...Europe’s journal on infectious disease epidemiolog y, prevention and control Special edition: Chikungunya and Zika virus October 2014 Featuring • Spread of chikungunya from the Caribbean to mainland Central and South America: a greater risk of spillover in Europe? • Aspects of Zika virus transmission • Cases of chikungunya virus infection in travellers returning to Spain from Haiti or Dominican Republic, April-June 2014 www.eurosurveillance.org Editorial team Editorial advisors Based at the European Centre for Disease Prevention and Control (ECDC), 171 83 Stockholm, Sweden Albania: Alban Ylli, Tirana Telephone number Belgium: Sophie Quoilin, Brussels +46 (0)8 58 60 11 38 E-mail eurosurveillance@ecdc.europa.eu Editor-in-chief Ines Steffens Austria: Reinhild Strauss, Vienna Belgium: Koen De Schrijver, Antwerp Bosnia and Herzogovina: Nina Rodić Vukmir, Banja Luka Bulgaria: Mira Kojouharova, Sofia Croatia: Sanja Musić Milanović, Zagreb Cyprus: to be nominated Czech Republic: Bohumir Križ, Prague Denmark: Peter Henrik Andersen, Copenhagen Senior editor Estonia: Kuulo Kutsar, Tallinn Kathrin Hagmaier Finland: Outi Lyytikäinen, Helsinki Scientific editors Karen Wilson Williamina Wilson France: Judith Benrekassa, Paris Germany: Jamela Seedat, Berlin Greece: Rengina Vorou, Athens Hungary: Ágnes Csohán, Budapest Assistant editors Iceland: Haraldur Briem, Reykjavik Alina Buzdugan Ireland: Lelia Thornton...
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...Peer-Reviewed Journal Tracking and Analyzing Disease Trends pages 557–740 EDITOR-IN-CHIEF D. Peter Drotman Associate Editors Paul Arguin, Atlanta, Georgia, USA Charles Ben Beard, Ft. Collins, Colorado, USA Ermias Belay, Atlanta, Georgia, USA David Bell, Atlanta, Georgia, USA Sharon Bloom, Atlanta, GA, USA Mary Brandt, Atlanta, Georgia, USA Corrie Brown, Athens, Georgia, USA Charles H. Calisher, Ft. Collins, Colorado, USA Michel Drancourt, Marseille, France Paul V. Effler, Perth, Australia David Freedman, Birmingham, Alabama, USA Peter Gerner-Smidt, Atlanta, Georgia, USA Stephen Hadler, Atlanta, Georgia, USA Nina Marano, Nairobi, Kenya Martin I. Meltzer, Atlanta, Georgia, USA David Morens, Bethesda, Maryland, USA J. Glenn Morris, Gainesville, Florida, USA Patrice Nordmann, Fribourg, Switzerland Didier Raoult, Marseille, France Pierre Rollin, Atlanta, Georgia, USA Ronald M. Rosenberg, Fort Collins, Colorado, USA Frank Sorvillo, Los Angeles, California, USA David Walker, Galveston, Texas, USA Senior Associate Editor, Emeritus Brian W.J. Mahy, Bury St. Edmunds, Suffolk, UK Managing Editor Byron Breedlove, Atlanta, Georgia, USA Copy Editors Claudia Chesley, Laurie Dietrich, Karen Foster, Thomas Gryczan, Jean Michaels Jones, Shannon O’Connor, P. Lynne Stockton Production William Hale, Barbara Segal, Reginald Tucker Editorial Assistant Jared Friedberg Communications/Social Media Sarah Logan Gregory Founding Editor Joseph E. McDade, Rome, Georgia, USA Emerging Infectious Diseases...
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...Introduction to Chikungunya Chikungunya fever is a viral disease transmitted to humans by the bite of infected Aedes Aegypti mosquitoes. Chikungunya virus (CHIKV) is a member of the genus Alphavirus, in the family Togaviridae. CHIKV was first isolated from the blood of a febrile patient in Tanzania in 1953, and has since been identified repeatedly in west, central and southern Africa and many areas of Asia, and has been cited as the cause of numerous human epidemics in those areas since that time. The virus circulates throughout much of Africa, with transmission thought to occur mainly between mosquitoes and monkeys. Symptoms of Chikungunya Symptoms of Chikungunya includes fever, debilitating arthralgia (joint pain), swelling of joints, stiffness of joints, myalgia (muscular pain), headache, fatigue (weakness), nausea, vomiting and rash. The incubation period (time from infection to illness) can be 2-12 days, but is usually 3-7 days. "Silent" CHIKV infections (infections without illness) do occur; but how commonly this happens is not yet known. Acute chikungunya fever typically lasts a few days to a couple of weeks, but some patients have prolonged fatigue lasting several weeks. Additionally, some patients have reported incapacitating joint pain, or arthritis which may last for weeks or months. No deaths, neuro-invasive cases, or hemorrhagic cases related to CHIKV infection have been conclusively documented in the scientific literature. CHIKV infection (whether clinical...
