...Muscles Targeted in Kipping Pull-ups: Basically, Kipping Pull Ups target latissimi dorsi. For the most, a part known as lats, are the long and wide muscles that begin in the ribs and vertebral segment. The lats are in charge of controlling developments in the shoulders and help with the despondency, revolution, and adduction of the scapula. Along these lines when all is said in done, Kipping Pull-ups focuses on the lats of the body. Instructions of Kipping Pull-ups: Here are the most vital guidelines that you need to recall while doing kipping pull-ups 1.In a legitimately performed conventional kipping pull-up, subsequent to locking out over the bar, the competitor pushes once more from the bar into a circular segment that heaps the forward push of the trunk through the arms before the accompanying rep. This is a smooth, controlled development; in no way, shape or form is it bumping or ballistic unless done disgracefully. 2.In any instance of kipping force ups, sufficient planning is vital for wellbeing. it is for the most part prescribed to keep some assistance with you while doing this workout. This is not extraordinary to the kipping pull-up; it's valid for any physical movement. Where this gets to be distinctly tricky regularly is circumstances in which insufficient movement exists because of restlessness or numbness. 3.With respect to kipping pull-ups, if an individual can scarcely string together two or three ring columns at a high point, bouncing them into kipping pull-ups...
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...1. What were the driving forces that lead Wells Fargo OFS to redesign their strategy and processes? Wells Fargo launched its online financial services much ahead of their competitors and with the astonishing response of the growing customer base, they enhanced the online services with all major banking services like reviewing their accounts and balances, bill payments etc. The OFS primarily focused on the maintaining the high attrition rate of online customers and provide all their customer with a low cost service medium. The OFS group recovered their cost by charging other department within the bank depending on the activity of the customer after logging into the portal. However due to this main the purpose of providing a low cost media to the customer was being lost in the need of generating OFS group revenue. Because of this the OFS had reached a point where the profits and costs were equal. Wells Fargo’s traditional approach to measure performance and strategies using the financial metrics led to poor decision making while the online banking needed a well-planned long term goal as it was one of the driving factor of the business in the coming years. Also, because of the rapidly changing technological trends on a daily basis in the internet media, the OFS had to be upstream in their approach to keep with the latest technologies. This involved new competitive threats and meeting the customer demands became a challenge due to the varied customer base in the online banking...
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...ANSWER THREE OF THE QUESTIONS ALL QUESTIONS SHOULD BE ANSWERED IN A SEPARATE BOOKLET Answer all parts of the chosen questions. All questions are for 22 marks. 1. (a) Discuss the design of a pharmacogenomic study, including pharmacokinetic and pharmacodynamic aspects, to evaluate the variability in response to warfarin in populations with different ancestries. [ 11 marks ] (b) Describe 2 different enzymes affecting pharmacokinetic factors and drug response. Include drug substrates, disease(s) implicated, their genetic variations and explain how the knowledge of genotype/phenotype relationship could be useful in clinical practice. [ 11 marks ] 2. (a) The MSc gene is expressed in the liver of the Wild-Type (WT) rat and its enzyme product metabolises a drug called Pharmaco. Sequencing of the MSc gene in a new rat strain called GLA has identified a single base change from the WT sequence. Depending on where this change occurs in the MSc gene, what effect – if any – would it have on the GLA rats’ ability to metabolise Pharmaco? [ 14 marks ] (b) Further investigation shows the base change in the MSc gene of GLA rats occurs in the promoter region and is likely to prevent the gene’s transcription in the liver. Briefly describe the methods that could be used to show the absence of MSc mRNA in GLA rat livers. What information might you need? What controls would you use? [ 8 marks ] 3. Gene therapy has been proposed...
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...What did caffeine and ethanol do to the heart rate of Daphnia? Increasing the concentration of ethanol in Daphnia decreases heart rate. Increasing the concentration of caffeine in Daphnia increases heart rate. Independent vs. Dependent Variable Independent Variable: One or more factors that the scientist varies during the experiment. Dependent Variable: A feature that the scientist measures in order to determine if it changed in response to the independent variable. What solutions were used to test for the 4 types of organic molecules? Iodine- Polysaccharide Benedict’s Reagent- Sugar Biuret Test- Protein Brown Paper Test- Lipids Vegetable Oil- Solubility of Lipids What does a positive test look like? -Iodine test for polysaccharide: dark purple/black/blue -Vegetable Oil test for solubility of lipids: 1 layer -Biuret test for protein: violet color -Benedict’s Reagent for sugar: very high concentration/orange-red How do you convert Celsius to Fahrenheit and vise versa? ...
