...Special episodeOn April 5, 2007, Fuji Television aired a three hour special of the series set five years after Aya's death and focuses on Haruto Asō, who has now become a doctor at the same hospital Aya was treated in and Ako Ikeuchi, Aya's younger sister who is a nurse in training. Haruto is caring for a 14-year-old female patient, Mizuki, who was bullied in school because of her disease, the same one that Aya had. Because of the bullying at school, Mizuki-chan decides not to receive therapy of any sort that would make her better, because she has lost her will to live. Haruto remembers how Aya fought her illness and lived her life with her disease; therefore, he offers support to his patient. Aya reappears in the episode using a number of flashbacks from the series and in new scenes.[1] [edit]Main cast Erika Sawajiri - Aya Ikeuchi Ryō Nishikido - Haruto Asō (Aya's later love interest) [edit]Other cast Naohito Fujiki - Hiroshi Mizuno (Doctor) Hiroko Yakushimaru - Ikeuchi Shioka Takanori Jinnai - Ikeuchi Mizuo Riko Narumi - Ikeuchi Ako Yuma Sanada - Ikeuchi Hiroki Ai Miyoshi - Ikeuchi Rika Saori Koide - Mari Sugiura (One of Aya's best friends) Kenichi Matsuyama - Yuji Kawamoto (Aya's first love interest) Yuya Endo - Takeda Makoto (Yuji's friend in the Basketball club) Kana Matsumoto - Saki Matsumura Momosuke Mizutani - Kohei Onda Ryo Hashidume - Keita Nakahara Hiroshi Katsuno - Yoshifumi Asō (Haruto's father) Asae Onishi (大西麻恵...
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...The Future of Cardiovascular Diagnostics THE MARKET, TRENDS & FUTURE DIRECTIONS Extracted on: 20 Apr 2011 Reference Code: BI00021-008 Publication Date: 02 Mar 2010 Publisher: Datamonitor © Datamonitor This content is a licensed product, no part of this publication shall be reproduced, sold, modified or stored in a retrieval system or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of Datamonitor. The information in this document has been extracted from published research by a registered user of the Datamonitor360 platform. Datamonitor shall not be responsible for any loss of original context and for any changes made to information following its extraction. All information was current at the time of extraction although the original content may have been subsequently updated. Please refer back to the website http://360.datamonitor.com/ to view the most recent content and the original source of the information. To the maximum extent permitted by applicable law we exclude all representations, warranties and conditions relating to the facts of all publications. At time of publication no guarantee of accuracy or suitability, whether express or implied, shall attach to this publication (including, without limitation, any warranties implied by law of satisfactory quality, fitness for purpose and/or the use of reasonable care and skill). Please note that the findings, conclusions and recommendations...
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...Ancient Literature Essay Ancient literature includes many themes that are relevant today. Many of these stories include a hero, villain, and epic battle or journey that leads to a resolve. Often, you can see similar characteristics among these ancient writings. These ancient peoples were not much different than we are today, and that is depicted by the themes that continue to be relevant in the Common Era. An analysis of the two ancient writings The Aeneid and Agamemnon show many similar themes and blatant differences apparent in each story. By examining these two stories in detail, a greater understanding and appreciation of ancient literature can be acquired. Since man first began engaging in religious practices, stories with religious elements and themes have resulted. These two stories are no exception. Ancient Greek and Roman religious themes are present in both The Aeneid and Agamemnon. Both stories revolve around the philosophy that what we do with our lives is controlled by the Gods and to disrespect and dishonor the Gods is blasphemy, which will automatically lead to punishment. Both stories are similar in that the Gods are the beholders of the ultimate supreme power and the deciders of our hero’s fates. In other words, if it is not written by the Gods, then it is not the will of the Gods, and is therefore not to be done. It is also apparent in both stories that pleasing the Gods is everything to the characters and ultimately a deciding factor in their roles...
