as polio. Polio also known as poliomyelitis is a common, acute viral disease that invades the central nervous system. The disease is sub-divided into three types as either; Sub-Clinical (no symptoms), Non-Paralytic (mild symptoms) or Paralytic (produces full/partial paralysis). Polio is caused by the pathogen poliovirus, a highly contagious virus specific to humans. There are three known types of polioviruses (1, 2 and 3) each causing a different strain of the disease. All are members of the viral genus Enterovirus; a group of RNA viruses that colonise the gastrointestinal tract (specifically the intestines). Polio is a highly infectious disease transmitted by direct contact to an infected individual, via primarily the faecal-oral route, which occurs with poor sanitary conditions. The virus enters the body through the mouth and multiplies in the lymphoid tissues in the throat and gastrointestinal tract. Once absorbed, it moves to the central nervous system through the bloodstream where it destroys the motor neuron...
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...Poliomyelitis (shortened to polio) has been around for thousands of years, and there is still no cure, but at the peak of its devastation in the United States, Dr. Jonas Salk introduced a way to prevent it. Polio attacks the nerve cells and sometimes the central nervous system, causing muscle wasting, paralysis, and even death. The disease, whose symptoms are flu like, struck mostly children, and in the first half of the 20th century the epidemics of polio were becoming more devastating. Salk, while working at the Virus Research Lab at the University of Pittsburgh, developed a polio vaccine, and the medical trials to prove its effectiveness and safety are still being analyzed. Fifty years ago the largest medical experiment in history took place to test Salk’s poliomyelitis vaccine. Close to two million children across the United States and Canada were involved in the trial, which was administered by the National Foundation for Infantile Paralysis (NFIP), also known as the March of Dimes. The foundation, created in 1938 by President Franklin D. Roosevelt (a polio victim) and his law partner Basil O’Connor. Across the United States, 623,972 school children were injected with the vaccine or a placebo, using a double blind technique in which neither recipient nor administrator knew which one there were getting. The results, announced in 1955, showed good statistical evidence that Jonas Salk’s “killed virus” preparation was 80-90% effective in preventing paralytic...
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...The movie begins with Mathilde Donnay’s fiancé and four other soldiers being reported killed in action. After the war, Mathilde receives a letter suggesting that Manech, long presumed dead, may have survived after all. She takes this as confirmation of what she has believed all along: If he had died, she would have felt it. With this insight, Mathilde hires a lawyer and a private investigator and sets out on a quest to unravel the truth. Unfortunately Mathilde suffers from a condition known as poliomyelitis, which has paralyzed her legs making her unable to walk. However this does not stop her from finding her fiancé. Through interviews, letters, telegrams, and visits to important places Mathilde gathers information that leads her to discover the whereabouts of her lover, Manech. She begins to discover clues, each one leading to the next. First she finds a stamp spoken of in one of the letters she finds. If the stamp is real, then the letter must be too and her lover was alive on the supposed day he died. She then receives a letter from a woman who has had an affair with another soldier and one of the condemned men. The letter to Mathilde helps her discover the whereabouts of a pair of German boots that have been traded several times among the soldiers. These boots lead her to a man who assisted Manech in no-man’s-land, carrying him out on his back. Mathilde and this man manage to crack the code of a letter from one of the condemned men to his wife, and with it she is able to...
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...One medical issue that has always made me ponder is polio. This virus struck America in 1916, causing many U.S. citizens fall ill. This disease has flu-like symptoms and paralyzes your body in certain areas depending on where the virus strikes. One of the most famous presidents, Franklin Roosevelt got polio in the late 1920’s. There is no such thing as a cure for polio, just vaccines and treatments, and I want to dive deeper into these specifics that could potentially benefit Americans. Although polio is no longer affecting Americans, I would like to learn more about the causes of this deadly virus such as where it came from. One thing that has helped people with polio is the Iron Lung. The Iron Lung came into play when physicians first...
