...Brochure More information from http://www.researchandmarkets.com/reports/2892292/ Hodgkin Lymphoma - Pipeline Review, H2 2014 Description: Hodgkin Lymphoma - Pipeline Review, H2 2014 Summary This, ‘Hodgkin Lymphoma - Pipeline Review, H2 2014’, provides an overview of the Hodgkin Lymphoma’s therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Hodgkin Lymphoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Hodgkin Lymphoma and special features on late-stage and discontinued projects. This report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from This proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by This team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box...
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...Lymphoma Lymphoma is when cells in the lymph system change and grow uncontrollably that may form a tumor. In the lymph system there are thin tubes that branch out to all different parts of the body ("Types of Cancer: Lymphoma"). Its job is to fight infections and diseases. In the lymph system it carries lymph which is colorless fluid containing lymphocytes that are white blood cells. The main job of a lymphocyte is to fight of germs in the body. Two main lymphocytes are B-lymphocytes and T-lymphocytes. B-lymphocytes also called B-cells make antibodies to fight off bacteria and T-lymphocytes kill viruses, foreign cells and triggers B-cells to make antibodies ("Types of Cancer: Lymphoma"). In different areas of the lymph systems there are lymph nodes through out the body. “Lymph nodes are found in clusters in the abdomen, groin, pelvis, underarms, and neck. Other parts of the lymph system include the spleen which makes lymphocytes and filters blood, the thymus an organ under the breast bone and the tonsils which are located in the throat” ("Types of Cancer: Lymphoma"). There are two types of lymphoma Hodgkin and Non Hodgkin. They both have different types and it is important to know which you have so the treatment is affective. Hodgkin is a blood cancer but may appear as a solid tumor in the glands, most common in teenagers and young adults. According how the cells look under a microscope is how they are identified ("Leukaemia & Lymphoma Research"). Most patients...
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...Running head: Treatment of Non-Hodgkin Lymphoma 1 Zevalin/Bexxar for the Treatment of Non-Hodgkin’s Lymphoma Treatment of Non-Hodgkin Lymphoma 2 Abstract Non-Hodgkin’s lymphoma is a cancer that attacks the cells of our immune system. It is a cancer that begins in our lymphatic system involving the B and/or T cells. Depending on the type of non-Hodgkin ‘s lymphoma, that is present in the body, will determine the method of treatment used. Monoclonal antibodies, Zevalin and Bexxar, are used to treat Non-Hodgkin’s Lymphoma by attaching radioactive molecules to them during radioimmunothearapy treatment. Keywords: non-Hodgkin’s lymphoma, monoclonal antibodies, Zevalin, Bexxar Treatment of Non-Hodgkin Lymphoma 3 Zevalin/Bexxar for the Treatment of Non-Hodgkin’s Lymphoma Non-Hodgkin lymphoma (NHL) is a cancer involving the lymph tissues, which are found in our lymph nodes, spleen, and other organs of our body’s immune system. White blood cells (B cell or B lymphocyte) help prevent infections in the human body and are where most lymphomas will begin. “Non-Hodgkin lymphoma is actually a complex group of about 50 different cancers and the 13 most common types account for 88 percent of all cases in the United States (MSKCC, 2014). The cause of non-Hodgkin lymphoma, for most individuals is unknown, but seems to be present in persons...
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...System Non-Hodgkin’s Lymphoma Non-Hodgkin lymphoma (NHL) is the most commonly occurring blood related malignancy effecting the lymphatic system. It is the sixth leading cause of cancer death in the United States, and its incidence is on the rise, since the early 1970's, incidence rates for NHL have nearly doubled. Of the nearly 500,000 Americans with lymphoma, approximately 332,000 have this form. Over 65,000 cases of NHL are diagnosed annually in the United States. (www.LYMPHOMA. Org 2015, n.d.) Lymphoma occurs when lymphocytes, a type of white blood cell, grow abnormally. The body has two main types of lymphocytes that can develop into lymphomas: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Cancerous lymphocytes can travel to many parts of the body, including the lymph nodes, spleen, bone marrow, blood or other organs, and can accumulate to form tumors. The two main forms of lymphoma are Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Non-Hodgkin lymphoma is not a single disease, but a group of several closely related cancers. The World Health Organization estimates that there are at least 61 types of NHL. (www.LYMPHOMA. Org 2015, n.d.) Non-Hodgkin lymphomas are broadly divided into two major groups: B-cell lymphomas and T-cell lymphomas. B-cell lymphomas develop from abnormal B-lymphocytes and account for 85 percent of all NHLs. T-cell lymphomas develop from abnormal T-lymphocytes and account for the remaining 15 percent of all NHLs. Non-Hodgkin lymphomas...
