... Chapter Opener What Information Is in a Human Genome? Clinical Connection 1.1 Exome Sequencing Saves a Boy’s Life Bioethics: Choices for the Future Genetic Testing and Privacy CHAPTER OVERVIEW Chapter 1 provides a glimpse of the basic concepts of genetics and genomics, and offers examples of DNA information impacting daily life. In this new era of genomics, individuals have access to their own genetic information, and health care providers are learning how to incorporate DNA data into diagnostic and therapeutic medicine. Bioethics deals with issues of privacy, discrimination, and justice that arise from use and misuse of genetic information. DNA, genes, chromosomes, and genomes are the levels of genetic information, and they impact biology at the cell, tissue, organ, individual, family, and population levels. Genes encode proteins, and the exome is the small part of the genome that does so. Most traits arise from interactions of genes and environmental factors. Genetic information is in health care to identify individuals, in investigating the environment, and in understanding evolution. CHAPTER OUTLINE 1.1 Introducing Genes and Genomes 1. Genetics is a branch of biology concerned with inherited traits and their variation, and how these traits are passed from one generation to the next (heredity). 2. With continuing analysis of human genome sequences, human genetics has grown from a largely academic...
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...Genetic testing is an important scientific-medical process. It is actually used very commonly and for many different purposes. Running genetic tests have a variety of use because doctors and scientist can identify a genetic disorders, diseases , study DNA, genes, and chromosomes, and it can even be used for forensic testing. Although genetic testing is a great medical tool, genetic testing does not prevent a disorder or disease. Genetic testing informs when there is a disorder or disease, it’s most useful for analyzing disorders and diseases like cancer. (Gates,2014) Cancer is one of the most common illness, but with a genetic test it can help identify it before it getting to advanced. There was one case with a middle age women named, Mary...
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...DNA is known to be the most common unit of genetic material in life on Earth; however, Genetic information is stored within the chemical structure of the DNA ,the two backbones, which form double helix , a chain of four chemicals which called bases , and they are running along the backbones , as well as base pairs which are Bridges between bases that located on opposite backbones , The four bases are indicated by the letters A, T, C and G, and their order form a genetic "code" , A,T,C,G can be called triads or codons ,they carry a specific code or message that cells can understand ,and each code or message tells the cell to make for examples black hair, or make green eyes or help a person to grow tall or shorter, however ,DNA molecules are able to make copies of themselves during cell division or when the cell reproduces, usually the DNA molecules contains two identical molecules that were produced from one single parent molecule. When fertilizing an egg cell with a sperm cell, the sperm gives DNA to the fertilized egg and the egg has its DNA already , as we know...
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...head: SIGNIFICANCE OF DNA Significance of DNA Significance of DNA Deoxyribonucleic acid (DNA) was first discovered in 1869 by Johann Friedrich Miescher, but it was not until the 1950s while studying viral replication did Alfred Hershey and Martha Chase determine DNA was Genetic material. In 1953 James Watson and Francis Crick discovered DNA was a double helix (a double helix looks like a twisted ladder). The discovery of Watson and Crick opened the door helping describe the significance and importance of DNA as the molecule of inheritance while addressing the structure of the DNA molecule, and why is a molecule of DNA so perfect for the job it performs. I will look at what exactly does DNA code for, how is that translated into actual traits, what are mitosis and meiosis, what are the similarities and differences, and what do mitosis and meiosis allow for. I will show how traits are passed from parents to offspring and lastly describe how knowledge of DNA and genetics can help in my life. The Significance and Importance of deoxyribonucleic Acid (DNA) as the Molecule of Inheritance The significance and importance of DNA “is the body’s instruction manual for making you who you are. It is present in any living being. It carries all the instructions and materials the body needs to function”(Leving, 2008). The DNA in cells is all the same for individuals, which create a specific identity for each individual. Discuss Briefly the structure of the DNA Molecule and Why is...
