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Herpes Simplex Essay

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Evaluation of Vaccinations for Genital Herpes Simplex Virus 2 Infection Herpes simplex virus type 2 (HSV-2) is the most common cause of genital ulcers. The seroprevelence of HSV-2 is increasing within the general population and seroprevelence of the virus correlates with increased sexual activity and age. Research by Cernik, Gallina, and Brodell (2008) states that STD’s causing genital ulcers affect nearly 22 percent of American adults, with nearly 20 million new cases annually worldwide. This DNA double-stranded virus, once contracted through direct contact with infected mucosa, invades the presacral ganglia and remains for life. HSV-2 is predominantly transmitted by sexual contact and has to be considered the major cause of genital herpes (Sauerbrei, 2016). There are many subsets of herpes virus. The two most known for causing ulcerations are HSV-1 and HSV-2. Herpes simplex virus type 1 can cause genital lesions, but is primarily affects the oral mucosa. Another difference between the viruses is the age of onset. Most HSV-1 outbreaks occur during childhood. Though a culture can be performed to differentiate the subtypes, serological testing that detect antibodies such as polymerase chain reaction (PCR) is the preferred method. …show more content…
Lesions are small, multiple, painful, and vesicular filled with clear-to-white fluid filled with the virus on a erythemous base. Grouped lesions normally appear around the external genitalia but can appear on the perianal regions, buttocks, or thighs. For males, vesicles can appear on the penile shaft or base of the shaft. For females, vesicles can appear external on the mons pubis, labia majora and minor, or internally on the cervix, vulva, or vagina. This grouped lesion is characteristic for herpes simplex virus. Lesions can persist for days to weeks with a primary infection until ultimately crusting

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