...Chagas disease, the parasitic infection caused by Trypanosoma cruzi, is found mainly in Latin America, where it is mostly transmitted to humans by the feces known as “kissing bugs”. The Triatoma or “kissing” bug. Image/CDC in 2013 the number of cases of Chagas disease in the United States to be somewhere between 300,000 and 1 million. The United States is ranked 7th among nations for the amount of cases. In Texas, approximately 45% of the collected kissing bugs have tested positive for T. cruzi, and Chagas is considered an endemic disease in dogs. From 2013 to 2014, 351 cases of Chagas disease in animals, primarily dogs, were reported from approximately 20% of Texas counties, representing all geographic regions of the state. Locally-acquired human cases are uncommon, but some have been reported. From 2013 to 2014, 39 human cases of Chagas disease were reported: 24 were acquired in another country, 12 were locally-acquired, and the location of acquisition was unknown for 3. Local transmission means that the kissing bugs in Texas are infected with the parasite, causing it to spread to humans. Chagas in Texas/Texas Department of Health The kissing bug can be found in poorly constructed homes, with cracks and crevices in the walls. Usually at night while sleeping, the insect feeds on people or other mammals. While feeding the insect defecates and the infected feces gets rubbed into the bite wound, eyes abrasions or other skin wounds. The parasite invades macrophages...
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...and Innovation April ,07,2016 Case Analysis: Genzyme’s CSR Dilemma: How to Play Its HAND Marcio Augusto da Matta augustod@ualberta.ca Dr. Anthony R. Briggs ------------------------------------------------- 1. Introduction Genzyme is a biotechnology company with a leading role in the world’s treatment for Orphan and neglected diseases. At the moment its Senior VP, Mr. Geragthy faces a time for decisions. The analysis momentum is over and he must propose the best direction for the company. I will go deeply inside the company and analyse the inside and outside scenario to be able to run the VRIO model and give my preference to Mr. Geragthy. 2. Genzyme’s history All started with the supply of enzymes, fine chemicals and reagents to research and pharmaceutical companies. Its founder, Mr. Henry Blair since the beginning had a vision to become a world leader and always focused by identifying patient’s needs, targeting a focused technology capability, and developing a set of values that clearly defined its role as a corporation society. Since the beginning the strategy was on orphaned diseases and it reflected in its portfolio of drugs and achieving the leadership with revenues of almost $4 billion in 2007. In 1983 Mr. Blair felt the need for help and brought on board Mr. Henri Termeer who had a very important role on the company’s development and together they have taken the company public and launched the orphan drug application for the enzyme...
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...only present in the feces for the first 2-3 weeks" (1). "The current lab test only indicates exposure to toxoplasmosis not the presence of an active infection." (1). "The history, signs of illness, and the supportive laboratory tests" will lead to a diagnosis (2). "A presumptive diagnosis may be made by demonstration of a fourfold or greater increase in antibody titers" (2). The uses of ELISA, western blot and latex agglutination tests have reliable results (4). Mainly the only people that really need to be tested for this disease are AIDS patients, immunosuppressed, and infants at birth. Symptoms: "Respiratory involvement is common in cats with both primary and secondary forms of the disease" (1). Fever, malaise, weight loss, and lack of appetite are common symptoms of this form (1). You have these symptoms in addition to vomiting, diarrhea, and abdominal lymph node enlargement (1). Signs of Disease: The disease can become latent. All exposed to this disease will have a chronic infection. Those that become immunosuppressed could have a reinfection occur. “AMEBIASIS” Definition: Amebiasis is caused by Entamoeba histolytica, a protozoan that is found worldwide. The highest prevalence of amebiasis is in developing countries where barriers between human feces and food and water supplies are inadequate. Causative Agent:...