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...X Resources: http://www.labcorp.com http://www.geneticdiseasefoundation.org http://www.fragilex.org http://www.nfxf.org/ Taylor Smallshaw Although there is no cure, special education, speech therapy, occupational and behavioral therapy could offer help to someone diagnosed with Fragile X. Additionally, there are medical treatments for aggression, anxiety, hyperactivity, and poor attention, which are common characteristics of Fragile X. Syndrome. There is no cure for Fragile X Syndrome. Treatment Fragile X Syndrome is a sex-linked inheritance of mental retardation. Although it can be found in all ethnic groups, it is predominantly found in males. There are physical and behavioral symptoms of Fragile X. There is no cure for this disorder, however there are many treatments in which a patient suffering from Fragile X can participate. Key Facts Praesent congue sapien sit amet justo. Fragile X Syndrome = Frequency of Fragile X Fragile X Syndrome can occur in all types of ethnic groups. However, it differs in the prominence in different genders. Because it is a sex-linked dominant gene, more males will be affected by this disorder. An estimated 1 in 4000 males are affected and 1 in 6000 females. One in 100/250 women are carriers for the gene. These female carriers often suffer from infertility and early menopause. Fragile X Syndrome is one of the most common forms of inherited mental retardation. Fragile X Syndrome is a sex-linked dominant...
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...Class Final: The genetics of cancer * Cancer is when mitosis goes wrong! * Cancer cells lack regulated ability to divide only when needed so they divide uncontrollably. * Hyperplasia- Beginning of cancer development; heightened cell division that can create tumor (neoplasm) * Dysplasia- The change in cells/tissue * Cancer cells go from being complex to primitive—which means cancer cells lose their shape, size and ability to function like normal cells * Cancer originates due to mutations within the DNA, in sequence of nucleotides of genes * Malignant tumors and neoplasms are referred to as cancer; benign neoplasms are NOT cancer * In situ tumors- Precurser to cancer/ precancerous * Very dangerous tumor cells (what’s detected in screenings) Causes of cancer: 1. If there’s mutation in the Proto-oncogenes (tumor suppressor genes), which code for proteins and regulates mitosis… then there will definitely be problem with normal cell division. 2. Carcinogens are substances or physical agents that lead to development of cancer when body is exposed to them. 3. General mutations due to internal/external factors can cause cancer. a. Internal factors- errors in DNA replication; Free radicals; errors in protein synthesis b. External factors- Infectious agents (bacteria/viruses); pollution and chemicals in environment; Radiation (sun); medical treatment (chemo); Lifestyle factors (diet, tobacco) Benign vs. Malignant ...
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...1. Terry, Greg, Jenny, and Bill all demonstrate principle 1. 2. Greg, Carl, and Terry represent principle 2. 3. Jessica, Terry, Florence, and Greg represent principle 3. 4. If a male has an X on their chromosome they automatically have the disease. A male cannot carry hemophila due to them only having a single X chromosome and hemophilia is a recessive x-linked trait. 5. The probability of Marcy and Tom having a child with hemophilia is 12.5%. This is because Marcy has a 50% chance of being a carrier. Marcy’s children in turn have a 50% chance of receiving a copy of the X chromosome. Thus, there is a 25% chance that any of the children would receive a copy of the recessive X allele from Marcy. Tom does not have hemophilia, so we know that the gene on his X chromosome is normal. Therefore, only Marcy and Tom’s sons could have hemophilia. The total probability of Marcy and Tom having a child with hemophilia is 12.5% which brakes down mathematically (0.5)(0.5)(0.5) = .125. 6. 7. 8. The drugs for chemotherapy target the rapidly dividing cells of the body, which include not only the cancer cells but the hair cells. Those drugs are used specifically to seize the ongoing replication of fast growing cells. This means that these drugs affect the fast replication of hair cells and new growth cannot occur because of the intensity these drugs apply to the cells. Fortunately hair loss is just when the chemotherapy is repeated throughout the body. Shortly after chemo is no longer...