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...A Case Of Non-Hodgkins Lymphoma A case was presented of a possible infection with non-hodgkins lymphoma. The patient is a 60 year old man that presented symptoms petering to the development of a follicular lymphoma. The patient has been suffering from colds and fevers more frequently in the past weeks and upon physical examination swelling was observed under his left armpit. Preliminary diagnosis suggests follicular lymphoma which is indicative of the lymphatic cancer Non-Hodgkins lymphoma. Hodgkins lymphoma is a malingnant disorder of the lymphoid tissue often characterized by the painless progressive enlargement of the lymph nodes (Braun and Anderson, 2011). The exact cause of HL is unknown. Risk factors include exposure to viruses such as Ebstein-Barr virus, genetic factors, and immunosuppression. Incidence is highest in the ages between the aggression. Incidence is highest in those between the ages of 10 and 30 years and in those older than 50 years (Braun and Anderson, 2011). HL is characterized by the presence of multinucleated giant cells (macrophages), called Reed-Sternberg cells, or mononuclear giant cells, called Hodgkin cells, surrounded by multiple other inflammatory cells, such as neutrophils, eosinophils, plasma cells, small lymphocytes, and fibroblasts. The pathogenesis of HL is still under investigation. The Reed-Sternberg or Hodgkins cell has been identified as the neoplastic cell diagnostic for HL. Susceptibility to specific viral oncogenes or certain HLA...
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...Hodgkin disease Mary-Beth Stilwell 7/7/2015 ITT Technical Institute There are many diseases of the lymphatic system. The one I am going to focus on today is Hodgkin Disease. I will begin by explaining what Hodgkin disease is. Followed by what are the causes, signs and symptoms. Next I will explain possible treatments for the disease. Then, I will discuss how Hodgkin disease affects everyday life of a person who suffers from it. “Hodgkin disease also known as Hodgkin lymphoma is a cancer of the lymphatic system. Cells in the lymphatic system grow abnormally and may spread beyond the lymphatic system” (mayoclinic.org, 2014).” Hodgkin disease is a type of lymphoma, a cancer that starts in white blood cells” (The American cancer society, 2015). There are two types of this disease Hodgkin disease and Non-Hodgkin disease. “The two types differ in how they behave, spread, and respond to treatment. So it is important to tell them apart. Doctors can usually tell the difference by looking at the cancer cells under a microscope or by doing special lab tests. Both children and adults can develop Hodgkin disease” (The American cancer society, 2015). Hodgkin disease spreads through the lymph vessels. “Because lymphoid tissue is in many parts of the body, Hodgkin disease can start almost anywhere. Most often it starts in lymph nodes in the upper part of the body. The most common sites are in the chest, neck or under the arms. It spreads lymph node to lymph node. Rarely and late in...
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...The disease I choose to write about is Cancer, specifically Non-Hodgkin’s Lymphoma. Non-Hodgkin’s Lymphoma is a large group of cancers of lymphocytes (white blood cells). The disease can occur at any age but most notably older than 60. Cancer is prominent on both sides of my family. On my mom’s side there is (my grandmother, my aunt) which have both passed with cancer and my mother, my uncle, and my grandfather all have cancer that is in remission at this time. On my dad’s side, there was my dad and a brother and a sister. All of these individuals have died from Cancer with the exception of my step-grandfather who was diagnosed around 65 in early stage of renal (kidney) cancer and my Aunt who was diagnosed with renal cancer 25 years ago. My grandfather is once again, fighting cancer and seems to be losing this time. My father’s oldest brother and oldest sister died from cancer. They died when I was young so I don't know much about their type of cancer or what their daily lives were like. My father on the other hand was a smoker and was diagnosed with cancer when he was 38. He went thru chemo and radiation but it did not help. He passed within six months of being diagnosed with the cancer. I was working at a fast food place when I was in high school and one night I fell at work decided I was ok to stay. Until, later that night when I got home and started having really bad pain in my back. I then decided I needed to go to the emergency room and there they did test. My kidney...
