...Vienna Yearbook of Population Research 2013 (Vol. 11), pp. 295–323 Determinants of exceptional human longevity: new ideas and findings Leonid A. Gavrilov and Natalia S. Gavrilova∗ Abstract Studies of centenarians are useful in identifying factors leading to long life and avoidance of fatal diseases. In this article we consider several approaches to study effects of early-life and midlife conditions on survival to advanced ages: use of non-biological relatives as controls, the within-family analysis, as well as a sampling of controls from the same population universe as centenarians. These approaches are illustrated using data on American centenarians, their relatives and unrelated shorterlived controls obtained from the online genealogies. The within-family analysis revealed that young maternal age at person’s birth is associated with higher chances of exceptional longevity. Comparison of centenarians and their shorter-lived peers (died at age 65 and sampled from the same pool of online genealogies) confirmed that birth timing in the second half of the calendar year predicts survival to age 100. Parental longevity as well as some childhood and midlife characteristics also proved to be significant predictors of exceptional longevity. 1 Introduction Studies of centenarians (people living to 100 and older) could be useful in identifying factors leading to long life and avoidance of fatal diseases. Even if some individual characteristics have a moderate protective effect on...
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...The Evolution of Menopause and the Grandmother Hypothesis Throughout the natural world trade-offs between reproductive success and longevity have been noted by scientists for many years. Most wild animals remain fertile until death, as do human males, and although human males do become less fertile with age, they in general experience no complete shutdown of fertility. Men as old as the age of 94 have been noted to father children (Diamond, 1996). The situation for human women is strikingly different. They undergo menopause, the permanent cessation of menstruation, by the time they are in their mid fifties (Lahdenpera et al., 2004). In fact, natural conception after the age of 50 is extremely rare. Menopause has become quite the evolutionary puzzle for modern scientists because natural selection favors increased reproduction, therefore increasing one’s own fitness. The essence of natural selection is that it promotes genes for traits that increase an animal’s number of descendents bearing those genes. Thus, the great question is: How could natural selection result in every female member of a species carrying genes that destroy her ability to leave more descendents? Many theories on the evolution of menopause have arisen in the past 50 years in an attempt to answer this question but they all also have key assumptions and limitations. Proponents of the Grandmother Hypothesis believe that their theory holds the greatest promise to answer this question. The Grandmother Hypothesis...
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...People are living longer thanks to medical achievements, economic well-being and no more war. So would society be better if life spans were increased? It is believed that increase of human lifespan would have implications for social security benefits, medical care, housing, economy, etc. This essay will look at the pros and cons of a longer lifespan in relation to family and workplace. First, I will write about the advantage and disadvantage of increased longevity with regard to family. On the plus side, people could have more quality time to enjoy life with loved one. Many people spend most of their lifespan working and spend less time for family. If human lifespan could be increased, people can enjoy family’s activities, such as taking care of grandchildren, doing housework. More importantly, elderly people not only share experiences and skills with young people ,but also see young generations grow up. I used to read an article about Georgia woman, Georgia woman Besse Cooper, the world’s oldest ,Cooper had four children with her husband, Luther, and now has 12 grandchildren and more than a dozen great-grandchildren and great-great grandchildren (‘World’s oldest woman celebrates her sweet 116th birthday’, 2012 August). I think she has a great life. However, when many generations live together, there may be a lot of disagreements, irritating situations happen. Because young people and elderly people often have differences in thought, so it is hard for young children to follow...
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...that our bodies and minds does, and will, change with age and one thing can be agree upon is that the end results in all these studies is that the body and minds does go through many changes during our life time. Since the life span varies between and within species and human longevity is partially hereditary, it is clear that genetic factors, the biology of the brain, and our culture effect the function of the brain and influence the aging process ( Johnson 1993, Schacter et al. 1993, Vijg et al. 1995). Twin studies show that genetic differences account for about a quarter of the variance in adult human lifespan. While a great deal of research has focused on diseases of aging, there are only a few informative studies on the molecular biology of the aging brain. Many molecular changes are due in part to a reduction in the size of the brain, as well as loss of brain plasticity, Recent genome-wide studies demonstrate that a relatively small number of genes exhibit age-dependent gene expression changes. Studies in rodent, monkey, and human brains estimate the number of genes exhibiting age-dependent changes to represent less than 10%, and commonly less than 5%, of the entire genome. Human studies of longevity face numerous theoretical and...