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...Alona Muzikansky2, Paula Ryan2, Ulysses J. Balis1{, Ronald G. Tompkins1, Daniel A. Haber2 & Mehmet Toner1 Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified in peripheral blood from cancer patients and are probably the origin of intractable metastatic disease1–4. Although extremely rare, CTCs represent a potential alternative to invasive biopsies as a source of tumour tissue for the detection, characterization and monitoring of non-haematologic cancers5–8. The ability to identify, isolate, propagate and molecularly characterize CTC subpopulations could further the discovery of cancer stem cell biomarkers and expand the understanding of the biology of metastasis. Current strategies for isolating CTCs are limited to complex analytic approaches that generate very low yield and purity9. Here we describe the development of a unique microfluidic platform (the ‘CTC-chip’) capable of efficient and selective separation of viable CTCs from peripheral whole blood samples, mediated by the interaction of target CTCs with antibody (EpCAM)-coated microposts under precisely controlled laminar flow conditions, and without requisite pre-labelling or processing of samples. The CTC-chip successfully identified CTCs in the peripheral blood of patients with metastatic lung, prostate, pancreatic, breast and colon cancer in 115 of 116 (99%) samples, with a range of 5–1,281 CTCs per ml and approximately 50% purity. In addition, CTCs were isolated in 7/7 patients...
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...Agamemnon puts Chryseis on a ship back to her father and sends heralds to have Briseis escorted from Achilles’ tent. Achilles prays to his mother, the sea-nymph Thetis, to ask Zeus, king of the gods, to punish the Achaeans. He relates to her the tale of his quarrel with Agamemnon, and she promises to take the matter up with Zeus—who owes her a favor—as soon as he returns from a thirteen-day period of feasting with the Aethiopians. Thetis makes her appeal to Zeus, as promised. Zeus is reluctant to help the Trojans, for his wife, Hera, favors the Greeks, but he finally agrees. Hera becomes livid when she discovers that Zeus is helping the Trojans, but her son Hephaestus persuades her not to plunge the gods into conflict over the mortals. Analysis But while the poem focuses most centrally on the rage of a mortal, it also concerns itself greatly with the motivations and actions of the gods. Even before Homer describes the quarrel between Achilles and Agamemnon, he explains that Apollo was responsible for the conflict. In general, the gods in the poem participate in mortal affairs in two ways. First, they act as external forces upon the course of events, as when Apollo sends the plague upon the Achaean army. Second, they represent internal forces acting on individuals, as when Athena, the goddess of wisdom, prevents Achilles from abandoning all reason and persuades him to cut Agamemnon with words and insults rather than his sword. But while the gods serve a serious function in partially...
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...JBMR ORIGINAL ARTICLE Osteoblast Maturation and New Bone Formation in Response to Titanium Implant Surface Features Are Reduced With Age Rene Olivares-Navarrete, 1 * Andrew L Raines, 1,2 * Sharon L Hyzy, 1 Jung Hwa Park, 1 Daphne L Hutton, 1 David L Cochran , 3 Barbara D Boyan , 1 and Zvi Schwartz 1,3 1 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA St. Joseph’s Translational Research Institute, Atlanta, GA, USA 3 University of Texas Health Science Center at San Antonio, San Antonio, TX, USA 2 ABSTRACT The surface properties of materials contribute to host cellular response and play a significant role in determining the overall success or failure of an implanted biomaterial. Rough titanium (Ti) surface microtopography and high surface free energy have been shown to enhance osteoblast maturation in vitro and increase bone formation in vivo. Whereas the surface properties of Ti are known to affect osteoblast response, host bone quality also plays a significant role in determining successful osseointegration. One factor affecting host bone quality is patient age. We examined both in vitro and in vivo whether response to Ti surface features was affected by animal age. Calvarial osteoblasts isolated from 1-, 3-, and 11-month-old rats all displayed a reduction in cell number and increases in alkaline phosphatase–specific activity and osteocalcin in response to increasing Ti surface microtopography...