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...Genetics is the study and the variation of inherited characteristics that make up a life. Every child inherits genes from both of their biological parents. Some of these traits may be physical; hair, eye color or skin colors, etc. The wonderful thing about genetics is the technology that has been made for it and how advanced it is to now do what ever it takes to fix the unborn. Each gene has its own piece of genetic information and DNA in the cell make up the human. Heredity genes is a biological process where a parent passes certain genes onto their children or offspring's which all falls under the study of genetics. Genes are rested inside the chromosomes in the human body. Some of these genes that are passed on can cause human genetic disorder. Human Genetic Disorder is an illness which is caused by chromosomes or genes abnormalities. Some disorders like the sickle cell trait disease are in part of genetic disorders. Other diseases like cancer are also caused by genetic disorders, but can also be caused by environmental factors. Most disorders are very rare and they affect only one person in a million. There are some types of recessive gene disorders which have an...
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...Associate Program Material DNA Worksheet Answer the following in at least 100 words: 1. Describe the structure of DNA. DNA molecules are composed of two strands that form a helical ascending spiral. They fit together like the opposing teeth of a zipper and are held together by weak interactions called hydrogen bonds. These two strands is a long string of subunits called nucleotides, each attached to the one immediately about it and the one immediately below it to form a long chain. Each nucleotide contains a five-carbon sugar. The five-carbon sugar contains a five-membered ring with an oxygen atom as one of the vertices. Each nucleotide also features a phosphate group and a nitrogen-containing base; these bases are typically represented by adenine, cytosine, thymine, and guanine. The base is attached to carbon 1 of the sugar, biologist denote each of the carbons in the sugar using a number from 1 through 5, where 1 represents the carbon to which the base is attached. 2. How does an organism’s genotype determine its phenotype? The genotype of an organism is the sum total of all the genes that it inherits. It is sort of like a blue print that is designed to serve as a guide in the development of the organism, so that it will become the same kind of creature as the parent or parents that it came from. The phenotype, the organism’s physical trait arises from the actions of a wide variety of proteins. For example structural proteins help make up the body of an...
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...Microevolutionary Process Notes * 1) Natural selection works on individuals * 2) Individuals do not evolve, populations do * Insecticide application didn’t result in insecticide resistance: some insects carry trait of resistance in their genes * Processes in Microevolution -Mutation -Non-random mating -Genetic Drift -Natural Selection -Gene Flow * Hardy-Weinburg Theorem: Frequencies of alleles and genotypes are preserved from generation to generation in populations that are not evolving -p2 + 2pq + q2 = 1 * Hardy-Weinburg tells us that we will never get rid of bad genes and it’s used to figure how gene populations change over time * The Hardy-Weinberg theorem describes a pop’n that is not evolving. It has 5 assumptions: 1. Genetic Drift: This represents random changes in small gene pools due to sampling errors in propagation of alleles. The bottleneck effect and founder effect are prime examples of genetic drift. In either case the number of individuals in a population is drastically reduced distorting the original allelic frequencies. (H-W assumes large population) 2. Gene Flow: The movement of alleles into and out of a gene pool. Migration of an organism into different areas can cause the allelic frequencies of that population to increase. Most populations are not isolated, which is contrary to the Hardy-Weinberg Theorem. (H-W assumes the population isolated from others) 3. Mutations: These changes in the genome of an organism are...
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...separate and each nucleus will have one copy of each chromosome. E. Anaphase. The pair chromosomes separate and move in the opposite directions.The separation is due to movement of kinetochore along the spindle fiber. Physical interactions of the polar microtubules also contribute in the movement of the chromosomes. F. Telophase. Now the chromatids are located at the poles. Membranes form around the daughter nuclei. The chromosomes are no longer visible under the light microscope. The spindle fibers disperse, and cell partitioning starts. G. Cytokinesis. Fiber rings around the center of the cell contract causing the cell to divide into two daughter cells. Each daughter cell has one nucleus. 2. What is the purpose of mitosis and when does it occur? What is the purpose of meiosis? Mitosis is purposed for growth and repair of the body. Mitosis takes place in somatic cells. Meiosis helps in production of gametes. 3. In what ways is meiosis different from mitosis? Be thorough. CHARACTER | MEIOSIS | MITOSIS | Types of reproduction | Sexual | Asexual | Take...
