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Cerebrovascular Disease Research Paper

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Chapter four

CEREBRO-VASCULAR DISEASE

Cerebrovascular disease is a leading cause of disability and death worldwide. The main disorders in this group of neurological disease are stroke, multi infarct (vascular) dementia, spontaneous subarachnoid haemorrhage and acute and chronic subdural haematoma.

STROKE

Definition and epidemiology
Stroke, also called a cerebrovascular event (CVE), is a focal neurological deficit that occurs suddenly and lasts more than 24 hours, or results in death, and can only be explained by vascular occlusion or haemorrhage. This condition is referred to as a transient ischaemic …show more content…
The total annual incidence of stroke (i.e. first-ever stroke and recurrent stroke) in the UK is between 100 and 290 per 100,000 of the population. There are variations between countries in the age-adjusted incidence of stroke which can be explained by ethnic, environmental and cultural behavioural differences in life style, and by socio-economic factors.

The incidence of stroke increases with increasing age and after the age of 55 years the risk of having a stroke doubles every 10 years. Men tend to have more strokes than women of the same age. Stroke in childhood and in young adults is relatively rare except in those with haemoglobinopathies, such as sickle cell disease.

Stroke risk factors
A stroke risk factor is a condition that predisposes to stroke and also predicts the recurrence of stroke in a person who had a previous cerebrovascular event. The main risk factors for stroke and TIA are old age, Afro-Caribbean, Japanese, or Chinese ethnic origin, hypertension, atrial fibrillation, diabetes mellitus, hyperlipidaemia, cigarette smoking and severe carotid artery stenosis. Frequently, more than one of these factors are present in the same …show more content…
In addition, dysphagia, fatigue, sleep disturbances and depression are common after stroke. The clinical features largely depend on the size and site of the infarct or haemorrhage and the condition of the collateral cerebral circulation. There is a good correlation between the clinical features of stroke and the vascular territory involved. Several stroke syndromes can be identified.

Stroke involving the middle cerebral artery (MCA) is common. The lenticulostriate branch of the MCA supplies the internal capsule, the corona radiata and part of the basal ganglia. The superficial branches supply the sensory and motor cortex (except the leg area), and the auditory and language areas. Consequently, MCA stroke typically results in hemiplegia (the arm is affected more severely than the leg), hemisensory loss and hemianopia. In addition, apraxia and aphasia are present with dominant hemisphere lesions and left hemispatial neglect and constructional apraxia with non-dominant hemisphere stroke. By contrast, stroke in the anterior cerebral artery territory is rare and causes crural monoplegia (weakness of one leg) or hemiparesis that predominantly affects the

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