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...Centenarians: The Biological, Sociological and Psychological Secrets to Human Longevity Amanda S. Primm Missouri State University Fall 2014 Abstract There is increasing interest from a multidisciplinary perspective in the study of centenarians, or individuals who live up to and beyond the age of 100. It is possible that these individuals are merely born to an excellent gene pool, or that they have superior coping skills that make it easier to deal with the stresses of life, thus prolonging their healthy status, or that the key to living a century and beyond resides very simply in healthy living, which includes regular exercise, and avoiding the detrimental effects of smoking, alcohol, and foods that contribute to...
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...1300 November 14, 2013 Abstract This paper explores articles that conduct research on obesity and its effects on the health and longevity of the body. The articles vary in their interpretations of the data and arrive at different conclusions in certain areas. The University of Oxford’s research and Samuel H. Preston’s article focus on the Body Mass Index (BMI) to interpret data, while articles from the Scientific American and Paul Campos assert that the BMI has its limitations and that obesity is only part of a greater problem of lifestyle choice. This paper examines the articles in relation to each other to suggest that greater scrutiny into the subject of obesity should be taken to fully understand its effects on health and mortality. The Effects of Obesity on Mortality Numerous studies have been conducted on obesity and its relation to mortality, however contradictory results appear because different studies lump data in different ways. In Crimmins, E. M. (2011) a person is of normal weight if he or she has a BMI between 18.50 and 24.99. A person with a BMI of 25 or more is considered overweight, while anyone with a BMI of 30 or more is considered obese. Obesity is further subdivided into Class 1 (30–34.99), Class 2 (35–39.99), and Class 3 (40 and above). While the University of Oxford (2009) argues that moderate obesity reduces lifespan, Reinagel (n.d.) introduces a new study which report findings that some people who are overweight may actually have a higher life expectancy...
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...Syner-Tech & Phyto-Alkatech contains the highest level of anti-oxidants with approximately 22,000 phyto-nutrients in one product. PHYTO-ALKATECH A powerful complex of natural Alkaline ingredients designed to enhance the Alkalinity of this formulation and also protect and neutralize possible acid damage when it reaches the stomach. Thus preserving the purity and potency of this breakthrough NATURA-CEUTICALS. SYNER-TECH Embodies the Science & Technology of the Combined Complimentary and Synergistic Effects of Nature’s Most Powerful elements and Phyto-chemical Nutrients. It has been proven over the years that many anti-oxidants are better taken with other anti-oxidants providing a more enhanced effects as compared to taking them alone. Each Capsule Contains: + 29 Vitamins & Minerals (Vitamin A, C, D, E, K, Thiamin, Riboflavin, Niacin, Folic Acid, Calcium, Iron, Iodine, Magnesium, Zinc, Selenium, etc.) + 12 Whole Fruit Juice Blend (Cranberry, Blueberry, Strawberry, Blackberry, Bilberry, Cherry, Plum, Apricot, Papaya,Orange, Grape, Pineapple) + 12 Whole Vegetables Juice Blend (Parsley, Kale, Spinach, Wheat Grass, Brussels, Asparagus, Garlic, Broccoli, Cauliflower, Beet, Carrot, Cabbage) + 14 Green Foods / Spirulina Blend (Spirulina, Alfalfa, Barley grass, Wheat grass, Lemon grass, Dandelion, Melissa, Nettle, Blessed Thistle, Plantain, Cilantro, Blue and Green Algae, Chlorella) + 12 Organic Mushrooms (Cordyceps, Reishi, Shitake, Hiratake...
