...The field of epigenetics allows us to get a better understanding of the effects of stress and how it can have a prolonged impact on gene activity. Many studies(N.A Hazel et al., 2005, V.J. Felitti 2002, Franklin et al., 2010) carried out on humans and animals have shown that even early life stress can lead to epigenetic changes which can affect us in adulthood. These changes can make us more susceptible to many neuropsychiatric and cardiovascular disorders. In a study carried out by Nätt et al., 2015 the epigenetic mechanisms caused by high stress levels were studied in children. They measured the levels of cortisol in children’s hair (assuming that stress levels were correlated with cortisol levels), according to this the children were divided into high and low stress groups....
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...Epigenetics What is epigenetics? Epigenetics refers to external modifications to DNA that turns genes "on" or "off". The DNA sequence is not changed, these modifications just affect how the genes are read. Epigenetic regulation involves the modification of DNA and the proteins associated with DNA, which results in changes to the conformation of DNA without a change in its sequence. In some cases, epigenetic modifications are stable and passed down to future generations, but in others cases they are dynamic and change in response to environmental stimuli. Two common molecular mechanisms that regulate epigenetics are DNA methylation and histone modifications. Epigenetic processes are essential for development and differentiation, but they...
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...What is Epigenetics? Conrad Waddington presented the term epigenetics in the early 1940s. Epigenetics referred to all molecular passageways moderating the expression of a genotype into a particular phenotype. The term epigenetics refers to heritable variations in gene expression that does not include changes to the original DNA sequence. It is actually a change in phenotype without a change in genotype. Epigenetic change is a consistent and natural existence but can also be influenced by several factors including age, the environment and disease state. Epigenetic change can have more destructive effects that can result in diseases like cancer. At least three systems including DNA methylation, histone modification and non-coding RNA are considered...
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...Santina Wood ENG101 Argosy University 03/4/2014 Instructor Benjamin Atkins Epigenetics -vs- Nature -vs- Nurture The nature vs nurture debate is still ongoing, and within this debate, the world of science and psychology are faced with two new questions. Today we find some researchers asking; "Is development predetermined at birth, by hereditary factors, or do experience and other environ -mental factors affect it?", and "Can the two work together in shaping human development and behavior?" Developmental psychologists still attempt to find the answers to these questions in order to discover the sources of growth in children's cognitive, language, and social skills. Most developmental psychologists believe that nature and nurture combine to influence biological factors playing a stronger role in some aspects, such as physical development, and environmental factors playing a stronger role in others, such as moral development. They are also beginning to acknowledge the role of a variable combination of both inborn factors and social experiences when explaining children's behavior. Scientists and Psychologists have a name for such an occurrence; epigenetics/epigenesis. In this essay, I will be presenting to my audience information on this highly, and sometimes heated debate, as well as the reasons as to why the belief of this dual influence called epigenetics is becoming more fact than theory. For as long as there has been life, and those...
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...Are Imprinted Genes Adaptive or Maladaptive? Epigenetics is referred to be the study of heritable changes other than those in the DNA sequence that encompass two major modifications of DNA or chromatin: DNA Methylation, the covalent modifications of cytosine, and post-translation modification of histones including methylation that is a highly intricate process that occurs within each cell as well as supplying fluid in the brain and within the liver, acetylation , phosphorylation and sumoylation (Callinan and Feinberg 2006) which is the is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle . Epigenetics is the mechanism that leads to parent-of-origin effects via imbalanced expression of maternally and paternally inherited copies of a gene. It plays a role in several Mendelian diseases and there is growing evidence for its role in common diseases as well as cancer. It is a dynamic mechanism with varying degrees of monoallelic expression between tissues and developmental stages (Wolf et al. 2008; Kong et al. 2009; Skaar et al. 2012; Lawson et al. 2013; Peters 2014). In addition, recent evidence suggests that noncoding RNAs predominantly microRNA contribute to the stock of epigenetic mechanisms that are found in major diseases and that can occur at critical developmental times (Esteller 2011)...
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...Epigenetic marks are paving the way for cell research and the health of future generations. These new developments allow us to make changes in our diets and behaviors to positively impact our offspring and our grandchildren. We might also hold the key to preventing cancer, saving lots of lives every year. Epigenetic marks (EM) are in all DNA and play a huge roll in how we act, our health, and our mentality. These EMs lay on the chromatin and affect how the cell reads the DNA. The EMs tell the cell what to do. They also chose what genes to turn on and turn off. This turning on and off of genes are the key to the health component of EM. Research has been done over the past few years and the studies show that silencers turn on and off...
