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An APIC Guide 2008

Guide to the Elimination of Catheter-Associated Urinary Tract Infections (CAUTIs)
Developing and Applying Facility-Based Prevention Interventions in Acute and Long-Term Care Settings

About APIC APIC’s mission is to improve health and patient safety by reducing risks of infection and other adverse outcomes. The Association’s more than 12,000 members have primary responsibility for infection prevention, control and hospital epidemiology in healthcare settings around the globe. APIC’s members are nurses, epidemiologists, physicians, microbiologists, clinical pathologists, laboratory technologists and public health professionals. APIC advances its mission through education, research, consultation, collaboration, public policy, practice guidance and credentialing.

Look for other topics in APIC’s Elimination Guide Series, including:
• • • • Catheter-Related Bloodstream Infections Clostridium difficile Mediastinitis MRSA in Long-Term Care

Copyright © 2008 by APIC All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without prior written permission of the publisher. All inquires about this document or other APIC products and services may be addressed to: APIC Headquarters 1275 K Street, NW Suite 1000 Washington, DC 20005 Phone: 202.789.1890 Email: APICinfo@apic.org Web: www.apic.org

ISBN: 1-933013-39-7

Guide to the Elimination of Catheter-Associated Urinary Tract Infections (CAUTIs)

Table of Contents
1. Acknowledgments ……………………………………………………….………………….….…. 2. Guide Overview……………………………………………………….…………………….….…. 3. Problem Identification………………………………………..…………………..………….….…. 4. Understanding the Definitions……………………………………………………………....….…. 5. Conducting a CAUTI Risk Assessment…….…………………………………………….....….…. 6. Surveillance Methodology Basics…………………………………..…………………….....….…. 7. Understanding the Big Picture: Healthcare Reimbursement……………………………......….…. 8. Prevention of Catheter-Associated Urinary Tract Infections……….…..............................….…. 9. Putting it All Together – The Bundle Approach – and Summary……..………..……….......….…. 4 5 8 16 22 26 30 34 42

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Guide to the Elimination of Catheter-Associated Urinary Tract Infections (CAUTIs)

Acknowledgments
The Association for Professionals in Infection Control and Epidemiology (APIC) acknowledges the valuable contributions of the following individuals: Authors Linda Greene, RN, MS, CIC James Marx, RN, MS, CIC Shannon Oriola, RN, CIC, COHN Reviewers Kathy Aureden, MS, MT(ASCP)SI,CIC Harriette Carr RN, MSN, CIC Carolyn Gould, MD, MS Russell Olmsted, MPH, CIC

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Guide to the Elimination of Catheter-Associated Urinary Tract Infections (CAUTIs)

Guide Overview
Purpose
The purpose of this document is to provide evidence-based practice guidance for the prevention of Catheter-Associated Urinary Tract Infection (CAUTI) in acute and long-term care settings.

Background
Healthcare-associated infections (HAIs) are infections acquired during the course of receiving treatment for other conditions within a healthcare setting. HAIs are one of the top 10 leading causes of death in the United States, according to the Centers for Disease Control and Prevention (CDC), which estimates that 1.7 million infections annually were reported among patients. (“Questions and Answers about Healthcare-Associated Infections” may be accessed on the web at http://www.cdc.gov/ncidod/dhpq/hai_qa.html.) It has long been acknowledged that CAUTI is the most frequent type of infection in acute care settings. In a study that provided a national estimate of healthcare-associated infections, urinary tract infections comprised 36% of the total HAI estimate. (See figure 2.1 below.)1
Figure 2.1. Infection types in acute care settings.

In a 2000 review of literature by Saint2 on urinary tract infections related to the use of urinary catheters, it was reported that 26% of patients who have indwelling catheters for two to 10 days will develop bacteriuria, after which 24% of those with bacteriuria will develop a CAUTI. Of these patients, approximately 3% will develop bacteremia. The 1997 APIC/SHEA position paper on urinary tract infections in long-term care (LTC) identifies CAUTI as the most common infection in LTC residents, with a bacteriuria prevalence without indwelling catheters of 25% to 50% for women, and 15% to 40% for men. Therefore, usage of indwelling urinary catheters in residents of LTC facilities can be expected to

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Guide to the Elimination of Catheter-Associated Urinary Tract Infections (CAUTIs)

result in higher CAUTI rates with an associated risk of CAUTI-related bacteremia, unless appropriate prevention efforts are implemented. The 2008 SHEA/APIC Guideline “Infection Prevention and Control in the Long-term Care Facility”3 notes that “guidelines for prevention of catheter-associated UTIs in hospitalized patients are generally applicable to catheterized residents in LTCFs.” Strategies contained in this resource will be helpful in any healthcare setting, when the facility’s infection risk assessment identifies CAUTI as an infection prevention priority.

