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Recurrent Stroke Case Study

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Risk of Recurrent Stroke in Children with Sickle Cell Disease Receiving Blood Transfusion Therapy for at Least Five Years After Initial Stroke
Taylor Kaplan
University of Bridgeport Physician Assistant Institute

Introduction
Sickle cell disease is an inherited blood disorder that is characterized by a defect in hemoglobin. Normally, red blood cells take the form of a biconcave disk and can easily move through the vessels throughout one’s body. Sickled red blood cells however are very different; these damaged red blood cells cluster together as a result of the loss of oxygen and can no longer easily move through blood vessels in the body. This cluster creates a blockage in small arteries or capillaries and prevents the …show more content…
Children with SCD and stroke are proven to have disabilities, such as paralysis, aphasia and difficulties in learning and cognition. If left untreated, these patients have 67% risk of a second stroke over 9 years (Scothorn et al, 2002). A case analysis done in 1976 by a man named Lusher, reported that recurrent strokes in children with SCD could be prevented by treatment with monthly blood transfusions. Subsequent studies throughout the years have proven that long term blood transfusion therapy reduces, but does not fully eliminate the risk of recurrent stroke throughout the SCD population. It has yet to be determined how long transfusion therapy needs to be continued for, but many prospective, as well as retrospective studies, have shown high risk of stroke after discontinuing blood transfusions in these …show more content…
The study that I chose to discuss, test the hypothesis that children with SCD who have an initial stroke temporarily unrelated to another medical event are at higher risk for recurrent stroke than are children who had strokes temporarily related to medical events (Scothorn et al, 2002). A multicenter, retrospective cohort study consisting of pediatric patients with SCD and stroke who received at least 5 years of continued blood transfusion therapy was performed. This article was published in the Journal of Pediatrics and it was funded by the Institutional Review Board, whom also received approval of the study by obtaining information from 14 participating medical centers when required; consent was not given from the patients or their families for this study because all the medical information provided was identified as part of routine care and were present in their medical records. However, actual patients’ identification was hidden and the medical records from the participating institutions were reviewed between October 1998 and March

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