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Bicarbonate Buffer System: The Synthetic Nervous System

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Like previously said, James spontaneously releases his hand from the hot cup of tea. Immediately after James feels stressed and anxious, and these are natural responses to help your body escape from danger or harm. To avoid any tissue damaged from the heat and pain, the sympathetic nervous system (SNS), a part of the involuntary nervous system, senses the stressful situation and causes the release of a hormone called epinephrine, also known as adrenaline.
Once the impulse is sent, it goes directly to the adrenal medulla, the inner layer of the adrenal glands situated on top of the kidneys. The adrenal glands secrete acetylcholine which stimulates the release of particular hormones. The adrenal medulla produces catecholamines which include …show more content…
This buffer consists of weak acid H2CO3 (pK1 = 6,1) and conjugated base HCO3- (bicarbonate).

Protein buffers
Body proteins (plasma proteins and intracellular) are the most abundant and the most powerful buffer system in whole organism. Some amino acids have acid or basic side chains (His, Lys, Arg, Glu, Asp). Among blood proteins haemoglobin is the most important. It provides 35 % of buffering capacity of blood, remaining proteins provide only 7 %.
Phosphate buffer
Phosphate buffer consists of inorganic and organic bound phosphate (i.e. esters of organic substances, e.g. AMP, ADP, and ATP). Phosphate buffer is important intracellular and urine buffer. In blood it accounts for only 5 % of buffering capacity.
Urine buffers
There are two important urine buffers: (1) ammonium buffer (NH3/NH4+) and (2) phosphate buffer. Every day is excreted 30-50 mmol of NH4+. This is important because excretion of NH4+ is significantly regulated when the acid-base balance is disturbed. That is excretion of ammonium could be much decreased or much increased. In acidosis is glutaminaseactivated in the kidneys. Glutaminase splits glutamine to glutamate and NH3. NH3 is then eliminated to the urine. This process includes also the liver, where less urea and more glutamine is produced in acidosis. Every day is excreted 20 mmol of phosphates (i.e. titratable urine …show more content…
Respiration reacts in 1-3 minutes. Respiratory system regulates carbon dioxide. Respiration is able to change pCO2 by its elimination or retention. Respiratory centre is in brainstem.
3) Kidneys
Kidneys react in hours-days. Their role in acid-base balance is very complex
H+ + HCO3- → H2O + CO2 (consumption of bicarbonate-

 Metabolic Alkalosis
Metabolic alkalosis happens when the blood is too alkaline due to the overproduction of bicarbonate. This state is known as primary bicarbonate excess.

The over production of adrenocorticotrophic hormone results in elevated aldosterone levels and an increased loss of potassium by urinary excretion. Other causes of metabolic alkalosis could be the loss of acids from the body like hydrochloric acid from the stomach through vomiting.
Respiratory compensation for metabolic alkalosis isto decrease the respiratory rate to conserve CO2.

Respiratory Alkalosis

Respiratory alkalosis occurs when the blood is excessively alkaline because of the deficiency of carbonic acid and CO2 levels in the blood. This condition is known as primary carbonic

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