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...HSC Biology – Blueprint of Life 4. The structure of DNA can be changed and such changes may be reflected in the phenotype of the affected organism. The phenotype of an organism is its total appearance determined during development by an interaction between its genetic make-up (genotype) and the environment. A genome is all of the genetic material (DNA) within a cell and is specific to each organism. Genomes influence nearly all the traits or phenotypes. The phenotypic appearance is therefore directly affected by gene expression. The extent of phenotypic differences depends on how different the DNA sequences are in individuals, but may also be influenced by the environment. • Outline evidence that led to Beadle and Tatum’s ‘one gene-one protein’ hypothesis and explain why this was altered to the ‘one gene – one polypeptide’ hypothesis Beadle and Tatum carried out experiments with red bread mould. The normal variety of mould can manufacture certain substances that it needs for living, including vitamin B1, B2, B4 and B12. The normal moult possesses specific enzymes that catalyse the different reactions that produce these vitamins. Beadle and Tatum produced several varieties of the bread mould, each of which had a change in one of its genes. They tested these varieties and found that some had lost their ability to make vitamin B2 while others could no longer make vitamin B4 and so on. The results obtained by Beadle and Tatum showed that a change in various...
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... DNA the nucleus controls the activities of a cell. The instructions for how an organism develops are found in the nuclei of its cells Chromosomes Chromosomes are structures found in the nucleus of most cells. They consist of long strands of a substance called deoxyribonucleic acid, or DNA for short. A section of DNA that has the genetic code for making a particular protein is called a gene. The proteins can either be: structural proteins such as the ones found in muscles and hair enzymes, such as proteases and other digestive enzymes Variation Individuals differ in all sorts of ways, even when they are offspring of the same parents. These differences are called variation. Most characteristics, such as height, are determined by several genes working together. They are also influenced by environmental factors. These include: Climate, diet, physical accidents, culture&lifestyle Identical twins Identical twins are genetically the same. They are a good example of the interaction between inheritance and the environment. For example, an identical twin who takes regular exercise will have better muscle tone than one who does not exercise. All of the differences that you see between identical twins, for example, in personality, tastes and aptitude, are due to differences in their experiences or environment. When an egg and sperm cell come together, the now fertilised egg contains 23 pairs of chromosomes. Sex chromosomes are responsible for certain genetic traits...
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...GENETICS CASE STUDY GENETICS CASE STUDY This case study is based on a high-risk pregnancy due to advanced maternal age, genetic test indicating the fetus to have Tay-Sachs Disease and the coping strategies for this family. Rita Trosack is a 43-year old white female, married for six years to husband, Peter, a 46-year old white male. They both work in the financial district of Chicago and live downtown. They have been trying to conceive for two years. They both work an average of sixty hours a week. Rita and Peter were both raised as Catholics; however, they choose not to practice at this time. Rita missed her menstrual period, began having typical signs and symptoms of pregnancy (nausea, dry heaving, tender breasts, and fatigue). The fatigue was so severe she decreased her hours at the bank. An early pregnancy test performed by Rita tested positive. She then calculated her due date as January 27, 2009, since her last menstrual period (LMP) began on April 20, 2008. Rita met with Dr. Zimmerly an obstetrician in a high-risk obstetric clinic. On this first visit he confirmed the estimated date of delivery (EDD) as late January 2009. Due to Rita’s age, the chorionic villus sampling (CVS) was recommended to screen for fetal genetic defects. Rita had the test in early July, which would place her around eleven weeks into her pregnancy; this is the appropriate time in which to perform the CVS. Amniocentesis could have been performed, but this is usually...