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...Anna Anderson PTLW CSUEB July 2011 Activity 1.1.2 MICROBIOLOGIST * Microbiologist Microbiologists study microscopic bacteria, fungi, protists, and viruses. Many of these organisms cause disease (pathogens) and many can provide useful products such as penicillin (antibiotic). * Education and/or Training Required In order to work in this field you must have at least an undergraduate degree in microbiology. Further training with a Masters or Doctorate would be required to do anything other than entry level positions. Excellent microscopy skills and training in aseptic techniques are a must. * Responsibilities and Daily Activities This job requires a strong academic background with a lot of math, chemistry, and biology. Computer and lab skills are essential. Microbiologists grow cultures of bacteria (and other organisms) in medium for study. Using aseptic technique, they grow cultures to measure and calculate the rate of growth and how it grows. They learn what can and cannot kill their organisms and if it is a pathogen, they study ways to stop or slow its growth. In the lab, they work with microscopes, grow cultures, measure the rate of growth, and perform experiments with these organisms. Lab safety is very important in their work. They would NEVER eat or drink in the lab because this could cause contamination or could infect the food they are eating. * Salary Range Microbiologists can work in the academic community, industry or government...
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...Chlamydia Chlamydia is one of the most common diseases in the United States. The infection is part of a 'silent epidemic' as most cases do not show symptoms and are left untreated. It can cause pelvic inflammatory disease and lead to scarring of the Fallopian tubes causing infertility and higher risk of ectopic pregnancy. The research was carried out at the Molecular Microbiology Group, at the University of Southampton, in conjunction with the Department of Virology, at the Ben Gurion University of the Negev, in Israel. Professor Ian Clarke, from the University of Southampton, says: "This is a very significant advance in the study of chlamydia and we are proud to be the first people to achieve this. "Previously people have been unable to study chlamydial genetics and this has created a barrier to the comprehensive study of this disease. "We, together with our colleagues in Israel, discovered that by treating the chlamydia with calcium ions we were able to introduce a piece of foreign DNA. "This will open up the field of chlamydia research and will enable a better understanding of chlamydial genetics. It could lead to the development of new approaches to chlamydial vaccines and therapeutic interventions." To prove that they had accessed the chlamydial genome, the research team inserted the gene for a fluorescent protein into C. trachomatis which identified the chlamydial-infected cells by making them glow green. Their paper detailing the breakthrough in the study of chlamydia...
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...30333, USA. The American Journal of Tropical Medicine and Hygiene [1997, 57(5):519-525] Type: Journal Article Abstract Highlight Terms Gene Ontology(1) Diseases(1) Species(7) A multi-faceted investigation was conducted in the United Arab Emirates to characterize the epidemiologic and ecologic factors underlying an outbreak of Crimean-Congo hemorrhagic fever (CCHF) noted in November 1994 among abattoir workers. A chart review was conducted among hospitalized suspected cases of viral hemorrhagic fever with onset between January 1994 and March 1995 coupled with serologic testing of available specimens for the presence of virus antigen and IgG and IgM antibodies by ELISA. Livestock handlers and animal skin processors were interviewed and tested for the presence of IgG antibody. Sera from imported and domestic ruminants were examined for antibody for CCHF virus, and ticks collected from these animals were tested with an antigen-capture ELISA. Thirty-five...
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...(350 × 270 nm) containing a double-stranded DNA genome with a size of approximately 200 kb, the ends of which are connected by covalent links - the different OPV species cannot be distinguished by means of electron microscopy - OPV are closely related to each other with regard to antigens and show marked homology at the genome level - The genome of the poxviruses encodes for 150–200 different genes - Unlike other DNA viruses, poxviruses replicate in the cytoplasm of infected cells in so-called virus factories (Guarnieri inclusion bodies) - Originally, four different infectious virus particles were distinguished during OPV replication: intracellular mature enveloped virus particles, intracellular enveloped virus particles, cell-associated enveloped virus particles, and extracellular enveloped virus particles. Both intracellular and extracellular viruses play an important part for pathogenesis. - Intracellular and cell-associated viruses are involved in the spreading of the virus from cell to cell, whereas viruses released from the cell enable the dissemination within the infected organism. QUESTION 1: Which of the following can be administered to an individual infected with orthopoxvirus? a. Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant b. Zoster Vaccine, Live, (Oka/Merck) c. Vaccinia Immune Globulin Intravenous (Human) d. Anthrax Vaccine Adsorbed ANSWER: C The only product currently available for treatment of complications of orthopox...
