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Osteoporosis: Anatomy And Physiology

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Osteoporosis Research Paper

Ericson Yabut
Anatomy and Physiology 200A
Dr. Edward Eivers
2/14/16

Introduction: Normal Physiology of the Bone
It is important to know the fundamental aspects of the skeletal system and the normal anatomy and physiology of the bone tissue in the system to understand osteoporosis. The skeletal system of the human body is essential in many functions, such as supporting body structure, storing minerals and bone growth factors, and being used as leverage for skeletal muscle locomotion. The skeletal system used to be made of hyaline cartilage, but the cartilage eventually ossifies into bone tissue as the body continues to age develop into adulthood. Bone growth and development is strongly affected by …show more content…
In bone remodeling, osteoblasts and osteoclasts serve as remodeling units that try to keep constant bone mass dependent on blood calcium levels. Osteoclasts are a part of a homeostatic negative feedback loop that involves increasing blood concentration of calcium levels needed for important physiological processes. Under blood calcium level decline, the parathyroid gland secretes parathyroid hormones (PTH), which stimulate the osteoclasts to resorb old and new bone matrix to release calcium into the blood. As blood calcium levels rise, parathyroid gland stops secreting PTH to stop the osteoclasts’ bone resorption. Next, osteoblasts secrete unmineralized bone matrix to make up for the loss of bone tissue and calcify the matrix by taking calcium from the blood, which contributes to the drop in blood calcium levels. This stimulates more PTH to be released to reactivate osteoclasts to repeat the process. While hormonal controls determine the need for remodeling, mechanical stress direct the locations of …show more content…
The reduction of bone mineral density is due to the higher rate of bone resorption than the rate of bone deposit. Because osteoporosis breaks down bone more than deposit bone, the bone tissue loses bone mass and becomes more light and fragile. As bones become more fragile, they are more likely to fracture, which means that the victim can break bone from a simple sneeze or a bump. In contrast to the smooth surface of normal bone, osteoporotic bone’s microarchitectural surface is more porous due to the lack of bone deposit activity to make up for resorbed

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