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Nuchal Translucency Case Study

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BACKGROUND
The research paper addresses the diagnosis of aneuploidy during the first trimester using Nuchal Translucency. The study was done in the fetal medicine unit in Chris Hani Baragwanath Hospital in South Africa. It included a total of 428 patients who were screened between July 2003 and July 2005. Those patients were chosen using a set of criteria that the Fetal Medicine Foundation (FMF) has established. The patients had a mean age of 30 years. Of all the patients, 59 were screened positive and the remaining 356 were screened negative. 24 of those that screened positive had Chorionic Villus Sampling (CVS) performed. CVS is an invasive prenatal test that takes a sample of the chorionic villi to asses for chromosomal defects4. Therefore, …show more content…
If the adjusted risk is greater than 1:300 it was considered positive, if it was less than 1:300 it was considered negative.
Result Analysis
The results will be analyzed using Epi-Info 6.04 software and the p-value will be set at <0.05. To determine statistical significance, all patients’ in whom the outcome of the pregnancy was not available, were to be excluded from the sub analysis.
Out of the 415 patients tested 355 were tested true negative and only 1 tested false negative. Comparing the adjusted risk to their a priori risk made the diagnosis. Thus giving the test a high true negative rate, while on the other hand the study had high false positive rates especially among male fetuses.
This may be due the fact that the average fetus age tested positive were a week younger than those who tested negative. Therefore the Crown Rump length was 5 mm shorter in those who screened positive. This may be one of the causes of the high false positive value
The cost of the first- trimester screening was equivalent to 29% of the second trimester screening yet, double its

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