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Chemistry: Click Chemistry

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“Click chemistry” describes a way to generate products reliably and quickly by connecting small units together, which resembles the way nature create substances. The term was first introduced by K. B. Sharpless in 2001, and then fully described by Hartmuth Kolb, Sharpless, and M.G. Finn. A desirable click reaction should fulfill the criteria including modular, wide in scope, high chemical yields, stereospecific, simple to perform, simple reaction conditions, inoffensive byproducts, physiologically stable, readily accessible reagents, and easily removable or benign solvents etc. It was identified that several types of reactions can satisfy these prerequisites, such as addition to carbon-carbon multiple bond (e.g. Michael Additions, oxidative formation of epoxides), non-aldol type carbonyl reactions (e.g. formation of heterocycles and hydrazones), and cycloaddition reactions. …show more content…
The starting mono-substituted azides and organic alkynes are often commercially available, or easily accessible through conversion of a variety of functional groups. Their cycloaddition gives 1,2,3-triazoles, selectively. It was described by Sharpless and Fokin as a reliable catalytic process independently, which offers "an unprecedented level of selectivity, reliability, and scope for those organic synthesis endeavors which depend on the creation of covalent links between diverse building

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