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Measles and Mumps Microbiology

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Submitted By foxglove
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Measles virus

Paramyxovirus
Morbillivirus
150 – 300 nm
Single strand RNA

Enveloped

Mumps virus
Paramyxoviru
Rubulavirus
60 – 70 nm
Enveloped
Single strand RNA

Heat
Light
Acidic pH
Ether
Trypsin
< 2 hours in the air

objects surfaces Respiratory Droplet Inhaled
Manually
Entry into body travels Throat
Lungs

Incubation period 14 days
4 days before – 4 days after Rash

High fever (up to 105°F or 40.6°C)
Tiredness
Muscle and body aches
Irritability
Conjunctivitis
Runny nose
Hacking cough
Koplik’s spots

Respiratory conditions
Eye conditions including blindness
Diarrhea
Ear infections
Stomach pain
Pneumonia
Encephalitis
Seizures
Death
Miscarriage

Normal childhood disease

50% of children had by age 6
90% of children had by age 15
3,000,000 to 4,000,000 cases annually
400 – 500 deaths

1,000 cases of Measles Encephalitis

1963 Measles vaccine
2000 Elimination Declared
1989 – 1991 55,622 cases reported
2nd dose of measles vaccine
1993 – Today

Fever
Tiredness
Muscle and Body aches
Loss of appetite
Sore throat
Chills

Swelling of the Parotid gland
Last about a week

2/3 cases - 5 days later
Swelling the other Parotid gland

Parotid gland
Meninges
Breasts
Liver
Pancreas
Thyroid
Heart
Testes or ovaries
Kidneys

Encephalitis and Meningitis
Inflammation of the testes
Inflammation of the ovaries and/or breasts
Miscarriage
Deafness
Pancreatitis

< 1967 100,000 to 200,000 cases
90% were < 15 yrs of age

Currently < 300

30 – 40% > 15 yrs of age

December 2005 to May 2006

1,824 reported cases in Iowa
Begun at Iowa College Campus

Possible spread to 11 state
Same genotype on in U.K. - 70,000 cases

No Cure
Drink plenty of Liquids
Rest
Nonsteroidal anti-inflammatory (Ibuprofen)
Cold compress for swollen glands
Soft/Liquid/Bland diet
Mumps immunoglobulin M (IgM)
Serum mumps immunoglobulin G (IgG)
Isolation of mumps virus from clinical specimen Detection of mumps viral RNA

1963 Measles - 1967 Mumps - 1971 MMR

12-15 months of age
4-6 years of age
28 days apart

Some are not vaccinated

MMR rare in the U.S.

Common, Epidemic parts of the World
#1 cause outbreaks

Foreign travel

eMedTV.com. “Mumps.” 3 July 2008. Schoenstadt, Arthur MD., http://mumps.emedtv.com/mumps/mumps.html eMedTV.com. “Measles.” 13 March 2009. Schoenstadt, Arthur MD., http://measles.emedtv.com/measles/measles.html CDC.gov. “Vaccines Work.” 9 June 2006 http://www.cdc.gov/vaccines/news/newsltrs/imwrks/2006/200606.htm Medical-dictionary.thefreedictionary.com http://medical-dictionary.thefreedictionary.com/Paramyxoviridae Tortora, Funke, and Case. Microbiology an Introduction. Edition 9. California: Person, 2007

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