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...Study #3 Trachoma and Chagas are tropical diseases that have been successfully treated through health efforts by the government and different organizations. Trachoma is the second leading cause of blindness in the world but is the number one preventable blindness. Trachoma is caused by transmission of eye and nose secretions, unsanitary conditions and flies. Chagas affects sixteen to eighteen million people in Latin America. Chagas is caused by kissing bugs transferring a parasitic infection into the host. Areas of poor socioeconomic status are typically the targets of these tropical diseases. The majority affected are young children. Trachoma loses an estimate of three billion dollars’ worth of potential productivity lost while Chagas is about four hundred million. The efforts implemented to prevent these diseases are estimated to be about seventy percent successful. Trachoma uses the strategy SAFE which stands for surgery, antibiotics, facial cleanliness, and environmental safeness. Chagas uses vector control which is a pyrethroid insecticide around areas of infected. The strategy of SAFE for Trachoma is very cost-effective costing about six dollars a person for surgery. The strategy for Chagas, pyrethroid insecticide, cost about thirty seven dollars for infected zones. Both of these strategies are very cost-effective for a large range of affected population. There are current and ongoing research of cost-effective ways for both Chagas and Trachoma. The government...
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...Some of them spread the livestock diseases blue tongue and African horse sickness,other species though, are at least partly nectar feeders and some actually suck insect bodily fluids (Alan Weaving; Mike Picker; Griffiths, Charles Llewellyn,2003). Biting midges are flies belonging to the family Ceratopogonidae. There are around 6000 species in 125 genera world wide and more than 1000 known species in China. Four genera, Austroconops, Lasiohelea, Leptoconops and most importantly Culicoides, feed on blood of vertebrates including human. In Hong Kong, at least 57 species from 10 genera of biting midges have been recorded....
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...Case 8-4: Genzyme’s CSR Dilemma: How to Play its HAND 1. In your opinion, which of the three major HAND initiatives: TB, Malaria, or Chagas should Jim Geraghty recommend? Defend you answer by detailing how your choice is better than the other two. I think that Jim Geraghty should recommend the Malaria initiative. The Malaria initiative is the best business decision for Genzyme. There are 250 million Malaria cases every year, compared to that of 16-18 million cases of Chagas and 25 million cases of Tuberculosis. Even though Tuberculosis has more deaths per year at 1.5-2 million and could possibly be the best initiative to recommend, I still believe the Malaria initiative is the best option. Malaria is spread by Anopheles mosquitos and there is still a great need for a cure of Malaria in today’s world. In the case, Genzyme’s goal is to have the most impact possible on a deadly disease, while doing something that is within their capabilities. All three initiatives have a very important medical need, but Genzyme has the molecular knowledge to create a vaccine for Malaria. They have done a lot of research for Chagas also, but they would have to basically start from scratch if they were to go towards the Tuberculosis initiative. By going with the Malaria initiative, they would more than likely partner with Harvard, MMV, and ICGEB, which would be great for the research and development capabilities. Jim Geraghty should recommend the Malaria initiative to Henri Teermer 2. Taking the...
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...there have been a number of flood events that have each affected more than a million people. The floods destroy crops and contaminate ground water leading to both famine and drought. In some parts of Africa fighting is being fuelled by the effects of climate change. The Darfur conflict began over tribal rivalries but today it is more about gaining control of the remaining agricultural land as the surrounding area becomes desert. The bacteria that cause diseases thrive in warmer and damp conditions. Climate change leads to both increased temperatures and increased precipitation, thus providing perfect breeding grounds. Many disease vectors are temperature dependent and as the isotherms spread, so too are the diseases. Amongst the diseases known to have spread are chagas disease, lymphatic, dengue fever, pneumonic plague, hantavirus, viral encephalitis and malaria. The World Health Organisation has worked out that 150,000 people die each year as a consequence of climate change and some 5,000,000 contract diseases and illnesses. The overwhelming majority of these occur in Africa and...
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...[1] o When a person is bitten a large oval lump may arise followed by itching, or no reaction or a delayed reaction may be experienced. The bite may be mistaken for a mosquito bite or even a flea bite. Because the bite reaction is similar to that caused by other insects, bed bug infestations are difficult to diagnose correctly when bites are first experienced. This allows the bed bug population to increase and possibly disperse before the culprit is identified.[2] o Bedbugs seem to possess all of the necessary prerequisites for being capable of passing diseases from one host to another. There is the possibility that the saliva of the bedbugs may cause anaphylactic shock as well as anemia in a some people. In addition bedbugs can also transmit Chagas disease as well as Hepatitis B.[1] SLEEPWELL BIOSENSOR o This biosensor is in the form of a sheet that can be spread over the mattress at all times. o It will be able to diagnose the presence of even a single bed bug. o This is done through the detection of its feces. o The picture shows a mattress with bedbugs with some fecal matter thrown in for good measure. o Bed bugs usually eliminate much of the water from the blood meal in the form of feces. These feces should contain intact or partially digested human hemoglobin molecules as well as other blood proteins. o The biosensor will have monoclonal antibodies/polyclonal antibodies bound...
