Enzyme Inhibition
Enzyme inhibitors are substances e.g. A drug, toxin, food which inhibits the action of a certain enzyme by inhibiting or decreasing their biosynthesis.
Two types of Enzyme Inhibition:
1. Reversible inhibition
Inhibitors bind to enzymes through non-covalent bonds, thus dilution of the enzyme-inhibitor complex results in dissociation of the reversibly bound inhibitor.

• Competitive inhibition: The enzyme inhibitor and the substrate competes to bind reversibly to the same site of the enzyme.
E.g. Lipitor, Zocor are statin drugs which inhibits HMG-CoA reductase competitively and inhibit synthesis of cholesterol by lowering plasma cholesterol levels.

• Noncompetitive inhibition: Inhibitor binds the enzyme somewhere different from where the substrate binds. The inhibitor binds to the enzyme and reduces its activity but does not affect the binding of substrate.
E.g. Lead noncompetitively binds with Ferro chelatase and inhibits insertion of iron into protoporphyrin.

2. Irreversible inhibition …show more content…
Treating Hyperbilirubinemia
Enzyme inducers have the ability to conjugate bilirubin which leads to the decrease of bilirubin content in the serum, thus helps treat Hyperbilirubinemia and also treat Criggler Najjar Type II disease (inherited disorder affecting the metabolism of bilirubin).

2. Monitoring of drug compliance
In chronic alcoholics, a very high concentration of y-glutamyltransferase activity occurs in their serum which is observed to reduce to normal levels upon withdrawal from consuming alcohol. Monitoring indicators of microsomal enzyme inducers can be helpful in deciding whether to increase/decrease or change a drug.

3. According to recent studies, inducers of liver microsomal enzymes enhance the hydroxylation of steroids in man. Phenobarbital, diphenylhydantoin, and phenylbutazonestimulate cortisol hydroxylase activity in guinea pig liver microsomes and enhance the urinary excretion of 6 β-hydroxycortisol in man.