Legislative Mandates and CAUTI Risk Assessment
The impact of external factors is germane to facility decisions and interventions involving healthcare-associated infections, including CAUTI. Agencies such as the CDC, National Quality Forum (NQF), Agency for Healthcare Research and Quality (AHRQ), and the Institute of Medicine (IOM) have been focusing on ways to improve the outcomes of care for patients. The Medicare program, which represents the largest healthcare insurance program in the United States, has generally paid for services for patients without regard to outcome. But the Centers for Medicare & Medicaid Services (CMS), as a result of the Medicare Modernization Act of 2003 and the Deficit Reduction Act of 2005, has identified CAUTI as a “never event.” It is reported that 12,185 CAUTIs, costing $44,043/hospital stay, occurred in fiscal year 2007.4 Effective October 1, 2008, changes in the CMS inpatient prospective payment resulted in non-reimbursement for CAUTIs not present on admission in inpatients who were later discharged from acute care hospitals (CR 5499 – Present on Admission indicator). 5 Requirements cited in the CMS survey “Protocols for Long-Term Care Facilities” provide information and guidance regarding use of urinary catheters and CAUTI prevention for these facilities.6

Infection Prevention Interventions for CAUTI
The role of the infection preventionist in efforts to reduce the incidence of CAUTI includes policy and best practice subject matter expertise, provision of surveillance data and risk assessment, consultation on infection prevention interventions, and facilitation of CAUTI-related improvement projects. It is important that the infection preventionist communicates and networks with all members of the patient care team regarding CAUTI-related infection prevention. Providing subject matter expertise to those involved with clinical management of the patients/residents, including physicians, physician assistants, and nurse practitioners, is essential. An understanding of the elements of surveillance definitions, compared to primary or secondary diagnoses and complications, is essential for appropriate documentation and coding. Direct patient/resident care personnel are responsible for insertion, care and maintenance of indwelling catheters. Therefore, success of a prevention project requires that these personnel be fully engaged and committed to this important patient safety initiative. Obtaining the resources that will engage direct care providers in CAUTI quality/performance improvement activities is a critical component of intervention development. Key players must be held accountable for compliance with the intervention. This can be facilitated through monitoring and reporting of the results of the intervention on a consistent basis, and instituting additional improvements when appropriate.

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References
Klevens RM, Edwards JR, Richards CL, et al. Estimating healthcare-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep. 2007; 122:160-167. http://www.cdc.gov/ncidod/dhqp/pdf/hicpac/infections_deaths.pdf
1 2

Saint S. Clinical and economic consequences of nosocomial catheter-related bacteriuria. Am J Infect Control 2000; 28:68-75.

Smith PW, et al. SHEA/APIC Guideline: Infection prevention and control in the long-term care facility. Am J Infect Control 2008; 36(7);504-535.
3 4

Wald HL, Kramer AM. Nonpayment for Harms Resulting From Medical Care. JAMA 2007, 298(23);2782-2784. CR5499 Instruction on the CMS web site at http://www.cms.hhs.gov/Transmittals/downloads/R1240CP.pdf