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...Eye Color of Drosophila: Sex Linked or Autosomal? Research Question: Is the eye color of drosophila a sex linked or autosomal trait? Introduction: Heredity is the study of acquiring traits by birth. A genotype is the alleles of an organism. A phenotype is the characteristics of an organism. Homozygous means having two identical alleles of a gene. A dominant allele is an allele that has the same effect on the phenotype whether it is present in the homozygous or heterozygous state. A recessive allele is an allele that only has an effect on the phenotype when present in the homozygous state. Heterozygous means having two different alleles of a gene. A carrier is an individual that has one copy of a recessive allele that causes genetic disease in individuals that are homozygous for this allele. We are going to do an experiment similar to what Gregor Mendel did with pea plants where we observe 3 generations and record the ratios of the phenotypes. The P generations were selected at the company that bred the flies for us (Carolina Biological). The P generation is purebred for their particular phenotype (Homozygous). The day that they were placed in the vials is marked on the vials, as well as the phenotypes of the p generation. After 2 weeks of breeding and laying eggs, the P generation was removed and the vials were shipped. The flies that you are working with today are the F1 generation. Then we selected 5 male and females flies and placed them in a vial with culture medium...
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...BACK THE TRUCK UP!/Ch.2-3 1. Disorders of the neonate may involve any system and are broken down into the following types. Congenital, Genetic, and Teratogenic 2. Disorders of the neonate cause ½ of all deaths in term newborns. True 3. A major anomaly in disorders of the neonate is usually apparent at birth in 3 to 4% of newborns. True 4. Which disorder or syndrome is most likely caused by a teratogen? Fetal Alcohol syndrome 5. The recessive disorders are easy to detect using carrier screening and have a high morbidity and mortality. True 6. What tow primary (least evasive) approaches are used to monitor fetal growth, development, and to identify pregnancy risks for a congenital anomaly? Maternal serum screening and ultrasonography 7. Five percent of all pregnant women screened will have abnormal test results when there is an unaffected pregnancy. True 8. Maternal Serum Screening can detect the risk for which condition? Possible Neural Tube Defect 9. The leading indication for invasive diagnostic is advanced maternal age. True 10. What would be the outcome for an autosomal recessive trait, statistically speaking, if a person who is a heterozygous carrier has children with a homozygous normal individual? (Use Boxes) Fifty percent of the children will be carriers and fifty percent will be normal. 11. Maternal Serum Screening is considered diagnostic test used to determine the type of disorder your baby will have when born. False 12. Which serum blood...
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...Sex chromosomes produce very unique patterns of inheritance in living organisms. In humans, there is an X chromosome and a Y chromosome that determines the sex of the offspring. A male has an X and Y chromosome, whereas a female has two X chromosomes. The sex of an offspring is determined by whether the sperm cell that fertilizes the egg is made up of an X or a Y chromosome; ultimately the male is the determining factor of the sex of the offspring. Even though the Y chromosome determines if the offspring will be male, the X chromosome has genes that control certain human characters; these genes are called sex-linked genes because they are linked to a certain sex. There are approximately 1,098 sex-linked genes that code unusual inheritance patterns other than the female sex trait. Some of these sex-linked genes carry unusual inheritance such as color blindness, Duchenne muscular dystrophy and hemophilia. (O’Neil, 2012). In the case of the recessive mutation that causes hemophilia, a female has to be the carrier of the mutated allele, since she has the X chromosomes only. If the female carrier of the disease mates with a male who has hemophilia (XhY), there would be a one-quarter chance that they would produce a female offspring that has hemophilia (XhXh). Males though are more susceptible to inheriting the hemophilia trait if the mother is a carrier, because the dominant gene (XH) will prevent the disease. (Simon, 2015). Since males can only have an X and a Y chromosome, there...
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...The Genetics of Fruit Flies can be Used to Understand Human Genetics Introduction: A gene is the functional and physical unit of heredity passed from parent to offspring. Genotype and phenotype are products of the different genes that one inherits. Genotype is the genetic constitution of an organism or cell. The observable physical and/or biochemical characteristics of the expression of a gene are the phenotypes (Genetics Home Reference 2013). A monohybrid cross is for a single trait when different alleles are combined through mating. A dihybrid cross calls focuses on two traits. Alleles on the sex chromosomes result in sex linked traits. In this experiment, multiple generations of Drosophilia melanogaster were examined and their hereditary traits analyzed. My hypotheses is that the traits will end up in a 1:1 ratio.The goal of this experiment was to note the traits of the fruit flies and how they relate to human genetics. Section Fri Tables F2 Generation Predictions Results Eye Color Wings Half Red, Half White Half winged, Half Not All Red All Males had Wings Materials and Methods: A parental generation of the fruit flies was obtained. Then 10 flies, 5 of each gender, of the F1 generation were obtained from the parent generation. Then 50-60 members of the F2 generation were obtained. At each stage, gender, eye color and wings were examined using a dissecting microscope after the flies were knocked out by FlyNap. Next, in the large petri dishes, crosses...