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...The Polio Epidemic: In the summer of 1916, a polio epidemic was killing and crippling children. Polio is a deadly infectious disease caused by a virus that spreads from person to person and invades a person’s brain and spinal cord, causing paralysis (Bush 281). Because the outbreak of polio occurred in an Italian community in New York, immigrants were to blame. Polio became one of the most feared diseases in industrialized countries. This was because it paralyzed hundreds of thousands of children every year (Bush 281). It was easy for polio to spread because there were few sanitary regulations. It was predominately a summertime disease because it was easy for flies to carry fecal contamination to food in summer. In 1916, researchers had little success in treating polio patients. They tried baths using almond metal and oxidized water, applications of different herbs and oils, and surgical treatments involving tendon transplants (Bush 281). One of the most impressive treatments at the time was the Iron Lung. It was powered by an electric motor attached to two vacuum cleaners and worked by changing the pressure inside the machine. To maximize on treating polio in the 1940’s and 1950’s, rows of iron lungs filled hospital to assisting the breathing of children and adults (mainly children) with polio (Bush 281). A polio patient with paralyzed lungs could spend up to a week inside an iron lung. During the polio epidemics, the iron lung saved many thousands of lives. However the...
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...Pharmacology Phunland When people go to an amusement park, what do they look forward to the most? Cool rides? Great food? How about learning in a themed atmosphere? At Pharmacology Phunland, you’ll get all three! Your family will have a blast in our park while learning all about medicine advances in the 20th century. There are three sections, all with their own specified theme and rides. Additionally, there are two cool restaurants in which your family can enjoy exotic foods. Learn all about the deadly virus in Polio Park! Featuring fun for the whole family, along with a valuable learning experience, Polio Park is themed around the highly infectious virus that swept the world. Being depicted as early as pre-history, polio is a virus that can affect the central nervous system and lead to the destruction of the motor neurons. This can lead to muscle weakness and paralysis. Before the 20th century, polio was found mostly in children between 6 months and 4 years old. However, before the mid-19th century, people who lived in poorer sanitation areas were constantly exposed to the virus, thus creating immunity. By the early 20th century, huge improvements were made in community sanitation. This lead to a pandemic outbreak of polio in Europe, North America, Australia, and New Zealand during the first half of the 19th century. By the mid-1950s, there were not one but two different versions of the polio vaccine. This cut polio outbreaks drastically. In this park, all of the rides have...
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...RUNNING HEAD: Combating Wild Poliovirus Combating Wild Poliovirus Peter Schuckert Kaplan University HS315-01 Dr. Jose Fierro March, 28 2012 Combating Wild Poliovirus In this day and age there are vaccines available to prevent a wide variety of diseases. The use of vaccines in a systematic fashion was successful in the eradication of smallpox. This has given many epidemiologists hope that society can eventually eradicate all infectious diseases. An example of a disease that is currently being combated and near eradication is poliomyelitis. Surveillance is the primary method of data collection used by epidemiologists to identify outbreaks, track the origin of the virus, and target vaccination efforts. The World Health Organization has identified the need and more importantly the medical ability to eradicate polio. Subsequently the World Health Organization launched the Global Polio Eradication Initiative with the goal of polio eradication in mind ("Progress towards global," 2012). When wild poliovirus is suspected the medical personal will have the samples tested at accredited facilities that identifies if wild poliovirus is present in the sample being tested. If wild poliovirus is present then further testing is conducted. Once a sample has tested positive for wild poliovirus genetic screening is used to identify which strain of wild poliovirus is present in the sample ("Progress...
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...Williams, Alexyss. Book Review of Polio:An American Story. By David M. Oshinsky. Oxford University Press, Inc., 2005. In David M. Oshinsky’s Polio:An American Story, he intriguingly writes history of a medical mystery. How this disease was discovered, who was first diagnosed, and then onto how the vaccination was created. He gives fascinating details about the sickness, its history, the medicine that was put on trial, the pain, the politics, and the people who fought to eradicate it. The processes scientist went through such as the research, the small discoveries, and the commencement of Polio all lead to the effective vaccine. The author takes us into the time where polio was dominate, and where heart break came every summer. Poliomyelitis, often shortened to Polio, is a highly infectious viral disease that enters the body system through direct person-to-person contact, contact with infected mucus or phlegm from the nose or mouth, or contact with infected feces. It then travels along the nerve pathways, and finally into the spinal cord causing partial or full paralysis. It mostly affected...
