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Monoamine Oxidase In The Brain

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As nerve cells in the brain begin progressively degenerate many physical, emotional and mental symptoms begin to occur. There are many reasons as to why nerve cells fail; this has been linked to old age and illicit drug abuse. However many patients are also diagnosed young and healthy and the reasons are still unknown. Nerve cells in the brain produce neurotransmitters such as Dopamine, Serotonin and Norepinephrine. The Monoamines are chemical messengers that transmit signals around the brain and affect a person’s emotions including their mood, alertness and motivation. When nerve cells begin to fail and the production of Dopamine in the brain is reduced the symptoms are both emotional and physical and can be known as Parkinson’s disease. …show more content…
Rasagiline is a novel drug as it is found to be an irreversible Monoamine oxidase (MAO) inhibitor.
Monoamine Oxidase is an extremely important enzyme in the body and plays an important role in the metabolism of Serotonin and Dopamine. MAOs are found in the in the nerve terminals around the body and is also heavily concentrated in the central nervous system (CNS). MAOs helps metabolise dopamine by actively catalyses the reaction of the neurotransmitters. The catalyst is present in to forms MAO-A and MAO-B both have potential to be used in treatment of neurodegenerative disorders. Rasagiline is selective to the (MAO) – B and is also very effective in inhibiting the

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