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The Long Term Care Survey F-tag# 441 Regulation § 483.65 (a) Infection Control Program Guidance to Surveyors Publisher American Health Care Association. September 2007, pp 619, Appendix PP - Guidance to Surveyors for Long Term Care Facilities Revisions of November 19, 2004 of the CMS Manual System State Operations Provider Certification Pub. 100-07. Department of Health & Human Services (DHHS), Centers for Medicare & Medicaid Services (CMS). http://www.cms.hhs.gov/Transmittals/Downloads/R5SOM.pdf
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Problem Identification
Basic Infection Prevention and Antimicrobial Stewardship
Although this guide focuses on infection prevention related to urinary catheter use, it is necessary to look at more global interventions that will impact HAIs, including urinary tract infections. It should be understood that the basics of infection prevention and control are the necessary underpinnings of programs, policies, and protocols that impact HAI1 (appropriate hand hygiene, environmental and equipment considerations, compliance with standard and transmissionbased precautions, etc.). One component of HAI prevention deserves added attention in this guide. As highlighted in the CDC’s campaign to prevent antimicrobial resistance, a program for antimicrobial stewardship in any healthcare setting (acute and longterm care) has the potential for positive impact on all HAIs. The development of biofilms, colonization, asymptomatic bacteriuria, and symptomatic urinary tract infections are common to urinary catheter use. Antimicrobial stewardship can play a role in minimizing the potential adverse outcomes of these occurrences. Inappropriate choice and utilization of antimicrobials has well-documented effects on patients and residents, and can lead to development of multidrug resistance in a healthcare setting. Preparing a facility or unit-based antibiogram can demonstrate the changes in antimicrobial resistance that develop over time, and can be used to track and monitor changes.2 The MDRO guide, or “Management of Multidrug-Resistant Organisms in Healthcare Settings,” produced by the CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC) in 2006, recommends that “systems are in place to promote optimal treatment of infections and appropriate antimicrobial use.”3 It is beyond the purview of this guide to explore the successful strategies for antimicrobial stewardship. A recent guideline developed by a joint Infectious Diseases Society of America and Society for Healthcare Epidemiology of America4 committee on antimicrobial stewardship is available for further information.

Prevalence of Urinary Tract Infections
The risk of urinary tract infection (UTI) depends on a variety of factors, including age, gender, lifestyle, anatomy, and disease process. Nearly half of all women will develop a bladder infection over a lifetime, due to the short length of the female urethra. Diseases or underlying conditions that lead to urinary obstruction, including genetic abnormalities, prostatitis, kidney stones, and others, increase the risk of UTI. Inability to maintain good hygiene, impaired voiding, and incontinence may also increase the risk of UTIs. Since the earliest days of national nosocomial infection reporting, UTIs have been shown to occur more frequently than other infections associated with healthcare, accounting for 36% of all HAIs in the United States.5 Most healthcareassociated UTIs are associated with an indwelling urinary catheter. The risk of acquiring a UTI depends on the method of catheterization, duration of catheter use, the quality of catheter care, and host susceptibility.6 Studies have shown a strong and direct correlation between catheter use greater than six days and CAUTI occurrence. In the same study, it was also reported that bacteriuria is nearly universal by day 30 of catheterization.7

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Table 3.1. Risk factors for CAUTI, based on prospective studies and use of multivariable statistical modeling.

Source: Dennis G. Maki and Paul A. Tambyah. Engineering Out the Risk of Infection with Urinary Catheters. Emerg Infect Dis 2001;7(2). http://www.cdc.gov/ncidod/EiD/vol7no2/pdfs/maki.pdf

A multivariate analysis reviewed by Salgado et al. reported five risk factors associated with the later development of a CAUTI: 1) duration of catheterization, 2) catheter care violations, 3) absence of systemic antibiotics, 4) female gender, and 5) older age.8 The presence of bacteria (bacteriuria) in the urine of otherwise healthy catheterized patients is often asymptomatic and will resolve spontaneously with the removal of the catheter. Even when not catheterized, older adults may have bacteria in their urine without any signs or symptoms of infection (asymptomatic bacteriuria, or ASB). ASB does not present an increased risk of progression to UTI unless other conditions that predispose the patient to UTI are present. The occurrences of uncomplicated ASB are problematic if antibiotics are inappropriately used as treatment or prophylaxis. Overuse of antibiotics, especially for ASB, may lead to selection for resistant strains.9

Urinary Catheter Use in Healthcare Settings
More than 30 million Foley catheters are inserted annually in the United States, and these catheterization procedures probably contribute to 1 million CAUTIs.10 Estimates of how many patients are catheterized at any one time have ranged from 10% in acute care hospitals, to 7.5% to 10% of patients in long-term care facilities,11 to a more recent estimate of 25%.12 Reasons for this increased use include complexities of care, increased acuity, and severity of illness and decreased staffing levels.13 Many investigations have shown high frequency of inappropriate and unjustified use of urinary catheters, especially in older, female patients. Inappropriate urinary catheter use in acute care hospitals has been reported to range from 21% to greater than 50%. It is estimated that 30% of all Foley catheters are inserted in the Emergency Department (ED). 14 Using retrospective chart review, Hazelett and colleagues reviewed charts of all patients greater than 65 years of age, admitted through the ED during a one-month period in 2004. Of the 1,633 patients admitted to the hospital from the ED, urinary catheters had been inserted in 379 (23%); 277 of whom (73%) were older than 65 years. Only 46% of these catheters were later identified as appropriately placed. 15
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Guide to the Elimination of Catheter-Associated Urinary Tract Infections (CAUTIs)