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...Task 1: 1.1 Define the following terms: A. Population – The collection of all individuals or items under consideration in a statistical study. B. Sample- That part of the population from which information is obtained (pg. 4) 1.7 Descriptive or inferential TV Viewing Times. The Nielsen Company collect sand publishes information on the television viewing habits of Americans. Data from a sample of Americans yielded the following estimates of average TV viewing time per month for all Americans 2 years old and older. The times are in hours and minutes (NA, not avail- able). [SOURCE: Nielsen’s Three Screen Report, May 2008] Answer: This is an example of a descriptive form of data, because of the summary of the number of Americans 2 years old and older watching TV. 1.14 Offshore Drilling. A CNN/Opinion Research Corporation poll of more than 500 U.S adults, taken in July 2008, revealed that a majority of Americans favor offshore drilling for oil and natural gas; specifically, of those sampled, about 69% were in favor. Answer: a. Identify the population and sample for this study. 1. Population is 500 U.S adults 2. Sample- 69% b. Is the percentage provided a descriptive statistic or an inferential statistic> Explain your answer. 1. Inferential because it is measuring the reliability of conclusions about a population based on information obtained. 1.17 The Salk Vaccine. In the 1940s and early 1950s, the public was greatly concerned about...
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...Task 1: 1.1 Define the following terms: A. Population – The collection of all individuals or items under consideration in a statistical study. B. Sample- That part of the population from which information is obtained (pg. 4) 1.7 Descriptive or inferential TV Viewing Times. The Nielsen Company collect sand publishes information on the television viewing habits of Americans. Data from a sample of Americans yielded the following estimates of average TV viewing time per month for all Americans 2 years old and older. The times are in hours and minutes (NA, not avail- able). [SOURCE: Nielsen’s Three Screen Report, May 2008] Answer: This is an example of a descriptive form of data, because of the summary of the number of Americans 2 years old and older watching TV. 1.14 Offshore Drilling. A CNN/Opinion Research Corporation poll of more than 500 U.S adults, taken in July 2008, revealed that a majority of Americans favor offshore drilling for oil and natural gas; specifically, of those sampled, about 69% were in favor. Answer: a. Identify the population and sample for this study. 1. Population is 500 U.S adults 2. Sample- 69% b. Is the percentage provided a descriptive statistic or an inferential statistic> Explain your answer. 1. Inferential because it is measuring the reliability of conclusions about a population based on information obtained. 1.17 The Salk Vaccine. In the 1940s and early 1950s, the public was greatly concerned about polio...
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...Mumps, also called epidemic parotitis acute, is a highly contagious viral infection. Parotitis refers to the inflammation of the parotid gland which is common in Mumps (National Center for Immunization and Respiratory Disease and Mumps, 2016). Mumps typically starts with a fever, headache, tiredness, and loss of appetite (Centers for Disease Control and Protection, 2016). After that, the salivary glands under the ears or jaws becomes swollen and tender (National Institutes for Health / U.S. Library of Medicine, 2017). This disease is mainly caused by paramyxovirus and spread by a nasal infection (Lowth,2013). Paramyxoviruses are pathogens of humans that are the common cause of respiratory disease in children. The Paramyxoviridae family was reclassified into two subfamilies, Paramyxoviridae and Pneumovirinae, by the International Committee on Taxonomy of Viruses in 1993 (n.d).** Some Historians believe that Mumps got its name long ago from the swollen cheek lumps and the way they made people mumble. “Mumble” and “Lumps” were combined to from Mumps (Saito et al., 1995). Mumps was a widely spread contagious viral infection. Medical Historians believe that documentation of Mumps dates back to Greco- Roman Times (National Center for Immunization and Respiratory Disease, 2017). Although many people suffered a long time with the disease, the first effective vaccine was introduced in 1948 and used from 1950-1978, preventing many people from contracting Mumps (National Center for Immunization...