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...Precision Worldwide, Inc. Case Study Involved Parties: Competitor-French Firm: Henri Poulenc Precision Worlwide, Inc.-German Firm Hans Thorborg-General Manager Gerhard Henk-Sales Manager Bodo Eisenbach- Development Engineer Patrick Corrigan-Parent Company Spokesman Background: Precision Worldwide, Inc. (PWI) manufactures industrial machines and equipment for sale in numerous countries. Repair and replacement parts account for a substantial part of the company’s business. The replacement part in question, steel rings, occur in the machines manufactured only in PWI’s Frankfurt Germany plant, but can also be used on some competitor’s machines. The steel ring manufactured by PWI has an average normal life of about 2 months. Machines require between 2 and 6 rings to operate. Individual rings are replaced as they wear out. Over the years, competition had increased and now a competitor company, the French firm Henri Poulenc, has entered the market with a superior plastic ring that replaces the steel ring. The plastic ring is less costly to manufacture and has a longer life. Situation: The PWI sales manager, Gerhard Henk, is asking when this product will be available for him to sell that his competitor already has on the market, particularly in France where the competitor is the strongest. Bodo Eisenbach, the PWI development Engineer, estimates the plastic rings can be produced in about 4 months at a tool and equipment cost of about $7,500. PWI currently has about $390...
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...An increases lifespan across the globe has led to the increased burden (Both financially and emotionally) of taking care of people with Parkinson’s disease. Patients with Parkinson’s disease have a higher hospitalization rate than the rest of the population with loner hospital rates, higher emergency admissions and generally higher hospital costs. In fact, a research conducted in England found that; there were 324,055 Parkinson's disease admissions in 182,859 patients over 4 years which included 232,905 non-elective admissions (72%). This resulted in expenditure of £907 million (£777 million for non-elective admissions). The main reasons for admission were pneumonia (13.5%), motor decline (9.4%), urinary tract infection (9.2%), and hip fractures (4.3%). These...
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...Wayne Harrison WR 222 24 April 2015 Why You Should Stop Vegetarian Diet In recent years, along with a variety of "diseases of affluence" increased and the wave of slimming craze, the vegetarian diet become more and more fashion in the western countries. Is vegetarian diet really the healthiest way for health and beauty? The answer is no. Vegan/ vegetarian diet is harmful for human beings. It is obvious and scientific that the omnivores is better than vegetarian. As a meat lover, the complete negation of animal foods makes me unacceptable. Eating meat is necessary for the health of humans. The main reason for the vegetarian supporters that they think that just eating plant is enough to stable the body healthy and functioning. But the opposite is true. The vegetarian diet may cause the micronutrient deficiencies and inadequate protein intake. Humans are omnivorous, in our lifestyle, the several of beneficial micronutrient elements are essential. No matter what kind of micronutrient elements lose; it would lead a potential danger for health. Kris Gunnars who works in Authority Nutrition claimed, “Docosahexaenoic Acid (DHA) is the most active form of Omega-3 fatty acids and is mainly contained in animal foods. The plant form of Omega-3s, ALA, is inefficiently converted to DHA for health”(Gunnars). It means that the plants cannot provide all the nutrition for body. The vegans would lose many important micronutrient elements and nutrition. And whatever the vegetarian agree or...
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...Design Flaw and Solution to the Micron Pen 005 Sydney Jacobson University of Minnesota—Twin Cities DES 1101V Intro to Design Thinking Design Flaw and Solution to the Micron Pen 005 Sydney Jacobson University of Minnesota—Twin Cities DES 1101V Intro to Design Thinking Abstract This paper serves to analyze the Micron Pen 005 and its efficiency. Created as a high quality item, with its aptness for high detail and sustainability, the soft tip of the pen shortens the lifespan through attrition. I propose a solution to increase the amount of soft tip available in the pen by redesigning the pen to assimilate a mechanical pencil. I then delve into detail about the Micron Pen 005’s reflection on society in regards to accessibility, quality, and frugality. This analysis is then concluded that my solution would create a more reliable product. Design Flaw and Solution to the Micron Pen 005 Even in today’s technology dependent world, a quality pen is a necessity. People desire something that has permanence and accuracy for daily tasks such as writing reports, scratching down notes, or drawing out rough drafts. A pen that glides onto the paper with precision is necessary to get the job done perfectly. Now enter Sakura’s Micron Pen. Designed with the user in mind, the average person is able to handle it with the simplest of motions. However, specifically with the Micron Pen 005, there are flaws that have some considering this pen as inefficient and thus needs to...