In a study by Gokula and colleagues of inappropriate urinary catheter use, the charts of 285 patients older than 65 who had an indwelling Foley catheter were reviewed for catheter indications. It was found that 46% of the patients had appropriate indications for catheterization. Only 13% of the time was there adequate documentation by nurses and physicians regarding the use of the catheter. In addition, 13% of the time, there was no documented order for the catheter. 16

Complications of Indwelling Urinary Catheters 17
A CAUTI is often perceived as a benign or acceptable side effect of a clinical process, yet there is a wide range of adverse outcomes associated with the use of urinary catheters. Infections related to indwelling urinary catheters include: • • • • Urinary tract infection (bladder) Secondary bacteremia/sepsis Acute pyelonephritis Late onset sequellae, e.g. metastatic osteomyelitis and meningitis

Adverse outcomes related to indwelling urinary catheters include: • • • • • • • • Prolonged hospital stay Secondary bacteremia /sepsis Increased mortality Late onset sequellae, e.g. metastatic osteomyelitis and meningitis Formation of encrustations and obstruction to flow Selection for multidrug-resistant organisms (MDROs) Urethral strictures, prostatitis and orchitis Reservoir for MDROs

Prevention of UTIs has been shown to decrease mortality in a large prospective study published in 1983.18 However, whether or not increased mortality remains a factor in healthcare-associated UTIs in more recent years is not certain. In the October 2008 “Society for Healthcare Epidemiology and Infectious Disease Society of America Supplement on Strategies to Reduce Catheter Associated Urinary Tract Infections in Acute Care Hospitals,” the authors note that although morbidity attributable to any single episode of catheterization may be limited, the high frequency of catheterization creates a substantial cumulative burden. 19 CAUTI is an often-overlooked cause of secondary bloodstream infections, responsible for 0.5% to 4% of these infections. Males develop secondary bacteremia twice as often as females.20 Although mortality is generally associated with bacteremia, one study found that bacteriuria was associated with an almost threefold higher chance of dying than for patients without bacteriuria. If urinary catheters were used only when deemed appropriate in a given population, thereby reducing the theoretical risk of CAUTI, it is logical to hypothesize that actual CAUTI rates would decrease. The impact of this intervention would be greatest in populations in which the duration of urinary catheter use is typically longer than a few days. Exposure to a urinary catheter is the major risk factor for infection.21 Duration of catheterization is the secondary risk factor. The best strategy to create the safest patient situation would be to avoid unnecessary catheter use and to use appropriate catheters for as short a duration as medically possible for each individual patient.22 Developed as part of a performance improvement project with ICU nurses at a San Diego hospital, the following fishbone diagram identifies the many factors associated with the subsequent development of CAUTI.23
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FOLEY RELATED URINARY TRACT INFECTIONS
Cause and Effect Diagram PATIENT RELATED FACTORS Primary Risks Secondary Risks
No hand washing prior to catheter manipulation Inappropriate use of catheters Drainage bag spigot/tube contaminated Catheter not secured to body Poor insertion techniques

CAREGIVER RELATED FACTORS

Female

Dehydration Age > 50yrs Sickle-cell anemia Diabetes Urethral colonization Immobility Other sites of infection Previous UTI Incomplete emptying of bladder Fecal incontinence Inappropriate antibiotic use

Breaks in closed system Other methods to control incontinence not used

Debilitated health Colonization with resistant organisms Poor personal hygiene

Foley bag raised above level of bladder

Catheter left in place longer than necessary

Foley Catheter Related UTI

Indications for appropriate catheter use not followed Lack of supplies to manage incontinence

Open drainage systems Standing columns of urine

Unsterile insertions Improper placement of drainage bag during transport Multi-patient use of measuring devices

No policy and procedures

Bacterial adherence to catheter surface No antiseptic coatings bonded to catheter

Clustering of catheterized patients No closed system

Routine catheter changes

Lack of preconnected urine meters

No catheter securing devices

Limited variety of trays/Foley sizes available

No sample port

Breaks in closed system

SYSTEMS / HOSPITAL

SYSTEMS / EQUIPMENT

SYSTEMS / ENVIRONMENT

Figure 3.1. Cause and effect diagram: Foley related urinary tract infections. Source: Carr HA. Catheter-Associated Urinary Tract Infections in Adults: Prevention through Care and Technology. Infection Control Today. Vol 2, No 8, August 1998, pp 26 – 29.

