...Report on Sickle Cell Disease Name: Professor: Course: Date: Sickle Cell Disease Sickle cell disease is a life threatening illness passed down from parents to children through the genes (Piel & Weatherall, 2015). The disease therefore, is present at birth but the signs come to the fore after the fourth month. The disease has been recognized as a major public health concern by international agencies and is common among many people in Africa, the Arabian Gulf, Turkey, India; the Mediterranean and their descendants spread around the world. For instance, in United States one in 400 African-American infants is born with sickle cell disease annually (Ibid). Description of Sickle Cell Disease Sickle cell disease comprises of red blood cell disorders whose main feature is abnormal hemoglobin in the red blood cells. Hemoglobin is an oxygen carrying protein in the red blood cells (Peterson, 2008). The abnormality of the hemoglobin is caused by a mutation in a gene of the hemoglobin protein. This abnormality hinders the proper formation globin genes of the hemoglobin molecules resulting in abnormal hemoglobin that may take the forms of “S” hemoglobin or “SC” hemoglobin or “beta-thalassemia” hemoglobin as noted by (Rees, Williams & Gladwin, 2010). Types of Sickle Cell Disease The disorders; sickle cell anemia disease (caused by “S” hemoglobin), “SC” disease (caused...
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...BACKGROUD: Sickle cell disease (SCD) is a hereditary blood disorder caused by mutation in the Hemoglobin genes or the red blood cells. When dehydration or law oxygen supply occur, the muted red blood cells begins to have sickle shape which adhere to the walls of blood vessels. This process leads to further decrease blood supply to body organs and cause further damage which mostly shown by sever painful episodes or “sickle cell crises”. According to the Center for Disease Control and Prevention, SCD affects 90,000 to 100,000 people in the US and is estimated to occur in one out of every 365-500 Black or African-American births. SCD is associated with serious complications due to the frequent damage of vital organs such as: brain, hear, lung...
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...Effects of Sickle Cell Disease Sickle cell disease is a genetic hemolytic anemia that is considered a significant public health issue (2). It is mostly common among black Americans and black Africans (3). Every year there are almost sixty million carriers of SCD, and 1.2 million sickle cell homozygotes are added worldwide (2). Not only 1 in 400 African Americans is affected by SCD, but also other families that have any ethnic background (3). Approximately 70% of inherited hemoglobin disorders seen worldwide result from SCD (2). It can cause serious complications that may lead to life-long disabilities and premature mortality (1). SCD can result in acute painful episodes, neurologic complications, and infection. The first effect of sickle cell disease is the acute episodes of pain. It can be the most frequent complication after the age of two, and the reason why patients seek medical help although some of these episodes can be managed at home (1). A higher death rate in patients over the age of 19 can be associated with more repeated episodes (1). The frequency and severity of episodes have a considerable variability among patients. Any area of the body can be affected by the episodes, especially the back, chest, extremities, and abdomen (1). An objective clinical signs such as fever, hypertension, nausea, and vomiting can accompany these...
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...Ashley McHugh Ms. Greve Biology I Academic (2)-1 11 January 2016 Sickle Cell Disease: A Chronic Cruelty Sickle cell disease is a collection of inherited blood cell disorders in which the hemoglobin in red blood cells mutates into a dangerous crescent shape. This crescent shape is “not flexible and can stick to vessel walls, causing a blockage that slows or stops the flow of blood.” Sickle cell disease is the most common genetic disorder in the United States, but it primarily affects African Americans. Victims suffer from lifelong complications wherein the worst of the pain lies in sporadic episodes. Sickle cell disease is an incurable hereditary condition which produces abnormally shaped red blood cells that trigger periods of severe pain;...
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...of Sickle Cell Disease Gene of Two Parents Traits on a Child Desmond Jefferson PSY104 Holly Johnson April 15, 2013 In trying to expound the reasons why the genes of the two parents influence the traits of an offspring, with in examination of how abnormalities can contribute to genetic and / or chromosomal disorder. I will use sickles cell disease to explain my reasoning. According to Wikipedia, Sickle-cell disease (SCD) is an autosomal recessive genetic blood disorder with over dominance, characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickle cell disease decreases the cells' flexibility and results in a risk of various complications. In this paper I will discuss how sickle cell disease occurs because of a mutation in the hemoglobin gene. Even though sickle cell gene of two parent’s traits affects a child, what are the chances of having a baby with sickle cell trait? Knowing that individuals with sickle cell trait can pass the sickle hemoglobin gene to their children and, when one parent has sickle cell trait and the other parent has normal hemoglobin the child may inherit. How do you know if you have sickle cell trait? You can easily get a blood test form most hospital, medical centers and doctor offices. When you get the blood test, it determines if you have sickle cell trait. As in women, they can find out if they have sickle cell traits during their pregnancy to find out if the child is going to have the trait or the disease. There...