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...The video I watched was a lecture given by Carol Barnes about aging of the brain. The video was part of a special lecture for the Arizona University. There are many mysteries of the brain. This can date back all the way through history. One example is the Egyptian God Thoth. He was in charge of governing memory and wisdom. Aristotle believed new impressions remain in young age and the surface of the brain as we age is no longer. This makes me wonder if people in history were questioning the longevity of the brain why has it taken so long to understand the concept now? The idea can be very scientific but the common conception is when we are over 50 years we become senescent, which leads to being senile, and having dementia. Today we can contribute this idea to genetics, environment, and life style. The idea of diseases such as Alzheimer’s is based on a change in brain pathology. As we age there is change taking place in memory and learning, which does not mean you are senile or have a cognitive disease. There are many influences someone puts on themselves that can contribute to the decline in brain health. This includes smoking, using too much alcohol, and...
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...building more dynamic, more diverse portfolios that these times require. Investing for a New World™ is designed to help investors large and small confront the challenges of low yields and volatile markets in today’s complex investment environment. The multi-media initiative – the first of its kind by BlackRock – includes a range of ongoing communications for retail and institutional investors, partners and financial advisors, as well as investor education and advertising in a variety of digital, print and social media around the world. “Investors are looking for answers in a new world where the returns they once took for granted are constrained by historically low yields, market volatility and shifting investment patterns. With today’s longer lifespans and uncertain returns, people are concerned about outliving their money in retirement and funding their children’s education. Wherever I go, the question I hear most often is: ‘So what do I do with my money?’ and we’re stepping forward to provide answers,” said Laurence D. Fink, BlackRock’s Chairman and Chief Executive Officer. “We have a responsibility to our clients – and the working people and retirees many of them serve – as well as to our shareholders to offer straight talk and practical guidance for investors. That’s especially true now, as we have grown and moved deeper into serving individuals through their financial advisors....
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...participation are crucial for health, well-being, and longevity. It is the inequality in these that plays a big part in producing the social gradient in health” (Marmot). People constantly compare themselves constantly based on jobs, income, or cars, and the lower socioeconomic classes have little control on how to spend their money, using it all towards shelter, transportation, and bills. They need their income to survive and cannot purchase items of status, which increases their stress, for they cannot reach a higher societal status. Work overtakes their lives, leaving them little time for social engagements. Planned Parenthood reduces one less cost, healthcare, and provides them both preventative and family planning services. By practicing preventative care, lower class individuals may miss fewer days of school, participate in more activities, and work more often, and with a higher education, a person can receive a better job, increasing their status. Also, it provides birth control, for a child changes everything, particularly teenagers, restricting their time for school and friends. By simply finishing high school, this increases your lifespan, and it gives you more autonomy in job choices and the option to spend more time on social relationships. Planned Parenthood provides individuals health services that prevents illnesses and it indirectly affects a person's social status, possibly increasing a person's lifespan. The Fundamental Cause hypothesis provides another explanation...
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...Farmacias Similares (Simi): Company Overview Founded by Victor Gonzalez Torres, Farmacias Similares is a pharmacy chain in Mexico dedicated exclusively to generic medicines, with their merchandise priced at least 30% lower than that of traditional branded medications. Using their publicity campaign slogan, loosely translated as “the same, but cheaper,” the stores targeted their sales at the low-income uninsured/underinsured “base of the pyramid” health care consumers in Mexico. In addition, Gonzalez Torres owned various other companies that did business related to Simi, such as Best Labs, Pharmacy Plastics (which produced pill containers), Pharmacy Transports (in charge of delivering merchandise to the Simi chain,), and SimiSeguros’ (Chu & Garcia-Cuellar, 2007). Simi: Mission, Vision, and Value Ananlysis Mission - Improve the level of human life by offering products and services of quality to all health. Vision - Be recognized as a model of quality, service and confidence, with efficient processes, in a pleasant working environment which generate well-being and pride in belonging. Values – Generosity, Commitment, Service Positive Aspects: As stated by Hill & McShane, a mission statement defines the purpose of the organization and focuses on the needs of the customer. Simi’s mission statement meets this criterion. Hill & McShane also state that a vision statement defines the desired future state of an organization and results in the generation of strategies...
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