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...A Protagonist of the Scientific Revolution: Galileo Galilei was one of the protagonists of the scientific revolution, best known for his astronomical discoveries by means of a telescope (including sunspots, Jupiter’s satellites, and the phases of Venus), for his defense of heliocentrism, and for his study of the natural laws regarding falling bodies. Galileo, however, gave key contributions also to the development of the modern scientific methodology; for this reason, he holds a special place in the philosophy of science and epistemology. Life: Galileo was born in or nearby Pisa from Vincenzo Galilei and Giulia Ammannati. His father was a well known lutenist and music theorist, and the young Galileo was well versed in the art as well (Galileo’s youngest sibling, Michelangelo, became indeed an accomplished lutenist). During his youth, Galileo moved through different locations in Tuscany, among which the monastery of Vallombrosa, run by Camaldolese monks. The story goes that until 1581 Galileo had not studied mathematics. After considering priesthood and enrolling into a program for physician at the University of Pisa, Galileo suddenly realized his mathematical vocation upon attending a geometry lecture. Immediately, he started discovering ingenious facts and creating crafts such as thermoscope. As early as 1589, Galileo held a chair in mathematics at the University of Pisa, which position he kept until 1592, when he moved to Padua. There, he remained until 1610. ...
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...crystal fiber, a full-field optical coherence tomography using a home-designed Mirau objective realized high quality images of in vivo and excised skin tissues. With a 40 × silicone-oilimmersion Mirau objective, the achieved spatial resolutions in axial and lateral directions were 0.9 and 0.51 μm, respectively. Such a high spatial resolution enables the separation of lamellar structure of the full epidermis in both the cross-sectional and en face planes. The number of layers of stratum corneum and its thickness were quantitatively measured. This label free and non-invasive optical probe could be useful for evaluating the water barrier of skin tissue in clinics. As a preliminary in vivo experiment, the blood vessel in dermis was also observed, and the flowing of the red blood cells and location of the melanocyte were traced. ©2014 Optical Society of America OCIS codes: (060.2380) Fiber optics sources and detectors; (170.4500) Optical coherence tomography; (160.1435) Biomaterials; (170.3880) Medical and biological imaging; (180.3170) Interference microscopy. References and links 1. T. Gambichler, S. Boms, M. Stücker, A. Kreuter, G. Moussa, M. Sand, P....
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...………………………………………………….13 3.4 Conclusions…..…………………………………………………………………………………………………………………….20 4. Turning research into novel medical devices………………………………………………………………………………….22 4.1 The Medical Device Development Process…..……………………………………………………………………..22 4.2 CIMIT: A Structure for Medical Device Innovation…..………………………………………………………….23 4.3 Stanford Biodesign: Innovation as a Discipline…..………………………………………………………………..26 4.4 Conclusions and Recommendations…..……………………………………………………………………………….28 5. Summary and Conclusions…………………………………………………………………………………………………………….30 6. Acknowledgements……………………………………………………………………………………………………………………….32 7. References…………………………………………………………………………………………………………………………………….33 Appendices A1 Selection of Key Institutes A2 Results Patent Analysis A3 Research Profiles 1. Introduction This report analyzes the R&D infrastructure in the United States in the field of new medical devices. It is part of the Innovative Medical Devices Initiative the Netherlands (IMDI.NL) thematic program that aims to focus the Netherlands’ R&D infrastructure for medical devices on health care demands and economic growth (1). The study is a collaboration...