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...Non Hodgkin's Lymphoma is cancer that begins in the lymph system in the white blood cells. These white blood cells are called lymphocytes and are in the immune system to fight off disease and infections. These white blood cells are found in the spleen, bone marrow, lymph nodes, as well as other areas of the body. When these cells are abnormal they either duplicate faster than normal cells or live too long, no longer fighting off disease. The cells duplicating faster causes a tumor to develop. The malignant lymphocytes take over the healthy cells in the bone marrow causing the lymph nodes to enlarge. Lymph nodes are small structures within the body that contain immune cells that help fight infection by attacking and destroying germs that are carried through the lymph fluid. The human body has 500-600 lymph nodes with the largest grouping in the neck, armpit and groin area. Enlarged lymph nodes in the neck, armpit, chest, abdomen or pelvis are the most common symptoms. Other symptoms could include fever, night sweats, difficulty breathing, rapid weight loss, being tired or an itchy rash. However, there are many common illnesses and infections...
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...Tamara Goins- Weekly Research- Week 5- Antonelli College- Ericca Peacock- Instructor For this weekly research, I have chosen Non-Hodgkin Lymphoma. From my research, Non-Hodgkin Lymphoma is also called NHL, and no, not for the National Hockey League! But for the acronym of Non-Hodgkin Lymphoma. Non-Hodgkin’s Lymphoma is a cancer that starts in your lymphatic system where it in turn, develops into tumors from our white blood cells, called lymphocytes. Non-Hodgkin’s Lymphoma is a more common type than that of the Hodgkin Lymphoma. Some of Non-Hodgkin’s Lymphoma’s symptoms may include painless, swollen lymph nodes in the neck, your armpits, and your groin area. There could also be abdominal pain and or swelling. You could have chest pain...
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...form of cancer that starts in certain types of nerve cells found in a developing embryo or fetus. This type occurs in infants and young children. It is most often found during the first year of life. It is rarely found in children older than 10. This type of cancer accounts for about 7% of childhood cancers. Wilms tumor is a cancer that starts in one, or rarely, both kidneys. It is most often found in children about three years old, and is uncommon in children older than six. It can show up as a swelling or lump in the belly. This type of cancer accounts for about 5% of childhood cancers (American Cancer Society, 2010). Non-Hodgkin lymphoma and Hodgkin lymphoma are cancers that start in the lymph tissues, such as the tonsils, lymph nodes, and thymus. These cancers may spread to bone marrow and other organs, which can cause different symptoms depending on where it is growing. Hodgkin's lymphoma can occur in both children and adults, and accounts for about 4% of childhood cancers. It is more common, though, in two age groups: early adulthood (age 15-40, usually people in their 20s) and late adulthood (after 55). Hodgkin lymphoma is rare in children younger than five years of age. About 10% to 15% of cases are diagnosed in children and teenagers. About 81 out of 100 people diagnosed with non-Hodgkin's lymphoma are alive one year after the disease is diagnosed. About 63 out of 100 people with the disease are alive at five years, and 49 out of 100 at 10 years (Non-Hodgkin's...
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...Non-Hodgkin's Lymphoma What is Non-Hodgkin's Lymphoma you may ask? It’s a cancer that starts in white blood cells called lymphocytes, which are a part of the body's immune system. Over the years the rate of NHL has increased rapidly. Non-Hodgkin's lymphoma is different from Hodgkins because NHL includes different types of lymphoma while Hodgkin's does not. You may ask, what’s the difference in NHL and HL? Non-Hodgkin's lymphoma doesn’t include the Reed-Sternberg cells although Hodgkin's does. Any type of lymphoma that doesn’t have to do with Reed-Sternberg cells is classified as Non-Hodgkin's lymphoma. All according to the Lymphoma Research Foundation. Non-Hodgkins is the 5th most common cancer and the 3rd fastest growing. Non-Hodgkin's...