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...pTextbook Scavenger Hunt 1. The book’s Index starts on what page? 1027 2. What abbreviation is used in the index to tell you there is a cartoon on page? crt 3. How many units are in the textbook? 11 4. How many Chapters are in the textbook? 32 5. What is the title and time frame (years covered) for Chapter 2? Exploring the Americas 1400- 1625 6. Looking at the Chapter 3 timeline, in what year did King Phillip’s War begin? 1675 7. Using the Auto Sales graph on page 710, between what years was the biggest down turn in auto sales? 1926-1927 8. What artist created Fight for the Colors? Reenact and take a picture of it. p. 459 9. What artist created Bunker Hill? Reenact and take a picture of it. Don Troinai Pl 131 9. What artist created Patrick Henry Before the Virginia House of Burgesses? Reenact and take a picture of it. Peter F. Rothermel p. 135 9. What artist created Washington Crossing the Delaware Reenact and take a picture of it? Emanuel Gottlieb Leutze p. 128 10. What did Jonas Salk discover? Cure for polio (polio vaccine) 11. According to the Chapter 23 Summary, what event occurred in 1919? p. 682, Treaty of Versailles signed 12. What is the title of Chapter 14’a Technology Skill Builder? Evaluating a Web Site 13. On what page does the Primary Source Library start? On what page would you find the Fallout Fears? p. 956 p. 976 14. Looking at the National Geographic map on page 117, what country claimed...
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...1. Microbiota increase pathogenesis by promoting intestinal infection of enteric viruses; specifically, poliovirus was used as a model in this paper. 2. The PVRtg-Ifnar1-/- mouse is a transgenic mouse that has been made susceptible to oral infection by poliovirus. The first aspect of the transgenic mouse is that human poliovirus receptor was introduced to allow for infection. Humans are the only known hosts for poliovirus so mice were engineered to allow them to be infected. However, this alone was not sufficient for oral infection. To make a proper model since most poliovirus infections are fecal-oral, the mice were made immunodeficient by knocking out interferon-α/β receptor. This mouse was used in the experiment to serve as a model for human poliovirus infection by the normal route of infection. 3. a. The purpose of the experiment in Figure 2C was to test if and how antibiotics affect poliovirus pathogenesis. b. The light sensitive poliovirus was created with a mixture of four different antibiotics. Subsequently, the mice were either left untreated or the growth of antibiotic-resistant bacteria was promoted. Then, the mice were either administered poliovirus or poliovirus mixed antibiotics (in vivo). Mouse mortality rate was measured for 12 days post challenge. c. The two controls were mice without antibiotic treatment and antibiotic-treated mice that were administered poliovirus. i. Mice without antibiotic treatment-negative control; looking at how normal flora affect...
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...In the book, Polio: An American Story, author David Oshinsky reexamines the steps of researchers in their search for the treatment and cure of polio. The first recorded polio epidemic in the Unites States of America occurred in 1894 in the rural country of Vermont. In the late spring of 1908, Karl Landsteiner, a researcher from Vienna who later in his career discovered the different types of human blood, isolated the virus by injecting an emulsion of spinal fluid from a young boy who had just died from the polio virus into monkeys. This experiment was a huge breakthrough for prevention of polio during the early twentieth century because it not only helped the fight of polio but tremendously helped in the battle against many deadly infectious diseases. A polio outbreak in New York City in the summer 1916 rapidly spread to neighboring states and killed 27,000. A great 80 percent of the dead were under five and lived in the inner city. In the fall of 1921, Franklin Delano Roosevelt, the president at the time, contracted the polio virus whilst on a vacation in Canada with his family. The nation was stunned because they believed the that disease could only occur in the poor young children in the ghettos and Roosevelt was a wealthy 39 year old man. Roosevelt was a major influence in the search for a vaccine because he symbolized that life could continue for those that were disabled by the disease. He helped find and fund the March of Dimes, known as the National Foundation for Infantile...
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