Urinary Tract Infection Pathogens24
Endogenous intestinal flora, including Escherichia coli, Enterobacter, Klebsiella, Enterococci, and Proteus, are common pathogens of the urinary tract and potential colonizers of urinary catheters. Inadequately decontaminated equipment and hands of healthcare workers may introduce environmental and common skin bacteria during insertion or maint:enance of the urinary catheter.25 Therefore, Pseudomonas, Serratia, coagulase-negative Staphylococci, Acinetobacter, and other non-intestinal or environmental microbes can result in healthcare-associated CAUTI. Patients with long-term indwelling catheters often have polymicrobial bacteriuria. Candida species are a common organism isolated from urine in the intensive care unit (ICU) setting. The use of antifungal drugs and of broad-spectrum antibiotics for empiric therapy has led to increasing prevalence of drug-resistant fungi and bacteria in intensive care and long-term care settings. Differences have been noted between the prevalence of pathogen-causing UTIs in different settings within a healthcare facility. The following table lists differences noted in pathogens recovered from patients with urinary tract infections in intensive care, as compared to the prevalence of pathogens hospital-wide.

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Table 3.2. Most Common UTI Pathogens

Hospital-wide Escherichia coli Enterococci P. aeruginosa Candida spp K. pneumoniae Enterobacter spp

Distribution 26% 16% 12% 9% 6% 6%

Intensive Care Unit Candida spp Escherichia coli Enterococci P. aeruginosa Enterobacter spp K. pneumoniae

Distribution 25% 18% 13% 11% 6% 6%

Source: Carr HA. Catheter-Associated Urinary Tract Infections in Adults: Prevention through Care and Technology. Infection Control Today 1998; 2(8):26-29. www.infectioncontroltoday.com

Pathogenesis
A urinary catheter provides a portal of entry into the urinary tract. Bacteria may ascend into the tract via either the external or internal surface of the catheter. Characteristics of each method of ascension are identified below. External (extraluminal) Bacterial Ascension • • • Microorganisms colonize the external catheter surface, most often creating a biofilm. Bacteria tend to ascend early after catheter insertion. This suggests a lack of asepsis during initial insertion. Bacteria can also ascend one to three days after catheterization, usually due to capillary action.

Internal (intraluminal) Bacterial Ascension • • • Bacteria tend to be introduced when opening the otherwise closed urinary drainage system. Microbes ascend from the urine collection bag into the bladder via reflux. Biofilm formation occurs, and damage to bladder mucosa facilitates biofilm on this surface.

Presence of the Catheter Predisposes Infection: • • • Presence of urinary catheter can lead to a level of bacteriuria in the range of greater than 105cfu/mL within 24-48 hours. Catheter interferes with normal host defenses. Consequently clearance of microbes from voiding and bladder mucosa is diminished. Absence of urinary catheter results in a lower level of bacteriuria (if any).

Bacteria can establish colonization of a patient’s bladder within three days of their introduction onto the inner or outer surface of urinary catheters.27 The introduction of bacteria with urinary catheter use is often associated with catheterrelated biofilms. Biofilms are complex structures that include bacteria, host cells and cellular by-products. Biofilm formation within invasive medical devices is proposed as a primary mechanism in the development of certain diseases, including CAUTI. 28Once a biofilm has developed on the inside or outside surface of a urinary catheter, the only way to eliminate the risk of CAUTI is to remove the catheter.

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Figure 3.2. Routes of entry of uropathogens to catheterized urinary tract. Source: Dennis G. Maki and Paul A. Tambyah. Engineering Out the Risk of Infection with Urinary Catheters. Emerg Infect Dis, Vol. 7, No. 2, March-April 2001. http://www.cdc.gov/ncidod/eid/vol7no2/makiG1.htm