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...Adriana Ambari Writing 100-14 December 6th, 2012 Project 4 Human Trafficking: A Global Epidemic When Abraham Lincoln signed the Emancipation Proclamation in 1963, we thought this was the end to slavery, but the sad truth is that it is still occurring today all over the world. This form of modern day slavery is called human trafficking. The United Nations defines human trafficking as "The recruitment, transportation, transfer, harboring or receipt of persons, by means of the threat or use of force or other forms of coercion, of abduction, of fraud, of deception, of the abuse of power or of a position of vulnerability or of the giving or receiving of payments or benefits to achieve the consent of a person having control over another person, for the purpose of exploitation."(United Nations Office on Drugs and Crime) Human trafficking is a global epidemic, which occurs everyday, in almost every single country in the world. It’s an international industry that is rapidly expanding. Patrick Belser of ILO has estimated human trafficking to be a $31.6 billion industry. This is second only to the drug trade. The 2010 Trafficking in Persons Report by the U.S. Department of State estimates that there are 12.3 million slaves being held captive around the world. This is second only to the drug trade. Globally 80% of human trafficking victims are women and 60% are children. In the minute it took you to read this paragraph two children have become victims to human trafficking. There...
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...1950 and 2010 the gap between life expectancy in the Tropics and the Rest of the World has narrowed. Over this period life expectancy in the Tropics increased by 22.8 years to 64.4 years and infant mortality reduced by 36%. The rate of change of mortality and morbidity has increased over the last two decades influenced by a range of different factors. Underlying life expectancy data are aggregated data, collected by the WHO to document the changing patterns of mortality. Table E3.1 provides the top ten causes of mortality in rank order over the last decade. Non-communicable diseases (NCDs) accounted for two-thirds of global deaths in 2011 and infectious diseases for one-third. In 2000 the relative proportions were 60% NCDs and 40% infectious diseases. This rapid shift reflects the massive scale up in recent efforts to prevent and treat a number of major infectious diseases. Although improvements in maternal and child mortality have been made these still remain unacceptably high. In 2011, 6.9 million children under the age of five died, 99% of these in low and middle income countries. Malaria, despite the enormous scale up in control activities still accounted for 14% of the under-five mortality in the Tropics. There are differences in the age at which mortality occurs stratified by income. In high income countries 70% of deaths occur in the over 70s and only one in 100 occurs in an individual under 15 years of age. In low income countries 40%...
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...Human Trafficking a Global Epidemic The Emancipation Proclamation was signed in 1963 by Abraham Lincoln. Many enslaved Americans were thought to be freed. slavery still exist today all over the world. This form of modern day slavery is called human trafficking. The United Nations defines human trafficking as "The recruitment, transport, transfer, harboring of persons, by means of the threat or use of excessive force. Strong-arming a person against their will is abduction then to receive payments for the purpose of exploitation."(United Nations Office on Drugs and Crime) is “Human trafficking”. Human Trafficking is a global epidemic, which occurs daily, in every country in the world. It’s an international industry that is a growing problem. (Patrick Belser) of ILO has estimated human trafficking to be a $31.6 billion industry. Human Trafficking is the second worst epidemic to the drug trade. The 2010 Trafficking Report by the (U.S. Department of State) estimates that there are 12.3 million people are being confined and held unwillingly around the world. Globally 80% of human trafficking victims are women and 60% are children. Many articles have shown that males are not exempt from trafficking. Human trafficking, is usually a forced act of a person, performing sex 3acts or hard labor in a sweat shop. Some victims agree to be trafficked in order to repay a debt for being brought to the U.S.A. others are transported...