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...Clinical manifestations of Non-Hodgkin Lymphoma: Non-Hodgkin lymphoma can bring about a wide range of signs and side effects, contingent upon where it is in the body. Now and again it won't not create any indications until it becomes very huge. Regular signs and manifestations include: Enlarged lymph nodes Swollen abdomen (belly) Feeling full after only a small amount of food Chest pain or pressure Shortness of breath or cough Fever Weight loss Night sweats Fatigue (extreme tiredness) Low red blood cell counts (anemia) Swollen lymph nodes: Non-Hodgkin lymphoma can make lymph hubs get to be distinctly broadened. At the point when this happens in lymph hubs near the surface of the body, (for example, on the sides of the neck, in the crotch or underarm regions, or over the neckline bone), they might be seen or felt as bumps under the skin. These are regularly found by the patient, a relative, or a medicinal services proficient. Albeit broadened lymph hubs are a typical indication of lymphoma, they...
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...| 2012 | | Leukemia and Lymphoma Society Tawanda Bryant | [Leukemia and Lymphoma Society] | The Leukemia & Lymphoma Society (LLS) is: Cure leukemia, lymphoma, Hodgkin’s disease and myeloma, and improves the quality of life of patients and their families. Providing free information and support services, Leukemia and Lymphoma funds lifesaving blood cancer research around the world. | LEUKEMIA & LYMPHOMA SOCIETY TAWANDA BRYANT 11410 COUNTY ROAD 20 BOLIGEE, AL 35443 (205) 336-9851 tbryant3030@yahoo.com LEADERSHIP and ORGANIZATIONAL MAR12 SEC AA March 9, 2012 INSTRUCTOR: SHAROLYN HERGOTT LEUKEMIA & LYMPHOMA SOCIETY I have picked this organization because my best friend passed away last year with leukemia and I wanted to find out more on this disease and what I can do to help. Been passionate and concern about not only her health but the health of her kids, my research will show why it is important to me as well as others. Having a passion for helping other in any way I can is what I am going for. I also like the face that I can somewhat relate to their illness and pain they endure within their life. I would love to find a quicker cure for these diseases, but I know others are working on something better. Having someone close to you with any type of disease, not just leukemia or lymphoma is hard to take in and understand. Having the ability to communicate, have critical thinking, collaboration, and the ability to problem solve is what I aim...
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...BRAC UNIVERSITY SUMMER 2014 BTE 310: MEDICAL BIOTECHNOLOGY DATE: 21.08.2014 ASSIGNMENT: LEUKEMIA SUBMITTED BY: Prateem Das ID: 12136014 BIOTECHNOLOGY, MNS SUBMITTED TO: ROMANA SIDDIQUE LECTURER MNS DEPARTMENT OF MATHEMATICS AND NATURAL SCIENCES Introduction Leukemia is a type of cancer that results in the body making too many abnormal white blood cells. This uncontrolled production results in an excessive amount of white blood cells that may be immature (acute leukemia) or mature (chronic leukemia). The leukemic cells may not function well to fight infection and may interfere with the production of red blood cells (which carry oxygen) and platelets (which control bleeding). Normally, white blood cells play an important role in the body's natural defence system. They target and destroy foreign invaders like viruses and bacteria. White blood cells are made in the marrow (the spongy core) of your bones. Without healthy and functioning white blood cells, the body is at risk of developing severe and sometimes fatal infections. Different types of leukemia Acute leukemia develops within days to weeks, and large numbers of immature cells called "blasts" build up. These cells can't function as well as normal white blood cells, so people with acute leukemia are at a higher risk of infection. Because the body is so busy producing "blasts," it can't make as many red blood cells or platelets, which can cause anemia and bleeding disorders. Chronic leukemia...
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...possible, the whole patient's lifetime. Furthermore, its epidemiology has enabled H. Pylori to seemingly go undetected as the cause for a variety of illness such as duodenal ulcer and stomach cancer. All of these factors have created a versatile pathogen. Before the discovery of H. Pylori the conventional thought of bacteria was that none could live in the acidic environment...
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