Diagnosis of CAUTI - Urine Specimen Collection
The quality of the urine specimen for culture is important when determining if a true infection is present. The specimen of choice is the first morning void, since it is generally more concentrated, due the length of time the urine was in the bladder. The preferred collection method is a midstream, clean-catch specimen. Techniques for this type of collect can be found in a standard nursing text and laboratory manuals. Specimens collected from a newly inserted urine catheter are reliable, providing that proper insertion technique had been followed. Only specimens collected from a specifically designed sampling port or from the catheter directly should be submitted for analysis. Under no circumstances should a sample from a drainage bag be submitted for analysis. Catheter tips should not be submitted for analysis.29 If a CAUTI is suspected, the best practice is removal of the old catheter before obtaining the specimen in order to eliminate the confounding factor of possible catheter biofilm. If an indication for urinary catheterization still exists in a patient suspected of having a CAUTI, obtain the urine specimen after replacing the old one. Specimens collected from an indwelling urine catheter must be noted on the laboratory requisition or in the urine culture order. The Clinical and Laboratory Standards Institute (CLSI) Guidelines recommend that the urine specimen is cultured within two hours of its collection. If the specimen cannot be cultured within two hours of collection, there are two options for maintaining the specimen integrity: (1) Collection of the urine specimen in a container with a chemical preservative (most commonly, buffered boric acid); (2) Holding the urine specimen at (2-8° C) until the specimen can be cultured. Overgrowth of bacteria can readily occur with mishandled specimens, and this will cause a false positive or unreliable culture result.

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The collection container should be sterile and hold at least 50 ml of specimen. It should have a wide mouth for easy collection, a wide base to prevent spillage, and secure lid closure. Proper labeling on the container (not on the lid) includes the patient’s name and/or unique identifier, collection date and time.30

References
1

CDC’s Campaign to Prevent Antimicrobial Resistance. http://www.cdc.gov/DRUGRESISTANCE/healthcare/default.htm

Analysis and presentation of cumulative antibiograms: A new consensus guideline from the Clinical and Laboratory Standards Institute. Clin Infect Dis. 2007. 44(6):867-873.
2

Siegel JD, Rhineheart E, Jackson M, Linda C.; Healthcare Infection Control Practices Advisory Committee. “Management of multidrug-resistant organisms in healthcare settings, 2006.” http://www.cdc.gov/ncidod/dhqp/pdf/ar/mdroGuideline2006.pdf.
3

Dellit TH, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007. 44(2):159-177.
4

Klevens RM, Edwards JR, Richards CL, et al. Estimating health care associated infections and deaths in U.S. hospitals, 2002. Public Health Rep. 2007; 122:160-167. http://www.cdc.gov/ncidod/dhqp/pdf/hicpac/infections_deaths.pdf
5

Crouzet J, Bertrand X, Venier AG, Badoz M, Husson C, Talon D. Control of the duration of urinary catheterization: impact on catheter-associated urinary tract infection. J Hosp Infect. 2007; 67(3):253-7.
6

Maki DG and Tambyah PA. Engineering Out the Risk of Infection with Urinary Catheters. Emerg Infect Dis, 2001; 7(2). http://www.cdc.gov/ncidod/EiD/vol7no2/pdfs/maki.pdf
7

Salgado CD, Karchmer TB, Farr BM. Prevention of Catheter-Associated Urinary Tract Infections. Wenzel R. Prevention and Control of Nosocomial Infections. Lippincott Williams & Wilkins, 2003, 297-311.
8

Nicolle, L. E. “Infectious Diseases Society of America Guidelines for the Diagnosis and Treatment of Asymptomatic Bacteriuria in Adult.” Clinical Infectious Diseases 2005; 40:643-654.
9

Infection Control Today Editors. Expert discusses strategies to prevent CAUTIs (interview with Dr Rabih Darouiche). Infection Control Today. 2005;9(6):74-82. http://www.infectioncontroltoday.com/articles/561feat 2.html
10

Kunin CM. Care of the Urinary Catheter. UTIs: Detection, Prevention and Management. Baltimore: Williams & Wilkins, 1997, 226-278.
11

Saint S. Wiese J, Amory JK, et al. Are Physicians Aware of Which of Their Patients Have Indwelling Urinary Catheters? American Journal of Medicine 2000; 109:476-480.
12 13

Chettle, Connie C. Nurses Critical as Reimbursement Dries Up for Catheter-Associated UTIs. http://www.nurse.com/ce/CE485.

Hazelett SE, Tsai M, et al. The association between indwelling urinary catheter use in the elderly and urinary tract infection in acute care. BMC Geriatrics 2006, 6:15. http://www.biomedcentral.com/1471-2318/6/15
14 15

Ibid.

