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Cardiovascular Embryo

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LEVEL I BLOCK IV MODULE II | CARDIOVASCULAR SYSTEM
CASE 1: LOVE AT FIRST SIGHT (TRIGGER 1)

What is the embryonic origin and development of the heart and blood vessels?
- The endocardium is derived from the hypoblast.
- The myocardium is derived from the mesoblast. FORMATION OF THE HEART TUBE
- Clusters of the cells arise in the mesenchyme at the cephalic end of the embryonic disc, cephalic to the site of the developing mouth and the nervous system.
- These clusters of cells form a plexus of endothelial blood vessels that fuse to form the right and left endothelial heart tubes, and fuse to form single mesodian endocardial tube.
- As the head fold of the embryo develops, the endocardial tube and the pericardial cavity rotate on a transverse axis through almost 180 degree, so that they come to lie to the esophagus and caudal to the developing mouth.
- The heart tube starts to bulge into the pericardial cavity.
- Meanwhile, the endocardial tube becomes surrounded by a thick layer of mesenchyme, which will differentiate into myocardium and the visceral layer of the serous pericardium.
- The primitive heart has been established, and the cephalic end is the arterial end and the caudal end is the venous end.
- The arterial end of the primitive heart is continuous beyond the pericardium with a large vessel, the aortic sac.
- The heart begins to beat during the third week.

FURTHER DEVELOPMENT OF THE HEART TUBE
- The heart then undergoes differential expansion so that several dilatations, separated by grooves, from the arterial to venous end, these dilatations are called the bulbous cordis, the ventricle, the atrium, and the right and left horns of the sinus venosus.
- The bulbous cordis and the ventricular parts of the tube now elongate more rapidly than the remainder of the tube, and since the arterial and venous ends are fixed by the pericardium,

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