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...ENG/102- Research Writing 3-30-2014 Sarah Ghoshal The Reality of AIDS The reality of the AIDS virus comes with bias opinions, fallacies and stereotypes of all kinds. To understand and know the truth about this virus, is to acknowledge facts and become educated. The speech "A Whisper of AIDS" by Mary Fisher addressed arguments and presented the growing concern of ignoring the severity of the disease. The speech by Mary Fisher addressed bias opinions and fallacies. As stated by Mary Fisher, "Because I was not gay, I was not at risk. Because I did not inject drugs, I was not at risk." (American Rhetoric, 2001). These fallacies and biased opinions were based on what people heard or believed, not what they knew. Mary Fisher also addressed the argument of AIDS to be recognized as a virus and not a political creature (American Rhetoric, 2001). Fisher's counter argument said, "Worldwide, forty million, sixty million, or a hundred million infections will be counted in the coming few years." (American Rhetoric, 2001). Her statements showed how ignorant society had been. People believing that they could not get infected, if they were not a drug user or not gay. The effects of her speech were global. As her speech was being broadcasted over numerous networks, 27 million people listened (Shaw, 2012). As stated by Normal Mailer, who was a guy covering the convention, "When Mary Fisher spoke like an angel that night, the floor was in tears, and conceivably the nation as well" (Shaw...
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...Prevención Primaria Prevención Primaria Educación de la higiene, en el uso de protección en relaciones sexuales, y educación en las formas de transmisión del virus en orden de evitarlas lo más posible. Educación de la higiene, en el uso de protección en relaciones sexuales, y educación en las formas de transmisión del virus en orden de evitarlas lo más posible. Buena higiene, protección y evasión de contacto directo con agujas y/o con fluidos corporales sobre todo si se hay sospecha de infección. Vacuna contra VHB. Visita a tu médico. Buena higiene, protección y evasión de contacto directo con agujas y/o con fluidos corporales sobre todo si se hay sospecha de infección. Vacuna contra VHB. Visita a tu médico. Prevención Terciaria Prevención Terciaria Reposo, aislamiento, esterilización de utensilios y tratamiento sintomático. Reposo, aislamiento, esterilización de utensilios y tratamiento sintomático. Ejercitarse cuando el paciente se sienta capaz. Medidas dietético-higiénicas. Ejercitarse cuando el paciente se sienta capaz. Medidas dietético-higiénicas. AGENTE AGENTE DiagnosticoTemprano y Tratamientos DiagnosticoTemprano y Tratamientos Examen Físico , palpación para valorar hepatomegalia, revisión de mucosas ictericia ocular e interrogatorio clínico sobre coluria y acolia. Examen sanguíneo en busca de bilirrubinas. Tratamiento sintomático. Examen Físico , palpación para valorar hepatomegalia, revisión de mucosas ictericia ocular e interrogatorio clínico sobre...
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...Objetivos del curos .......................................................................................................... III. Contenidos del curso ...................................................................................................... 1. Principios fundamentales de Microbiología ...................................................................... 1.1 Aspectos generales de la microbiología .................................................................... 1.2 Importancia de la microbiología para el aseguramiento de la inocuidad de los alimentos .................................................................................................................. 2. Aspectos generales de los microorganismos: Bacterias, hongos, virus ............................ 2.1 Características .......................................................................................................... 2.2 Clasificación .............................................................................................................. 2.3 Reproducción ............................................................................................................ 2.4 Parámetros intrínsecos y extrínsecos relacionados con el desarrollo microbiano ...... 2.5 Principales microorganismos en los alimentos .......................................................... 3. Enfermedades transmitidas por alimentos ....................................................................... 3.1...
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...Henderson 1.When an organism is transfected with a virus, it triggers several mechanisms to protect itself from the viral genes affecting it. Such mechanisms involve the innate immune response of the D. Melanogaster against the virus. Another mechanism that has been discovered not too long ago is the ability of silencing viral genes using an RNA interference pathway. The Argonaute paper has focused on the RNAi pathway of D. Melanogaster. The pathway involves a RISC complex composed of Argonaute 2 , viral siRNA and other proteins that act as a “strike and search” antagonist against viral genes and silencing them. In counter-defense, Viruses try to protect themselves by encoding viral suppressors of RNAi VSR to suppress the RNAi pathway. This leads to an “arms race” of adaptation and counter-adaptation by the host and virus. An important aspect of viral genome is its ability to undergo mutations to protect its self. Viral RNA is capable of antigenic shift and antigenic drift to cause mutations in its own genome and remain adaptable in host environment. The RNA Polymerase of the virus is phage-induced, so it is going to replicate the mutated genome and is different than eukaryotic Polymerase in that manner. In turn, host will evolve according to the viral genome to silence the “new” mutated genes. The evolutionary significance of VSRs in the Argonaute paper has enabled to understand how a conserved protein VP1 from Nora Virus is able to suppress viral siRNA in D. Melanogaster...