Gokula RRM, Hickne JA, Smith MA. Inappropriate use of urinary catheters in elderly patients at a Midwestern community teaching hospital. AJIC 2004; 32(4):196-199.
16

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Adapted from Kunin CM. Care of the Urinary Catheter. UTIs: Detection, Prevention and Management. Baltimore: Williams & Wilkins, 1997, 226-278.
17

Christophe Clec’h, MD et.al. Does Catheter-Associated Urinary Tract Infection Increase Mortality in Critically Ill Patients? ICHE 2007; 28(12):1367-1373.
18

Lo E, Nicolle L, Classen, D et al. Strategies to Prevent Catheter-Associated Urinary Tract Infections in Acute Care Hospitals. Infection Control and Hospital Epidemiology, Oct. 2008, Volume 29, Supplement 1 S41.
19

Krieger JN, Kaiser DL, Wenzel RP. Urinary tract etiology of bloodstream infections in hospitalized patients. J Infect Dis. 1983;148(1):57-62.
20

Stephan F, Sax H, Waschsmuth M, et al. Reduction of Urinary Tract Infection and Antibiotic Use after Surgery: A Controlled, Prospective, Before-After Intervention Study. Clinical Infectious Diseases 2006; 42:1544-1551.
21

Saint S, Kaufman SR, Thompson M et al. A Reminder Reduces Urinary Catheterization in Hospitalized Patients. Journal on Quality and Patient Safety 2005; 31(8): 455-462.
22

Carr HA. Catheter-Associated Urinary Tract Infections in Adults: Prevention Through Care and Technology. Infection Control Today 1998; 2(8):26-29.
23 24

2005 APIC Text of Infection Control and Epidemiology. Chapter 25, Urinary Tract Infections by Debra Leithauser.

Maki DG and Tambyah PA. Engineering Out the Risk of Infection with Urinary Catheters. Emerg Infect Dis 2001; 7(2). http://www.cdc.gov/ncidod/EiD/vol7no2/pdfs/maki.pdf
25

Carr HA. Catheter-Associated Urinary Tract Infections in Adults: Prevention through Care and Technology. Infection Control Today 1998; 2(8):26-29. www.infectioncontroltoday.com
26 27

Donlan RM. Biofilms and device-associated infections. Emerg Infect Dis 2001 March-April;7(2):277. 2005 APIC Text of Infection Control and Epidemiology. Chapter 96. Biofilms by John G. Thomas, PhD. Gross Peter A. Positive Foley Catheter Tip Cultures – Fact or Fancy. JAMA, April 1974.

28

29

NCCLS GP-16A2, Vol. 21, No. 19. Urinalysis and Collection, Transportation and Preservation of Urine Specimens; Approved Guideline, Second Edition:4-21.
30

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Understanding the Definitions
Clinical Definitions of Urinary Tract Infection
In hospital settings, clinicians may use guideline-based definitions in the diagnosis of urinary tract infections. The Infectious Diseases Society of America definitions are included here for reference.1 • Asymptomatic bacteriuria, or asymptomatic urinary infection: Isolation of a specified quantitative count of bacteria in an appropriately collected urine specimen obtained from a person without symptoms or signs referable to urinary infection. • Acute uncomplicated urinary tract infection: Symptomatic bladder infection characterized by frequency, urgency, dysuria, or suprapubic pain in a woman with a normal genitourinary tract, and is associated with both genetic and behavioral determinants. • Acute nonobstructive-pyelonephritis: Renal infection characterized by costovertebral angle pain and tenderness, often with fever; it occurs in the same population that experiences acute uncomplicated urinary infection. • Complicated urinary tract infection: Symptomatic urinary infection involving either the bladder or kidneys, found in individuals with functional or structural abnormalities of the genitourinary tract. • Pyuria: The presence of increased numbers of polymorphonuclear leukocytes in the urine, evidence of an inflammatory response in the urinary tract.

Catheter Definition
A catheter is defined as a drainage tube that is inserted into the bladder through the urethra, is left in place, and is connected to a closed drainage system. The catheter is sometimes called a “Foley catheter” or indwelling urinary catheter. CAUTI surveillance does not include straight in-and-out catheterizations. Suprapubic catheters and other urological diversions are also not included in CAUTI surveillance.

Surveillance Definitions
Definitions for the CDC and the National Healthcare Safety Network (NHSN), as well as the McGeer definitions for longterm care facilities, are included in this guide. CMS has determined that it will utilize administrative data for CAUTI not present on admission (see section on Value Based Purchasing or VBP).