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...“Alcoholism affected approximately 4.65 percent of the U.S. population in 2001–2002, producing severe economic, social, and medical ramifications” (Sloan, Sayarath and Moore). As many know, genetics plays a strong role in the component of alcoholism. As more genes are linked to the development of an alcohol addition, the finding will be proven useful in developing the necessary tools to better identify those who are at risk (Perry). For the last 25 years, a variety of human studies have supported the “theory of a genetic component in the susceptibility to alcoholism” (Begleiter). Researchers now estimated that between 50 and 60 percent of alcoholism risk is determined by genetics (Sloan, Sayarath and Moore). “It has sparked numerous linkage and association studies to include, investigating the roles of chromosomal regions and genetic variants in determining alcoholism susceptibility” (Sloan, Sayarath and Moore). There have been multiple studies to identify the gene that could potentially lead to a higher risk for alcoholism. For example, family studies have been conducted to measure the frequency of alcoholism as well as related conditions consistently found that “biological relatives of people who abused or were dependent on alcohol were at a significant risk of developing the disorder themselves” (Begleiter). However, “the complex etiology of alcoholism lends itself to further investigation that takes into account the multiple layers of...
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...sychologyHow depression affects people Kim Branim Psychology 326 Sonja Bethune October 16, 2012 Introduction This study was design to find loci major depression via linkage analysis of a large sibling pair sample. Depressions in twins and families have been shown moderate high. “However the gene that caused depression had not been detected says” Lewis Cathryn but Gerome Breen “says that Chromosome3 it a link to severe depression. Breen study took 417 families with 479 concordant sibling pairs to perform genome-wide linkage analysis. Breen used the first wave of families, suggestive and modest suggestive and modest evidence for linkage was found on chromosomes 1p36, 12q, 13q, and 15q. The peaks on chromosomes 12q and 15q also showed evidence for linkage in other samples (8-10). In the present study, we report linkage analysis results using an expanded sample that includes 325 additional families contributing 474 sibling pairs, resulting in a total of 971 concordant sibling pairs with recurrent depression. The total sample also consisted of 118 discordant sibling pairs and 12 unaffected sibling pairs. Linkage can be detected when heterogeneity and error in phenotype are decreased. Also for depression, reliability is improved by focusing on severe cause ad indexed by symptom count or impairment. (Breen,2011) . Literature review The article name is Genome-Wide Association Study of Major Recurrent Depression in the U.K. Population. The Studies of major depression...
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...INTRODUCTION The fruit fly, Drosophila melanogaster, was used as a model organism to study the law of segregation and the law of independent assortment in Mendelian genetics. Drosophila was chosen as our model organism not only because of its short life cycle and fast breeding time but also because they are easy to maintain and handle in the laboratory. In this experiment a monohybrid cross and a dihybrid cross were performed. The law of segregation establishes the concept of dominance. The law of segregation states that an individual organism possesses two alleles that can encode a trait and that these alleles separate when gametes are formed and one of the two alleles go into each gamete. The concept of dominance states that when two alleles that encode for a trait are present in an individual only the “dominant” trait will be observed. For a dihybrid cross these statements still hold true but the law of independent assortment can also be observed. This law states that alleles at different loci on a chromosome that encode for different things separate independently of one another. METHOD Before beginning the experiment it was important to determine the sexes of the flies using a dissecting microscope and then to predict which phenotypes would be expressed. To distinguish between the sexes it was helpful to observe size, shape, and color of the flies, and to also check for the existence of sex combs. Only male flies have sex combs. Female flies are usually somewhat larger...
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...Loreen Whitfield 11/6/12 Section 6 Drosophila I. Introduction Over the course of this lab we are to familiarize ourselves with Drosophila, fruit flies, which is an important experimental organism. It is useful for genetic research because of its genome which represents eukaryotic organisms. The life cycle of the fruit fly is short which allows it to be easily observed over its lifetime. Also it can be reproduced and handled in large numbers. From this lab we can expect to learn how to etherize the flies and avoid killing them and to determine the sex of the flies. Finally we will be able to identify the differences between a normal, wild type, and a mutant fly. Determining the sex of the flies can be done because of different characteristics between the sexes. Females tend to be larger than males, an alternating banded posterior, and an oviposterior plate. Males are usually smaller than females and have sex combs located on the forelegs. The normal Drosophila physical characteristics can be grouped into four main features. The body consists of a yellow and gray pigmentation, eyes are brick red, and wings are in an elliptical shape with veins along them. Differentiation from this can result in a mutant fly which are more commonly found in a lab as opposed to nature. Mutant characteristics can appear in one or more different aspects of the Drosophila appearance. The purpose for this lab is to conduct a cross between two different mutations to determine whether they...
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