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...Addison’s Disease Addisonian Anemia Albright’s Syndrome Alport’s Syndrome Alzheimer’s Argyll-Robertson Pupil Arnold-Chiari Malformation Barrett’s Bartter’s Syndrome Becker’s Muscular Dystrophy Bell’s Palsy Berger’s Disease Bernard-Soulier Disease Berry Aneurysm Bowen’s Disease Brill-Zinsser Disease Briquet’s Syndrome Broca’s Aphasia Brown-Sequard Bruton’s Disease Budd-Chiari Buerger’s Disease Burkitt’s Lymphoma Caisson Disease Chagas’ Disease Chediak-Higashi Disease Conn’s Syndrome Cori’s Disease Creutzfeldt-Jakob Crigler-Najjar Syndrome Crohn’s Curling’s Ulcer Cushing’s Cushing’s Ulcer de Quervain’s Thyroiditis Primary adrenocortical deficiency Pernicious anemia (antibodies to intrinsic factor or parietal cells → ↓IF → ↓Vit B12 → megaloblastic anemia) Polyostotic fibrous dysplasia, precocious puberty, café au lait spots, short stature, young girls Hereditary nephritis with nerve deafness Progressive dementia • Loss of light reflex constriction (contralateral or bilateral) • “Prostitute’s Eye” – accommodates but does not react • Pathognomonic for 3°Syphilis • Lesion pretectal region of superior colliculus Cerebellar tonsil herniation through foramen magnum = see thoracolumbar meningomyelocele Columnar metaplasia of lower esophagus (↑ risk of adenocarcinoma)- constant gastroesophageal reflux Hyperreninemia Similar to Duchenne, but less severe (mutation, not a deficiency, in dystrophin protein) CNVII palsy (entire face; recall...
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...geriatric medicine. As a physician you will be faced daily with the concepts of microbial disease and antimicrobial therapy. Microbiology is one of the few courses where much of the "minutia" is regularly used by the practicing physician. This book attempts to facilitate the learning of microbiology by presenting the information in a clear and entertaining manner brimming with memory aids. Our approach has been to: 4) Create a conceptual, organized approach to the organisms studied so the student relies less on memory and more on logical pathophysiology. The text has been updated to include current information on rapidly developing topics, such as HIV and AIDS (vaccine efforts and all the new anti-HIV medications), Ebola virus, Hantavirus, E. coli outbreaks, Mad Cow Disease, and brand-new antimicrobial antibiotics. The mnemonics and cartoons in this book do not intend disrespect for any particular patient population or racial or ethnic group but are solely presented as memory devices to assist in the learning of a complex and important medical subject. We welcome suggestions for future editions. 1) Write in a conversational style for rapid assimilation. 2) Include numerous figures serving as "visual memory tools" and summary charts at the end of each chapter. These can be used for "cram sessions" after the concepts have been studied in the text. 3) Concentrate more on clinical and infectious disease issues that are both interesting and vital to the actual practice of medicine. MARK...
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...between developed and developing countries were retained for further analysis. Of 227 articles retained through initial screening, 65 were included in the final analysis. The results were two-fold: some articles pointed to intangible benefits accrued by developed country partners, but the majority of information pointed to developing country innovations that can potentially inform health systems in developed countries. This information spanned all six WHO health system components. Ten key health areas where developed countries have the most to learn from the developing world were identified and include, rural health service delivery; skills substitution; decentralisation of management; creative problem-solving; education in communicable disease control; innovation in mobile phone use; low technology simulation training; local product manufacture; health financing; and social entrepreneurship. While there are no guarantees that innovations from developing country experiences can effectively transfer to developed countries, combined developed-developing country learning processes can potentially generate effective solutions for global health systems. However, the global pool of knowledge in this area is virgin and further work needs to be undertaken to advance understanding of health innovation diffusion. Even more urgently, a standardized method for reporting partnership benefits is needed—this is perhaps the single most immediate need...
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...globalization: trade and transactions, capital and investment movements, migration and movement of people and the dissemination of knowledge. Further, environmental challenges such as climate change, cross-boundary water, air pollution, and over-fishing of the ocean are linked with globalization. Globalizing processes affect and are affected by business and work organization, economics, socio-cultural resources, and the natural environment. Overview Humans have interacted over long distances for thousands of years. The overland Silk Road that connected Asia, Africa, and Europe is a good example of the transformative power of translocal exchange that existed in the "Old World". Philosophy, religion, language, the arts, and other aspects of culture spread and mixed as nations exchanged products and ideas. In the 15th and 16th centuries, Europeans made important discoveries in their exploration of the oceans, including the start of transatlantic travel...
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