CDC/NHSN Surveillance Definitions for CAUTI 2
Acute care hospitals often use the CDC/NHSN classification of CAUTI, which currently falls into two groups: symptomatic urinary tract infection (SUTI) and asymptomatic bacteremic urinary tract infection (ABUTI). CAUTI includes those infections in which a patient had an indwelling urinary catheter at the time or within 48 hours before onset of the event. NOTE: There is no minimum period of time that the catheter must be in place in order for the UTI to be considered catheter-associated.
16 ASSOCIATION FOR PROFESSIONALS IN INFECTION CONTROL AND EPIDEMIOLOGY

Guide to the Elimination of Catheter-Associated Urinary Tract Infections (CAUTIs)

Identification and Categorization of SUTI Indwelling Catheter Discontinued in Prior 48 Hours

Figure 1

Patient had an indwelling urinary catheter at the time of specimen collection

Signs and Symptoms

At least 1 of the following with no other recognized cause: fever (>38°C) suprapubic tenderness costovertebral angle pain or tenderness
OR

Urinalysis

A positive urinalysis demonstrated by at least 1 of the following findings: positive dipstick for leukocyte esterase and/or nitrite pyuria (urine specimen with 10 WBC/mm3 or 3 WBC/high power field of unspun urine) microorganisms seen on Gram stain of unspun urine

Culture Evidence

A positive urine culture of 105 CFU/ml with no more than 2 species of microorganisms

A positive urine culture of 103 and 38°C) urgency suprapubic tenderness frequency costovertebral angle pain or tenderness
OR

Signs and Symptoms

Urinalysis

A positive urinalysis demonstrated by at least 1 of the following findings: positive dipstick for leukocyte esterase and/or nitrite pyuria (urine specimen with 10 WBC/mm3 or 3 WBC/high power field of unspun urine) microorganisms seen on Gram stain of unspun urine

Culture Evidence

A positive urine culture of 105 CFU/ml with no more than 2 species of microorganisms

A positive urine culture of 103 and 38°C if patient 65 years of age

NONE of the following:

Signs and Symptoms

- fever (>38°C core) - hypothermia ( 48 hours after admission. Assess location, frequency and prevalence of MDROs or other epidemiologically significant organisms associated with UTIs. This information may be obtained by working with your facility’s Microbiology Department or through the usage of electronic data systems. Use NHSN definitions of bloodstream infections attributable to CAUTI. Determine frequency and overall impact of these infections.





Step 4: Determine financial impact.
Several methods exist to identify the financial impact of these infections: Method 1: Obtain a list of patients who met one of the UTI codes and the 999.64 catheter association code in which the UTI was coded “not present on admission.” Identify direct revenue loss. (Refer to section on Value Based Purchasing). Method 2: Utilize published data to estimate financial impact, based on average frequency and cost of UTIs. In 2005, Stone and colleagues published their review of the current literature addressing the economic ramifications of adverse events such as HAIs. They examined more than 150 studies conducted from 2001 to 2004 that looked at the simple cost of infections or performed a cost analysis of interventions. The studies examined the average costs of the following common HAIs: surgical site infections, ($25,546); bloodstream infections, ($36,441); ventilator-associated pneumonia, ($9,969); and urinary tract infections, ($1,006).1 Method 3: Calculate actual excess costs of infections and excess length of stay. Tools such as APIC’s HAI Cost Calculator Tool are available and can generate tables and graphs which can help describe the impact of a urinary tract infection in your own organization. The HAI Cost Calculator Tool is included as part of APIC’s Dispelling the Myths: The True Cost of Healthcare-Associated Infections, available at www.apic.org/store.
24 ASSOCIATION FOR PROFESSIONALS IN INFECTION CONTROL AND EPIDEMIOLOGY

Guide to the Elimination of Catheter-Associated Urinary Tract Infections (CAUTIs)

Step 5: Use all of the above information to complete the CAUTI portion of the overall organizational risk assessment.
The risk assessment should involve a multidisciplinary team and is a crucial step in developing the overall organizational surveillance plan. Two examples of facility risk assessments are included below.

Figure 5.1. Risk assessment chart. Source: Connie Steed, MSN, RN, CIC, Greenville Hospital System University Medical Center, Greenville, SC

Scope of Services

Sharp Healthcare Infection Control Risk Assessment
Benchmark High Risk Pot ent ial Negat ive Out comes (relative risk rating on a scale of 0-3) 0 0 0 1 1 1 2 2 2 3 3 3 High Volume Nat ional Init iat ive Financial Incentive Risk Rat ing

0 1 2 3 Device Related Risk Central Line Sepsis (ICU) House-wide Central Line Sepsis House-wide Central Line site care/dressing change CAUTI (ICU) VAP (ICU) House-wide UTI

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