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...Epigenetic adjustment the regular and natural occurrence also can be effected by several factors including age , Epigenetic changes can show as ordinarily as the way in which cells terminally separate to wind up as skin cells, liver cells, brain cells, and so forth. On the other hand, epigenetic change cadditionally harming impacts that can result in diseases like cancer . Examples of epigenetics : Epigenetic changes modify the physical structure of DNA. One case of an epigenetic change is DNA methylation — the expansion of a methyl group, or a chemical cap , to part of the DNA particle or molecules , which keeps certain genes from being communicated or expressed...
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...Chelsea Doolittle College Biology 11.3.2015 Mr. Muller Epigenetics Epigenetics is the study, in the field of genetics, of cellular and physiology phenotypic trait variations that are caused by external or environmental factors that switch genes on and off. The term epigenetics refers to heritable changes in gene expression, active versus inactive genes, that does not involve changes to the underlying DNA sequence which is a change, in phenotype without a change in genotype. Often the genome changes and does not become involved with the DNA. Identical twins make scientist question nature versus nurture. Many times identical or fraternal twins...
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...heritable genetic material, other factors, including the environment are considered to play an important role in the activity and expression of those genes. Summarize the role that epigenetics & developmental epigenetics play in health & disease. Epigenetic modifications are a dynamic process reflecting a complex interplay between an organism and its environment. For example, the acetylation of lysine residues in histone subunits usually can result in promoting gene transcription, or the methylation of Lys9 or Lys27 of histone H3 is correlated with gene repression. However, the methylation of Lys4, Lys36, or Lys79 of H3 is ordinarily associated with gene activity[44]. The heritable quantity of gene expressions is about 30%, while this percentage is decreased to about 23% in cells grown in culture. Such associations between methylation levels and genetic variations have...
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...Epigenetics Can what our ancestors and grandparents experienced environmentally effect what we or our children’s development or health be? Epigenetics is where our genes can be turned on or off and how our cells read our genes. What our ancestors, grandparents and parents were exposed to can have a long term effect on how we end up with specific diseases and also our emotional state. Documentary Review We came to learn how we as humans are created or put together in the early 90’s with the human genome project, which was going to help and allow us to find the genetic cure and diagnosis for every disease, but in the end it didn’t allow us to have all the answers. In the documentary I learned that we have several illnesses and diseases that are in our genetic code already, but then we have some that are caused by changes in how our genes are structured that we have inherited from our...
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...Introduction: Epigenetics is the study of heritable variations in gene activity and expression without alternation in DNA sequence, this kind of stable alternations can be passed down to progeny in short term, however, in some broader definitions, heritability is not necessary condition, for example, in the overview of the Roadmap Epigenomics Project, epigenetics is regarded as ‘also stable, long-term, alterations in the transcriptional potential of a cell that are not necessarily heritable’. Patterns of epigenetic modifications are thought to include: (1) methylation on cytosine (DNA methylation); (2) modification of histone proteins and chromatin architecture; (3) small and non-coding RNA-based mechanisms. Two major epigenetic modifications: DNA methylation and histone modifications have been focused in studies of development and cell proliferation over the past few years [1,2]. Recently, the epigenetic modifications are found associating with memory, behaviour and environment. For instance, memories formation, dynamic regulation in behaviour changes...
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...One of the most intriguing medical mysteries today is autism, research in this area has exploded within the past decade. Medical professionals and other researchers are looking at a variety of different areas that might provide important insight on mechanisms that may cause this disorder. Epigenetics is the study of how various changes may arise from gene expression rather than alterations in the genetic code itself. The connection between epigenetics and autism is best articulated by Dr. Alycia Halladay, the director of research for environmental sciences for Autism Speaks. Dr. Halladay explains, “because epigenetics gives us a way to look at the interaction between genes and environment, it holds great potential for identifying ways to prevent or reduce the...
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...Epigenetics: What is it and how does it influence human health? 1.1 Introduction The classic approach to genetics cannot explain such things like the dissimilarity of phenotypes in a population or why monozygotic twins have different phenotypes. Epigenetics is used to describe how changes like this happen (Esteller, 2008). The word epigenetics originates from the Greek word epi which means over, above or outer and it describes processes above genetics, which refers to above the order of base-pair nucleotides in the DNA making the genes (Mc Ewen, 2015). Epigenetics can be defined as genetic operations that make phenotypic changes without changing the base pair nucleotide sequence (Gilbert and Epel, 2009). These changes repeat during many...
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...Epigenetics is the study of chemical changes that alter the genome and lead to a resultant change in expression of the genes. These changes may result in detrimental effects, especially in an individual's early life, when most organs are developing. Epigenesist brings such changes in development because it will lead to expression of undesired proteins from the genome which the core requirement for phenotypic expression (Mitchell et al., 2013). After the process, the genomes formed will be different from the usual ones hence a different protein will be expressed by the affected cell; and this may be an adverse effect. The epigenetics video shows how various chemical modifications occur to the genome, interacting specifically with DNA, and the...
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