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...Sickle Cell Disease (SCD) is a blood disorder that affects more than 90,000 Americans. This condition is due to a genetic defect that mutates the structure of hemoglobin which is the oxygen carrying protein of red blood cells. Normal red blood cells are round like the letter “O” so they can move easily through the blood vessels. Red blood cells with the hemoglobin genetic defect have reduced oxygen carrying capacity. They are sickle-shaped like the letter “C” which reduces their ability to traverse small blood vessels. This can lead to blood clot formation in the capillaries and organ damage. There is no readily available cure for SCD but some children with the disease have been treated successfully with bone marrow transplants. High dose...
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...SICKLE CELL ANAEMIA Name: Institution: Introduction The sickle cell anaemia is a relentless hereditary kind of anemia in which a transmuted form of hemoglobin disfigures the red blood cells into a hemispherical outline at low oxygen levels (Sickle cell anaemia, 2015). The disorderedly affects individuals of the Caribbean, African as well as Asian origin, in the United Kingdom sickle cell disorders is mostly usually experienced in the Caribbean along with African persons. Consequently, this paper is going to talk about sickle cell anaemia along with alternate issues related to it. What causes sickle cell anaemia? Sickle cell anaemia is brought about by an alteration as well as uncharacteristic alteration in the gene that initiates the body to create hemoglobin. The sickle cell DNA is mostly inherited whereby it is conveyed from one generation to another in the family. To acquire sickle cell anaemia one must inherit the flawed DNA from mutually all the parents. Should one get the DNA from only one parent then this condition can be described as a sickle cell condition? There is a high chance that the person’s blood will have some sickle cell, and will also be able to generate the ordinary hemoglobin but not experience the signs of the disease. Conversely, the individual will be perceived as the carrier of sickle cell anaemia...
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...Sickle Cell Disease is an illness that affects people all across the globe. This paper will give a description of the sickness through the discussion of the causes, symptoms, and possible cures. Sickle Cell Disease (SCD) is a "group of inherited red blood cell disorders."(1) These disorders can have various afflictions, such as pain, damage and a low blood count--Sickle Cell Anemia. Sickle cell disease is the most common inherited blood disorder in the United States. Approximately 80,000 Americans have the disease. In the United States, sickle cell disease is most prevalent among African Americans. About one in 12 African Americans and about one in 100 Hispanic Americans carry the sickle cell trait, which means they are carriers of the disease. Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels. In people with sickle cell disease, abnormal hemoglobin molecules - hemoglobin S - stick to one another and form long, rod-like structures. These structures cause red blood cells to become stiff, assuming a sickle shape. Their shape causes these red blood cells to pile up, causing blockages and damaging vital organs and tissue. Sickle cells are destroyed rapidly in the bodies of people with the disease, causing anemia. This anemia is what gives the disease...
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...Sickle-cell disease From Wikipedia, the free encyclopedia This article is about the disease itself. For the genetic transmission of sickle-cell disease and its carrier state, see sickle cell trait. Not to be confused with Sick cell syndrome. Sickle-cell disease Classification and external resources Figure (A) shows normal red blood cells flowing freely through veins. The inset shows a cross section of a normal red blood cell with normal haemoglobin. Figure B shows abnormal, sickled red blood cells log jamming, sticking and accumulating at the branching point in a vein. The inset image shows a cross-section of a sickle cell with long polymerized HbS strands stretching and distorting the cell shape. ICD-10 D57 ICD-9 282.6 OMIM 603903 DiseasesDB 12069 MedlinePlus 000527 eMedicine med/2126 oph/490ped/2096 emerg/26emerg/406 MeSH C15.378.071.141.150.150 GeneReviews • Sickle-cell disease Sickle-cell disease (SCD), or sickle-cell anaemia (SCA) or drepanocytosis, is a hereditary blood disorder, characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various complications. The sickling occurs because of a mutation in the haemoglobin gene. Individuals with one copy of the defunct gene display both normal and abnormal haemoglobin. This is an example of codominance. Life expectancy is shortened. In 1994, in the US, the average life expectancy of persons with...
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...Sickle Cell Disorder Research Paper Sickle cell anemia is a disease passed down through families in which red blood cells form an abnormal sickle or crescent shape. Red blood cells carry oxygen to the body and are normally shaped like a disc. Sickle cell disease refers to a group of inherited red blood cell disorders. It is the most common genetic disease in the U.S. An estimated 70,000-80,000 Americans have sickle cell disease. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. What is sickle cell trait? A person with the sickle cell trait does not have (and will never have) sickle cell disease. However, the presence of the trait may impact his/her children How do you get sickle cell disease? Sickle cell disease is not contagious; you cannot "catch" it. You inherit it from your parents. If, for example, one parent has normal hemoglobin ( type AA) and the second parent has abnormal hemoglobin ( type AS, or the sickle cell "trait"), there is a 50% chance that each child will have the sickle cell trait, but they will not have sickle cell disease ( type SS). The three most common forms of the disease in the United States are: 1. Hemoglobin...
