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What Causes Lyme Disease

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The infectious agent responsible for Lyme disease is the spirochete microorganism B. burgdorferi. Lyme disease is a zoonotic disease that is transmitted from host to mammalian by vector ticks of the Ixodes genus (Transmission, 2015). B. burgdorferi is an obligate parasite, whose natural host are a wide variety of mammals, is transferred to humans to cause Lyme disease by a blood meal of a tick. Although a natural host may contain the microorganism, not all mammals undergo the symptoms of Lyme disease like that of the immunopathological response in humans. The parasitic nature of B. burgdorferi is due to the fact that the organism does not possess the genes responsible for synthesis of common biomolecules such as amino acids, nucleotides, and …show more content…
burgdorferi induces Lyme disease, there is much know about the disease itself. Various signs and symptoms may occur within days of infections, while other symptoms may occur months after a tick bite. For this reason Lyme disease is divided into three clinical stages. The first stage is erythema chronicum migrans, a characteristic a skin lesion originating at the site of the tick bite with additional annular lesions around site of origin (Steere, 1983). The second stage, commonly referred to as early disseminated stage, is present weeks to months after initial contact. Stage two affects the central nervous system causing meningoencephalitis and cranial neuritis, as well as affecting cardiac tissue which results in myocarditis, pericarditis, arrhythmia, and heart block. Other symptoms of stage two can include joint and muscle pain, and lymphadenopathy. Stage three, the late disseminated stage, occurs two to three years after initial contact. In this stage, chronic arthritis may be accompanied with severe damage to joints, as well as variance of encephalitis (Robbins, 1979). Although Lyme disease is not fatal directly, complications with cardiac function can result in …show more content…
burgdorferi can be eliminated by the use of several antibiotics. Different antibiotic medication can be used to effectively eliminate the B. burgdorferi depending on which symptoms the patient is experiencing. In early Lyme disease with the presence of erythema migrans and in late Lyme disease with presence of arthritis, patients may be prescribed to take either 100mg of doxycycline twice a for a range of ten to twenty-one days, 500mg amoxicillin three times per day for a range of fourteen to twenty-one days, or 500 mg of cefuroxime axetil twice a day for fourteen days. If patients exhibit meningitis or other neurologic manifestation of Lyme disease, the patient can be treated two g per ounce a day of ceftriaxone intravenously for a range of ten to twenty-eight days (Wormser, 2006). Each one of the medications has been proven to be effective against B. burgdorferi, although they perform different

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