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...Associate Program Material DNA Worksheet Answer the following in at least 100 words: 1. Describe the structure of DNA. A DNA molecule which is abbreviation for deoxyribonucleic acid is made up of very long chains of monomers and polymers that are called nucleotides. These two chains in particular which composes of DNA strain are then formed by the grouping of the nucleotides into the polynucleotides. The nucleotide is made up of a nitrogenous base, of sugar and of a phosphate group. In the DNA case, there are four nucleotides that are found along the DNA chain, the four nucleotides ate (T) thyme, (A) adenine, (C) cytosine, and (G) guanine. These four nucleotides are joined together by their covalent bonds, or more specific, the phosphates and the sugar which composes the sugar/phosphate back bone of the polynucleotide. 2. How does an organism’s genotype determine its phenotype? The genotype of an organism is the genetic makeup of that organism, it is the nucleotide bases in the organism’s DNA. The phenotype is considered the physical traits of the organism which comes from the actions of the broad variety of proteins. The body of an organism is made up by the structural proteins and the metabolic activities are catalyzed by the enzymes. The synthesis of the proteins is specified by the DNA. However, a protein is not directly built by a gene, but dispatches the instructions to do so in the form of the RNA, which in turn programs the synthesis of...
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...Task Two How Genetic information is stored in a sequence of Nitrogenous bases in DNA DNA is the principle molecule responsible for carrying genetic information within almost all living organisms for their development. They also provide some of the apparatus by which the instructions are carried out. This excludes viruses, as they use RNA, to carry their genetic information. (Image 1: DNA molecule, nucleotide, base pairing. Reference: http://www.britannica.com/EBchecked/topic/422006/DNA-sequencing ) Structurally, the DNA molecule consists of two intertwined strands, the margins of which are chains of sugar and phosphate groups. The chains are linked by pairs of substances called bases, of which there are: adenine, guanine, thymine and...
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...“steps” in natural selection as Sagan describes them? What questions does he raise for you? Natural Selection happens when human’s changes have created other changes without humans directly deciding to do so. Sagan describes the basic steps as there are more creatures then can survive. Less adapted have a less chance of surviving and producing off spring. Sudden changes in heredity can be pushed on to the off springs. Environmental changes can have an impact on what mutations will help survival. Thus, slow changes produce new species. Natural Selection was discovered by Charles Darwin and Alfred Russel Wallace. Explain the Watchmaker Hypothesis as an argument against natural selection. How does Sagan address it? “Our ancestors looked at the intricacy and the beauty of life and saw evidence for a great designer. The simplest organism is a far more complex machine than the finest pocket watch. And yet, pocket watches don’t spontaneously self-assemble or evolve in slow stages on their own from say, grandfather clocks”. (Sagan, C) It’s impossible to just look at something and understand as a whole. Sagan comments that all life on this planet shares a number of characteristics, including one three-letter answer to the question of what is the master molecule? DNA What IS the master molecule? Do you think it is significant that all life on the planet shares the use of this code? Why or why not? DNA is made of nucleotides which have four chemical parts, “adenine,...
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...How Cells Transmit Information and Transform with DNA and RNA Shelley Gutierrez, RNC Western Governors University Student ID: 391502 Sgutie6@wgu.edu How Cells Transmit Information and Transform with DNA and RNA All of our body cells are made up of 46 chromosomes. Each of the 46 chromosomes contains one DNA molecule. These chromosomes and proteins are found compressed in the nucleus of the cells. DNA and RNA are biological molecules that are nucleic acids. Both DNA and RNA are polymers. When polymers are linked together in DNA, they are called polynucleotides (Devlin, T. 2002). The polymers of DNA, known as nucleotides are composed of a phosphate group, 5 carbon sugar molecules, and 1 of 4 nitrogen bases. The four nitrogenous bases: adenosine, thymine, cytosine and guanine is where the genetic coding is found. DNA has twin molecules that twist together. This is known as the double helix. The double helix bonds with sugars and phosphates to form twin Strands. Chemically the sugar phosphate bonds travel down each side of the helix in opposite directions. One strand begins at the top of the 1st phosphate connected at the sugar molecules 5th carbon and ending where the next phosphate would go with the free end at the sugar’s 3rd carbon. This results in a pattern of 5 prime and 3 prime. The opposite occurs with the other strand resulting in a pattern of 3 prime and 5 prime. (Adams, R., & Knowler, J. 1986). Once they are bonded they are now known...
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