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Hiv: a Retrospective Overview

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Submitted By EJHill1
Words 2102
Pages 9
Edwin Hill
Professor Skolnik
English 1280-05
Final Research Paper

HIV: Introspective Overview What is HIV? Figure 1 HIV 1 virus electron micrograph, (Goldsmith) Human immunodeficiency virus (HIV) is a retrovirus of the lentivirus genus. HIV attacks the immune system by invading and destroying certain white blood cells such as helper T cells (mainly CD4+ T cells), dendritic cells, and macrophages. The infection and destruction of the CD4+ T cells takes place through three methods: The direct viral killing of the infected cells, the apoptosis (programmed cell death) of infected cells, and the killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. Once the CD4+ T cells are diminished to a certain critical level, the immunity catalyzed and mediated by these cells is lost, leaving the body vulnerable to infection from other viruses (Noble, AVERT). The last stage of HIV infection is AIDS (acquired immunodeficiency syndrome). This stage is reached due to lack of treatment while in the earlier stage of HIV. Those who reach this stage commonly die due to infections associated with the progressive failure of the immune system. There are two known types of HIV: HIV-1 and HIV-2. Both are transmitted by either sexual contact, through blood, or from mother to child, and they both appear to cause clinically indistinguishable AIDS. However, HIV-2 is less easily transmitted, and the period between initial infection and illness is longer in the case of HIV-2. The globally predominant virus is HIV-1, and is therefore the most commonly referred to when the type is not specified (in popular culture, science, etc.). The practically rare cases of HIV-2 infections are concentrated in West Africa and are seldom found elsewhere. During the last few years, it has become possible not only to determine

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