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Skeletal Muscle Homeostasis

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The job of the lungs is to bring in oxygen and then oxygenate the blood, but COPD disrupts this. As less fresh air enters the lungs, the less oxygen someone will get to oxygenate their blood which can lead to hypoxia. The likelihood for a heart attack increases as the heart receives less oxygen. Pulmonary hypertension can also occur as COPD progresses. This can be caused by the pulmonary arteries constricting due to hypoxia, dysfunction in the endothelial tissue, and the pulmonary capillary bed being destroyed. When the heart can’t beat fast enough to pump blood, blood may stay in the lungs longer which is why shortness of breath occurs (Orenstein, 2013). The lack of oxygen for the heart is serious because that blood needs to oxygenate …show more content…
As breathing becomes harder, people with COPD tend to exercise less and live a more sedentary lifestyle causing muscular atrophy. Muscles become more susceptible to fatigue due to the fiber change. Biopsies were done of the quadriceps of people diagnosed with COPD. Although there is muscular atrophy, they found that there was a smaller amount of slow twitch fibers and a larger amount of fast twitch glycolytic fibers. Fast twitch glycolytic may help with preserving strength but fatigue much faster than slow twitch (Mador and Bozkanat, 2001). This will also affect the skeletal muscle pump which functions to increase venous return. Less venous return will then lead to a decreased stroke volume and cardiac output. So as they atrophy, it becomes harder for the skeletal muscle pump to work and return enough blood. Less blood is returned and less oxygen is reaching the blood (Visca et al, …show more content…
Researchers looked at the likelihood of someone with obstructive disorders like asthma and COPD also having anxiety and/or depression. They are interested in this due to the affect breathing disorders have on peoples’ lives. If someone struggles to breathe, they may be less likely to participate in social activities which can lead to a feeling of isolation. The subjects were recruited from out-patient clinics that were related to allergies or pulmonology, rather than a psychiatric facility. Researchers found that both people with COPD or asthma had anxiety similar to each other while people with COPD tend to experience depression more than asthmatics (Ozcan et al,

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