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...ALLEGOR AND IRONY IN 'OTHELLO' Y ANTOINETT B. DAUBER E Othello is Shakespeare's Spenserian tragedy, in which the theme of slandere d chastity becomes a vehicle for exploring the problems of an allegorica l art . Allegory is the mode of selfconscious faith, and Spenser's corpus may be rea d as a portrai t of the artis t as allegorist , wrestling first with the burdens of selfconsciousness and then with the burdens of faith.l In Othello, Shakespeare compresses and objectifies this struggle. Unlike Spenser, he is not committed to the maintenance of allegory, and so he freely dramatizes the interna l weaknesses and external onslaughts that lead to its destruction. What I am calling the 'Spenserian ' quality begins with the chivalric elements in the tragedy. Truly, Othello is a kind of Savage Knight, Desdemona, the absolutely, almost miraculously, worthy lady, and Iago, something of a manipulator like Archimago.2 But more particularl y I would call attention to a specific engagement with Spenserian rhetoric . Consider Cassio' s words of welcome to the disembarking Desdemona: Tempests themselves, high seas, and howling winds, The gutter'd rocks and congregated sands, Traitors ensteep'd to enclog the guiltless keel, As having sense of beauty, do omit Their mortal natures, letting go safely by The divine Desdemona. (2.1.68-73)3 He sets her in the line of Spenser's heavenly allegories . As a parallel , we may recal l Una , slandere d by the arch-magician , abandone d by 123 her...
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...Food Hydrocolloids 23 (2009) 1827–1836 Contents lists available at ScienceDirect Food Hydrocolloids journal homepage: www.elsevier.com/locate/foodhyd Effect of replacement of fat with sesame oil and additives on rheological, microstructural, quality characteristics and fatty acid profile of cakes M. Sowmya a, T. Jeyarani b, R. Jyotsna a, D. Indrani a, * a b Flour Milling, Baking and Confectionery Technology Department, Central Food Technological Research Institute, Mysore 570 020, Karnataka, India Lipid Science and Traditional Foods Department, Central Food Technological Research Institute, Mysore 570 020, Karnataka, India a r t i c l e i n f o a b s t r a c t Article history: Received 25 August 2008 Accepted 2 February 2009 Effect of replacement of fat with 25, 50, 75 and 100% sesame oil (on fat basis); 50% sesame oil, hydrocolloids and emulsifiers on the rheological, microstructural, quality characteristics and fatty acid profile of cake was studied. Addition of increasing amount of sesame oil decreased viscosity, increased specific gravity of cake batter; decreased cake volume and overall quality score. Microstructure studies showed disrupted gluten matrix. Among the two different hydrocolloids [hydroxypropylmethylcellulose (HPMC) and xanthan] and emulsifiers [glycerol monostearate (GMS) and sodium stearoyl-2-lactylate (SSL)] tried, HPMC and SSL increased the batter viscosity, decreased the specific gravity, increased the volume and overall quality...
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...Julius Caesar full title · The Tragedy of Julius Caesar author · William Shakespeare type of work · Play genre · Tragic drama, historical drama language · English time and place written · 1599, in London date of first publication · Published in the First Folio of 1623, probably from the theater company’s official promptbook rather than from Shakespeare’s manuscript publisher · Edward Blount and William Jaggard headed the group of five men who undertook the publication of Shakespeare’s First Folio narrator · None climax · Cassius’s death (V.iii), upon ordering his servant, Pindarus, to stab him, marks the point at which it becomes clear that the murdered Caesar has been avenged, and that Cassius, Brutus, and the other conspirators have lost in their attempt to keep Rome a republic rather than an empire. Ironically, the conspirators’ defeat is not yet as certain as Cassius believes, but his death helps bring about defeat for his side. protagonists · Brutus and Cassius antagonists · Antony and Octavius setting (time) · 44 b.c. setting (place) · Ancient Rome, toward the end of the Roman republic point of view · The play sustains no single point of view; however, the audience acquires the most insight into Brutus’s mind over the course of the action falling action · Titinius’ realization that Cassius has died wrongly assuming defeat; Titinius’ suicide; Brutus’s discovery of the two corpses; the final struggle between Brutus’s men and the troops...
