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Essay On Sickle Cell Disease

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Effects of Sickle Cell Disease

Sickle cell disease is a genetic hemolytic anemia that is considered a significant public health issue (2). It is mostly common among black Americans and black Africans (3). Every year there are almost sixty million carriers of SCD, and 1.2 million sickle cell homozygotes are added worldwide (2). Not only 1 in 400 African Americans is affected by SCD, but also other families that have any ethnic background (3). Approximately 70% of inherited hemoglobin disorders seen worldwide result from SCD (2). It can cause serious complications that may lead to life-long disabilities and premature mortality (1). SCD can result in acute painful episodes, neurologic complications, and infection.

The first effect of sickle cell disease is the acute episodes of pain. It can be the most frequent complication after the age of two, and the reason why patients seek medical help although some of these episodes can be managed at home (1). A higher death rate in patients over the age of 19 can be associated with more repeated episodes (1). The frequency and severity of episodes have a considerable variability among patients. Any area of the body can be affected by the episodes, especially the back, chest, extremities, and abdomen (1). An objective clinical signs such as fever, hypertension, nausea, and vomiting can accompany these …show more content…
It is estimated that almost 24% of the patients experience stroke by the age of 45 (1). Additionally, 25% of children with SCD have silent ischemic lesions that may damage neurocognitive function and cause progressive illness (1). As the patients age, their risk of neurocognitive decay and intracranial hemorrhage increases. Most children with SCD have obvious growth retardation that affects weight more than height by the age of two years (1). Therefore, neurodevelopment and skeletal growth can often be delayed produce growth failure and late

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