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...Choice “E is the best answer. Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS). Given that this patient has sickle cell disease, he must have inherited two abnormal copies of the hemoglobin gene, one from each parent. Normally, humans have hemoglobin A, which consists of two alpha and two beta chains, hemoglobin A2, which consists of two alpha and two delta chains, and hemoglobin F, consisting of two alpha and two gamma chains in their bodies. Of these, hemoglobin F dominates until about 6 weeks of age. Afterwards, hemoglobin A dominates throughout life. Sickle-cell conditions have an autosomal-recessive pattern of inheritance from parents. The types...
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...one parent is a carrier of the recessive gene then the offspring could also become a carrier of the mutated gene. An example of a recessive inherited disorder is sickle cell disease. Sickle cell disease leads to chronic hemolytic anemia, pain, and organ failure due to abnormal hemoglobin....
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...of disease and poor diet. There are three different blood disorders that stem from theses causes: sickle cell anemia, thrombocytopenia, and iron deficiency anemia. Each of these blood disorders are diagnosed, treated, and have different prevention methods. Sickle cell anemia causes normal round red blood cells to become crescent shaped. Normal red blood cells can easily move throughout the body’s blood vessels and supply the body with the adequate amount of oxygen enriched blood. But crescent or sickle shaped red blood cells often get stuck in the blood vessels blocking the vessels and causing the stop of oxygen from getting to the bodies organs, tissue, muscle, and bones. Sickle cell anemia is caused by an inherited genetic trait by both of the parents of the affected child. If the child only inherits the sickle cell gene from one parent then the child is said to have the trait but not the disease. However, the child that has only the trait is considered a carrier of the disease and can pass the gene to his or her children. Most people are diagnosed with sickle cell anemia when they are born by having a simple blood test that most hospitals require at birth. Antibiotics are the first course of treatment and it is given to children between the ages of two months to five years of age. Parents are also encouraged to have their children’s routine childhood immunizations on time. The hardest part of this disease is the pain that the patient goes through by the sickle cells blocking...
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...interesting genetic cases in classroom which improved my knowledge about the basic concepts of genetics, about role of the environment in genetic diseases, and about various risk factors associated with genetic diseases. By taking this course I now identify how to construct a family pedigree that can be used to take detailed family history in a clinical setting. I have learnt that family history not only holds important information about an individual’s past but can so be used to predict the future health of patients. Information from family history can be used as a diagnostic tool and help guide decisions about genetic and screening tests for the patient and family members at risk. An accurate family history will be important to establish a pattern of transmission. The genetic course has also made me think about my own family history. I do know that my grand father died of colon cancer and my other grand father died of type 1 diabetes. I know that this type of common diseases can run in families, because of this I was a little concerned about the fact that my parents and siblings including myself could be affected by it. However, taking this course helped me to conduct genetic risk assessments for our family based one the lessons I learnt from the course. This has enabled me to have a better understanding of the actual risk of developing these diseases. Instead of my prior misconception that it is guaranteed that the my father will get a colon cancer due to the fact that his father had...
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...1 Personal Impact Paper on Sickle Cell Disease Glenda Kessen NUR427 9/8/14 Amy Highland 2 Sickles Cell Anemia is a chronic, serious red blood cell disorder that is lifelong. "It is the most common genetic disease in the United States." (Guyatt, GH 2007). Sickle Cell Disease (SCD) is inherited and results in a decrease of the ability of red blood cells to carry much-needed oxygen through the body. The cells become clogged, due to their crescent shape, which keeps them from delivering oxygen. This can cause unbearable pain, damage to the body organs, and even death. The frequency of the pain episodes can range from several a year to multiple times a day. SCD is caused by hemoglobin S, which is an abnormal type of hemoglobin. When the cells are exposed to low oxygen levels, the Hemoglobin S changes the shape of the red blood cells. Red blood cells are made of marrow that is located inside the large bones of the body. The bone marrow is constantly making new red blood cells to replace the old cells. The life of the normal red blood cell life is about 120 days. Their purpose is to carry oxygen and remove the carbon dioxide, which is a waste product, from the body. Sickle-shaped cells die about ten to twenty days that prevents the bone marrow from making new red blood cells. Ethnicity plays a part in SCD, with African Americans more likely to be affected. Both parents are carriers of the sickle cell trait which is passed on to the child. The child will inherit...
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