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...Nintendo Co., Ltd. (???????, Nintendo Kabushiki gaisha?) is a multinational corporation located in Kyoto, Japan. Founded on September 23, 1889[2] by Fusajiro Yamauchi, it produced handmade hanafuda cards.[6] By 1963, the company had tried several small niche businesses, such as a cab company and a love hotel.[7]}} Nintendo developed into a video game company, becoming what is arguably the most influential in the industry, and Japan's third most valuable listed company, with a market value of over US$85 billion.[8] Also, Nintendo of America is the majority owner of the Seattle Mariners Major League Baseball team.[9] The name Nintendo can be roughly translated from Japanese to English as "leave luck to heaven".[10] As of October 18, 2010, Nintendo has sold over 565 million hardware units and 3.4 billion software units.[11] Contents * 1 History o 1.1 As a card company (1889–1956) o 1.2 New ventures (1956–1974) o 1.3 Electronic era (since 1974) + 1.3.1 Handheld console history * 2 Infrastructure o 2.1 Key Executives o 2.2 Offices and locations * 3 Software development studios o 3.1 First-party studios o 3.2 Second-party studios o 3.3 Former affiliates * 4 Policy o 4.1 Emulation o 4.2 Content guidelines o 4.3 License guidelines o 4.4 Seal of Quality + 4.4.1 NTSC regions + 4...
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...Ancient Greece The Parthenon, a temple dedicated to Athena, located on the Acropolis in Athens, is one of the most representative symbols of the culture and sophistication of the ancient Greeks. Part of a series on the | Modern Greece.Septinsular Republic.War of Independence.First Hellenic Republic.Kingdom of Greece.National Schism.Second Hellenic Republic.4th of August Regime.Axis occupation (collaborationist regime).Civil War.Military Junta.Third Hellenic Republic | History by topic.Art.Constitution.Economy.Military.Names | History of Greece | | Neolithic Greece.Neolithic Greece | Greek Bronze Age.Helladic.Cycladic.Minoan.Mycenaean | Ancient Greece.Homeric Greece.Archaic Greece.Classical Greece.Hellenistic Greece.Roman Greece | Medieval Greece.Byzantine Greece.Frankish and Latin states.Ottoman Greece | | Ancient Greece was a civilization belonging to a period of Greek history that lasted from the Archaic period of the 8th to 6th centuries BCto the end ofantiquity (c. 600 AD). Immediately following this period was the beginning of the Early Middle Ages and the Byzantine era. Included in ancient Greece is the period ofClassical Greece, which flourished during the 5th to 4th centuries BC. Classical Greece began with the repelling of a Persian invasion by Athenian leadership. Because of conquests by Alexander the Great of Macedonia, Hellenistic civilization flourished fromCentral Asia to the western end of the Mediterranean Sea. Classical Greek culture...
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... 1. India India never invaded any country in her last 10,000 years of history. It is the only society in the world which has never known slavery. India was the richest country on Earth until the time of the British in the early 17th Century Robert Clive’s personal wealth amassed from the blunder of Bengal during 1750’s was estimated at around £401,102 It has been estimated that the total amount of treasure that the British looted from India had already reached £1,000,000,000 (£1Billion) by 1901. Taking into consideration interest rates and inflation this would be worth close to $1,000,000,000,000 ($1Trillion) in real-terms today. 2. Vedic Civilization Indus & Saraswati Civilizations Rise of Jainism and Buddhism Mauryan Period Golden Age of Indian Arts & Sciences Muslim Invasions The Mughal Empire Portuguese Invasion The British East-India Company The British Empire India's Freedom Struggle Independence Modern India 2020 Vision A Brief History of Time 3. India India invented the Number System. Zero was invented by Aryabhatta . The place value system, the decimal system was developed in India in 100 BC. Aryabhatta was the first to explain spherical shape, size ,diameter, rotation and correct speed of Earth in 499 AD. The World's first university was established in Takshila in 700 BC. Students from all over the World studied more than 60 subjects. The University of Nalanda built in the 4th century was one of the greatest achievements of ancient India in the field...
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