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...itself. In this paper I will discuss the nine properties and how things like a virus, prion, and viroid can reproduce, but are not considered to be alive. Also how things like these that are not considered to be alive can “evolve”? Viruses reproduce via bacterial gene transfer. Prions are proteins so they replicate with the rest of the genome. Viroids are small RNA plant pathogens that do not code any protein products, therefore replicate by stealing what is needed from the host. However, it may be important to keep in mind that there is a great deal of discussion about whether viruses should be defined as live or not. They contain some of the structures and exhibit some of the activities that are common to the definition of organic life, but are missing others. Unlike viroids and prions, they contain both RNA and DNA. Scientifically they are classified in a place between supra molecular complexes and extremely simple biological entities. Viruses are composed of a single strand of genetic information encapsulated in protein. One of the most compelling arguments against viruses being live is that they lack most of the organelles necessary for biosythesis, thus reproduction. In order for a virus to reproduce it must find a suitable host. A virus is a bacteriophage, or intracellular parasite that multiplies inside a bacteria making use of the biosythetic organelles and structure that they lack. A virus expands through the mechanism of bacterial gene transfer....
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...condition. With the rising predominance of HIV/AIDS, organizations are progressively worried about the effect of the infection on their organizations concerns that are all around established. At the broadest level, organizations are subject to the quality and essentialness of the economies in which they work. HIV/AIDS raises the expenses of working together, decreases profitability and brings down general interest for merchandise and administrations. It in this way makes sense to put resources into avoidance, mind and bolster programs to stem declining business efficiency and benefit. AIDS definitely have an impact on the employers because sickness keeps workers away from work and it effects the work productivity, it is important to observe the virus and make sure that the workplace is safe and well...
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...MICROBIOLOGIA PRIMER PARCIAL Estudio de los organismos vivos Virus, Bacterias, Parásitos y Hongos VIRUS HONGOS Organismo más pequeño conocido Compuesto de ADN o ARN (Nunca ambos) Rodeado por una capa proteica Gran tamaño Más complejos que bacterias Material genético organizado Núcleo Parásitos intracelulares estrictos Regulación proteica regulada por el retículo endoplásmico BACTERIAS Mayor tamaño Contienen ADN y ARN Información genética NO organizada dentro del núcleo División libre Excepto Chlamydia y Rickettsias (Son intracelulares estrictos) Pared Celular o Gram (+) Peptidoglicano grueso Carece de lípidos y proteínas Contienen ácidos teicoicos Virulencia Carbohidratos Constituyen la capsula (Resistencia a fagocitos) o Gram (-) Más agresivas Peptidoglicano delgado Pared celular con 2 capas Espacio periplasmático Enzimas hidrolíticas Destruyen Membrana externa: Filtro molecular que regula la entrada de moléculas de 700 Daltons, tiene una capa externa compuesta por lipopolisacaridos (LPS) LPS: Molécula anfipática (Extremo hidrofóbico y otro hidrofílico), contiene toxinas termoestables que pueden producir la muerte dentro de 2 a 3 horas, causa agregación plaquetaria, es pirógeno y compuesta por 3 regiones. 1. Lípido A hidrofóbico Parte exterior del LPS Endotoxina que produce shock séptico 2. Polisacárido Central Une lípido A –...
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...Disease and Evolution The human body has been plagued with diseases since the beginning of time—pathogens like viruses and bacteria have made us privy to Mother Nature. As humans evolve, so do the diseases we are susceptible to. Some diseases that were once rare have become common, others have disappeared and newer, more daunting ones have emerged. Many of these changes have taken place in the wake of important transformations in human civilizations and ecology. It is therefore feasible to propose that diseases succeed and fail in response to humanity's advances. Natural selection is unable to provide us with perfect protection against all pathogens, because they tend to evolve much faster than humans do. E. coli, for example, with its rapid rates of reproduction, has as much opportunity for mutation and selection in one day as humanity gets in a millennium. And our defenses, whether natural or artificial, make for potent selection forces. Pathogens either quickly evolve a counter defense or become extinct. Diseases such as AIDS, Ebola, Polio have shown their wrath and humans have sought to find cures and treatment options. By definition, disease is essentially “a disorder of structure or function that produces specific signs or symptoms or that affect a specific location (not just from a physical injury)” (WHO, 2007). The true boundaries and limitations of disease remain elusive. Healthcare specialists and researchers use “normal” conditions as their basis in order to understand...
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